Abstract: Provided are antibodies and antigen binding fragments thereof that bind to human interleukin-11 receptor subunit ? (IL-11R?) and related compositions, which may be used in any of a variety of therapeutic or diagnostic methods, including the treatment or diagnosis of cancers, inflammatory diseases, autoimmune diseases, and others.

Abstract: The present invention relates to a process for preparing aromatic acyl derivatives of formula (I) using methanesulfonic acid. The invention further relates to methods for preparing biological active ingredients. such as paracetamol.

Abstract: The present invention relates to systems and methods to produce recombinant adeno-associated virus (rAAV) utilizing one or more DNA constructs manufactured via polymerase chain reaction (PCR).

Abstract: A low-temperature continuous-flow preparation method of bedaquiline includes the following steps. (a) A first feed liquid and a second feed liquid are subjected to a first continuous flow reaction for 30-600 seconds to obtain a first reaction mixture. (b) The first reaction mixture and a third feed liquid are subjected to a second continuous flow reaction for 30-600 seconds to obtain a second reaction mixture. (c) The second reaction mixture was quenched to afford bedaquiline.

Abstract: A process for consolidating a hydrogel including alginate and gelatin, which includes a step of consolidation by crosslinking of the hydrogel using a suitable solution, in order to give it particularly advantageous mechanical properties. Also, the use of this crosslinking solution for consolidating the structure of a hydrogel including alginate and gelatin, and to a hydrogel obtained by this process. Additionally, a process for consolidating the structure of a hydrogel including alginate and gelatin, this process including preparing the hydrogel, shaping it, then bringing it into contact with suitable consolidation agents. Further, the hydrogel obtained by this process. In all these aspects, the hydrogel can further include fibrinogen and/or living cells.

Abstract: An overcurrent protection device for a circuit to be monitored, having at least one trigger unit, which is configured for an interruption of the circuit in at least one trigger situation and which includes at least one conductor section which is configured for a conduction of a current to be monitored, at least one conductive trigger element, which includes at least one thermo magnetically-shiftable material configured for a magnetic property change in dependence on the temperature induced by a current that flows through the conductor section, a conductive magnetic module, a conductive magnetic core, the conductive magnetic module being movable between a first position faced against the conductive trigger element permitting the conduction of the current through the conductor section and a second position faced against said conductive magnetic core breaking the conduction of the current through the conductor section.

Abstract: Antenna includes at least one first resonant cavity and a second resonant cavity, each resonant cavity being closed by a base at one end and including a radiating element superimposed on the base of the resonant cavity, the radiating element of the first cavity being able to transmit a signal on a first frequency band and the radiating element of the second cavity being able to transmit a signal on a second frequency band separate from the first frequency band, characterized in that a first distance between the base and radiating element of the first cavity differs from a second distance between the base and radiating element of the second cavity.

Abstract: The present invention provides an improved electric lock that allows for electrically controlled retraction of latch bolt to allow for opening of the door in which the lock is installed. The components that allow for retraction are primarily internal to the lock and have means for conducting electrical signals to the lock to allow for remote control of the latch retraction. In some embodiments, the locks comprise an electrically controllable actuator and at least one retraction lever configured to retract the latch bolt against an applied bias. The actuator can be configured with various other internal components such that movement of the other internal components in one direction, such as toward the actuator, causes movement of the latch bolt in the opposite direction, such as away from the actuator. This opposing movement can allow for different electrical arrangements within different locks having relatively small internal spaces.

Abstract: A ligand of Formula (A): or a carboxylate salt thereof; wherein Y1, Y2 and Y3 each independently represents —COOH or a picolinate of Formula (i): wherein each R1 independently represents a chromophore group; L1, L2 and L3 each independently represents a single bond or a linker; and X1, X2 and X3 each independently represents a hydrogen atom, a coupling function or a bio-vectorizing group. Also, a process for manufacturing the ligand and to a process for manufacturing a chelate by complexation by the ligand of a rare-earth cation, preferably a lanthanide cation. Further, a use of the ligand and/or the chelate in biological imaging and/or photoluminescence imaging.

Abstract: An article of footwear comprising: a sole; an upper, attached to the sole; and a full length footbed located inside the upper; wherein a portion of an underside of the full length footbed is attached relative to the sole with an underside of a forward portion of the full length footbed being unattached for placement of a forefoot cushion thereunder and/or an underside of a rearward portion of the full length footbed being unattached for placement of a heel raise thereunder.

Abstract: A method for increasing the number of CD4+ T-lymphocytes in the serum of a subject in need of such treatment comprising administering to the subject a pharmaceutical composition comprising an amount of an L-isomer of ?-lactam effective to increase the number of CD4+ T-lymphocytes in said patient's serum.

Abstract: A bollard sleeve with a removable or replaceable cover is described. In one example, the bollard sleeve includes a cover portion and a sleeve portion coupled to the cover portion. The cover portion can have a cover removably coupled to a skirt, and the sleeve portion can have a tab. When the tab is in a first position, the tab can prevent the cover from being removed. When the tab is in a second position, the tab can form an opening that allows the cover to be removed. The tab can be bent from the first position to the second position, or the tab can be removed from the sleeve portion.

Abstract: The present disclosure is related to the use of compositions and their use in reducing and treating pain.

Abstract: The present disclosure is related to the use of compositions and their use in reducing and treating pain.

Abstract: The invention relates to a synthetic sialoside presenting the formula (I): Neu5-Ac-?2-6-R1(R2)[GlcNAc?1-4]n-GlcNAc Formula wherein: -GlcNAc is N-acetylglucosamine; -GlcNAc?1-4 ia a N-acetylglucosamine unit linked with a ?1-4 link; -n is a superior or equal to 1; -R1 is a glycan structure comprising at least one galactose (Gal); and -R2 is chosen among the following groups: H, fucose linked with a ?1-3 link (Fuc?1-3) or a1-4 link (Fuc?1-4).

Abstract: A novel and useful system wiring apparatus and related techniques that address the need to feed power and electronic signals to and from a sample board between the cold, low pressure region in a vacuum chamber and outside room temperature and atmospheric pressure. The wiring apparatus balances electrical resistance with the thermal conductivity of the power and signal conductors. Printed flexible cables are used having an annular sealing region which together with O-rings provide vacuum sealing while allowing electrical signals to pass between integrated circuit(s) inside the vacuum chamber and equipment outside the chamber. A thermal anchor is placed along the printed flexible cable to maintain a desired temperature along the cable. The printed flexible circuits are multilayer with two outer layers serving as an RF shield while two inner layers comprise the signal lines which typically require shielding, electrical isolation from each other and from external electromagnetic fields.

Abstract: A picture coding device, for coding a moving picture using inter prediction based on inter prediction information in units of blocks and forming a bitstream, includes a coding information storage unit configured to store inter prediction information used in the inter prediction of a coded block in a history-based motion vector predictor candidate list, a spatial merging candidate derivation unit configured to derive a spatial merging candidate from inter prediction information of a block spatially neighboring a coding target block and to add the spatial merging candidate to a merging candidate list, and a history-based merging candidate derivation unit configured to derive a history-based merging candidate from the inter prediction information stored in the history-based motion vector predictor candidate list and to add the history-based merging candidate to the merging candidate list.

Abstract: A process for preparing a catalyst material, includes the steps of: (a) providing a support material having surface hydroxyl (OH) groups, wherein the support material is ceria (CeO2), zirconia (ZrO2) or a combination of thereof; (b) reacting the support material having surface hydroxyl (OH) groups of step (a) with a precursor containing two transition metal atoms, each chosen independently from the group consisting of: W, Mo, Cr, Ta, Nb, V, Mn; (c) calcining the product obtained in step (b) in order to provide a catalyst material showing dual site surface species containing pairs of transition metal atoms derived from the precursor that are present in oxide form on the support material. Additionally, a catalyst material is obtained by the process set out above, and the catalyst material is used as an ammonia selective catalytic reduction (NH3-SCR) catalyst for nitrogen oxides (NOx) reduction.

Abstract: The invention provides a clonal cell line derived from a liver cancer cell line, preferably derived from a Huh7 hepatocarcinoma cell line, engineered to produce and secrete viral particles containing pregenomic RNA of the hepatitis B virus (HBV), predominantly over DNA of HBV, to calibrate quantitative HBV RNA assays.

Abstract: A system and a method for assigning a money sign to a user. The system receives a request to identify a money sign for a user. Further, the system renders a set of questions. Furthermore, the system receives a set of answers from the user. Subsequently, the system extracts a key component from the set of answers received from the user. Further, the system scores the key component for the set of answers based on a scoring matrix and deep learning algorithms. Subsequently, the system compares a user score for each of the key component against a facet score for each of a set of predefined money signs. Further, the system generates a match score for each of a set of predefined money signs. Finally, the system assigns the money sign identified with a maximum match score to the user.