Patents Represented by Attorney Theodore R. Furman

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  • Phosphonate, phosphinate derivatives useful as antihypertensive agents
    Patent number: 5153347
    Abstract: Novel angiotensin II receptor antagonists of the formula ##STR1## wherein X, X.sub.1, X.sub.2, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined herein, are disclosed. These compounds are useful, for example, in the treatment of hypertension, congestive heart failure and cardiac hypertrophy.
    Type: Grant
    Filed: January 31, 1991
    Date of Patent: October 6, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: John E. Lloyd
  • N-heterocyclic alcohol derivatives
    Patent number: 5151513
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is an N-heterocyclic group as defined herein, are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.
    Type: Grant
    Filed: April 29, 1988
    Date of Patent: September 29, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Denis E. Ryono
  • Pyranyl cyanoguanidine derivatives
    Patent number: 5140031
    Abstract: Novel compounds having the formula ##STR1## wherein ##STR2## are disclosed. These compounds have potassium channel activating activity and are useful, for example, as cardiovascular agents, especially as antiischemic agents.
    Type: Grant
    Filed: February 27, 1991
    Date of Patent: August 18, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karnail Atwal, Gary J. Grover, Kyoung S. Kim
  • Tablet composition and method for problem pharmaceutical materials using citric acid
    Patent number: 5137730
    Abstract: In accordance with the present invention an improved tablet composition for drugs or active ingredients prone to poor tabletting properties is disclosed. The improved composition comprises a premixture, consisting essentially of between about 85 and 99.9 percent by weight of the active ingredient and between about 0.1 and 15 percent by weight of citric acid, and one or more other formulation ingredients added to premixture. The present invention also involves the process for making such compositions and products therefrom.
    Type: Grant
    Filed: May 28, 1991
    Date of Patent: August 11, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Andrew B. Dennis, Peter Timmins, Himadri Sen
  • Rhenium tris dioxime complexes
    Patent number: 5118797
    Abstract: Rhenium tris dioxime complexes are useful in the synthesis of boronic acid adducts of rhenium dioxime complexes which are useful as radiotherapeutic agents.
    Type: Grant
    Filed: August 28, 1989
    Date of Patent: June 2, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Silvia Jurisson, Karen E. Linder, Lynn C. Francesconi
  • Pharmaceutical composition and method for treating cardiovascular diseases using substituted anilides and sulfonamides
    Patent number: 5116851
    Abstract: A novel pharmaceutical composition and method is disclosed for the treatment of cardiovascular diseases, e.g. myocardial ischemia and/or arrhythmia. The method and composition include an effective amount of a compound of the formula ##STR1## wherein X, Y, R, R.sub.1, A, A', m, n, p, p' and B are as defined herein.
    Type: Grant
    Filed: January 26, 1990
    Date of Patent: May 26, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: John Krapcho, James L. Bergey, Gary J. Grover
  • Piperidinyl carbonyl derivatives
    Patent number: 5106982
    Abstract: Novel compounds having the general formula ##STR1## wherein A and A' are amino acid residues linked by a peptidal bond to the nucleus, are disclosed. These compounds are CNS agents with anxiogenic activity.
    Type: Grant
    Filed: December 10, 1990
    Date of Patent: April 21, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Callixtus E. Ita, Peter Egli
  • Intermediates for a process for making 2-oxo-1-[[(substituted sulfonyl)-amino]carbonyl]azetidines
    Patent number: 5106977
    Abstract: Novel intermediates for preparing 2-oxo-1-[[(substituted sulfonyl)-amino]carbonyl]azetidines are disclosed. These intermediates have the formula ##STR1## wherein Prot is as defined herein.
    Type: Grant
    Filed: September 27, 1990
    Date of Patent: April 21, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jollie D. Godfrey, Jr., Richard H. Mueller
  • Dihydropyrimidine lactone derivatives
    Patent number: 5103006
    Abstract: Novel compounds of the formula ##STR1## wherein X is sulfur or oxygen, R.sub.2 is aryl or heterocyclo and R.sub.1 is as defined herein, are disclosed. Compounds of formula I possess calcium channel activating activity.
    Type: Grant
    Filed: August 21, 1990
    Date of Patent: April 7, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: George C. Rovnyak, Spencer D. Kimball
  • Gram-positive and gram-negative antibacterial compounds from the microorganism, Janthinobacterium lividum
    Patent number: 5081225
    Abstract: A novel antibiotic substance, janthinocin, is prepared by cultivation of a strain of the microorganism Janthinobacterium lividum, ATCC No. 53,857.
    Type: Grant
    Filed: July 31, 1989
    Date of Patent: January 14, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph O'Sullivan, John E. McCullough, Janice H. Del Mar
  • Pyranyl quinoline calcium channel blockers
    Patent number: 5070088
    Abstract: Novel calcium channel blockers having the formula ##STR1## wherein X is oxygen or sulfur and wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 are as defined herein, are disclosed. These compounds are useful, for example, as anti-ischemic agents.
    Type: Grant
    Filed: December 19, 1989
    Date of Patent: December 3, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal
  • Boronic acid adducts of technetium-.sup.99m dioxime-imine complexes
    Patent number: 5069900
    Abstract: Boronic acid adducts of technetium-.sup.99m imine-dioxime complexes are useful for imaging the myocardium, hepatobiliary system, brain and blood pool in humans and other mammalian species.
    Type: Grant
    Filed: August 28, 1989
    Date of Patent: December 3, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karen E. Linder
  • Substituted cyanoimino benzopyranes
    Patent number: 5061813
    Abstract: Novel compounds are disclosed having the formula ##STR1## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are as defined herein. These compounds are useful, for example, as cardiovascular agents and especially as anti-ischemic agents.
    Type: Grant
    Filed: April 2, 1990
    Date of Patent: October 29, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal
  • N-morpholino derivatives and their use as anti-hypertensive agents
    Patent number: 5055466
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.
    Type: Grant
    Filed: December 14, 1989
    Date of Patent: October 8, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Denis E. Ryono
  • Process for benzazepine intermediates
    Patent number: 5053504
    Abstract: A process is disclosed for providing benzazepine intermediates of the formulae ##STR1## wherein R.sub.3, R.sub.4 and Y are as defined herein, which intermediates are useful in a process for the preparation of pharmaceutically useful benzazepine derivatives.
    Type: Grant
    Filed: November 29, 1989
    Date of Patent: October 1, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Wen-Sen Li, John K. Thottathil, Michael Murphy
  • Preparation of boronic acid derivatives
    Patent number: 5039795
    Abstract: An improved process for preparation of compounds of the formula ##STR1## as disclosed. These compounds are useful as intermediates in the preparation of boronic acid adducts of technetium 99m dioxime complexes of the formula.sup.99m Tc X(Y).sub.3 Zwhich are useful as imaging agents.
    Type: Grant
    Filed: June 21, 1989
    Date of Patent: August 13, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Richard H. Mueller
  • Dactylocycline A and dactylocycline B
    Patent number: 5024839
    Abstract: Cultivation of a strain of the microorganism Dactylosporangium sp. A.T.C.C. No. 53693, yields the antibiotic substance EM5586 which contains the novel useful components dactylocycline A and dactylocycline B.
    Type: Grant
    Filed: December 24, 1987
    Date of Patent: June 18, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Carol A. Aklonis, Helen A. Ax, Donald R. Kirsch, Joseph O'Sullivan, Adrienne Tymiak, J. Scott Wells
  • Aryl cyanoguanidines: potassium channel activators and method of making same
    Patent number: 5011837
    Abstract: Novel compounds of the formula ##STR1## and tautomers thereof, wherein at least one of R.sub.2, R.sub.3 and R.sub.4 is a strong electron withdrawing group, are disclosed. These compounds possess potassium channel activating activity and, as such, are useful as antihypertensive agents. Advantageously, the compounds of the present invention have shown less cardiac effects than known potassium channel activators.Also disclosed is a process for preparing these and other compounds.
    Type: Grant
    Filed: May 8, 1989
    Date of Patent: April 30, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karnail Atwal, John R. McCullough, Gary J. Grover
  • Composite compression and support dressing
    Patent number: 5006401
    Abstract: In accordance with the present invention a novel composite compression and support dressing is disclosed. This dressing comprises an extensible bandage having a stretchable hydrocolloid adhesive composition laminated thereto.
    Type: Grant
    Filed: November 23, 1988
    Date of Patent: April 9, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Margaret A. Frank
  • Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers
    Patent number: 5006523
    Abstract: Novel compounds of the formula ##STR1## and tautomers thereof are disclosed. These compounds possess potassium channel blocking activity and, as such, are useful as antiarrhythmic agents.
    Type: Grant
    Filed: October 26, 1989
    Date of Patent: April 9, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal