Patents Represented by Attorney Walter Patton

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  • 2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic acid aldose reductase inhibitors
    Patent number: 4900829
    Abstract: Disclosed herein are 2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic acids and pharmaceutically acceptable salts thereof and methods of their preparation. The compounds are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: July 20, 1988
    Date of Patent: February 13, 1990
    Assignee: American Home Products Corporation
    Inventors: Jehan F. Bagli, John W. Ellingboe, Thomas R. Alessi
  • Process for the production of substituted 2-oxocyclohexaneacetic acid esters
    Patent number: 4898967
    Abstract: Process for the production of substituted 2-oxocyclohexaneacetic acid esters and intermediates used for their production. The substituted 2-oxocyclohexaneacetic acid esters are themselves useful intermediates for the manufacture of substituted 2,3,4,9-tetrahydro-1H-carabazole-1-acetic acid derivatives having useful analgesic and anti-inflammatory activity.
    Type: Grant
    Filed: February 13, 1989
    Date of Patent: February 6, 1990
    Assignee: American Home Products Corp.
    Inventors: Philip F. Hughes, Dominick Mobilio, Leslie G. Humber
  • Novel naphthalenylalkyl-3H-1,2,3,5-oxathiadiazole 2-oxides useful as antihyperglycemic agents
    Patent number: 4897405
    Abstract: This invention relates to novel [(substituted naphthalenyl)alkyl]-3H-1,2,3,5-oxathiadiazole 2-oxides, to the processes for their preparation, to methods for using the compounds, and to pharmaceutical compositions thereof. The compounds have pharmaceutical properties which render them beneficial for the treatment of diabetes mellitus and associated conditions.
    Type: Grant
    Filed: April 21, 1989
    Date of Patent: January 30, 1990
    Assignee: American Home Products Corporation
    Inventors: Thomas R. Alessi, Terence M. Dolak, John W. Ellingboe, Louis J. Lombardo
  • Production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
    Patent number: 4897493
    Abstract: Process for the production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids having useful analgesic and anti-inflammatory activity.
    Type: Grant
    Filed: January 31, 1989
    Date of Patent: January 30, 1990
    Assignee: American Home Products Corporation
    Inventors: Chia-Cheng Shaw, Karel Pelz
  • Novel naphthalenyl-3H-1,2,3,5-oxathiadiazole 2-oxides useful as antihyperglycemic agents
    Patent number: 4895861
    Abstract: This invention relates to novel substituted 3H-1,2,3,5-oxathiadiazole 2-oxides, processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the treatment of diabetes mellitus and associated conditions.
    Type: Grant
    Filed: April 21, 1989
    Date of Patent: January 23, 1990
    Assignee: American Home Products Corporation
    Inventors: Louis J. Lombardo, Thomas R. Alessi
  • Novel substituted 3H-1,2,3,5-oxathiadiazole 2-oxides useful as anthihyperglycemic agents
    Patent number: 4895860
    Abstract: This invention relates to novel substituted 3H-1,2,3,5-oxathiadiazole 2-oxides, to the processes for their preparation, to methods for using the compounds, and to pharmaceutical compositions thereof. The compounds have pharmaceutical properties which render them beneficial for the treatment of diabetes mellitus and associated conditions.
    Type: Grant
    Filed: April 21, 1989
    Date of Patent: January 23, 1990
    Assignee: American Home Products Corporation
    Inventors: Thomas R. Alessi, John W. Ellingboe
  • Novel benzyl-3H-1,2,3,5-oxathiadiazole 2-oxides useful as antihyperglycemic agents
    Patent number: 4895862
    Abstract: This invention relates to novel benzyl-3H-1,2,3,5-oxathiadiazole 2-oxides, to the processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the treatment of diabetes mellitus and associated conditions.
    Type: Grant
    Filed: April 21, 1989
    Date of Patent: January 23, 1990
    Assignee: American Home Products Corp.
    Inventors: Thomas R. Alessi, Terence M. Dolak
  • Process for the preparation of substituted fused tetrahydrocarbazole acetic acid derivatives
    Patent number: 4888431
    Abstract: Substituted fused tetrahydrocarbazole acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful analgesic and anti-inflammatory agents.
    Type: Grant
    Filed: June 15, 1989
    Date of Patent: December 19, 1989
    Assignee: American Home Products Corporation
    Inventor: Dominick Mobilio
  • Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
    Patent number: 4886886
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1-, 4-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: July 25, 1988
    Date of Patent: December 12, 1989
    Assignee: American Home Products Corporation
    Inventors: Brian A. McKittrick, Alan H. Katz
  • 2-pyridinecarbothioamides and pharmaceutical compositions comprising the same useful as anti ulcer agents
    Patent number: 4886821
    Abstract: There are provided gastric antiulcer and cytoprotective substituted N-phenyl-2-pyridinecarbothioamides. The process for their production and formulation is disclosed.
    Type: Grant
    Filed: November 23, 1987
    Date of Patent: December 12, 1989
    Assignee: American Home Products Corporation
    Inventors: William A. Kinney, Amadeo A. Failli, Ghulam N. Mir
  • Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives, composition and use
    Patent number: 4886826
    Abstract: Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful analgesic, anti-inflammatory, anti-asthmatic and anti-allergic agents.
    Type: Grant
    Filed: June 1, 1989
    Date of Patent: December 12, 1989
    Assignee: American Home Products Corporation
    Inventor: Dominick Mobilio
  • Use of rapamycin in treatment of certain tumors
    Patent number: 4885171
    Abstract: Methods for using rapamycin in the treatment of certain cancers or tumors are disclosed.
    Type: Grant
    Filed: March 22, 1984
    Date of Patent: December 5, 1989
    Assignee: American Home Products Corporation
    Inventors: Sehgal N. Surendra, Claude Vezina
  • 2-Pyridinecarbothioamides and pharmaceutical compositions comprising the same
    Patent number: 4873238
    Abstract: There are provided gastric antiulcer and cytoprotective substituted N-phenyl-2-pyridinecarbothioamides. The process for their production and formulation is disclosed.
    Type: Grant
    Filed: September 19, 1988
    Date of Patent: October 10, 1989
    Assignee: American Home Products Corporation
    Inventors: William A. Kinney, Nancy E. Lee
  • Susbtituted fused tetrahydrocarbazole acetic acid derivatives
    Patent number: 4873257
    Abstract: Substituted fused tetrahydrocarbazole acetic acid derivatives and methods for their preparation and use are disclosed. The compouns are useful analgesic and anti-inflammatory agents.
    Type: Grant
    Filed: August 9, 1988
    Date of Patent: October 10, 1989
    Assignee: American Home Products Corporation
    Inventor: Dominick Mobilio
  • Inhibition of bone loss by (-)-N-[[(5-chloro-2-benzothiazolyl)thio]phenylacetyl]-L-cysteine
    Patent number: 4866082
    Abstract: A method for modifying the balance between bone production and bone resorption in a host animal by administration of (-)-N-[[(5-chloro-benzothiazolyl)-thio]phenylacetyl]-L-cysteine to inhibit bone loss.
    Type: Grant
    Filed: April 6, 1988
    Date of Patent: September 12, 1989
    Assignee: American Home Products Corporation
    Inventors: Marshall Hayward, Jean Schmid
  • Production of N-((2-alkoxy-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl)carbonyl)-N-me thylglycine esters
    Patent number: 4866197
    Abstract: Process for the production of N-[[2-alkoxy-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-meth ylglycine esters and intermediates for their production. Said esters are themselves intermediates for the manufacture of compounds which inhibit aldose reductase and are useful for the treatment of diabetic complications.
    Type: Grant
    Filed: December 23, 1987
    Date of Patent: September 12, 1989
    Assignee: American Home Products Corporation
    Inventor: John G. Bauman
  • Process for the production of substituted 2-oxocyclohexaneacetic acid esters
    Patent number: 4861910
    Abstract: Process for the production of substituted 2-oxocyclohexaneacetic acid esters and intermediates used for their production. The substituted 2-oxocyclohexaneacetic acid esters are themselves useful intermediates for the manufacture of substituted 2,34,9-tetrahydro-1H-carbazole-1-acetic acid derivatives having useful analgesic and anti-inflammatory activity.
    Type: Grant
    Filed: December 11, 1987
    Date of Patent: August 29, 1989
    Assignee: American Home Products Corporation
    Inventors: Philip F. Hughes, Dominick Mobilio, Leslie G. Humber
  • 2-substituted 1,2-benzisothiazol-3(2H)-one 1,1-dioxide useful as an anxiolytic agent
    Patent number: 4859671
    Abstract: There is disclosed the compound 2-[4-[4-(2,7-naphthyridin-1-yl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3( 2H)-one 1,1-dioxide, and the method of producing said compound, and the pharmaceutically acceptable salts thereof, and the use of said compound as an anxiolytic agent having a low liability for extrapyramidal side effects.
    Type: Grant
    Filed: July 8, 1988
    Date of Patent: August 22, 1989
    Assignee: American Home Products Corporation
    Inventor: Amedeo A. Failli
  • Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
    Patent number: 4855445
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing substituents in position 1-,5-,6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and/or analgesic agents. Methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: January 9, 1989
    Date of Patent: August 8, 1989
    Assignee: American Home Products Corporation
    Inventors: Alan H. Katz, Christopher A. Demerson
  • Diuretic and antihypertensive substituted-5-pyrimidinesulfonylureas
    Patent number: 4853389
    Abstract: This invention relates to substituted 5-pyrimidinesulfonamides, pharmaceutically acceptable salts thereof and to processes for synthesis thereof. Other aspects of the invention concern pharmaceutical compositions containing an instant compound as active ingredient and methods of treatment where there is an indicated need for an antihypertensive and/or diuretic agent.
    Type: Grant
    Filed: April 26, 1988
    Date of Patent: August 1, 1989
    Assignee: American Home Products Corporation
    Inventors: Terence M. Dolak, Sung J. Lee, James L. Bullington