Patents Represented by Attorney Steven J. Goldstein

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  • Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone
    Patent number: 4537776
    Abstract: Topical pharmaceutical compositions comprising a pharmaceutically-active agent and a novel, penetration-enhancing vehicle or carrier are disclosed. The vehicle or carrier comprises a binary combination of N-(2-Hydroxyethyl) pyrrolidone and a "cell-envelope disordering compound". The compositions provide marked transepidermal and percutaneous delivery of the active selected. A method of treating certain pathologies and conditions responsive to the selected active, systemically or locally, is also disclosed.
    Type: Grant
    Filed: June 21, 1983
    Date of Patent: August 27, 1985
    Assignee: The Procter & Gamble Company
    Inventor: Eugene R. Cooper
  • Compounds and compositions useful for producing analgesia
    Patent number: 4532139
    Abstract: Alkynamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R is straight or branched alkyne having from 11 to 23 carbon atoms; R.sub.1 is H, OH, or OCH.sub.3 ; R.sub.2 is OH or a short-chain ester; and wherein at least one of R.sub.1 and R.sub.2 is OH or OCH.sub.3. Compositions, useful for producing analgesia in humans or lower animals, comprise a safe and effective amount of: an alkynamide, pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkynamides are N-vanillyl-alkynamides. Methods of treatment, comprising administering a safe and effective amount of these alkynamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.
    Type: Grant
    Filed: July 14, 1983
    Date of Patent: July 30, 1985
    Assignee: The Procter & Gamble Company
    Inventors: John M. Janusz, Thomas R. LaHann
  • Synthesis of alpha-dithiophosphato amides
    Patent number: 4528140
    Abstract: A process for synthesizing alpha-substituted O,O-dialkyl dithiophosphato amides, comprising the step of contacting a C.sub.8 -C.sub.22 alpha-chloro amide with an aqueous solution of a salt of an O,O-dialkyl dithiophosphoric acid, at a temperature above the melting point of the alpha-chloro amide and in the range of from about 100.degree. C. to about 200.degree. C., is disclosed.
    Type: Grant
    Filed: July 8, 1983
    Date of Patent: July 9, 1985
    Assignee: The Procter & Gamble Company
    Inventor: Robert J. Crawford
  • Alpha-phosphono lauramide lubricant additives
    Patent number: 4525289
    Abstract: Alpha-phosphono amides useful as antiwear and friction-reducing additives for lubricants and liquid hydrocarbon fuels are disclosed. The compounds are non-corrosive and effective at relatively low concentrations when compared with common phosphorus-based additives.
    Type: Grant
    Filed: June 19, 1984
    Date of Patent: June 25, 1985
    Assignee: The Procter & Gamble Company
    Inventors: John K. Howie, Steven S. Bullock
  • Synthesis of higher polyol fatty acid polyesters using high soap:polyol ratios
    Patent number: 4518772
    Abstract: An improved solvent-free transesterification process for producing higher polyol fatty acid polyesters is disclosed. In this process a mixture of a polyol, a fatty acid methyl, 2-methoxy ethyl or benzyl ester, an alkali metal fatty acid soap, and a basic catalyst, having a molar ratio of soap:polyol of from about 0.6:1 to about 1:1, preferably from about 0.75:1 to about 1:1, is heated to form a homogeneous melt. To this melt is subsequently added excess fatty acid methyl, 2-methoxy ethyl or benzyl ester, yielding the desired polyol fatty acid polyesters.
    Type: Grant
    Filed: June 23, 1983
    Date of Patent: May 21, 1985
    Assignee: The Proctor & Gamble Company
    Inventor: Robert A. Volpenhein
  • Animal litter composition
    Patent number: 4517919
    Abstract: Solid absorbent materials, having adsorbed thereto from about 1000 ppm to about 10,000 ppm of a undecylenic acid, when used as animal litter products, effectively prevent the development of urine odors. Absorbent pads having absorbed thereto from about 5000 ppm to about 100,000 ppm of the undecylenic acid when used as liners in litter boxes likewise effectively control odor development.
    Type: Grant
    Filed: November 1, 1983
    Date of Patent: May 21, 1985
    Assignee: The Procter & Gamble Company
    Inventors: Lawrence Benjamin, Sheila S. Rodriguez, Nancy A. Meinberg
  • Synthesis of higher polyol fatty acid polyesters using carbonate catalysts
    Patent number: 4517360
    Abstract: An improved solvent-free transesterification process for producing polyol fatty acid polyesters is disclosed. In this process, a mixture of a polyol, a fatty acid methyl, 2-methoxy ethyl or benzyl ester, an alkali metal fatty acid soap, and potassium carbonate, sodium carbonate or barium carbonate as a catalyst is heated to form a homogeneous melt. To this melt is subsequently added excess fatty acid methyl, 2-methoxy ethyl or benzyl ester, yielding the desired polyol fatty acid polyesters.
    Type: Grant
    Filed: June 23, 1983
    Date of Patent: May 14, 1985
    Assignee: The Procter & Gamble Company
    Inventor: Robert A. Volpenhein
  • Agents for preparing cross-linked polymers and paint and plastic compositions containing those agents
    Patent number: 4506048
    Abstract: A class of polymer precursor materials, which, under appropriate conditions, react to form cross-linked polymers, is disclosed. These materials contain a backbone segment, such as polyacrylate, having pendant therefrom mono- or disubstituted olefinic groups, such as vinyl itaconate, having specific polymerization rates. This class of materials, especially when coupled with specifically-defined oxygen-activated catalyst systems, provide paint and plastic compositions which exhibit excellent film formation, strength and durability characteristics.
    Type: Grant
    Filed: October 31, 1983
    Date of Patent: March 19, 1985
    Assignee: The Procter & Gamble Company
    Inventors: Rodney D. Bush, Medford D. Robbins
  • Novel prostaglandin analogues and process for making same
    Patent number: 4496759
    Abstract: A novel process for the oxidation of olefins to the corresponding alpha-epoxy alcohols which can be incorporated in the total synthesis of members of a novel class of prostaglandin analogues.Olefins are reacted with singlet oxygen in the presence of a group IVB, VB or VIB transition metal catalysts, excluding chromium. The reaction is fast and highly selective to the alpha-epoxy alcohol. When cyclopentene is oxidized in the process of the invention, high yields of cis 2,3-epoxy cyclopentan-1-01-are obtained. The latter compound is used as a starting material in the synthesis of prostaglandin analogues. The prostanoids of the invention are characterized by an oxa group replacing the methylene group at the 7-position, and the absence of a hydroxyl or other substituent at the 11-position.Members of this class of prostanoids show important cytoprotective properties in animal tests.
    Type: Grant
    Filed: May 5, 1982
    Date of Patent: January 29, 1985
    Assignee: The Procter & Gamble Company
    Inventor: Edward D. Mihelich
  • Compositions and methods useful for producing analgesia
    Patent number: 4493848
    Abstract: A composition, useful for producing analgesia in humans or lower animals, comprising a safe and effective amount of: an N-[(substituted phenyl)methyl]-cis-monounsaturated alkenamide pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkenamides are N-vanillyl-cis-monounsaturated alkenamides. Methods of treatment, comprising administering a safe and effective amount of these alkenamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.
    Type: Grant
    Filed: July 14, 1983
    Date of Patent: January 15, 1985
    Assignee: The Procter & Gamble Company
    Inventors: Thomas R. LaHann, Brian L. Buckwalter
  • Detergent compositions containing polyethylene glycol and polyacrylate
    Patent number: 4490271
    Abstract: Detergent compositions comprising a mixture of polyethylene glycol and polyacrylate of specified molecular weight are disclosed.
    Type: Grant
    Filed: June 30, 1983
    Date of Patent: December 25, 1984
    Assignee: The Procter & Gamble Company
    Inventors: Gianfranco L. Spadini, Antoinette L. Larrabee, Don K. K. Liu
  • Intravenous solutions with antimicrobial agent
    Patent number: 4489097
    Abstract: Antifungal/antibacterial materials are added to sterile compositions intended for administration to humans or lower animals to minimize bacterial and mycotic contamination which can cause infections associated with the medical and veterinary use of such compositions.
    Type: Grant
    Filed: July 8, 1982
    Date of Patent: December 18, 1984
    Assignee: The Procter & Gamble Company
    Inventor: Roger L. Stone
  • Bodies containing stabilized bleach activators
    Patent number: 4486327
    Abstract: The invention relates to bodies containing bleach activators. The bodies comprise specific peroxygen bleach activators and select binder or enrobing materials. When formulated in such bodies the peroxygen bleach activators have excellent storage stability and maintain excellent dispersibility in wash water.
    Type: Grant
    Filed: December 22, 1983
    Date of Patent: December 4, 1984
    Assignee: The Procter & Gamble Company
    Inventors: Alan P. Murphy, Ali Kassamali, John D. Curry
  • Peroxygen bleach activators and bleaching compositions
    Patent number: 4483778
    Abstract: This invention relates to peroxygen bleaching activator compounds and bleaching compositions. The peroxygen bleach activator compounds, used in combination with peroxygen bleach compounds which yield hydrogen peroxide in an aqueous solution, provide effective and efficient bleaching of textiles over a wide range of temperatures. In a highly preferred embodiment the bleaching compositions of the invention are detergent compositions.
    Type: Grant
    Filed: December 22, 1983
    Date of Patent: November 20, 1984
    Assignee: The Procter & Gamble Company
    Inventors: James E. Thompson, Charles D. Broaddus
  • Method of catalyzing oxygen-initiated free-radical polymerization and catalysts used therein
    Patent number: 4483967
    Abstract: A class of new oxygen-activated free-radical polymerization catalysts, comprising specifically-defined autoxidizable cyclic hydrocarbons together with cobalt(II) compounds, is disclosed. A method of catalyzing an oxygen-initiated free-radical polymerization reaction using these catalysts is also disclosed.
    Type: Grant
    Filed: May 27, 1983
    Date of Patent: November 20, 1984
    Assignee: The Procter & Gamble Company
    Inventors: David J. Eickhoff, Medford D. Robbins
  • Antimicrobial polymer compositions
    Patent number: 4479795
    Abstract: The present invention relates to medical polymers and devices made therefrom, and is based on the discovery that certain carboxylate antimicrobial agents can be releasably incorporated into permeable polymers. The walls of medical devices such as catheters can be fashioned from such polymers. In use, the antimicrobial agent diffuses from the walls to the surface of the device to form an antimicrobial barrier on the surface of the device and a zone of microbial inhibition on tissue surfaces surrounding the device, thereby effectively supplementing the body's own natural microbial barriers where they have been compromised. The bacterial contamination-resistant carboxylate-plus-polymer compositions herein can be used in the manufacture of a wide variety of medical devices, especially urinary catheters, intravenous catheters, wound dressings, and the like.
    Type: Grant
    Filed: July 27, 1982
    Date of Patent: October 30, 1984
    Assignee: The Procter & Gamble Company
    Inventors: Robert V. Mustacich, Donald S. Lucas, Roger L. Stone
  • Storage stable topical pharmaceutical composition containing zinc erythromycin and low dielectric solvents
    Patent number: 4469684
    Abstract: A storage stable topical pharmaceutical composition containing zinc erythromycin, particularly useful in the topical treatment of acne vulgaris, is disclosed. This composition contains a solvent having a dielectric constant, measured at 25.degree. C., of from about 5.5 to about 15, preferably from about 8 to about 12, such as t-butanol, to impart storage stability to the zinc erythromycin component. The composition may additionally contain particularly selected pharmaceutically-acceptable nitrogen-containing stabilizer components, such as diisopropanolamine.
    Type: Grant
    Filed: October 15, 1982
    Date of Patent: September 4, 1984
    Assignee: The Procter & Gamble Company
    Inventors: James E. Huggins, Mary L. Batt, William J. Kozarek
  • Silica coated absorbent fibers
    Patent number: 4469746
    Abstract: Fibrous webs comprising fibers coated with a continuous film comprising silica have excellent absorbent and wicking properties. The fibers themselves may be hydrophilic (e.g., cellulose) or hydrophobic (e.g., a polyolefin or a polyester).
    Type: Grant
    Filed: June 1, 1982
    Date of Patent: September 4, 1984
    Assignee: The Procter & Gamble Company
    Inventors: Paul T. Weisman, Herbert L. Retzsch
  • Polyol esters of alpha-hydroxy carboxylic acids
    Patent number: 4469635
    Abstract: Polyol esters of alpha-hydroxy carboxylic acids are disclosed which are excellent oil-in-water emulsifiers for food products, drug delivery vehicles, cosmetic ointments and the like. The compounds are also useful as detergent surfactants and can be combined with cosurfactants, builders and detergent adjunct materials.
    Type: Grant
    Filed: April 22, 1982
    Date of Patent: September 4, 1984
    Assignee: The Procter & Gamble Company
    Inventor: Donald J. Peterson
  • Hydrophilic microfibrous absorbent webs
    Patent number: 4468428
    Abstract: Fibrous absorbent webs having a low density (about 0.01 g/cm.sup.3 to about 0.15 g/cm.sup.3) and comprising at least about 50% hydrophilic microfibers, such as cellulose microfibers, having a diameter of from about 0.01 microns to about 15 microns possess superior absorption properties, especially under typical usage conditions.Hydrophobic microfibers may also be used, provided such fibers are hydrophilized before or after web formation.
    Type: Grant
    Filed: June 1, 1982
    Date of Patent: August 28, 1984
    Assignee: The Procter & Gamble Company
    Inventors: Allen D. Early, David W. Cawlfield, Trevor Walker, Paul T. Weisman