Patents Represented by Attorney, Agent or Law Firm William T. Han
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Patent number: 8338369Abstract: The present invention relates to methods and pharmaceutical compositions relating to administering hypoglycemic agents and/or GLP-1 agonists wherein the mean maximum plasma concentration (Cmax) and/or Area Under the Curve (AUC) values of the hypoglycemic agent are increased and/or sustained.Type: GrantFiled: September 12, 2007Date of Patent: December 25, 2012Assignee: Glaxosmithkline LLCInventors: Mark A. Bush, Jessica E. Matthews, Susan E. Walker
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Patent number: 7132262Abstract: The present invention relates to methods and compositions useful in the treatment and prevention of human papilloma virus infections and the symptoms and diseases associated therewith. More particularly, the invention relates to polynucleotide sequences which encode human papilloma virus (HPV) amino acid amino acid sequences, wherein the codon usage pattern of the polynucleotide sequences resemble those of highly expressed mammalian genes.Type: GrantFiled: July 30, 2003Date of Patent: November 7, 2006Assignee: SmithKline Beecham Corp.Inventors: Peter Franz Ertl, Gerald Wayne Gough, Christopher Jeffrey Alan Ring, Vanita Parmar, Sarah Marina Walcott
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Patent number: 7105316Abstract: LbpB polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing LbpB polypeptides and polynucleotides in the design of protocols for the treatment of neisserial disease, among others, and diagnostic assays for such conditions.Type: GrantFiled: December 12, 2003Date of Patent: September 12, 2006Assignees: University of Utrecht, Technology FoundationInventors: Annika Margareta Pettersson-Fernholm, Johannes Petrus Maria Tommassen
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Patent number: 7087748Abstract: A novel process for the removal of impurities from clavulanic acid using a selective adsorption material, in particular a molecularly imprinted polymer. Novel selective adsorption materials suitable for the process, and a process for the preparation of such selective adsorption materials, are also disclosed.Type: GrantFiled: September 17, 2001Date of Patent: August 8, 2006Assignee: SmithKline Beecham P.L.C.Inventors: Klaus Mosbach, Lei Ye, Yihua Yu
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Patent number: 6455575Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.Type: GrantFiled: June 6, 1997Date of Patent: September 24, 2002Assignee: Bristol-Myers Squibb CompanyInventors: Jerzy Golik, Dolatrai Vyas, John J. Wright, Henry Wong, John F. Kadow, John K. Thottathil, Wen-Sen Li, Murray A. Kaplan, Robert K. Perrone, Mark D. Wittman
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Patent number: 6432678Abstract: Macaca cynomolgus IL18 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize Macaca cynomolgus IL18. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: cancer and auto-immune diseases.Type: GrantFiled: June 20, 2000Date of Patent: August 13, 2002Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.Inventors: Alexander H. Taylor, Han N. Trinh
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Patent number: 6433156Abstract: Rabbit G alpha 16 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing rabbit G alpha 16 polypeptides and polynucleotides in screening of antagonists or agonists of cells co-expressing a G-protein coupled receptor and rabbit G alpha 16.Type: GrantFiled: December 22, 1998Date of Patent: August 13, 2002Assignees: SmithKline Beecham Corporation, SmithKline Beecham plcInventors: Robert S. Ames, John A. Feild, Tania Testa
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Patent number: 6399573Abstract: IL-1ra beta polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1ra beta polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, septicemia, arthritis, inflammatory bowel disease, graft vs. host disease, autoimmunity, stroke, cardiac ischemia, acute respiratory disease syndrome (ARDS), psoriasis, restenosis, traumatic brain injury, AIDS, cachexia, allergy, parasite infection, allergic rhinitis, allergic asthma, atopic dermatitis, allergic inflammatory diseases, and delayed hypersensitivity, among others, and diagnostic assays for such conditions.Type: GrantFiled: January 28, 2000Date of Patent: June 4, 2002Assignee: SmithKline Beecham CorporationInventor: Peter Ronald Young
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Patent number: 6388055Abstract: Mouse CC-CKR5 polypeptides and DNA (RNA) encoding such mouse CC-CKR5 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such mouse CC-CKR5 in the development of gene knockout mice for use as a model for human immunodeficiency virus.Type: GrantFiled: October 3, 1996Date of Patent: May 14, 2002Assignee: SmithKline Beecham CorporationInventors: Derk J. Bergsma, Mary E. Brawner, Usman Shabon
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Patent number: 6376214Abstract: p38beta2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed.Type: GrantFiled: February 18, 1997Date of Patent: April 23, 2002Assignee: SmithKline Beecham CorporationInventor: Sanjay Kumar
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Patent number: 6369045Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule incoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.Type: GrantFiled: October 8, 1996Date of Patent: April 9, 2002Assignee: SmithKline Beecham p.l.c.Inventors: Colin Houston Macphee, David Graham Tew, Deirdre Mary Bernadette Hickey
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Patent number: 6368823Abstract: hKv4.3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hKv4.3 polypeptides and polynucleotides in the design of protocols for the treatment of cardiac arrhythmias and Alzheimer's disease, among others, and diagnostic assays for such conditions.Type: GrantFiled: February 2, 1999Date of Patent: April 9, 2002Assignee: SmithKline Beecham Laboratoires PharmaceutiquesInventors: Antoine Michel Alain Bril, Thierry Paul Gerard Calmels, Jean-Francois Simon Pierre Faivre, Jean-Luc Javre, Sabine Rouanet
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Patent number: 6365715Abstract: HC/BTLP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hC/BTLP polypeptides and polynucleotides in the design of protocols for the treatment of restenosis, atherosclerosis, congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), benign prostatic hypertrophy (BPH), nephritis, fibrosis, glomerulonephritis, gliosis, cirrhosis and anomalies of wound healing, such as keloids among others, and diagnostic assays for such conditions.Type: GrantFiled: November 1, 1999Date of Patent: April 2, 2002Assignee: SmithKline Beecham CorporationInventors: Anthony J Arleth, Nabil A Elshourbagy, Xiaotong Li, Robert N Willette
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Patent number: 6361975Abstract: mASP-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize mASP-2. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: Alzheimer's disease, cancer and prohormone processing.Type: GrantFiled: November 15, 2000Date of Patent: March 26, 2002Assignees: SmithKline Beecham Corporation, SmithKline Beecham plcInventors: Gary Christie, Xiaotong Li, David J. Powell, Yuan Zhu
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Patent number: 6362326Abstract: The present invention relates to 11cby, in particular 11cby polypeptides and 11cby polynucleotides, recombinant materials and methods for their production. In another aspect, the invention relates to methods for using such polypeptides and polynucleotides, including the treatment of bacterial, fungal, protozoan and viral infections, particularly infection caused by HIV-1 or HIV-2; pain; cancers; diabetes; obesity; feeding and drinking abnormalities, such as anorexia and bulimia; asthma; Parkinson's disease; both acute and congestive heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia or severe mental retardation, and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, hereinafter referred to as “the Diseases”, among others.Type: GrantFiled: December 22, 1998Date of Patent: March 26, 2002Assignee: SmithKline Beecham CorporationInventors: Ganesh Sathe, Catherine E. Ellis, Wendy Halsey, Derk Bergsma
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Patent number: 6358695Abstract: HNEAA81 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are screening methods for identifying agonists and antagonists of the interaction of the HNEAA81 receptor and its ligands in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.Type: GrantFiled: April 26, 2000Date of Patent: March 19, 2002Assignees: SmithKline Beecham Corporation, SmithKline Beecham plcInventors: Ganesh Madhusudan Sathe, Wendy S Halsey, Jon Chambers, Alison Muir, Philip Szekeres
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Patent number: 6359116Abstract: HE8AN36 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HE8AN36 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: February 9, 2000Date of Patent: March 19, 2002Assignee: SmithKline Beecham plcInventor: Stephen L Mathias
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Patent number: 6358721Abstract: SVP4b polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SVP4b polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: March 9, 2001Date of Patent: March 19, 2002Assignees: SmithKline Beecham Corporation, SmithKline Beecham plcInventor: Lisa Patel
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Patent number: 6358707Abstract: F11 antigen polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing F11 antigen polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: January 5, 2000Date of Patent: March 19, 2002Assignee: SmithKline Beecham CorporationInventors: Shalley Kant Gupta, Kodandaram Pillarisetti
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Patent number: 6355465Abstract: Rattus YAK1 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize rattus YAK1. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to osteoarthritis, osteoporosis, rheumatoid arthritis.Type: GrantFiled: September 11, 2000Date of Patent: March 12, 2002Assignee: SmithKline Beecham plcInventors: Caretha Lee Creasy, Tania Tamson Testa