Abstract: This invention is directed to compounds of the formula ##STR1## which are useful as hypotensive agents.

Abstract: New mercaptoacyl derivatives of substituted prolines which have the general formula ##STR1## are useful as hypotensive agents.

Abstract: This invention is directed to compounds of the formula ##STR1## and various intermediates therefore. The final products possess useful hypotensive activity.

Abstract: The invention relates to new compounds useful as hypotensive agents, of the formula: ##STR1## wherein R is hydrogen or lower alkyl;R.sub.1 is hydrogen, lower alkyl or halo substituted lower alkyl;R.sub.2 is hydrogen, ##STR2## or ##STR3## R.sub.3 is lower alkyl, phenyl or phenyl lower alkyl; Pr--COOR is a substituted or unsubstituted proline.

Abstract: This invention is directed to compounds of the formula ##STR1## and various intermediates therefore. The final products possess useful hypotensive activity.

Abstract: Compounds, compositions and method of alleviating hypertension using a compound of the formula ##STR1## wherein R is hydrogen or lower alkyl;R.sub.1 is hydrogen, lower alkyl or phenyl-lower alkyl;R.sub.2 is hydrogen, lower alkyl or phenyl lower alkyl or halo substituted lower alkyl;R.sub.3 is hydroxy, --NHOH or lower alkoxy;Pr-COOR is a substituted proline of the structures ##STR2## R.sub.4 is halogen, keto, azido, cycloalkyl, phenyl, substituted phenyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, ##STR3## or Y--R.sub.6 ; R.sub.5 is hydrogen or lower alkyl;Y is oxygen or sulfur;R.sub.6 is lower alkyl, phenyl, substituted phenyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, 1- or 2-naphthyl, substituted 1- or 2- naphthyl, biphenyl, or substituted biphenyl;R.sub.7 is halogen or --Y--R.sub.8 ;R.sub.8 is lower alkyl, phenyl, phenyl-lower alkyl substituted phenyl-lower alkyl, biphenyl, napthyl, or the R.sub.

Abstract: A compound of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, phenyl lower alkyl or halo substituted lower alkyl;R.sub.2 is hydrogen, lower alkyl, phenyl lower alkyl or halo substituted lower alkyl;n is 0, 1 or 2;X is--(CH.sub.2).sub.m Z--;Z is oxygen, sulfur or imino;m is 0 or 1;Y is S-R or ##STR2## R is hydrogen, lower alkyl, ##STR3## R.sub.3 is lower alkyl, phenyl or phenyl lower alkyl; and R.sub.4 is hydroxy, amino, hydroxyamino or lower alkoxy. These compounds are useful as hypotensive agents.

Abstract: An ostomy bag having a drain valve at a lower region thereof. The valve is formed of a short flexible tube that can be bent or kinked over a support web and a stopper which can be pushed into the open end of the kinked tube.

Abstract: This invention is directed to compounds of the formula ##STR1## which are useful in the treatment of hypertension.

Abstract: A new antibiotic, designated kristenin, is produced by the microorganism Bacillus subtilis. The antibiotic possesses activity against gram positive bacteria.

Abstract: A lyophilized foam sponge product having medically useful hemostatic and adhesive properties formed from the hydrocolloids, gelatin, pectin, and sodium carboxymethylcellulose and having a density of from about 0.01 to about 0.10 grams/cc. The gelatin is present at from about 20% to about 80% by weight of the final product and the pectin and sodium carboxymethylcellulose are each present at from about 10% to about 50% by weight of the final product. The product is prepared by forming an aqueous colloidal dispersion of hydrocolloids, aerating or foaming, freezing, and lyophilizing.

Abstract: This invention is directed to compounds of the formulas ##STR1## and various intermediates therefore. The final products possess useful hypotensive activity.

Abstract: This invention is directed to compounds of the formula ##STR1## wherein A and A.sub.1 are amino acid residues, X is and .alpha.-imino acid residue, and R.sub.1 is hydrogen, lower alkyl, or halo substituted lower alkyl. These compounds are useful as hypotensive agents.

Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.

Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.

Abstract: An attachable and detachable filter for use with an ostomy bag includes a plastics housing member having two sections hinged together by an integral hinge and each section has a peripheral wall. One section has at least one aperture in the wall and the other section carries a sharp-pointed resilient-headed generally cylindrical stud which is a push fit through the aperture in the other to clamp the two sections together. There is a layer of gas filtering material within one or both of the housing sections.

Abstract: An adhesive composition adapted for use with an ostomy appliance consisting of a mixture of a hydrocolloid gum, a pressure sensitive adhesive, and a cohesive strengthening agent. The cohesive strengthening agent is either an inert natural or synthetic fibrous material, finely divided cellulose, a cross-linked dextran, a cross-linked carboxymethylcellulose, or a starch-acrylonitrile graft copolymer.

Abstract: A process for removing the acyl sidechain from penicillins and cephalosporins which comprises chlorinating the acyl compound and treating the resulting iminochloride with an o-aminothiophenol to obtain the corresponding 6.beta.-aminopenicillin or 7.beta.-aminocephalosporin.