Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.

Abstract: An audio navigation device comprising an input means for inputting two or more audio pieces into the navigation device; a spatialization means for allocating a position in the form of a unique spatial coordinate to each audio piece and arranging the audio pieces in a multi-dimensional arrangement; a generating means for generating a binaural audio output for each audio piece, wherein the audio output simulates sounds that would be made by one or more physical sources located at the given position of each audio piece; an output means for simultaneously outputting multiple audio pieces as binaural audio output to a user; a navigation means for enabling a user to navigate around the audio outputs in the multi-dimensional arrangement; and a selection means for allowing a user to select a single audio output.

Abstract: Provided is a process for preparing a compound, comprising the steps of a) Reacting a compound of Formula A (Formula A) with the compound 3 (3) to provide the compound 5 (5) or a salt or solvate thereof, wherein R is a linear or branched C1-C5 alkyl. Further provided is the compound 5 or a salt or solvate thereof. (5) The use of these compounds in the synthesis of 3-[5-Amino-4-(3-Cyanobenzoyl)-Pyrazol-1-yl]-N-Cyclopropyl-4-Methylbenzamide is also provided.

Abstract: According to some embodiments, disclosed are systems and methods for machine learning-based image detection and the determination of slippery conditions based therefrom. The disclosed systems and method identify a set of images that depict captured imagery in relation to at least one area of a floor at a location. These images are then analyzed via at least one slippery condition detection machine learning algorithm, which results in a determination of a classification of the area of the floor (e.g., does a puddle exist or other type of slippery condition). This information is stored and later used for training of the at least one slippery condition detection machine learning algorithm. Moreover, the information is communicated to beacons in/around the location, to alert users to the condition.

Abstract: A laser projecting device and a light-combining lens are provided. The light-combining lens is a one-piece structure, and has a difference of refractive indexes less than 0.2. The light-combining lens includes collimation surfaces, reflection surfaces, and a light emergent surface. Each collimation surface defines a collimation path inside the light-combining lens. The reflection surfaces respectively located at the collimation paths are parallel to each other and arranged along an arrangement direction. The light emergent surface is located at the arrangement direction. Each reflection surface and the corresponding collimation path have an acute angle therebetween to define a reflection path. The reflection paths are overlapped in the light-combining lens to define a light-combining path.

Abstract: Antibodies that bind to programmed cell death protein 1 (PD-1), compositions comprising such antibodies, and methods of making and using such antibodies are disclosed.

Abstract: Disclosed herein is an implantable blood pump assembly that includes a housing defining an inlet, an outlet, and a flow path extending from the inlet to the outlet, a rotor positioned within the flow path, a stator positioned within the housing and operable to drive the rotor, and an outflow cannula. The outflow cannula includes a coupler assembly configured for removable mechanical connection to the outlet coupler, and includes a first component of an anti-rotation mechanism and a first component of an axial lock. The housing includes an outlet coupler that includes a second component of the anti-rotation mechanism and a second component of the axial lock. The first and second components of the anti-rotation mechanism are positioned to engage one another prior to the first and second components of the axial lock during insertion of the outflow cannula into the housing outlet.

Abstract: A ventricular assist device is disclosed. The ventricular assist device may include a centrifugal pump and a controller. The controller may be configured to cause the centrifugal pump to operate at a first speed above a predetermined flow rate. The controller may also be configured to cause the centrifugal pump to operate at a second speed below the predetermined flow rate, wherein the predetermined flowrate is indicative of a crossover point between systole and diastole phases of a person's cardiac cycle.

Abstract: Aspects of the invention are directed towards systems and methods for providing the user with customized video content from a platform. Embodiments of the invention describes a user interface on the user terminal for receiving user preferences from the user. A number of buckets for the video content to be consumed by the user based on the user preferences are disclosed. The video content to be filled in each of the buckets is determined based on a real time criteria. The buckets are which are filled with the video content are assembled and a predetermined video content is interspersed between each of the bucket to form the customized video content.

Abstract: A novel and useful quantum computing machine architecture that includes a classic computing core as well as a quantum computing core. A programmable pattern generator executes sequences of instructions that control the quantum core. In accordance with the sequences, a pulse generator functions to generate the control signals that are input to the quantum core to perform quantum operations. A partial readout of the quantum state in the quantum core is generated that is subsequently re-injected back into the quantum core to extend decoherence time. Access gates control movement of quantum particles in the quantum core. Errors are corrected from the partial readout before being re-injected back into the quantum core. Internal and external calibration loops calculate error syndromes and calibrate the control pulses input to the quantum core.

Abstract: A catheter pump is disclosed. The catheter pump can include an impeller and a catheter body having a lumen therethrough. The catheter pump can also include a drive shaft disposed inside the catheter body. A motor assembly can include a chamber. The motor assembly can include a rotor disposed in the at least a portion of the chamber, the rotor mechanically coupled with a proximal portion of the drive shaft such that rotation of the rotor causes the drive shaft to rotate. The motor assembly can also comprise a stator assembly disposed about the rotor. The motor assembly can also include a heat exchanger disposed about the stator assembly, the heat exchanger may be configured to direct heat radially outward away from the stator assembly, the rotor, and the chamber.

Abstract: The present invention is directed to a retaining wall system including a retaining wall having with at least one retaining wall rebar extending along a vertical direction, the at least one retaining wall rebar includes an end formed into a first retaining wall rebar hook, at least one deadman spaced from the retaining wall, each deadman including a concrete base extending along the vertical direction, the concrete base including rebar extending past the concrete base and having an end formed into a deadman rebar hook, at least a first hole at a top portion of the retaining wall and extending into the retaining wall to expose the retaining wall rebar hook, and a first cable attached to the retaining wall rebar hook and to the deadman rebar hook to support the retaining wall.

Abstract: A photopolymerizable composition comprises at least a polymerizable resin, a photosensitizer, an annihilator, and a photoinitiator. The photosensitizer is formulated to absorb an excitation light signal received in a first range of wavelengths. The annihilator is formulated to emit a light signal in a second range of wavelengths different from the first. During the absorption of light by the photosensitizer in the first range of wavelengths, the annihilator emits a light signal in the second range, a photon energy of the emitted light signal being greater than a photon energy of the light signal received by the photosensitizer. The annihilator is also formulated to implement an energy transfer mechanism to excite the photoinitiator for polymerization of the resin. The excited photoinitiator is formulated to generate at least one polymerizable initiator to cause the polymerization reaction. Related methods, such as three-dimensional printing methods, and materials are also disclosed.

Abstract: An access management system includes a mobile device with a processor and a memory and a software platform including at least a processor and a memory. The software platform is configured to analyze data obtained from the mobile device and other devices connected to the software platform. Specifically, the software platform is operable to determine if an access key received, read, or captured by a mobile device matches an access key for an authorized account, object, device, or space for the mobile device, and to provide access to the mobile device if the access key received, read, or captured by the mobile device matches the authorized access key.

Abstract: The invention concerns a multicistronic nucleic acid, in particular an isolated multicistronic nucleic acid, comprising: A) a sequence comprising successively: A1) a sequence encoding the light chain variable domain of an antibody of interest, fused in the frame with A2) a sequence encoding the constant region of the light chain of an immunoglobulin Ig; and B) a sequence comprising successively: B1) a sequence encoding the heavy chain variable domain of said antibody of interest, fused in the frame with B2) a sequence encoding the constant regions of the heavy chain of an immunoglobulin Ig? in secretory form; B3) an intronic sequence of the gene of the heavy chain of said immunoglobulin Ig?, said intronic sequence comprising an internal 5? splice site enabling the splicing of said intronic sequence B3) and a secretory-specific poly(A) (p AS) signal from the 3? terminal exon of said gene; B4) a sequence, in frame with sequence B1), encoding the transmembrane and cytoplasmic domains M1 and M2 of the immunoglobu

Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRD and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.