Abstract: The invention concerns a method of in vitro or ex vivo evaluation of the risk of complications in a patient who has sustained an insult or an infection generating a systemic inflammatory response syndrome, the method being characterized in that it comprises the step of detecting, in a biological sample obtained from said patient, at least one transcript of the IL7R gene, as well as measuring, in vitro or ex vivo, the quantity of at least one transcript of the IL7R gene, in a biological sample from a patient who has sustained an insult or an infection generating a systemic inflammatory response syndrome, in order to evaluate the risk of complications, and in particular of mortality, in said patient. The invention also concerns kits for measuring, in vitro or ex vivo, the quantity of at least one transcript of the IL7R gene in a biological sample.
Type:
Grant
Filed:
December 1, 2016
Date of Patent:
May 24, 2022
Assignees:
BIOMERIEUX, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BENARD LYON 1
Inventors:
Elisabeth Cerrato, Benjamin Delwarde, Guillaume Monneret, Estelle Peronnet, Julien Textoris, Fabienne Venet
Abstract: The present invention relates to the use of a peptide to prevent biofilm formation by microorganisms on a surface, wherein said peptide is (i) a peptide consisting of 6 to 37 consecutive amino acids from a peptide of sequence SEQ ID NO: 1, (ii) a peptide of sequence SEQ ID NO: 4, or (iii) a peptidomimetic of (i) or (ii).
Type:
Application
Filed:
February 20, 2020
Publication date:
May 19, 2022
Applicants:
UNIVERSITE DE RENNES 1, Centre national de la recherche scientifique, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL UFRGS
Inventors:
Rafael GOMES VON BOROWSKI, Aline RIGON ZIMMER, Simone Cristina BAGGIO GNOATTO, Alexandre José MACEDO, Muriel PRIMON DE BARROS, Karine RIGON ZIMMER, Reynald GILLET, Grace GOSMANN
Abstract: A local stimulation method of a predetermined region of brain tissue, the brain tissue including at least GABAergic neuron type. The method includes at least one activation step of a set of bipolar electrodes, according to a predetermined electric intensity and a predetermined biphasic pulse frequency, delivering a predetermined electric field. The predetermined electric field induces an activation of the GABAergic type neurons and a virtual absence of activation of other types of neurons.
Type:
Grant
Filed:
March 31, 2017
Date of Patent:
May 17, 2022
Assignees:
UNIVERSITE DE RENNES 1, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Abstract: A particle detector includes at least one resonant cavity partially formed at least by a first reflector, a second reflector disposed at a distance from the first reflector and a channel located between the first and second reflectors, the channel being intended to receive at least one fluid comprising particles and to receive at least one light radiation; and at least one detection system having at least one photodetector. The particle detector is configured so that a portion of the light radiation present in the channel escapes from the cavity throughout the second reflector and reaches the detection system, thereby enabling the at least one photodetector to detect leakage of the cavity. The second reflector is a photonic crystal membranes PCM based reflector.
Type:
Application
Filed:
December 23, 2019
Publication date:
May 12, 2022
Applicants:
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CPE LYON, ECOLE CENTRALE DE LYON, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1
Inventors:
Gabriel JOBERT, Salim BOUTAMI, Maryse FOURNIER, Christian SEASSAL
Abstract: An oil control valve for a cam phaser of an internal combustion engine, the oil control valve including a valve housing, including a first operating connection, a second operating connection, a supply connection, and a tank drain connection configured to drain a hydraulic fluid; a piston assembly, including a piston, a hollow check valve tube, a first check valve and a second check valve configured to provide cam torque recirculation, wherein the piston assembly is arranged in the housing axially displaceable by an actuator, wherein a control chamber is arranged within the piston between the first check valve and the second check valve and wherein a check valve compression spring which closes the first check valve and the second check valve is arranged within the piston between the first check valve and the second check valve.
Abstract: A method for increasing the number of CD4+ T-lymphocytes in the serum of a subject in need of such treatment comprising administering to the subject a pharmaceutical composition comprising an amount of an L-isomer of ?-lactam effective to increase the number of CD4+ T-lymphocytes in said patient's serum.
Abstract: A method, system, and medium are provided for distributing transportation alerts to computing devices in accordance with factors, such as device-specific and location-specific factors. In embodiments of the present invention, travel alerts, including public alerts associated with certain areas, are formatted or held odor to delivery, based on safety concerns, legal requirements, device settings, or other considerations.
Type:
Application
Filed:
January 10, 2022
Publication date:
May 5, 2022
Applicant:
III Holdings 1, LLC
Inventors:
Stephen Haag, Carlos J. Lebrilla, Marc Rush, Linda Rolfes
Abstract: The invention relates to poly(oligo(ethylene glycol) methacrylate) microgels, to the process for preparing same and the uses thereof in various fields of application such as optics, electronics, pharmacy and cosmetics. These microgels have the advantage of being monodisperse, pH-responsive and temperature-responsive. They can carry magnetic nanoparticles or biologically active molecules. These microgels may also form transparent films, which have novel optical and electromechanical properties.
Type:
Grant
Filed:
July 13, 2020
Date of Patent:
May 3, 2022
Assignees:
LVMH RECHERCHE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE PAU ET DES PAYS DE 1'ADOUR
Abstract: An arrangement configured to introduce a force from a fastening element into a plastic component, the arrangement including a force-limiting element that is embedded in the plastic component; wherein the fastening element is configured to fasten the plastic component at a body; wherein the fastening element is insertable through the force-limiting element, and wherein the plastic component includes a retention device which protrudes at least partially into an interior of the force-limiting element so that the fastening element that is inserted into the force-limiting element is retained in the force limiting element.
Type:
Grant
Filed:
December 14, 2019
Date of Patent:
May 3, 2022
Assignee:
ECO Holding 1 GmbH
Inventors:
Daniel Stanhope, Brent Brower, Matt Carlson, Matt Stolzman
Abstract: A wireless peripheral mode is provided by a host system that communicates to a WiFi infrastructure and, utilizing the same WiFi RF subsystem, also communicates to peripherals. The host system may employ additional RF channels for communicating with high bandwidth peripherals, such as display devices, where high levels of QoS may be managed locally. The host system may be a conventional desktop computer system, a notebook computer system, a multi-media access point, a cell phone, a game machine, a portable game machine, a Personal Digital Assistant (PDA), a smart phone or any other type of device that benefits from accessing both a WiFi infrastructure and local peripherals.
Abstract: A bicycle includes a frame, a motor, a battery, a key interface, a crank set, and a shell. The frame defines a cavity and an opening providing access to the cavity. The motor is coupled to frame beneath the cavity. The battery extends at least partially into the frame. The battery is configured to power the motor. The key interface is positioned along an exterior of the frame. Turning a key in the key interface releases the battery to facilitate removing the battery from the frame. The crank set is coupled to the motor. The crank set includes crank arms. The shell extends at least partially over the opening.
Type:
Application
Filed:
January 6, 2022
Publication date:
April 28, 2022
Applicant:
Serial 1 Cycle Company, LLC
Inventors:
Benjamin Raymond Bass, Ben M. Lund, Andrew Schmidt
Abstract: The present invention solves some of the problems of the prior art by providing a method, system and apparatus for readily refilling the reservoir of a smoking-substitute device with liquid from a dispenser. The method, system and apparatus of the present invention prevents liquid from being dispensed until the dispenser is securely and sealably engaged to the smoking-substitute device, provides independent liquid and gas pathways between the dispenser and reservoir, and substantially alleviates the problems of spillage and/or leakage when dispensing liquid from the dispenser into the reservoir of the smoking-substitute device.
Type:
Grant
Filed:
February 5, 2016
Date of Patent:
April 26, 2022
Assignee:
Fontem Holdings 1 B.V.
Inventors:
Kenneth Scott, Christopher Lord, David Jones, Stephen J. McDonald
Abstract: Provided is a process for reducing the size of ethylcellulose polymer particles comprising (a) providing a slurry comprising (i) water (ii) said ethylcellulose particles, wherein said ethylcellulose polymer particles have D50 of 100 ?m or less; (iii) surfactant comprising 1.2% or more anionic surfactants by weight based on the solid weight of said slurry, with the proviso that if the amount of anionic surfactant is 2.5% or less by weight based on the solid weight of said slurry, then said surfactant further comprises 5% or more stabilizers by weight based on the solid weight of said slurry, wherein said stabilizer is selected from the group consisting of water-soluble polymers, water-soluble fatty alcohols, and mixtures thereof. (b) grinding said slurry in an agitated media mill having a collection of media particles having a median particle size of 550 ?m or smaller. Also provided is a dispersion made by such a process.
Type:
Grant
Filed:
December 10, 2015
Date of Patent:
April 26, 2022
Assignee:
NUTRITION & BIOSCIENCES USA 1, LLC
Inventors:
Jorg Theuerkauf, Robert B. Appell, Peter E. Pierini, Christopher J. Tucker
Abstract: An interior rear view mirror assembly for a vehicle includes a mirror housing rotatably attached to a housing holder which is adapted to be attached to an interior of the vehicle, the mirror housing including a first rear view side to which a reflective mirror element is attached, and a second rear view side to which a display device with a display screen is attached to, where a camera is connected to the display device establishing a display system to provide an image to the display screen; and an actuator unit configured to automatically rotate the mirror housing to the first or second rear view side. A vehicle and a method may be used to operate the interior rear view mirror assembly.
Abstract: A method for the detection and quantification, in a complex aqueous fluid, of additives and water-soluble polymers used in the enhanced recovery of oil and shale gas.
Type:
Grant
Filed:
April 20, 2016
Date of Patent:
April 26, 2022
Assignees:
TOTAL SA, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors:
Mattéo Martini, Olivier Tillement, Arthur Marais, Christian Hurtevent, Stéphane Jouenne
Abstract: Valve control device (100) for a coolant circuit of a motor vehicle, said valve control device (100) comprising a first valve (120) having an assigned first functional element (125) comprising a first engagement unit (122), a second valve (150) having an assigned second functional element (155) comprising a second engagement unit (152), wherein the first valve (120) and the second valve (150) in terms of the switch position thereof are configured so as to be variable by rotating the respective assigned functional element (125, 155), a locking mechanism (200) comprising an entrainment installation ( ), wherein the locking mechanism (200) is configured so as to be able to be driven by means of a drive (300), wherein the locking mechanism (200) in a rotating movement, by means of the entrainment installation (210) engaging in the first engagement unit (122), is configured for transferring the first functional element (125) from a first switch position to a second switch position, and/or, by means of the entrainm
Abstract: The invention relates to an in vitro process for classifying a glioma, comprising the following steps: a. Measuring at least, from a glioma patient biological sample, the Alternative Lengthening of Telomeres (ALT) status of said glioma; b. Optionally, determining the isocitrate dehydrogenase genes mutation status (IDH status) of said glioma; c. Based on the data obtained in steps (a) and optionally (b) and, if available, on the histological grade of said glioma, classifying said glioma in one of the five following classes: oligodendroglioma-like, glioblastoma IDHwt-like, glioblastoma IDHmt-like, low-grade astrocytoma-like, and other gliomas.
Type:
Application
Filed:
February 19, 2020
Publication date:
April 21, 2022
Applicants:
HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1
Abstract: In a terminal, a control unit transmits a bundle response signal using a resource in a basic region of an uplink control channel in an uplink unit band of a unit band group when no error is detected in each of a plurality of pieces of downlink data of the unit band group, the uplink control channel in the uplink unit band being associated with a downlink control channel in a basic unit band that is a downlink unit band in which a broadcast channel signal including information relating to the uplink unit band is transmitted, and the control unit transmits the bundle response signal using a resource in an additional region of the uplink control channel when an error is detected in each of the plurality of pieces of downlink data.
Abstract: A method, apparatus, and system of pause and replay of media content through bookmarks on a server device are disclosed. In one embodiment, a method of a server device includes authenticating a user of a client device, communicating a media content to the client device through a network, processing a pause request of the client device to pause the media content, storing a bookmark location indicating a current playback location of the media content in the client device on the server device, processing a play request of the user to play the media content from the bookmark location (e.g., the play request may be received from a different client device of the user), and communicating the media content from the bookmark location to the user.