Patents Represented by Attorney, Agent or Law Firm William T. Han
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Patent number: 5912159Abstract: The invention relates to Arginase II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.Type: GrantFiled: August 20, 1997Date of Patent: June 15, 1999Assignees: Smithkline Beecham Corp., Human Genome Sciences, Inc.Inventors: Joseph G Vockley, Patrick J Dillon
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Patent number: 5885800Abstract: TR4 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TR4 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (eg inflammatory bowel disease, psoriasis), transplant rejection, graft vs. host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, Bone diseases, cancer (eg lymphoproliferative disorders), atheroschlerosis, and Alzheimers disease among others, and diagnostic assays for such conditions.Type: GrantFiled: February 4, 1997Date of Patent: March 23, 1999Assignee: Smithkline Beecham CorporationInventors: John Emery, KB Tan, Alemseged Truneh, Peter R. Young
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Patent number: 5863769Abstract: IL-1ra beta polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1ra beta polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, septicemia, arthritis, inflammatory bowel disease, graft vs. host disease, autoimmunity, stroke, cardiac ischemia, acute respiratory disease syndrome (ARDS), psoriasis, restenosis, traumatic brain injury, AIDS, cachexia., among others, and diagnostic assays for such conditions.Type: GrantFiled: January 28, 1997Date of Patent: January 26, 1999Assignee: SmithKline Beecham CorporationInventor: Peter Ronald Young
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Patent number: 5861298Abstract: The invention relates to cathepsin K polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.Type: GrantFiled: May 7, 1997Date of Patent: January 19, 1999Assignees: SmithKline Beecham Corporation, Human Genome SciencesIncInventors: Mark D. Adams, Judith A. Blake, Christine M. Debouck, Fred H. Drake, Lisa M. Fitzgerald, Claire M. Fraser, Maxine Gowen, Gregg A. Hastings, Ewen F. Kirkness, Norman H. Lee, Julie Rood
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Patent number: 5851798Abstract: Human GPR14 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human GPR14 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parlinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.Type: GrantFiled: January 27, 1997Date of Patent: December 22, 1998Assignee: SmithKline Beecham CorporationInventors: Usman Shabon, Derk Bergsma
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Patent number: 5834587Abstract: Human HLTEX11 polypeptides and DNA (RNA) encoding such HLTEX11 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HLTEX11 for the treatment of atherosclerosis, inflammatory conditions, and infections, particularly viral infections, such as AIDS, among others, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HLTEX11 and for detecting altered levels of the polypeptide in a host.Type: GrantFiled: October 8, 1996Date of Patent: November 10, 1998Assignee: SmithKline Beecham CorporationInventors: Winnie Chan, Derk J. Bergsma, Catherine E. Ellis
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Patent number: 5824504Abstract: Human HBMBU14 polypeptides and DNA (RNA) encoding such HBMBU14 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HBMBU14 for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 and HIV-2, pain, cancers, anorexia, bulimia, asthma, Parkinson's disease, acute heart failure, atherosclerosis, hypotension, hypertension, urinary retention, osteoporosis, angina pectoris, myocardial infarction, ulcers, asthma, allergies, benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia or severe mental retardation, and dyskinesias, such as Huntington's disease or Gilles dela Tourette's syndrome, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides.Type: GrantFiled: October 31, 1996Date of Patent: October 20, 1998Inventors: Nabil A. Elshourbagy, Derk J. Bergsma, Catherine E. Ellis
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Patent number: 5817481Abstract: Benign prostatic hypertrophy specific polynucleotides and polypeptides are provided. Methods of diagnosing benign prostatic hypertrophy using these polynucleotides and polypeptides are also provided. Human BPH1 polypeptides and DNA (RNA) encoding such BPH1 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such BPH1 for the treatment of prostate disease. Antagonists against such BPH1 and their use as a therapeutic to treat prostate disease are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the BPH1 and for detecting altered levels of the polypeptide in a host.Type: GrantFiled: May 9, 1997Date of Patent: October 6, 1998Assignee: SmithKline Beecham CorporationInventor: Julie A. Rood
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Patent number: 5789200Abstract: Human ELF3 polypeptides and DNA (RNA) encoding such ELF3 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ELF3 for the diagnosis and treatment of cancers, in particular prostate, breast, lung or other epithelial tumors, among others.Type: GrantFiled: November 15, 1996Date of Patent: August 4, 1998Assignees: SmithKline Beecham Corporation, Monash UniversityInventors: Ismail Kola, Martin J. Tymms, Christine Debouck
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Patent number: 5780609Abstract: Nucleic acid molecules encoding a human B cell surface molecule are provided. Polypeptides and antibodies which bind to these polypeptides are also provided. In addition, methods of detecting mutated forms of the molecule are provided.Type: GrantFiled: October 16, 1996Date of Patent: July 14, 1998Assignee: SmithKline Beecham CorporationInventors: Lisa A. Marshall, Amy K. Roshak
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Patent number: 5780286Abstract: The invention relates to Arginase II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.Type: GrantFiled: August 20, 1996Date of Patent: July 14, 1998Assignees: SmithKline Beecham Corporation, Human Genome Sciences Inc.Inventors: Patrick J. Dillon, Joseph G. Vockley
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Patent number: 5776750Abstract: The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.Type: GrantFiled: January 17, 1997Date of Patent: July 7, 1998Assignee: Smithkline Beecham p.l.c.Inventors: John Edward Hodgson, Elizabeth Jane Lawlor
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Patent number: 5773259Abstract: The invention relates to a method of diagnosing artherosclerosis by detecting mutation or altered expression of HC gp-39.Type: GrantFiled: March 10, 1997Date of Patent: June 30, 1998Assignee: SmithKline Beecham CorporationInventor: Robert B. Kirkpatrick
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Patent number: 5763218Abstract: Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.Type: GrantFiled: August 14, 1996Date of Patent: June 9, 1998Assignees: Human Genome Science, Inc., TakedaInventors: Ryo Fujii, Shuji Hinuma, Yi Li, Steven M. Ruben, Daniel R. Soppet
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Patent number: 5747264Abstract: The present invention provides a new method for diagnosing and treating cancers or BPH. Further provided are therapeutic agents and pharmaceutical compositions for treating cancers and BPH.Type: GrantFiled: September 16, 1996Date of Patent: May 5, 1998Assignee: SmithKline Beechum CorporationInventors: Carl J. Schmidt, Frank Tobin, Francis E. Wilkinson
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Patent number: 5726061Abstract: Methods of screening for colorectal cancer by measuring levels of HC gp-39 are provided. Methods of monitoring patients with colorectal cancer are also provided. In addition, kits for detection of HC gp-39 useful in screening for and monitoring of colorectal cancer in a patient are provided.Type: GrantFiled: October 8, 1996Date of Patent: March 10, 1998Assignee: SmithKline Beechum CorporationInventors: David Robbins, Robert B. Kirkpatrick, Stephen D. Holmes
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Patent number: 5710024Abstract: Human CGRP-RCF polypeptides and DNA (RNA) encoding such CGRP-RCF and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such CGRP-RCF for the treatment of diabetes, migrane, pain and inflammation, Parkinson's disease, acute heart failure, hypotension, urinary retention, osteoporosis, hypertension, angina pectoris, myocardial infarction, ulcers, asthma, allergies, psychosis, depression, vomiting, benign prostatic hypertrophy, Paget's disease, obesity, cancer, gigantism and the like. Antagonists against such CGRP-RCF and their use as a therapeutic to treat diabetes, migrane, pain and inflammation, Parkinson's disease, acute heart failure, hypotension, urinary retention, osteoporosis, hypertension, angina pectoris, myocardial infarction, ulcers, asthma, allergies, psychosis, depression, vomiting, benign prostatic hypertrophy, Paget's disease, obesity, cancer, gigantism and the like are also disclosed.Type: GrantFiled: July 23, 1996Date of Patent: January 20, 1998Assignee: SmithKline Beecham CorporationInventors: John E. Adamou, Nabil Elshourbagy
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Patent number: 5703111Abstract: This invention relates to a stable, easy to constitute, injectable formulation of anticancer agent BMY-25067. More specifically, the present invention concerns a formulation of BMY-25067 obtained from lyophilizing a solution comprising up to 4 mg of BMY-25067 per mL of 65% t-butanol/water, further comprising about 2% PVP (K-12 or K-17), optionally comprising pharmaceutically acceptable carrier(s).Type: GrantFiled: December 4, 1996Date of Patent: December 30, 1997Assignee: Bristol-Myers Squibb CompanyInventors: Uday S. Gogate, Shreeram N. Agharkar, Lawan Phusanti
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Patent number: 5693666Abstract: The present invention provides paclitaxel derivatives of formula I ##STR1## and pharmaceutical compositions.Type: GrantFiled: January 3, 1996Date of Patent: December 2, 1997Assignee: Bristol-Myers Squibb CompanyInventors: Shu-Hui Chen, Vittorio Farina, Gregory Roth, John Kadow
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Patent number: 5646176Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.Type: GrantFiled: May 19, 1995Date of Patent: July 8, 1997Assignee: Bristol-Myers Squibb CompanyInventors: Jerzy Golik, Dolatrai Vyas, John J. Wright, Henry Wong, John F. Kadow, John K. Thottathil, Wen-Sen Li, Murray A. Kaplan, Robert K. Perrone, Mark D. Wittman