Patents Represented by Attorney Walter Patton

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  • N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-[substituted imino]methyl]-n-methylglycines
    Patent number: 4853412
    Abstract: Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl][substituted imino]methyl]-N-methylglycines and methods for their preparation. The N-methylglycines are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: December 23, 1987
    Date of Patent: August 1, 1989
    Assignee: American Home Products Corporation
    Inventors: Jay E. Wrobel, Kazimir Sestanj
  • N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylg lycine S-oxide and the amide thereof
    Patent number: 4853484
    Abstract: Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylgly cine S-oxide (tolrestat S-oxide) and the amide thereof and methods of their preparation. The S-oxides are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: October 28, 1987
    Date of Patent: August 1, 1989
    Assignee: American Home Products Corporation
    Inventors: Eckhardt S. Ferdinandi, Michael S. Malamas, Kazimir Sestanj, Surendra N. Sehgal
  • Production of substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives
    Patent number: 4847389
    Abstract: Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful analgesic and anti-inflammatory agents.
    Type: Grant
    Filed: June 13, 1988
    Date of Patent: July 11, 1989
    Assignee: American Home Products
    Inventors: Dominick Mobilio, Leslie G. Humber
  • N-acyl-N-napthoylglycines as aldose reductase inhibitors
    Patent number: 4843062
    Abstract: Disclosed herein are N-acyl-N-napthoylglycines and methods of their preparation. The N-acyl-N-napthoylglycines are novel aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: December 23, 1987
    Date of Patent: June 27, 1989
    Assignee: American Home Products Corporation
    Inventors: Kazimir Sestanj, Jay E. Wrobel, Joseph M. Kelly
  • Production of substituted 1,3,4,9-tetrahydropyrano(3,4-B)indole-1-acetic acids
    Patent number: 4826994
    Abstract: Production of indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: February 26, 1988
    Date of Patent: May 2, 1989
    Assignee: American Home Products Corporation
    Inventors: Alan H. Katz, Christopher A. Demerson, Leslie G. Humber
  • Production of substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids
    Patent number: 4824961
    Abstract: Process for the production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids having useful analgesic and anti-inflammatory activity.
    Type: Grant
    Filed: August 27, 1987
    Date of Patent: April 25, 1989
    Assignee: American Home Products Corporation
    Inventors: Chia-Cheng Shaw, Karel Pelz
  • Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids
    Patent number: 4822781
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing substituents in position 1-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and/or analgesic agents. Methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: June 1, 1988
    Date of Patent: April 18, 1989
    Assignee: American Home Products
    Inventors: Alan H. Katz, Christopher A. Demerson
  • Production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
    Patent number: 4822893
    Abstract: Process for the production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid having useful analgesic and anti-inflammatory activity.
    Type: Grant
    Filed: February 8, 1988
    Date of Patent: April 18, 1989
    Assignee: American Home Products
    Inventor: Amedeo A. Failli
  • N-acyl-N-naphthoylglycines as aldose reductase inhibitors
    Patent number: 4820727
    Abstract: Disclosed herein are N-acyl-N-naphthoylglycines and methods of their preparation. The N-acyl-N-naphthoylglycines are novel aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: December 23, 1987
    Date of Patent: April 11, 1989
    Assignee: American Home Products Corporation
    Inventors: Jay E. Wrobel, Kazimir Sestanj
  • Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids, pharmaceutical compositions containing them, and methods for treating inflammatory conditions and for analgesic purposes using them
    Patent number: 4810699
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1,5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: September 21, 1987
    Date of Patent: March 7, 1989
    Assignee: American Home Products Corporation
    Inventors: Joseph P. Sabatucci, Christopher A. Demerson, Amadeo A. Failli
  • 2,6-disubstituted-5-cyano-4-pyrimidinyloxyacetic acid aldose reductase inhibitors
    Patent number: 4786640
    Abstract: Disclosed herein are 2,6-disubstituted-5-cyano-4-pyrimidinyloxyacetic acids and pharmaceutically acceptable salts thereof and methods of their preparation. The compounds are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: June 12, 1987
    Date of Patent: November 22, 1988
    Assignee: American Home Products Corporation
    Inventors: Jehan F. Bagli, John W. Ellingboe, Thomas R. Alessi
  • 2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic acid aldose reductase inhibitors
    Patent number: 4786638
    Abstract: Disclosed herein are 2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic acids and pharmaceutically acceptable salts thereof and methods of their preparation. The compounds are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: June 12, 1987
    Date of Patent: November 22, 1988
    Assignee: American Home Products Corporation
    Inventors: Jehan F. Bagli, John W. Ellingboe, Thomas R. Alessi
  • Substituted 1,3,4,9-tetrahydropyrano [3,4-B]indole-1-acetic acids
    Patent number: 4785015
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1-, 4-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: November 5, 1987
    Date of Patent: November 15, 1988
    Assignee: American Home Products Corporation
    Inventors: Brian A. McKittrick, Alan H. Katz
  • Substituted fused tetrahydrocarbazole acetic acid derivatives, compositions and use
    Patent number: 4783479
    Abstract: Substituted fused tetrahydrocarbazole acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful analgesic and anti-inflammatory agents.
    Type: Grant
    Filed: April 21, 1988
    Date of Patent: November 8, 1988
    Assignee: American Home Products Corporation
    Inventor: Dominick Mobilio
  • Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives, composition and use
    Patent number: 4782076
    Abstract: Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods of their preparation and use are disclosed. The compounds are useful analgesic and anti-inflammatory agents.
    Type: Grant
    Filed: March 1, 1988
    Date of Patent: November 1, 1988
    Assignee: American Home Products Corporation
    Inventors: Dominick Mobilio, Leslie G. Humber
  • 2,3-dihydro-9-methyl-1H-pyrrolo[1,2-a]indol-1-amines and derivatives thereof
    Patent number: 4778812
    Abstract: Herein is disclosed 2,3-dihydro-9-methyl-1H-pyrrolo[1,2-a]indol-1-amines and derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives, and pharmaceutical compositions. The derivatives are chemically novel agents with antihypoxic, cerebroactive, and cognition activating properties.
    Type: Grant
    Filed: June 12, 1987
    Date of Patent: October 18, 1988
    Assignee: American Home Products Corporation
    Inventor: Ivo L. Jirkovsky
  • Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids
    Patent number: 4775690
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: January 13, 1987
    Date of Patent: October 4, 1988
    Assignee: American Home Products Corporation
    Inventors: Alan H. Katz, Christopher A. Demerson, Leslie G. Humber
  • Substituted 2-oxocyclohexaneacetic acid esters
    Patent number: 4748266
    Abstract: Process for the production of substituted 2-oxocyclohexaneacetic acid esters and intermediates used for their production. The substituted 2-oxocyclohexaneacetic acid esters are themselves useful intermediates for the manufacture of substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives having useful analgesic and anti-inflammatory activity.
    Type: Grant
    Filed: March 2, 1987
    Date of Patent: May 31, 1988
    Assignee: American Home Products Corporation
    Inventors: Philip F. Hughes, Dominick Mobilio, Leslie G. Humber
  • Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
    Patent number: 4748252
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at position 8. The derivatives are useful anti-inflammatory and analgesic agents and methods and chemical intermediates for their preparation are also disclosed.
    Type: Grant
    Filed: January 28, 1987
    Date of Patent: May 31, 1988
    Assignee: American Home Products Corporation
    Inventors: Eckhardt S. Ferdinandi, Dominick Mobilio, Joseph P. Sabatucci, Leslie G. Humber
  • Naphthalenylsulfonylimidazolidinediones and their thioxo analogs useful as aldose reductase inhibitors
    Patent number: 4743611
    Abstract: Disclosed herein are naphthalenylsulfonylimidazolidinediones and their thioxo analogs and methods for their preparation. The compounds are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: February 9, 1987
    Date of Patent: May 10, 1988
    Assignee: American Home Products Corp.
    Inventors: Michael S. Malamas, Kazimir Sestanj