Abstract: A wireless peripheral mode is provided by a host system that communicates to a WiFi infrastructure and, utilizing the same WiFi RF subsystem, also communicates to peripherals. The host system may employ additional RF channels for communicating with high bandwidth peripherals, such as display devices, where high levels of QoS may be managed locally. The host system may be a conventional desktop computer system, a notebook computer system, a multi-media access point, a cell phone, a game machine, a portable game machine, a Personal Digital Assistant (PDA), a smart phone or any other type of device that benefits from accessing both a WiFi infrastructure and local peripherals.
Abstract: An isolated monoclonal antibody against the interleukin 1-alpha or beta receptor antagonist, known as IL-1RA. The antibody inhibits the interaction of IL-1RA with the membrane-binding chain thereof, the interleukin-1 receptor. Also, nucleic acid molecule encoding for a light chain of the monoclonal antibody, and a nucleic acid molecule encoding for a heavy chain of the monoclonal antibody. Also, a method for treating an inflammatory, infectious or autoimmune disease, which includes administering the isolated monoclonal antibody or a nucleic acid coding for the isolated monoclonal antibody, and a method of or the diagnosis of an inflammatory, infectious or autoimmune diseases, which includes contacting a biological sample with the isolated monoclonal antibody.
Type:
Application
Filed:
April 30, 2021
Publication date:
June 1, 2023
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE RENNES 1
Abstract: Embodiments of the systems and methods disclosed herein provide a prescriptive analytics platform, a polarity analysis engine, and a semantic analysis engine in which a user can identify a target objective and use the system to find out whether the user's objectives are being met, what predictive factors are positively or negatively affecting the targeted objectives, as well as what recommended changes the user can make to better meet the objectives. The systems and methods may include a polarity analysis engine configured to determine the polarity of terms in free-text input in view of the target objective and the predictive factors and use the polarity to generate the recommended changes. The systems and methods may also include a semantic analysis engine to extend the results of the polarity analysis engine for improved determination of predictive factors and improved recommendations.
Abstract: The invention relates to an antenna comprising a radiative antenna element able to emit a signal in at least two disjoint frequency bands and a waveguide covered by the radiative antenna element, comprising two nested resonant cavities, each single-mode or mostly single-mode in a separate frequency band.
Type:
Grant
Filed:
September 3, 2021
Date of Patent:
May 23, 2023
Assignees:
ARIANEGROUP SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE RENNES 1
Inventors:
Nicolas Attaja, Mauro Ettorre, Ronan Sauleau, Davy Guihard
Abstract: A method for catalytic asymmetric synthesis of a phosphorus-stereogenic (P-stereogenic) nucleoside derivative of formula (3) and a catalyst used therein. The P-stereogenic nucleoside derivative (3) can be hydrolyzed to obtain remdesivir.
Abstract: A bicycle includes a frame, a motor, a battery, a key interface, a crank set, and a shell. The frame defines a cavity and an opening providing access to the cavity. The motor is coupled to frame beneath the cavity. The battery extends at least partially into the frame. The battery is configured to power the motor. The key interface is positioned along an exterior of the frame. Turning a key in the key interface releases the battery to facilitate removing the battery from the frame. The crank set is coupled to the motor. The crank set includes crank arms. The shell extends at least partially over the opening.
Type:
Grant
Filed:
January 6, 2022
Date of Patent:
May 23, 2023
Assignee:
SERIAL 1 CYCLE COMPANY, LLC
Inventors:
Benjamin Raymond Bass, Ben M. Lund, Andrew Schmidt
Abstract: An audio navigation device comprising an input means for inputting two or more audio pieces into the navigation device; a spatialization means for allocating a position in the form of a unique spatial coordinate to each audio piece and arranging the audio pieces in a multi-dimensional arrangement; a generating means for generating a binaural audio output for each audio piece, wherein the audio output simulates sounds that would be made by one or more physical sources located at the given position of each audio piece; an output means for simultaneously outputting multiple audio pieces as binaural audio output to a user; a navigation means for enabling a user to navigate around the audio outputs in the multi-dimensional arrangement; and a selection means for allowing a user to select a single audio output.
Type:
Grant
Filed:
May 6, 2021
Date of Patent:
May 16, 2023
Assignee:
III Holdings 1, LLC
Inventors:
Mark Brian Sandler, Rebecca Lynne Stewart
Abstract: Provided is a process for preparing a compound, comprising the steps of a) Reacting a compound of Formula A (Formula A) with the compound 3 (3) to provide the compound 5 (5) or a salt or solvate thereof, wherein R is a linear or branched C1-C5 alkyl. Further provided is the compound 5 or a salt or solvate thereof. (5) The use of these compounds in the synthesis of 3-[5-Amino-4-(3-Cyanobenzoyl)-Pyrazol-1-yl]-N-Cyclopropyl-4-Methylbenzamide is also provided.
Type:
Grant
Filed:
September 26, 2019
Date of Patent:
May 16, 2023
Assignee:
MEREO BIOPHARMA 1 LIMITED
Inventors:
Mark Meisenbach, Benjamin Martin, Niek Johannes Ronde, Carmen Ruiz
Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.
Type:
Grant
Filed:
February 12, 2021
Date of Patent:
May 16, 2023
Assignees:
Institut National De La Sante Et De La Recherche Medicale (INSERM), Centre National De La Recherche Scientifique (CNRS), Ecole Normale Superieure De Lyon, Universite De Claude Bernard Lyon 1
Inventors:
Théophile Ohlmann, Philippe Mangeot, Emiliano Ricci
Abstract: The present technology relates to luminescent lanthanide complexes comprising a chelating agent, formed of a macrocycle or ligand, complexing a lanthanide ion Ln3+ selected from terbium and dysprosium, the chelating agent comprising at least one group of the structure (B) below; and a process for detecting a biomolecule using said lanthanide complex comprising coupling a luminescent lanthanide complex of the present technology having a reactive group with said biomolecule.
Type:
Grant
Filed:
July 5, 2018
Date of Patent:
May 16, 2023
Assignees:
ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1
Abstract: Antibodies that bind to programmed cell death protein 1 (PD-1), compositions comprising such antibodies, and methods of making and using such antibodies are disclosed.
Type:
Grant
Filed:
December 27, 2019
Date of Patent:
May 2, 2023
Assignee:
PD-1 Acquisition Group, LLC
Inventors:
Najmia Amirina, Hareesh Chamarthi, Maria Isabel Chiu, Daniel Doty, Bin Feng, Aleksander Jonca, Thomas McQuade, Anhco Nguyen, Sheila Ranganath, Hans Albert Felix Scheuplein, Vikki A. Spaulding, Lei Wang, Jennifer Watkins-Yoon, Sri Sahitya Vadde
Abstract: The present invention is directed to a retaining wall system including a retaining wall having with at least one retaining wall rebar extending along a vertical direction, the at least one retaining wall rebar includes an end formed into a first retaining wall rebar hook, at least one deadman spaced from the retaining wall, each deadman including a concrete base extending along the vertical direction, the concrete base including rebar extending past the concrete base and having an end formed into a deadman rebar hook, at least a first hole at a top portion of the retaining wall and extending into the retaining wall to expose the retaining wall rebar hook, and a first cable attached to the retaining wall rebar hook and to the deadman rebar hook to support the retaining wall.
Abstract: A photopolymerizable composition comprises at least a polymerizable resin, a photosensitizer, an annihilator, and a photoinitiator. The photosensitizer is formulated to absorb an excitation light signal received in a first range of wavelengths. The annihilator is formulated to emit a light signal in a second range of wavelengths different from the first. During the absorption of light by the photosensitizer in the first range of wavelengths, the annihilator emits a light signal in the second range, a photon energy of the emitted light signal being greater than a photon energy of the light signal received by the photosensitizer. The annihilator is also formulated to implement an energy transfer mechanism to excite the photoinitiator for polymerization of the resin. The excited photoinitiator is formulated to generate at least one polymerizable initiator to cause the polymerization reaction. Related methods, such as three-dimensional printing methods, and materials are also disclosed.
Type:
Grant
Filed:
July 31, 2018
Date of Patent:
April 18, 2023
Assignees:
ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: The invention concerns a multicistronic nucleic acid, in particular an isolated multicistronic nucleic acid, comprising: A) a sequence comprising successively: A1) a sequence encoding the light chain variable domain of an antibody of interest, fused in the frame with A2) a sequence encoding the constant region of the light chain of an immunoglobulin Ig; and B) a sequence comprising successively: B1) a sequence encoding the heavy chain variable domain of said antibody of interest, fused in the frame with B2) a sequence encoding the constant regions of the heavy chain of an immunoglobulin Ig? in secretory form; B3) an intronic sequence of the gene of the heavy chain of said immunoglobulin Ig?, said intronic sequence comprising an internal 5? splice site enabling the splicing of said intronic sequence B3) and a secretory-specific poly(A) (p AS) signal from the 3? terminal exon of said gene; B4) a sequence, in frame with sequence B1), encoding the transmembrane and cytoplasmic domains M1 and M2 of the immunoglobu
Type:
Grant
Filed:
July 8, 2016
Date of Patent:
April 11, 2023
Assignees:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE LYON
Inventors:
Floriane Fusil, Els Verhoeyen, Thierry Defrance, François-Loïc Cosset
Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRD and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.
Type:
Application
Filed:
October 4, 2022
Publication date:
April 6, 2023
Applicants:
NANOH, UNIVERSITE LYON 1 CLAUDE BERNARD, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON
Inventors:
François LUX, Olivier TILLEMENT, Maxime SAINT JEAN, Pierre MOWAT, Pascal PERRIAT, Stéphane ROUX, Anna MIGNOT
Abstract: The present invention concerns a solid nanocomposite material consisting of a polymer-matrix in which are dispersed alkali metal, hydronium or ammonium salts of polyanionic components, wherein the polymer-matrix comprises at least a linear or branched polymer or copolymer containing one or several poly(ethylene oxide) (PEO) chains, said polymer or copolymer being optionally crosslinked and each PEO chain having at least 4 ethylene oxide monomer units. The present invention relates also to a photonic, e.g. optoelectronic, device comprising such a nanocomposite material. Such material and device can be used as phosphorescence emitter, for crop growth lighting or for generating singlet oxygen.
Type:
Grant
Filed:
October 30, 2018
Date of Patent:
April 4, 2023
Assignees:
Universite de Rennes 1, Centre National de la Recherche Scientifique (CNRS), Universidade de Franca—UNIFRAN
Inventors:
Yann Molard, Maria De Los Angeles Amela-Cortes, Malo Robin, Stephane Cordier, Eduardo Ferreira Molina
Abstract: The present invention relates to a method and system for determining a central pulse wave velocity in a pregnant woman. The method comprises receiving an indication of a measurement of a length of a human aortic path outside the body to provide an aortic length, arranging a sound transducer at the position of the anatomical projection of the uterine artery, identifying the opening of the maternal aortic valve with measurement from the sound transducer as a first time, and the pulse wave arrival time at the uterine artery with measurements from the sound transducer as a second time, determining the central transit time based on the difference between the second time and the first time, and calculating the central pulse wave velocity based on the aortic length and the central transit time.
Type:
Grant
Filed:
June 7, 2017
Date of Patent:
April 4, 2023
Assignee:
VIEWCARE TECHNOLOGIES 1 APS
Inventors:
Diana Kjær Thing Riknagel, Johannes Jan Struijk
Abstract: Disclosed is a radio antenna comprising a substrate of dielectric material; a ground plane of electrically conductive material on a first face of the substrate; a resonator for converting an incident electrical signal into an electromagnetic wave and for resonating at at least two different resonant frequencies. The resonator comprises at least three elements, each in the form of strips of conductive material and arranged on a second face of the substrate opposite the first face. A second element is electrically connected to the ground plane by means of a via passing through the substrate at a first end of the corresponding strip, forms an extension of the first element, and is electrically connected directly to the first element at a second end of said strip which is opposite the first end.
Type:
Grant
Filed:
January 7, 2022
Date of Patent:
March 28, 2023
Assignees:
BODYCAP, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE RENNES 1