Patents Represented by Attorney Stephen B. Davis

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  • Substituted 4-phenoxy or 4-phenylthio prolines
    Patent number: 4681886
    Abstract: This invention is directed to substituted 4-phenoxy and 4-phenylthio prolines of the formula ##STR1## which possess useful hypotensive activity.
    Type: Grant
    Filed: April 25, 1983
    Date of Patent: July 21, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rudiger D. Haugwitz, Peter W. Sprague
  • .alpha.-acyloxy phosphonate angiotensin converting enzyme inhibitors
    Patent number: 4670422
    Abstract: Compounds of the formula ##STR1## wherein X is various amino or imino acids and esters are disclosed. These compounds are useful as anti-hypertensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: March 27, 1986
    Date of Patent: June 2, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Tamara Dejneka
  • Amino acid ester renin inhibitors
    Patent number: 4665193
    Abstract: Compounds of the formula ##STR1## wherein A is ##STR2## intervene in the conversion of angiotensinogen to angiotensin II by inhibiting renin and thus are useful as anti-hypertensive agents.
    Type: Grant
    Filed: June 27, 1986
    Date of Patent: May 12, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Denis E. Ryono, Edward W. Petrillo, Jr.
  • Antihypertensive 1,5-benzothiazepine derivatives, compositions, and method of use therefor
    Patent number: 4654335
    Abstract: Compounds of formula ##STR1## wherein X is S or SO.sub.2, R.sub.4 is aryl or hetero, and R.sub.1 is hydrogen or ##STR2## are disclosed. These compounds are useful as cardiovascular agents and especially as anti-hypertensive agents.
    Type: Grant
    Filed: July 11, 1985
    Date of Patent: March 31, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karnail Atwall
  • Substituted 1,5-benzodiazepine compounds
    Patent number: 4650797
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is alkyl, alkenyl, alkynyl, cycloalkyl, or substituted alkyl, and R.sub.4 is aryl or heterocyclo are disclosed. These compounds are useful as cardiovascular agents and especially as anti-hypertensive agents.
    Type: Grant
    Filed: July 18, 1986
    Date of Patent: March 17, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal
  • 1,5-benzodiazepine compounds
    Patent number: 4647561
    Abstract: Compounds of formula ##STR1## wherein R.sub.4 is aryl or heterocyclo are disclosed. These compounds are useful as cardiovascular agents and especially as anti-hypertensive agents.
    Type: Grant
    Filed: August 5, 1985
    Date of Patent: March 3, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal
  • Incontinence insert
    Patent number: 4643726
    Abstract: The hourglass-shaped insert includes a moisture permeable inner layer and a moisture impermeable layer enclosing a layer of moisture absorbent core material. Located between the cut-out leg sections of the insert and interposed between the inner layer and the absorbent material is a uni-directional moisture barrier layer and a wicking layer. The barrier layer is a laminate containing a polymer that expands when wetted and includes a plurality of apertures. Adhesive strips are mounted on the outer layer to releasably secure the insert to an undergarment.
    Type: Grant
    Filed: June 29, 1984
    Date of Patent: February 17, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Anthony A. Gegelys
  • Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
    Patent number: 4642315
    Abstract: Peptides of the formula ##STR1## wherein X is various amino or imino acids or esters are useful as hypotensive agents.
    Type: Grant
    Filed: October 22, 1984
    Date of Patent: February 10, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Harold N. Weller, III
  • Adapter for use with two piece ostomy system
    Patent number: 4642107
    Abstract: An adapter comprising a channel shaped coupling member and a rib shaped coupling member connected by a continuous wall. The adapter coupling members are sized so as to fit between the body side and pouch of a two piece ostomy system.
    Type: Grant
    Filed: October 14, 1983
    Date of Patent: February 10, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ronald Arnone, Keith Ferguson
  • Ester substituted aminoalkanoylureido amino and imino acid and ester compounds
    Patent number: 4638010
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: February 28, 1985
    Date of Patent: January 20, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Eric M. Gordon
  • Acylaminoalkanoyl urethanes or thiourethanes
    Patent number: 4636522
    Abstract: Compounds of the formula ##STR1## wherein Z is oxygen or sulfur are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: March 22, 1985
    Date of Patent: January 13, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Eric M. Gordon
  • Amino acid ester and amide renin inhibitors
    Patent number: 4629724
    Abstract: Compounds of the formula ##STR1## wherein A is ##STR2## intervene in the conversion of angiotensinogen to angiotensin II by inhibiting renin and thus are useful as anti-hypertensive agents.
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: December 16, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Denis E. Ryono, Edward W. Petrillo, Jr.
  • Acylalkylaminocarbonyl substituted amino and imino acid compounds
    Patent number: 4623729
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: July 22, 1982
    Date of Patent: November 18, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Eric M. Gordon
  • Substituted proline compounds, composition and method of use
    Patent number: 4621092
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: July 14, 1983
    Date of Patent: November 4, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Eric M. Gordon
  • Amino acid ester and amide renin inhibitor
    Patent number: 4616088
    Abstract: Compounds of the formula ##STR1## wherein A is ##STR2## intervene in the conversion of angiotensinogen to angiotensin II by inhibiting renin and thus are useful as anti-hypertensive agents.
    Type: Grant
    Filed: December 14, 1984
    Date of Patent: October 7, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Denis E. Ryono, Edward W. Petrillo, Jr.
  • Hydroxy substituted ureido amino and imino acids
    Patent number: 4604402
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: March 30, 1984
    Date of Patent: August 5, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jollie D. Godfrey, Jr., Eric M. Gordon, Sesha I. Natarajan
  • Certain 3-phosphinyl-amino-2-oxo-1H-azocine or azonine-1-acetic acid derivatives having anti-hypertensive properties
    Patent number: 4598071
    Abstract: Phosphonamide substituted lactams of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents.
    Type: Grant
    Filed: November 28, 1984
    Date of Patent: July 1, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Donald S. Karanewsky
  • Process for preparing (3S)-3-[[[2-(protected or unprotected amino)-4-thiazolyl]acetyl]amino]-2-oxo-1-azetidinesulfonic acid and 4-substituted derivatives thereof
    Patent number: 4596777
    Abstract: A compound having the formula ##STR1## can be prepared by enzymatically coupling a compound of the formula ##STR2## with a compound of the formula ##STR3## in the presence of Escherichia coli acylase at a pH of from about 4.0 to about 6.0.
    Type: Grant
    Filed: August 10, 1983
    Date of Patent: June 24, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph O'Sullivan, Carol A. Aklonis
  • Incontinence pad
    Patent number: 4592751
    Abstract: The cover sheet includes a moisture permeable top section and moisture impermeable side and bottom sections. The edges of the interior surface of the impermeable section overlap and are joined to the edges of the exterior surface of the permeable section to form an enclosure. A layer of a moisture absorbent core material is situated within the enclosure. A uni-directional barrier layer comprising a laminate of a base or carrier and an absorbent polymer which gels and expands when wetted is interposed between the permeable cover section and the absorbent core. The barrier layer includes a plurality of apertures which decreases in size as the polymer gels and expands.
    Type: Grant
    Filed: June 29, 1984
    Date of Patent: June 3, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Anthony A. Gegelys
  • Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
    Patent number: 4587234
    Abstract: Peptides of the formula ##STR1## wherein X is various amino or imino acids or esters are useful as hypotensive agents.
    Type: Grant
    Filed: October 22, 1984
    Date of Patent: May 6, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Harold N. Weller, III