Patents Represented by Attorney, Agent or Law Firm William T. Han
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Patent number: 6200777Abstract: Human p101 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human p101 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: August 27, 1998Date of Patent: March 13, 2001Assignee: SmithKline Beecham plcInventors: Colin Houston MacPhee, Lisa Patel
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Patent number: 6197069Abstract: Putative Adrenomedullin Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Putative Adrenomedullin Receptor polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension, urinary retention, osteoporosis; angina pectoris; myocardial infarction, ulcers; asthma; allergies; benign prostatic hypertrophy; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome; and pre-eclampsia, among others and diagnostic assays for such conditions.Type: GrantFiled: September 3, 1998Date of Patent: March 6, 2001Assignees: SmithKline Beecham Corporation, SmithKline Beecham Laboratoires PharmaceutiquesInventors: George Henry Poste, Michel Louis Souchet, Philippe Laurent Robert, Stephane Clement Krief, Bernard Emile Joseph Gout, Eve Mahe
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Patent number: 6197544Abstract: SBSEMVL polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilising SBSEMVL polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: January 29, 1999Date of Patent: March 6, 2001Assignee: SmithKline Beecham plcInventors: David Michalovich, Philip David Hayes
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Patent number: 6187908Abstract: Tubby 2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Tubby 2 polypeptides and polynucleotides in the design of protocols for the treatment of diabetes, obesity, and atherosclerosis, among others, and diagnostic assays for such conditions.Type: GrantFiled: November 25, 1997Date of Patent: February 13, 2001Assignee: SmithKline Beecham, P.L.C.Inventors: Jonathan Alexander Terrett, Tania Tamson Testa, Israel Simon Gloger, Stephen A. Hughes, Trudy Rachel Doe
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Patent number: 6187544Abstract: The present invention provides a method for high throughput cloning of full length cDNA sequences using a pooling strategy. This method uses a plurality of clone arrays prepared from cDNA libraries which have been preferably enriched for 5 ′ mRNA sequences and size fractionated into several discrete ranges (sub-libraries). These arrays are used to rapidly identify the full length cDNA sequence for a DNA segment of interest.Type: GrantFiled: November 3, 1999Date of Patent: February 13, 2001Assignee: SmithKline Beecham CorporationInventors: Derk Jon Bergsma, Jeffrey L Mooney
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Patent number: 6187560Abstract: HNFCW60 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNFCW60 polypeptides and polynucleotides in the design of protocols for the treatment of obesity, diabetes, hyperlipademia and body weight disorder, among others, and diagnostic assays for such conditions.Type: GrantFiled: June 30, 1999Date of Patent: February 13, 2001Assignee: SmithKline Beecham plcInventors: Lee James Beeley, Kelly Paine, Robert James Godden
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Patent number: 6187562Abstract: SPHINGLY polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SPHINGLY polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: January 27, 1999Date of Patent: February 13, 2001Assignee: SmithKline Beecham plcInventors: David Malcolm Duckworth, Robert James Godden, Tania Tamson Testa
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Patent number: 6183990Abstract: Rhotekin polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing rhotekin polypeptides and polynucleotides in diagnostic assays.Type: GrantFiled: May 14, 1999Date of Patent: February 6, 2001Assignee: SmithKline Beecham, plcInventors: Klaus Norbert Duecker, Thierry Paul Gerard Calmels
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Patent number: 6180365Abstract: The mouse GPR43 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing mouse GPR43 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: November 6, 1998Date of Patent: January 30, 2001Assignee: SmithKline Beecham CorporationInventors: Nabil Elshourbagy, Pamela Lane, Ping Tsui, Lisa Vawter
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Patent number: 6180384Abstract: METPRO02 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing METPRO02 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: September 24, 1998Date of Patent: January 30, 2001Assignee: SmithKline Beecham plcInventors: Christopher Donald Southan, Nicola Anne Burgess, Conrad Gerald Chapman
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Patent number: 6174716Abstract: p101 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing p101 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: August 20, 1999Date of Patent: January 16, 2001Assignee: SmithKline Beecham plcInventors: Colin Houston MacPhee, Lisa Patel
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Patent number: 6096868Abstract: ECR673 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ECR673 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: June 8, 1999Date of Patent: August 1, 2000Assignee: SmithKline Beecham CorporationInventors: Wendy S. Halsey, Joyce Yue Mao, Ganesh M. Sathe
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Patent number: 6020157Abstract: HFGAN72X polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HFGAN72X polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthema; Parkinson's disease; acute heart failure; hypotension; hypertension; unary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.Type: GrantFiled: April 30, 1997Date of Patent: February 1, 2000Assignee: SmithKline Beecham CorporationInventors: Derk J. Bergsma, Catherine Elizabeth Ellis
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Patent number: 6010848Abstract: Disclosed are screening methods to identify molecules which activate or inhibit the activity of an ATPase protein of the Flaviviridae family, particularly NS4B protein of Hepatitis C Virus (HCV). These inhibitors and activators of HCV NS4B protein potentially can be used as antiviral compounds and as therapeutic agents for the treatment of viruses linked to the Flaviviridae family, particularly HCV, flaviviruses such as yellow fever virus, Dengue virus types 1-4, and pestiviruses such as bovine viral diarrhea virus and classic swine fever, among others.Type: GrantFiled: June 19, 1998Date of Patent: January 4, 2000Assignee: Smithkline Beecham CorporationInventors: Alfred M. Delvecchio, Weidong Zhong
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Patent number: 5965420Abstract: hYAK3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed.Type: GrantFiled: April 7, 1997Date of Patent: October 12, 1999Assignee: SmithKline Beecham CorporationInventors: Caretha L. Creasy, Wei Xie
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Patent number: 5948669Abstract: Rat cathepsin k polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing rat cathepsin k polypeptides and polynucleotides in the design of protocols for the treatment of osteoporosis, periodonatal disease, arthritis, cancer, tumor metastasis, and Paget's disease, among others, and diagnostic assays for such conditions.Type: GrantFiled: February 26, 1997Date of Patent: September 7, 1999Assignee: SmithKline Beecham CorporationInventors: John A. Feild, Kimberly Brun
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Patent number: 5942405Abstract: Human C3a Receptor polypeptides and DNA (RNA) encoding such C3a Receptor and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such C3a Receptor for the treatment of inflammatory and auto-immune disorders, among others. Antagonists against such C3a Receptor and their use as a therapeutic to treat inflammatory and auto-immune disorders, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the C3a Receptor and for detecting altered levels of the polypeptide in a host.Type: GrantFiled: June 16, 1997Date of Patent: August 24, 1999Assignee: SmithKline Beecham CorporationInventors: Robert S Ames, Derk Jon Bergsma, James J Foley, Chandrika Saidapet-Kumar, Henry M Sarau
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Patent number: 5935814Abstract: HFGAN72Y polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HFGAN72Y polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.Type: GrantFiled: April 30, 1997Date of Patent: August 10, 1999Assignee: Smithkline Beecham CorporationInventors: Derk J. Bergsma, Catherine Elizabeth Ellis
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Patent number: 5932702Abstract: Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.Type: GrantFiled: January 29, 1998Date of Patent: August 3, 1999Assignees: Human Gene Sciences, TakedaInventors: Ryo Fujii, Shuji Hinuma, Yi Li, Steven M. Ruben, Daniel R. Soppet
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Patent number: 5928881Abstract: The invention provides a method of screening compounds to identify those which enhance or block the action of CC-CKR5. Further provided are compounds which blcok (antagonists) or enhance (agonists) the action of CC-CKR5.Type: GrantFiled: July 11, 1997Date of Patent: July 27, 1999Assignee: SmithKline Beecham CorporationInventors: Mary S. Barnette, Mary Ellen Brawner