Patents Represented by Attorney Stephen B. Davis

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  • N-Acyl-.gamma.-glutamyl imino and amino acids and esters
    Patent number: 4568489
    Abstract: Compounds of the formula ##STR1## wherein X is various imino or amino acids or esters are disclosed. These compounds possess angiotensin converting enzyme inhibition activity and depending upon the definition of X also possess enkephalinase inhibition activity.
    Type: Grant
    Filed: June 29, 1984
    Date of Patent: February 4, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: David Floyd
  • Certain 3-phosphinyl-2-oxo-piperidine-1-acetic acid derivatives having anti-hypertensive activity
    Patent number: 4567167
    Abstract: Phosphonamide substituted lactams of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents.
    Type: Grant
    Filed: November 28, 1984
    Date of Patent: January 28, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Donald S. Karanewsky
  • Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides
    Patent number: 4560506
    Abstract: Compounds of the formula ##STR1## wherein A is a cycloalkyl ring, a substituted cycloalkyl ring, a phenyl ring, or a substituted phenyl ring and ##STR2## are various dipeptide groups are disclosed. The compounds possess angiotensin converting enzyme inhibition activity and depending upon the terminal amino acid may also possess enkephalinase inhibition activity.
    Type: Grant
    Filed: May 25, 1984
    Date of Patent: December 24, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Eric M. Gordon, Norma G. Delaney
  • Phosphinylmethylaminocarbonyl imino acid compounds useful for treating hypertension
    Patent number: 4560681
    Abstract: This invention is directed to phosphinylmethylaminocarbonyl imino acid compounds of the formula ##STR1## wherein X represents various unsubstituted or substituted imino acids or esters.
    Type: Grant
    Filed: March 9, 1984
    Date of Patent: December 24, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Donald S. Karanewsky
  • Intermediates for preparing amino thiol dipeptides
    Patent number: 4558150
    Abstract: Intermediates of the formula ##STR1## are disclosed. These compounds are useful in the preparation of amino thiol dipeptides possessing angiotensin converting enzyme inhibition activity and enkephalinase inhibition activity.
    Type: Grant
    Filed: December 10, 1984
    Date of Patent: December 10, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Jollie D. Godfrey, Jr.
  • Phosphorus containing compounds and use as hypotensives
    Patent number: 4555506
    Abstract: Phosphorus containing compounds of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid and A is ##STR2## These compounds possess angiotensin converting enzyme activity and are thus useful as hypertensive agents.
    Type: Grant
    Filed: December 24, 1981
    Date of Patent: November 26, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
  • Wound care and drainage system having hand access port
    Patent number: 4553967
    Abstract: A pouch having a bottom wall secured to an adhesive layer that can be cut to fit around a wound or surgical opening, gusseted side walls, and a top wall provided with one or more access openings. An irrigation port and a catheter access port can be secured to these top wall openings. The bottom wall extends beyond the adhesive layer and is provided with a large exit port oriented so that gravity will drain wound exudate from the pouch. This exit port is also large enough to accommodate a hand to aid in locating the pouch on the body and permit access to the wound site without removing the pouch from the body.
    Type: Grant
    Filed: October 14, 1983
    Date of Patent: November 19, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Keith Ferguson, Nancy McClees
  • Adhesive composition resistant to biological fluids
    Patent number: 4551490
    Abstract: Medical grade pressure sensitive adhesive compositions comprising a homogeneous mixture of one or more polyisobutylenes or blends of one or more polyisobutylenes and butyl rubber, one or more styrene radial or block type copolymers, mineral oil, one or more water soluble hydrocolloid gums, and a tackifier. One or more water swellable cohesive strengthening agents, an antioxidant, and various other optional ingredients may be included within the adhesive composition.
    Type: Grant
    Filed: December 30, 1983
    Date of Patent: November 5, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Arthur Doyle, Frank M. Freeman
  • Dressings, granules, and their use in treating wounds
    Patent number: 4538603
    Abstract: This invention is directed to an occlusive dressing useful for treating skin lesions and a granular material capable of interacting with wound exudate. Wounds emitting a large amount of fluid can be treated by first packing with the granular material and then covering the wound with the occlusive dressing.
    Type: Grant
    Filed: February 27, 1985
    Date of Patent: September 3, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: John M. Pawelchak, Frank M. Freeman
  • Substituted 4-phenoxy or 4-phenylthio prolines
    Patent number: 4536501
    Abstract: Compounds of the formula ##STR1## are disclosed. They possess angiotensin converting enzyme inhibition activity and diuretic activity and are therefore useful as antihypertensive agents.
    Type: Grant
    Filed: March 30, 1984
    Date of Patent: August 20, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph E. Sundeen, Rudiger D. Haugwitz, Peter W. Sprague
  • Intermediates for substituted peptide compounds
    Patent number: 4535176
    Abstract: Intermediates of the formula ##STR1## are disclosed. These compounds are useful in preparing substituted peptide compounds which possess hypotensive and analgesic activity.
    Type: Grant
    Filed: May 29, 1984
    Date of Patent: August 13, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Eric M. Gordon
  • Certain 3-phosphinyl-amino-2-oxo-1H-azepine-1-acetic acid derivatives having anti-hypertensive activity
    Patent number: 4533661
    Abstract: Phosphonamide substituted lactams of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents.
    Type: Grant
    Filed: March 28, 1983
    Date of Patent: August 6, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Donald S. Karanewsky
  • Acyloxyketone substituted imino and amino acids
    Patent number: 4524212
    Abstract: Acyloxyketone substituted imino and amino acids of the formula ##STR1## are disclosed. These compounds are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
    Type: Grant
    Filed: September 27, 1982
    Date of Patent: June 18, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Jollie D. Godfrey, Jr.
  • Hydroxy substituted peptide compounds
    Patent number: 4514391
    Abstract: Hydroxy substituted peptide compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: July 21, 1983
    Date of Patent: April 30, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Jollie D. Godfrey, Jr., Sesha I. Natarajan
  • Acylamino oxo or hydroxy substituted alkylamino thiazines and thiazepines
    Patent number: 4512988
    Abstract: Compounds of the formula ##STR1## and X is an oxo substituted thiazine or thiazepine are disclosed. These compounds possess angiotensin converting enzyme inhibition activity and are thus useful as hypotensive agents.
    Type: Grant
    Filed: March 1, 1984
    Date of Patent: April 23, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Eric M. Gordon, Donald S. Karanewsky, Denis E. Ryono
  • Iminothiazolyl ureido cephalosporins
    Patent number: 4501743
    Abstract: Cephalosporins of the formula ##STR1## wherein R is hydrogen, sodium, potassium or certain ester groups; R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy; R.sub.2 is hydrogen, ##STR2## X is hydrogen, ##STR3## R.sub.4 is hydrogen or lower alkyl; R.sub.5 is hydrogen, lower alkyl, ##STR4## --(CH.sub.2).sub.n --N--(lower alkyl).sub.2 ; R.sub.6 is hydrogen, sodium, or potassium; n is an integer from 1 to 4; are disclosed. These compounds are useful as anti-bacterial agents.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: February 26, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Uwe D. Treuner, Theodor Denzel
  • Amino thiol dipeptides
    Patent number: 4500518
    Abstract: Amino thiol substituted dipeptides of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: April 19, 1984
    Date of Patent: February 19, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Jollie D. Godfrey, Jr.
  • Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
    Patent number: 4499079
    Abstract: Peptides of the formula ##STR1## wherein X is various amino or imino acids or esters are useful as hypotensive agents.
    Type: Grant
    Filed: November 18, 1982
    Date of Patent: February 12, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Harold N. Weller, III
  • Certain-4-hydroxy-proline derivatives
    Patent number: 4499287
    Abstract: Compounds of the formula ##STR1## are useful as intermediates in the preparation of various hypotensive agents.
    Type: Grant
    Filed: July 29, 1982
    Date of Patent: February 12, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: John Krapcho
  • Drainage bag assembly with drip tray
    Patent number: 4496354
    Abstract: A drainage bag having one wall of substantially rigid liquid-impermeable material and a second wall of flexible liquid-impermeable material secured thereto to define a container. The rigid sheet has at least two apertures with an inlet fitting fixed to one and an outlet fitting fixed to the other. The bottom portion of the rigid sheet extends below the lower edge of the flexible wall to provide a drip tray.
    Type: Grant
    Filed: November 22, 1982
    Date of Patent: January 29, 1985
    Assignee: Craig Medical Products Limited
    Inventors: Peter L. Steer, John V. Edwards