Patents Represented by Attorney, Agent or Law Firm William T. Han
  • Nucleic acids encoding the G-protein coupled receptor HNFDS78
    Patent number: 6287801
    Abstract: Human G-Protein Coupled Receptor HNFDS78 polypeptides and DNA (RNA) encoding such G-Protein Coupled Receptor HNFDS78 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such G-Protein Coupled Receptor HNFDS78 for the treatment of diseases, such as, atherosclerosis, inflammatory disease, and infectious disease. Antagonists against such G-Protein Coupled Receptor HNFDS78 and their use as a therapeutic to treat disease are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding G-protein coupled receptors and for detecting altered levels of the polypeptide in a host.
    Type: Grant
    Filed: July 22, 1996
    Date of Patent: September 11, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk Bergsma, Nabil Elshourbagy, Henry Sarau, Steven Ruben
  • KIAA0551 polynucleotides and polypeptides use
    Patent number: 6277979
    Abstract: The use of KIAA0551 polypeptides and polynucleotides in the design of protocols for the treatment of neuropathies, neuropathic pain, inflammatory and chronic pain, neurodegenerative conditions such as Motor Neuron Disease, Parkinson's Disease, Alzheimer's Disease and other dementias, as well as ischaemic damage in neuronal and cardiac tissues, through disease or infectious agents, among others, and diagnostic assays for such conditions. Also disclosed are methods for producing such polypeptides by recombinant techniques.
    Type: Grant
    Filed: September 10, 1999
    Date of Patent: August 21, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Sharon Bingham, Patrick Case, Sally Neale Lawson, Richard Anthony Newton, Oliver Lars Rausch, Alastair David Reith, Gareth John Sanger
  • Cacnglike3 polynucleotides and expression systems
    Patent number: 6274380
    Abstract: CACNGLIKE3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing CACNGLIKE3 are calcium ion channel family members and CACNGLIKE3 polynucleotides encode for these calcium ion family proteins. Polynucleotides comprising the nucleotide sequences of the present invention provide means for production and manipulation of the CACNGLIKE3 polypeptides. The present invention also provides for the use of CACNGLIKE3 polynucleotides in recombinant expression systems.
    Type: Grant
    Filed: September 8, 1999
    Date of Patent: August 14, 2001
    Assignee: SmithKline Beecham PLC
    Inventors: David Malcolm Duckworth, Philip David Hayes
  • P101 Polypeptides
    Patent number: 6258580
    Abstract: Human p101 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human p101 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: July 10, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Colin Houston Macphee, Lisa Patel
  • MPROT12 polynucleotides and methods thereof
    Patent number: 6255468
    Abstract: MPROT12 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing MPROT12 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: May 5, 1999
    Date of Patent: July 3, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Christopher Donald Southan, Joanne Rachel Evans
  • Human G protein coupled lysophosphatidic acid receptor
    Patent number: 6242572
    Abstract: HOFNH30 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HOFNH30 polypeptides and polynucleotides in terapy, and diagnostic assays for such.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: June 5, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Ping Tsui, Catherine E. Ellis, Ganesh M. Sathe, Stephanie Van Horn, Robert S. Ames, James J. Foley, Laura R. Fitzgerald, Henry M. Sarau, Jonathan K. Chambers
  • h-TREK1 polypeptides and h-TREK1 polynucleotides
    Patent number: 6242217
    Abstract: h-TREK1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing h-TREK1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: January 25, 1999
    Date of Patent: June 5, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Helen Jane Meadows, Conrad Gerald Chapman
  • VANILREP1 polynucleotides and VANILREP1 polypeptides
    Patent number: 6239267
    Abstract: VANILREP1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing VANILREP1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: May 29, 2001
    Assignee: SmithKline Beecham plc
    Inventors: David Malcolm Duckworth, Philip David Hayes, Helen Jane Meadows, John Beresford Davis
  • Compounds
    Patent number: 6238886
    Abstract: SVP-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SVP-1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: May 29, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Lisa Patel, Colin Houston MacPhee
  • Neurotransmitter transporter SC6
    Patent number: 6238883
    Abstract: The SC6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SC6 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: October 29, 1998
    Date of Patent: May 29, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Anthony M Brown, Conrad Gerald Chapman, Israel Simon Gloger, Joanne Rachel Evans, William Cairns, Hugh Jonathan Herdon
  • ppGaNTase-T6
    Patent number: 6235510
    Abstract: ppGaNTase-T6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ppGaNTase-T6 polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: May 22, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael W Lark, Sanjay Kumar, Marion M Van Horn
  • PIGR-1, a member of immunoglobulin gene superfamily
    Patent number: 6232441
    Abstract: PIGR-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PIGR-1 polypeptides and polynucleotides in the design of protocols for the treatment of rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: April 28, 1999
    Date of Patent: May 15, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Shujian Wu, Raymond W Sweet, Alemseged Truneh, Mark Robert Hurle
  • Platelet factor-4 receptor assay
    Patent number: 6232084
    Abstract: The ligand PF-4 has been identifed as a ligand for the 7TM receptor HBMBU14, also known as TYMSTR, STRL-33 and BONZO.
    Type: Grant
    Filed: March 24, 1999
    Date of Patent: May 15, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Colin Houston MacPhee, Kitty Moores, Theodorus Antonius Berkhout
  • Hepatitis C virus NS5B truncated protein and methods thereof to identify antiviral compounds
    Patent number: 6228576
    Abstract: The invention provides HCV NS5B polypeptides and DNA (RNA) encoding HCV NS5B polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing HCV NS5B polypeptides to screen for antiviral compounds.
    Type: Grant
    Filed: December 9, 1998
    Date of Patent: May 8, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Alfred M. DelVecchio
  • Compounds
    Patent number: 6225090
    Abstract: SVP4b polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SVP4b polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: May 1, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventor: Lisa Patel
  • Process for the aminocarbonylation of benzazepines and benzodiazepines
    Patent number: 6225465
    Abstract: A new process for preparing substituted 7-aminocarbonyl-3-oxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepines is disclosed.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: May 1, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Stephen K. Etridge, Timothy Charles Walsgrove, Jerome Hayes, Andrew S. Wells
  • Expression vectors and process for producing human B cell surface molecule RP105
    Patent number: 6221629
    Abstract: Nucleic acid molecules encoding a human B cell surface molecule are provided. Polypeptides and antibodies which bind to these polypeptides are also provided. In addition, methods of detecting mutated forms of the molecule are provided.
    Type: Grant
    Filed: January 14, 1998
    Date of Patent: April 24, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Lisa A. Marshall, Amy K. Roshak
  • cDNA clone HDPB130 that encodes a novel human 7-transmembrane receptor
    Patent number: 6221627
    Abstract: HDPBI30 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HDPBI30 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: February 24, 1997
    Date of Patent: April 24, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Ganesh Sathe, Stephanie Van Horn
  • Polynucleotides encoding human sodium bicarbonate cotransporters
    Patent number: 6200776
    Abstract: The hNBC3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hNBC3 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: July 15, 1998
    Date of Patent: March 13, 2001
    Assignees: Yale University School of Medicine, SmithKline Beecham Corporation P.L.C., SmithKline Beecham Laboratories Pharmaceutiques
    Inventors: Walter F Boron, Antoine Michel Alain Bril, Nassirah Khandoudi, Xavier Martin, Steven Charles Jupe, Christopher John Rawlings, Trudy Rachel Doe
  • 7-0-ethers of taxane derivatives
    Patent number: 6201140
    Abstract: The present invention concerns novel 7-ethers of taxane derivatives, their use as antitumor agents and pharmaceutical compositions containing the novel compounds.
    Type: Grant
    Filed: July 28, 1994
    Date of Patent: March 13, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Henry Wong, Mark D. Wittman