Patents Represented by Attorney Walter Patton

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  • Psychotropic benzisothiazole derivatives
    Patent number: 4968792
    Abstract: Disclosed herein are novel benzisothiazole derivatives having pharmacological activity, to a process for preparing them, to pharmaceutical compositions containing them, and to their use in the treatment of a variety of central nervous system disorders.
    Type: Grant
    Filed: September 25, 1989
    Date of Patent: November 6, 1990
    Assignee: American Home Products Corporation
    Inventors: Gary P. Stack, Magid A. Abou-Gharbia, Thomas D. Golobish
  • N-naphthoylglycines as aldose reductase inhibitors
    Patent number: 4962224
    Abstract: Disclosed herein are N-naphthoylglycines and methods of their preparation. The N-naphthoylglycines are novel aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: August 22, 1989
    Date of Patent: October 9, 1990
    Assignee: American Home Products Corporation
    Inventors: Jay E. Wrobel, Kazimir Sestanj
  • Trifluoromethoxy substituted 1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids
    Patent number: 4960902
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a trifluoromethoxy substituent in the 5-, 6-, 7-, or 8-position, and methods for their preparation and use, are disclosed. The derivatives are useful anti-inflammatory and analgesic agents.
    Type: Grant
    Filed: August 19, 1988
    Date of Patent: October 2, 1990
    Assignee: American Home Products Corporation
    Inventor: Amedeo A. Failli
  • 2-pyridinecarbothioamides, processes for preparation thereof and pharmaceutical compositions comprising the same
    Patent number: 4958023
    Abstract: There are provided gastric antiulcer and cytoprotective substituted N-phenyl-2-pyridinecarbothioamides. The process for their production and formulation is disclosed.
    Type: Grant
    Filed: June 29, 1989
    Date of Patent: September 18, 1990
    Assignee: American Home Products Corporation
    Inventors: William A. Kinney, Nancy E. Lee
  • 2-pyridinecarbothioamides, processes for preparation thereof
    Patent number: 4950762
    Abstract: There are provided gastric antiulcer and cytoprotective substituted N-phenyl-2-pyridinecarbothioamides. The process for their production and formulation is disclosed.
    Type: Grant
    Filed: July 10, 1989
    Date of Patent: August 21, 1990
    Assignee: American Home Products Corporation
    Inventors: William A. Kinney, Amadeo A. Failli, Ghulam N. Mir
  • Novel spirosuccinimides as aldose reductase inhibitors and antihyperglycemic agents
    Patent number: 4946858
    Abstract: This invention relates to novel spirosuccinimide derivatives, to the processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the treatment of diabetes mellitus and associated conditions.
    Type: Grant
    Filed: June 28, 1989
    Date of Patent: August 7, 1990
    Assignee: American Home Products Corporation
    Inventor: Jay E. Wrobel
  • N-naphthoylglycine derivatives
    Patent number: 4946987
    Abstract: Herein disclosed are N-naphthoylglycine derivatives having aldose reductase inhibiting activity. The derivatives are useful for treating, diabetic complications.
    Type: Grant
    Filed: June 20, 1988
    Date of Patent: August 7, 1990
    Assignee: Ayerst, McKenna & Harrison, Inc.
    Inventors: Kazimir Sestanj, Nedumparambil A. Abraham, Francesco Bellini, Adi Treasurywala
  • Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
    Patent number: 4927831
    Abstract: This invention relates to spiro-isoquinoline-pyrrolidine tetrones and their pharmaceutically acceptable salts thereof, to processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the prevention of diabetes mellitus associated complications.
    Type: Grant
    Filed: May 26, 1989
    Date of Patent: May 22, 1990
    Assignee: American Home Products
    Inventor: Michael S. Malamas
  • 2,3,4,9-tetrahydro-1H-carbazole acetic acid derivatives, composition and use as anti-inflammatories
    Patent number: 4927842
    Abstract: Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful anti-inflammatory agents.
    Type: Grant
    Filed: September 29, 1989
    Date of Patent: May 22, 1990
    Assignee: American Home Products Corporation
    Inventor: Dominick Mobilio
  • N-acyl-N-naphthoylglycines as aldose reductase inhibitors
    Patent number: 4925968
    Abstract: Disclosed herein are N-acyl-N-naphthoylglycines and methods of their preparation. The N-acyl-N-naphthoylglycines are novel aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: January 9, 1989
    Date of Patent: May 15, 1990
    Assignee: American Home Products Corporation
    Inventors: Kazimir Sestanj, Jay E. Wrobel, Joseph M. Kelly
  • Novel antihypertensive benzopyran derivatives
    Patent number: 4925839
    Abstract: Disclosed herein are novel benzopyrans having pharmacological activity, to a process for preparing them, to pharmaceutical compositions containing them, and to their use in the treatment of hypertension.
    Type: Grant
    Filed: June 24, 1988
    Date of Patent: May 15, 1990
    Assignee: American Home Products Corporation
    Inventors: Dominick A. Quagliato, Leslie G. Humber
  • Resolution of (1S,4R)-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl) pyrano[3,4-B]indole-1-acetic acid using brucine
    Patent number: 4925955
    Abstract: This invention relates to a process for resolving (.+-.)-cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indole- 1-acetic acid (pemedolac) usinig brucine to obtain the corresponding (1S,4R)-eutomer. Said eutomer is useful as an analgesic.
    Type: Grant
    Filed: February 28, 1989
    Date of Patent: May 15, 1990
    Assignee: American Home Products Corporation
    Inventors: Andre A. Asselin, Jean Schmid
  • Inhibition of bone loss by 4-substituted-5-hydroxy-2(5H)-furanones
    Patent number: 4916241
    Abstract: This invention relates to 4-substituted-5-hydroxy-2(5H)-furanones, to the process for their preparation, to pharmaceutical compositions containing said 4-substituted-5-hydroxy-2(5H)-furanones and to the use of said 4-substituted-5-hydroxy-2(5H)-furanones for modifying the balance between bone production and bone resorption in a host animal, including man.
    Type: Grant
    Filed: June 6, 1988
    Date of Patent: April 10, 1990
    Assignee: American Home Products Corporation
    Inventors: Marshall A. Hayward, Joseph P. Sabatucci, Ivo L. Jirkovsky, Yvon Lefebvre
  • Production of 2-alkoxy or aryl(lower)alkoxy-6-methoxy-1-naphthalenecarboxaldehyde
    Patent number: 4914243
    Abstract: Process for the production of 2-alkoxy or aryl(lower)alkoxy-6-methoxy-1-naphthalenecarboxaldehyde chemical intermediates by demethylating 2,6-dimethoxy-1-naphthalenecarboxaldehyde with a nucleophilic sulfide reagent at the 2-position and reacting the resulting phenolate salt with an alkylating reagent. Said aldehydes are themselves intermediates for the manufacture of compounds which inhibit aldose reductase and are useful for the treatment of diabetic complications.
    Type: Grant
    Filed: April 27, 1989
    Date of Patent: April 3, 1990
    Assignee: American Home Products Corporation
    Inventor: John G. Bauman
  • 5 step process for preparing certain 2,4-diamino-5-pyrimidine-sulfonyl ureas
    Patent number: 4914203
    Abstract: This invention relates to substituted 5-pyrimidinesulfonamides, pharmaceutically acceptable salts thereof and to processes for synthesis thereof. Other aspects of the invention concern pharmaceutical compositions containing an instant compound as active ingredient and methods of treatment where there is an indicated need for an antihypertensive and/or diuretic agent.
    Type: Grant
    Filed: April 5, 1989
    Date of Patent: April 3, 1990
    Assignee: American Home Products Corporation
    Inventors: Terence M. Dolak, Sung J. Lee, James L. Bullington
  • Benzopyran derivatives and antihypertensive use thereof
    Patent number: 4908378
    Abstract: Disclosed herein are novel benzopyrans having pharmacological activity, to a process for preparing them, to pharmaceutical compositions containing them, and to their use in the treatment of hypertension.
    Type: Grant
    Filed: April 12, 1989
    Date of Patent: March 13, 1990
    Assignee: American Home Products Corporation
    Inventors: Richard M. Soll, Paul J. Dollings
  • N-(6-methoxy-5-(trifluoromethyl)-1-naphthalenyl)-substituted imino)methyl)-N-methylglycines
    Patent number: 4906766
    Abstract: Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl][substituted imino]methyl]-N-methylglycines and methods for their preparation. The N-methylglycines are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: March 20, 1989
    Date of Patent: March 6, 1990
    Assignee: American Home Products Corporation
    Inventors: Jay E. Wrobel, Kazimir Sestanj
  • Preparation of 2,6-disubstituted-5-cyano-4-pyrimidinyloxyacetic acid aldose reductase inhibitors
    Patent number: 4906753
    Abstract: Disclosed herein are 2,6-disubstituted-5-cyano-4-pyrimidinyloxyacetic acids and pharmaceutically acceptable salts thereof and methods of their preparation. The compounds are new aldose reductase inhibitors useful for the treatment of prevention of diabetic complications.
    Type: Grant
    Filed: July 20, 1988
    Date of Patent: March 6, 1990
    Assignee: American Home Products Corporation
    Inventors: Jehan F. Bagli, John W. Ellingboe, Thomas R. Alessi
  • Preparation of tryptophols
    Patent number: 4904799
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1-, 4-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: August 8, 1989
    Date of Patent: February 27, 1990
    Assignee: American Home Products Corp.
    Inventors: Brian A. McKittrick, Alan H. Katz
  • Novel spirosuccinimides as aldose reductase inhibitors and antihyperglycemic agents
    Patent number: 4900739
    Abstract: This invention relates to novel spirosuccinimide derivatives, to the processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the treatment of diabetes mellitus and associated conditions.
    Type: Grant
    Filed: October 20, 1988
    Date of Patent: February 13, 1990
    Assignee: American Home Products Corp.
    Inventor: Jay E. Wroel