Patents Represented by Attorney, Agent or Law Firm William T. Han
  • Patent number: 8338369
    Abstract: The present invention relates to methods and pharmaceutical compositions relating to administering hypoglycemic agents and/or GLP-1 agonists wherein the mean maximum plasma concentration (Cmax) and/or Area Under the Curve (AUC) values of the hypoglycemic agent are increased and/or sustained.
    Type: Grant
    Filed: September 12, 2007
    Date of Patent: December 25, 2012
    Assignee: Glaxosmithkline LLC
    Inventors: Mark A. Bush, Jessica E. Matthews, Susan E. Walker
  • Patent number: 7132262
    Abstract: The present invention relates to methods and compositions useful in the treatment and prevention of human papilloma virus infections and the symptoms and diseases associated therewith. More particularly, the invention relates to polynucleotide sequences which encode human papilloma virus (HPV) amino acid amino acid sequences, wherein the codon usage pattern of the polynucleotide sequences resemble those of highly expressed mammalian genes.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: November 7, 2006
    Assignee: SmithKline Beecham Corp.
    Inventors: Peter Franz Ertl, Gerald Wayne Gough, Christopher Jeffrey Alan Ring, Vanita Parmar, Sarah Marina Walcott
  • Patent number: 7105316
    Abstract: LbpB polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing LbpB polypeptides and polynucleotides in the design of protocols for the treatment of neisserial disease, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: September 12, 2006
    Assignees: University of Utrecht, Technology Foundation
    Inventors: Annika Margareta Pettersson-Fernholm, Johannes Petrus Maria Tommassen
  • Patent number: 7087748
    Abstract: A novel process for the removal of impurities from clavulanic acid using a selective adsorption material, in particular a molecularly imprinted polymer. Novel selective adsorption materials suitable for the process, and a process for the preparation of such selective adsorption materials, are also disclosed.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: August 8, 2006
    Assignee: SmithKline Beecham P.L.C.
    Inventors: Klaus Mosbach, Lei Ye, Yihua Yu
  • Patent number: 6455575
    Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.
    Type: Grant
    Filed: June 6, 1997
    Date of Patent: September 24, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jerzy Golik, Dolatrai Vyas, John J. Wright, Henry Wong, John F. Kadow, John K. Thottathil, Wen-Sen Li, Murray A. Kaplan, Robert K. Perrone, Mark D. Wittman
  • Patent number: 6433156
    Abstract: Rabbit G alpha 16 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing rabbit G alpha 16 polypeptides and polynucleotides in screening of antagonists or agonists of cells co-expressing a G-protein coupled receptor and rabbit G alpha 16.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: August 13, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Robert S. Ames, John A. Feild, Tania Testa
  • Patent number: 6432678
    Abstract: Macaca cynomolgus IL18 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize Macaca cynomolgus IL18. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: cancer and auto-immune diseases.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: August 13, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Alexander H. Taylor, Han N. Trinh
  • Patent number: 6399573
    Abstract: IL-1ra beta polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1ra beta polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, septicemia, arthritis, inflammatory bowel disease, graft vs. host disease, autoimmunity, stroke, cardiac ischemia, acute respiratory disease syndrome (ARDS), psoriasis, restenosis, traumatic brain injury, AIDS, cachexia, allergy, parasite infection, allergic rhinitis, allergic asthma, atopic dermatitis, allergic inflammatory diseases, and delayed hypersensitivity, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: June 4, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: Peter Ronald Young
  • Patent number: 6388055
    Abstract: Mouse CC-CKR5 polypeptides and DNA (RNA) encoding such mouse CC-CKR5 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such mouse CC-CKR5 in the development of gene knockout mice for use as a model for human immunodeficiency virus.
    Type: Grant
    Filed: October 3, 1996
    Date of Patent: May 14, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk J. Bergsma, Mary E. Brawner, Usman Shabon
  • Patent number: 6376214
    Abstract: p38beta2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed.
    Type: Grant
    Filed: February 18, 1997
    Date of Patent: April 23, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: Sanjay Kumar
  • Patent number: 6369045
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule incoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Grant
    Filed: October 8, 1996
    Date of Patent: April 9, 2002
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Colin Houston Macphee, David Graham Tew, Deirdre Mary Bernadette Hickey
  • Patent number: 6368823
    Abstract: hKv4.3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hKv4.3 polypeptides and polynucleotides in the design of protocols for the treatment of cardiac arrhythmias and Alzheimer's disease, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: February 2, 1999
    Date of Patent: April 9, 2002
    Assignee: SmithKline Beecham Laboratoires Pharmaceutiques
    Inventors: Antoine Michel Alain Bril, Thierry Paul Gerard Calmels, Jean-Francois Simon Pierre Faivre, Jean-Luc Javre, Sabine Rouanet
  • Patent number: 6365715
    Abstract: HC/BTLP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hC/BTLP polypeptides and polynucleotides in the design of protocols for the treatment of restenosis, atherosclerosis, congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), benign prostatic hypertrophy (BPH), nephritis, fibrosis, glomerulonephritis, gliosis, cirrhosis and anomalies of wound healing, such as keloids among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: April 2, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Anthony J Arleth, Nabil A Elshourbagy, Xiaotong Li, Robert N Willette
  • Patent number: 6361975
    Abstract: mASP-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize mASP-2. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: Alzheimer's disease, cancer and prohormone processing.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: March 26, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Gary Christie, Xiaotong Li, David J. Powell, Yuan Zhu
  • Patent number: 6362326
    Abstract: The present invention relates to 11cby, in particular 11cby polypeptides and 11cby polynucleotides, recombinant materials and methods for their production. In another aspect, the invention relates to methods for using such polypeptides and polynucleotides, including the treatment of bacterial, fungal, protozoan and viral infections, particularly infection caused by HIV-1 or HIV-2; pain; cancers; diabetes; obesity; feeding and drinking abnormalities, such as anorexia and bulimia; asthma; Parkinson's disease; both acute and congestive heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia or severe mental retardation, and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, hereinafter referred to as “the Diseases”, among others.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: March 26, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Ganesh Sathe, Catherine E. Ellis, Wendy Halsey, Derk Bergsma
  • Patent number: 6358721
    Abstract: SVP4b polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SVP4b polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: March 19, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventor: Lisa Patel
  • Patent number: 6358695
    Abstract: HNEAA81 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are screening methods for identifying agonists and antagonists of the interaction of the HNEAA81 receptor and its ligands in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: April 26, 2000
    Date of Patent: March 19, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Ganesh Madhusudan Sathe, Wendy S Halsey, Jon Chambers, Alison Muir, Philip Szekeres
  • Patent number: 6359116
    Abstract: HE8AN36 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HE8AN36 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: February 9, 2000
    Date of Patent: March 19, 2002
    Assignee: SmithKline Beecham plc
    Inventor: Stephen L Mathias
  • Patent number: 6358707
    Abstract: F11 antigen polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing F11 antigen polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: January 5, 2000
    Date of Patent: March 19, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Shalley Kant Gupta, Kodandaram Pillarisetti
  • Patent number: 6355465
    Abstract: Rattus YAK1 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize rattus YAK1. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to osteoarthritis, osteoporosis, rheumatoid arthritis.
    Type: Grant
    Filed: September 11, 2000
    Date of Patent: March 12, 2002
    Assignee: SmithKline Beecham plc
    Inventors: Caretha Lee Creasy, Tania Tamson Testa