Patents Represented by Attorney Sewall P. Bronstein
  • Patent number: 4872561
    Abstract: A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula:(CNX)R,where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR.sup.1 and CONR.sup.2 R.sup.3 where R.sup.1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms. R.sup.2, and R.sup.3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3 can be the same of different is disclosed. Kits that can be used to form these complexes are also disclosed.
    Type: Grant
    Filed: December 29, 1987
    Date of Patent: October 10, 1989
    Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Alun G. Jones, Alan Davison, James Kronauge, Michael J. Abrams
  • Patent number: 4826961
    Abstract: A method for preparing radiopharmaceutical complexes that are substantially free of the reaction materials used to produce the radiopharmaceutical complex is disclosed. The method involves admixing in a suitable first solvent in a container a target seeking ligand or salt or metal adduct thereof, a radionuclide label, and a reducing agent for said radionuclide, thereby forming said radiopharmaceutical complex; coating the interior walls of the container with said pharmaceutical complex; discarding the solvent containing by-products and unreacted starting reaction materials; and removing the radiopharmaceutical complex from said walls by dissolving it in a second solvent, thereby obtaining said radiopharmaceutical complex substantially free of by-products and unreacted starting materials.
    Type: Grant
    Filed: January 22, 1987
    Date of Patent: May 2, 1989
    Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Alun G. Jones, Alan Davison, Michael J. Abrams
  • Patent number: 4757006
    Abstract: The protein having factor VIII:C procoagulant activity has been produced by culturing a cell transformed with a recombinant expression vector encoding the gene for that activity.
    Type: Grant
    Filed: October 28, 1983
    Date of Patent: July 12, 1988
    Assignee: Genetics Institute, Inc.
    Inventors: John J. Toole, Jr., Edward Fritsch
  • Patent number: 4746505
    Abstract: A bisamide-bisthiol ligand containing fatty acid substituted thiol useful for producing Tc-labelled radiodiagnostic imaging agents is described. The ligand forms a complex with the radionuclide .sup.99m Tc suitable for administration as a radiopharmaceutical to obtain images of the heart for diagnosis of myocardial disfunction.
    Type: Grant
    Filed: April 26, 1985
    Date of Patent: May 24, 1988
    Assignees: President and Fellows of Harvard College, Children's Medical Center Corp., Massachusetts Institute of Technology
    Inventors: Alun G. Jones, John Lister-James, Alan Davison
  • Patent number: 4735793
    Abstract: A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula:(CNX)R,where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR.sup.1 and CONR.sup.2 R.sup.3 where R.sup.1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, R.sup.2, and R.sup.3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3 can be the same or different is disclosed. Kits that can be used to form these complexes are also disclosed.
    Type: Grant
    Filed: August 30, 1985
    Date of Patent: April 5, 1988
    Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Alun G. Jones, Alan Davison, James Kronauge, Michael J. Abrams
  • Patent number: 4707544
    Abstract: A method for preparing a coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta is disclosed. The method comprises preparing a soluble metal adduct of said isonitrile ligand by admixing said ligand with a salt of a displaceable metal having a complete d-electron shell selected from the group consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi to form a soluble metal-isonitrile salt, and admixing said metal isonitrile salt with a salt comprising said radioactive metal in a suitable solvent to displace said displaceable metal with the radioactive metal thereby forming said coordination. The complex is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells containing lipid membranes, such as blood clots, myocardial tissue, gall bladder tissue, etc.
    Type: Grant
    Filed: November 28, 1984
    Date of Patent: November 17, 1987
    Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Alun G. Jones, Alan Davison, Michael J. Abrams
  • Patent number: 4638032
    Abstract: A support system for organic synthesis comprising magnetic particles in a dispersion medium covalently attached to functional groups having affinity for polymer subunits, and methods for making and using the support system, e.g. for synthesis of oligodeoxynucleotides and polypeptides.
    Type: Grant
    Filed: August 10, 1984
    Date of Patent: January 20, 1987
    Assignee: Genetics Institute, Inc.
    Inventor: Steven A. Benner
  • Patent number: 4596773
    Abstract: A sterilization indicator for testing the effectiveness of a sterilization process and a sterilization process using such an indicator are described. The indicator includes a container for holding a number of viable microorganisms and a quantity of nutrient medium; a separation member that prevents the nutrient medium from contacting the microorganisms; a penetration member that penetrates the separation member to allow the nutrient medium to contact the microorganisms and a cap, coupled to the penetration member, to seal the microorganisms and nutrient medium within the container.
    Type: Grant
    Filed: September 30, 1983
    Date of Patent: June 24, 1986
    Assignee: Concord Laboratories, Inc.
    Inventor: Robert P. Wheeler, Jr.
  • Patent number: 4590919
    Abstract: The cover guard includes an invertible hood consisting of a top section including an opening, of a side wall section and a skirt section, the latter consisting of a grooved section and a level section such that the cover guard may be placed on a cooking vessel such that the level section rests on the upper edge or rim, respectively, of the vessel. This design of the skirt section secures on the one hand a safe resting of the cover guard on the cooking vessel and on the other hand an impeccable dripping off of any material condensed on or having been splashed against the hood.
    Type: Grant
    Filed: January 14, 1985
    Date of Patent: May 27, 1986
    Assignee: Lispa R. Lichtenstein
    Inventors: Toni Spani, Rita Lichtenstein
  • Patent number: 4529882
    Abstract: A gamma radiation camera and a method are disclosed for creating an image of the radiation density of a source of photons. The camera comprises a detecting device made with solid-state material capable of generating electron-hole pairs as a result of collisions between photons and such material. The camera further includes an identifying device which identifies an ordered pair of said collisions in which both collisions result from a common photon. The camera further includes apparatus for determining an image of said source of common photon from the locations of the collisions of, and the number of electron-hole pairs generated by said ordered pair of collisions.The apparatus for determining an image determines a collision line between two collisions of an ordered pair, and determines the angle of Compton scattering relative to the collision line which occurs at a first of the collisions of such a selected pair.
    Type: Grant
    Filed: August 9, 1982
    Date of Patent: July 16, 1985
    Assignee: E. I. du Pont de Nemours & Company
    Inventor: Denny L. Y. Lee
  • Patent number: 4526776
    Abstract: An hepatobiliary imaging agent is disclosed which is a cationic complex of Tc-99m, a cyanate or thiocyanate ion, and a mono or polydentate organic ligand having one or more donor atoms, each with a free-electron pair available for accepting a proton or for complexing with Tc-99m to form a cationic complex. These complexes can provide images of the hepatobiliary transit in as little as ten minutes.
    Type: Grant
    Filed: April 15, 1983
    Date of Patent: July 2, 1985
    Assignee: E. I. du Pont de Nemours & Company
    Inventors: Vinayakam Subramanyam, Algis Rajeckas
  • Patent number: 4525454
    Abstract: A process is described for producing L-4-phenyl-2-amino butanoic acid. The process comprises reacting 4-phenyl-2-oxobutanoic acid or an ester thereof with L-aspartic acid in the presence of transaminase enzyme to produce L-4-phenyl-2-aminobutanoic acid and oxaloacetate, and decarboxylating said oxaloacetate.
    Type: Grant
    Filed: August 23, 1984
    Date of Patent: June 25, 1985
    Assignee: Genetics Institute, Inc.
    Inventor: J. David Rozzell
  • Patent number: 4522742
    Abstract: Water soluble fluors useful in enhancing images obtained in autoradiography have the general formula:[F].sub.x [B].sub.y [S].sub.zF is a moiety which acts as a fluor, e.g., a dehydro derivative of a compound which is a fluor; preferred examples include 4-(2,5-diphenyloxazolyl), 1-naphthylmethyl, 2-naphthyl, and 4-[5-(2-phenyloxazolyl)]phenyl. S is a surfactant moiety which makes the molecule hydrophilic, e.g., dehydro derivatives of surfactants; preferred examples include polyethylene glycol derivatives, sulfonic acids or salts thereof, aryl sulfonates, amines and quaternary ammonium compounds. B is a binding moiety which chemically binds the fluor moiety F with the surfactant S, and may be a chemical bond, or a disubstituted moiety such as an alkylene, e.g., methylene group. The variables x, y and z are integers which can generally vary from 1 to 10.
    Type: Grant
    Filed: February 25, 1982
    Date of Patent: June 11, 1985
    Assignee: E. I. Du Pont de Nemours and Company Inc.
    Inventors: Duk H. Lee, Susan Feierberg, Robert E. O'Brien
  • Patent number: 4520146
    Type: Grant
    Filed: September 27, 1983
    Date of Patent: May 28, 1985
    Assignee: Canusa Coating Systems Limited
    Inventor: Ralph H. Hansen
  • Patent number: 4518692
    Abstract: A process is described for producing alpha amino acids or derivatives thereof. The process comprises reacting an alpha-keto acid with L-aspartic acid in the presence of transaminase enzyme to produce (1) an alpha amino acid corresponding to said alpha-keto acid and (2) oxaloacetate; and decarboxylating said oxaloacetate.
    Type: Grant
    Filed: September 1, 1983
    Date of Patent: May 21, 1985
    Assignee: Genetics Institute, Inc.
    Inventor: J. David Rozzell
  • Patent number: 4514533
    Type: Grant
    Filed: September 27, 1983
    Date of Patent: April 30, 1985
    Assignee: Canusa Coating Systems Limited
    Inventor: Ralph H. Hansen
  • Patent number: 4512967
    Abstract: A cationic lipophilic complex of technetium is disclosed wherein all of the coordination positions of the technetium atom are filled with a neutral donor atom having a pair of electrons available for forming a coordinate bond with technetium. The donor atoms are provided by target-seeking ligands or salts thereof, said ligands having the following structure of one of formulas I, II or III. Such complexes are useful for imaging heart and hepatobiliary tissues.
    Type: Grant
    Filed: August 2, 1982
    Date of Patent: April 23, 1985
    Assignee: E. I. Du Pont de Nemours and Compamy
    Inventor: Karen E. Linder
  • Patent number: 4505888
    Abstract: An improved tracer particle is described comprising an ion exchange core having a polymer coating thereon, the coated ion exchange core having a reaction site capable of reacting with a compound containing an oxirane group, said coated ion exchange core having been treated with a compound containing an oxirane group to react with said coated ion exchange core causing an increase in mass of the tracer particle. Preferably, the ion exchange core is labelled with a radionuclide. These particles have improved characteristics including improved stability against leaching and improved handling properties. Such particles are useful in circulatory determinations involving the injection of the particles as a suspension in a physiologically acceptable carrier or medium into the circulatory system of animals.
    Type: Grant
    Filed: May 27, 1983
    Date of Patent: March 19, 1985
    Assignee: E. I. Du Pont de Nemours & Company
    Inventors: Herbert Moore, Stephen Santos, Robert D. Wysong
  • Patent number: 4498048
    Abstract: An NMR imaging apparatus is described having a desired imaging volume for imaging of biological tissue, said apparatus comprising bias means for generating a bias field, means for generating gradient fields, and radio frequency means for applying a pulse of electromagnetic radiation to the biological tissue and for detecting the resultant signals emitted from said tissue; wherein said bias means comprises a plurality of dipole ring magnets, each dipole ring magnet comprising a plurality of segments, each segment comprising an oriented, anisotropic permanent magnet material arranged in a ring so that there is a substantially continuous ring of permanent magnet material; wherein the inner radius of at least one dipole ring magnet is different from the inner radius of an adjacent dipole ring magnet.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: February 5, 1985
    Assignee: E. I. Du Pont de Nemours and Company, Inc.
    Inventors: Denny L. Y. Lee, Robert D. Hay
  • Patent number: 4497790
    Abstract: The present invention relates to methods for making cationic radiodiagnostic agents and, in particular, to methods for preparing .sup.99m Tc-labelled cationic radiodiagnostic agents.
    Type: Grant
    Filed: September 3, 1982
    Date of Patent: February 5, 1985
    Assignee: E. I. du Pont de Nemours and Company, Inc.
    Inventor: Manuel S. Rodriguez