Patents Represented by Attorney Theodore R. Furman

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  • N-substituted imidazole and benzimidazole derivatives useful as angiotenson II antagonists
    Patent number: 5466704
    Abstract: Compounds are disclosed having the formula ##STR1## These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: November 14, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Percarbonate based cleaner for cosmetic and pharmaceutical manufacturing facilities
    Patent number: 5445761
    Abstract: The present invention claims and describes an environmentally sound percarbonate based cleaner for removing cosmetic and pharmaceutical soils from pharmaceutical or cosmetic manufacturing surfaces. The invention includes a combination of a percarbonate; an ethylene oxide/propylene oxide block copolymer surfactant; and a bicarbonate salt. The invention is useful for removing hard-to-remove soils from a pharmaceutical or cosmetic manufacturing surface.
    Type: Grant
    Filed: September 24, 1993
    Date of Patent: August 29, 1995
    Assignee: E.R. Squibb and Sons, Inc.
    Inventors: Sadiq Shah, Fred Kirchner
  • Process for separation of enantiomeric 3-mercapto-2-substituted alkanoic acid using lipase P30 and synthesis of captopril type compounds
    Patent number: 5420037
    Abstract: S-enantiomers of the formula ##STR1## result from the reaction of a racemic form of compound I with an alcohol in the presence of an enzyme capable of selectively esterifying the R-enantiomers of the racemic compound.
    Type: Grant
    Filed: January 12, 1994
    Date of Patent: May 30, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jeffrey M. Howell, Ramesh N. Patel, Laszlo J. Szarka
  • Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
    Patent number: 5374615
    Abstract: Novel compounds are disclosed having the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are substituents. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: February 7, 1992
    Date of Patent: December 20, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Chromanyl substituted indole potassium channel openers
    Patent number: 5310932
    Abstract: Novel compounds are disclosed having the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are as defined herein.
    Type: Grant
    Filed: September 11, 1991
    Date of Patent: May 10, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karnail Atwal, George C. Rovnyak
  • Scopularin
    Patent number: 5294725
    Abstract: A novel antibiotic substance, Scopularin, is prepared by cultivation of a strain of the microorganism, Scopulariopsis, A.T.C.C. No. 20,914. This compound and its alcohol derivative have also been found to have cytochrome P450 inhibition activity.
    Type: Grant
    Filed: January 31, 1989
    Date of Patent: March 15, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald R. Kirsch, Joseph O'Sullivan, Douglas W. Phillipson
  • Radiolabeling of proteins using alkoxyphenol derivatives
    Patent number: 5290937
    Abstract: Novel compounds, useful as radiolabeling reagents, including an alkoxy group on the phenyl ring and having the formula ##STR1## wherein X is a radionuclide are disclosed. The invention further includes novel radiohalogenated proteins as well as processes for preparing such reagents and radiohalogenated proteins.
    Type: Grant
    Filed: November 12, 1992
    Date of Patent: March 1, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Frank P. Tomasella
  • Method of treating or prevention of fibrillation of the heart
    Patent number: 5278169
    Abstract: A method for the treatment and prevention of fibrillation using one or more potassium channel activators. Also, disclosed is a process for the preparation of compounds of the formula ##STR1## and the tautomeric forms ##STR2## wherein R''and R" are as defined herein.
    Type: Grant
    Filed: July 9, 1990
    Date of Patent: January 11, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karnail Atwal, Gary J. Grover
  • Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
    Patent number: 5276168
    Abstract: A new method for the treatment of ischemic conditions and arrhythmia is disclosed. The method uses compounds of the formula ##STR1## wherein A can be --CH.sub.2 --, --O--, --NR.sub.9 --, --S--, --SO--, --SO.sub.2 --; X can be oxygen or sulfur; Y can be --NR.sub.8, --O--, --S--, --CH.sub.2 -- and the R groups are as defined herein. Novel compounds within the definition of formula I are also disclosed.
    Type: Grant
    Filed: June 19, 1992
    Date of Patent: January 4, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal
  • Tetrahydroethanonaphthaleneamine derivatives
    Patent number: 5276026
    Abstract: Tetrahydronaphthaleneamine derivatives having the formula ##STR1## wherein R, R', R.sub.1 and R.sub.2 are as defined herein, are novel calcium channel blockers.
    Type: Grant
    Filed: January 21, 1993
    Date of Patent: January 4, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joel C. Barrish, Steven H. Spergel
  • 4-methoxy-5-methyl-pyran-3-ol natural products and derivatives thereof
    Patent number: 5270334
    Abstract: Novel antibiotic substances, including novel natural products, having the general formula ##STR1## wherein R.sub.1 and R.sub.2 are as defined herein, are disclosed. These compounds have been found to be cytochrome P450 inhibitors.
    Type: Grant
    Filed: July 1, 1992
    Date of Patent: December 14, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph O'Sullivan, Douglas W. Phillipson, Henner Straub, Peter H. Ermann
  • Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activator
    Patent number: 5262419
    Abstract: Ulcerative conditions of the gastro-intestinal tract, e.g., antiinflammatory-drug-induced ulcers, are treated or prevented by the administration of a potassium channel activator. Methods and combination products are also disclosed for the treatment of inflammatory conditions without causing ulceration of the gastrointestinal tract.
    Type: Grant
    Filed: June 11, 1992
    Date of Patent: November 16, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: A. K. Gunnar Aberg, Martin L. Ogletree, Eugene H. O'Keefe
  • 1,2-hydroxy phosphonates and derivatives thereof
    Patent number: 5217958
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.
    Type: Grant
    Filed: April 12, 1990
    Date of Patent: June 8, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Dinesh V. Patel
  • Instantaneous delivery film
    Patent number: 5206026
    Abstract: In accordance with the present invention an instantaneous delivery film useful in the delivery of a therapeutic agent to a wound site is provided. The present delivery film comprises a therapeutic agent, e.g. an enzyme or medicament, incorporated into a delivery material which forms the film. The delivery material is capable of rapidly dissolving in aqueous and saline solutions and comprises a water soluble and nonaqueous-solvent soluble film-forming polymer in an amount of from about 20 to about 100 percent by weight of the delivery material, and a plasticizer in an amount of from about 0 and 80 percent by weight of the delivery material. The present system is useful, for example, as a dry enzymatic debridement film suitable for the treatment of mammalian burns and ulcers.
    Type: Grant
    Filed: January 2, 1990
    Date of Patent: April 27, 1993
    Inventor: Clyde L. Sharik
  • Tetrahydroethanonaphthaleneamine derivatives
    Patent number: 5202486
    Abstract: Tetrahydronaphthaleneamine derivatives having the formula ##STR1## wherein R, R', R.sub.1 and R.sub.2 are as defined herein, are novel calcium channel blockers.
    Type: Grant
    Filed: July 31, 1990
    Date of Patent: April 13, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joel C. Barrish, Steven H. Spergel
  • Imidazole and benzimidazole derivatives
    Patent number: 5191086
    Abstract: Novel angiotensin-II receptor antagonists are disclosed having the general formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, W and X are as defined herein.
    Type: Grant
    Filed: March 19, 1991
    Date of Patent: March 2, 1993
    Assignee: E.R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Boronic acid adducts of metal dioxime complexes useful in labelling proteins and other amine-containing compounds
    Patent number: 5183653
    Abstract: Boronic acid adducts of metal dioxime complexes are useful as reagents for labeling proteins and other amine-containing compounds.
    Type: Grant
    Filed: April 13, 1990
    Date of Patent: February 2, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karen E. Linder, Adrian D. Nunn, Kondareddiar Ramalingam
  • Method for preventing onset of restenosis after angioplasty employing an ace inhibitor
    Patent number: 5166143
    Abstract: A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering an ACE inhibitor such as fosinopril or ceranapril, prior to, during and/or after angioplasty.
    Type: Grant
    Filed: June 13, 1991
    Date of Patent: November 24, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, A. K. Gunnar Aberg, Patricia Ferrer
  • Peptifluorin and neopeptifluorin
    Patent number: 5165931
    Abstract: Two related, novel antibiotic substances, peptifluorin and neopeptifluorin, are prepared by cultivation of strains of Pseudomonas fluorescens, A. T. C. C. No. 53,958 and A. T. C. C. No. 55,129, respectively.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: November 24, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Edward Meyers, Wen-Chih Liu, Gordon W. Robinson
  • Benzodiazolo analogs
    Patent number: 5164509
    Abstract: Novel potassium channel activators of the formula ##STR1## where Y, X, X.sub.1, X.sub.2 (N or O), and R.sub.1 -R.sub.4 are as defined herein, are disclosed.
    Type: Grant
    Filed: November 26, 1990
    Date of Patent: November 17, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal