Abstract: The present invention relates to a process for preparing aromatic acyl derivatives of formula (I) using methanesulfonic acid. The invention further relates to methods for preparing biological active ingredients. such as paracetamol.

Abstract: The present invention relates to systems and methods to produce recombinant adeno-associated virus (rAAV) utilizing one or more DNA constructs manufactured via polymerase chain reaction (PCR).

Abstract: The objective of the invention is the development of a new process for producing sulfur from phosphogypsum. During this process, the phosphogypsum is mixed with a source of carbon and hydrogen forming a slurry after mixing. This source of carbon and hydrogen is a natural or synthetic organic polymer, as an example that is not limiting, biomass, used tires or plastic, kerogen or tars. The granules undergo a heat treatment (100 to 150° C.) to evaporate the mixing water. The product obtained undergoes a heat treatment (550 to 900° C.) under a neutral atmosphere and/or partially oxidizing. The generated gases are bubbled in deionized water, sodium hypochlorite solution or a basic aqueous solution which allows the trapping, among others, of organosulfur molecules and the precipitation of sulfur S8. Non-entrapped gases are recovered to extract volatile sulfur products.

Abstract: A low-temperature continuous-flow preparation method of bedaquiline includes the following steps. (a) A first feed liquid and a second feed liquid are subjected to a first continuous flow reaction for 30-600 seconds to obtain a first reaction mixture. (b) The first reaction mixture and a third feed liquid are subjected to a second continuous flow reaction for 30-600 seconds to obtain a second reaction mixture. (c) The second reaction mixture was quenched to afford bedaquiline.

Abstract: A process for consolidating a hydrogel including alginate and gelatin, which includes a step of consolidation by crosslinking of the hydrogel using a suitable solution, in order to give it particularly advantageous mechanical properties. Also, the use of this crosslinking solution for consolidating the structure of a hydrogel including alginate and gelatin, and to a hydrogel obtained by this process. Additionally, a process for consolidating the structure of a hydrogel including alginate and gelatin, this process including preparing the hydrogel, shaping it, then bringing it into contact with suitable consolidation agents. Further, the hydrogel obtained by this process. In all these aspects, the hydrogel can further include fibrinogen and/or living cells.

Abstract: An overcurrent protection device for a circuit to be monitored, having at least one trigger unit, which is configured for an interruption of the circuit in at least one trigger situation and which includes at least one conductor section which is configured for a conduction of a current to be monitored, at least one conductive trigger element, which includes at least one thermo magnetically-shiftable material configured for a magnetic property change in dependence on the temperature induced by a current that flows through the conductor section, a conductive magnetic module, a conductive magnetic core, the conductive magnetic module being movable between a first position faced against the conductive trigger element permitting the conduction of the current through the conductor section and a second position faced against said conductive magnetic core breaking the conduction of the current through the conductor section.

Abstract: A traffic barrier and soundwall system is disclosed having wide-flanged [or h-posts] vertical posts oriented with a flange facing a roadway. Traffic barriers are located between them. The barriers have recesses at the intersection of their backs and ends. Sound panels are stacked on top of the traffic barriers. A crash panel is located between the vertical posts, above one or more sound panels. The crash panels have recesses at the intersection of their backs and ends. Additional sound panels are stacked above the crash panels. An angle bracket is located in the recess. U-shaped connectors connect the recesses of adjacent traffic barriers together around a post. U-shaped connectors connect the recesses of adjacent crash panels together around a post, and above the traffic barriers and sound panels to achieve a MASH TL-4 crash test rating.

Abstract: The present invention provides an improved electric lock that allows for electrically controlled retraction of latch bolt to allow for opening of the door in which the lock is installed. The components that allow for retraction are primarily internal to the lock and have means for conducting electrical signals to the lock to allow for remote control of the latch retraction. In some embodiments, the locks comprise an electrically controllable actuator and at least one retraction lever configured to retract the latch bolt against an applied bias. The actuator can be configured with various other internal components such that movement of the other internal components in one direction, such as toward the actuator, causes movement of the latch bolt in the opposite direction, such as away from the actuator. This opposing movement can allow for different electrical arrangements within different locks having relatively small internal spaces.

Abstract: A catheter pump includes a cannula having an inlet, an outlet, and a blood flow channel extending between the inlet and the outlet along a longitudinal axis. At least one impeller blade is operable to convey blood through the blood flow channel between the inlet to the outlet, wherein the at least one impeller blade is axially movable relative the cannula in a first direction toward the inlet and in a second direction away from the inlet.

Abstract: Antenna includes at least one first resonant cavity and a second resonant cavity, each resonant cavity being closed by a base at one end and including a radiating element superimposed on the base of the resonant cavity, the radiating element of the first cavity being able to transmit a signal on a first frequency band and the radiating element of the second cavity being able to transmit a signal on a second frequency band separate from the first frequency band, characterized in that a first distance between the base and radiating element of the first cavity differs from a second distance between the base and radiating element of the second cavity.

Abstract: A recreational assembly includes a body, the body defining an aperture extending through the thickness of the body from the upper surface to the lower surface, and two lumens extending within the body. The assembly also includes two or more stringers removably insertable into the lumens, respectively, and a plug removably insertable into the aperture of the body. The plug includes upper and lower plates configured to be secured within the aperture. Each of the upper and lower plates includes an anchor on one side configured to connect with an end of one of the stringers.

Abstract: An article of footwear comprising: a sole; an upper, attached to the sole; and a full length footbed located inside the upper; wherein a portion of an underside of the full length footbed is attached relative to the sole with an underside of a forward portion of the full length footbed being unattached for placement of a forefoot cushion thereunder and/or an underside of a rearward portion of the full length footbed being unattached for placement of a heel raise thereunder.

Abstract: A catheter pump is disclosed herein. The catheter pump can include a catheter assembly that comprises a drive shaft and an impeller coupled to a distal end of the drive shaft. A driven assembly can be coupled to a proximal end of the drive shaft within a driven assembly housing. The catheter pump can also include a drive system that comprises a motor and a drive magnet coupled to an output shaft of the motor. The drive system can include a drive assembly housing having at least one magnet therein. Further, a securement device can be configured to prevent disengagement of the driven assembly housing from the drive assembly housing during operation of the pump.

Abstract: An anchor and railing assembly for anchoring a baluster or balustrade to both outdoor and indoor structures, such as raised, generally flat or angled roof-like structures or indoor stairs or floors, which includes an anchor baseplate with a top surface and a bottom surface, and an internally threaded bore extending at least partially from the top surface generally towards the bottom surface, a baluster, fasteners for fastening the baluster to the anchor baseplate via its bore, and fasteners for fastening the anchor baseplate to either an outdoor or indoor structure.

Abstract: A self-adjusting variable pitch propeller included a central hub with an axial propeller centre line defining the rotational axis of the propeller. A plurality of blades extend radially from the hub. The hub exhibits a central bore arranged to receive a rotating drive shaft. Each blade is pivotally fixed to the hub and pivotal about a respective blade pivot axis which extends radially from the hub through the respective blade. Each blade exhibits a leading edge, a trailing edge, a pressure side exhibiting a pressure side area and a suction side exhibiting a suction side area. The blades are mechanically interconnected to freely transfer pivotal movement of each blade to all other blades. The pivotal axis of each blade is positioned such that >50% of the suction side area and of the pressure side area is arranged between the trailing edge and the pivotal axis of the respective blade.

Abstract: A ligand of Formula (A): or a carboxylate salt thereof; wherein Y1, Y2 and Y3 each independently represents —COOH or a picolinate of Formula (i): wherein each R1 independently represents a chromophore group; L1, L2 and L3 each independently represents a single bond or a linker; and X1, X2 and X3 each independently represents a hydrogen atom, a coupling function or a bio-vectorizing group. Also, a process for manufacturing the ligand and to a process for manufacturing a chelate by complexation by the ligand of a rare-earth cation, preferably a lanthanide cation. Further, a use of the ligand and/or the chelate in biological imaging and/or photoluminescence imaging.

Abstract: The present invention generally relates to heart treatment systems. In some aspects, methods and systems are provided for facilitating communication between implanted devices. For example, an implantable cardiac rhythm management device may be configured to communicate with an implantable blood pump. The implantable cardiac rhythm management device may deliver heart stimulation rate information in addition to information associated with any detected abnormalities in heart function. In response, the pump may be configured to adjust pumping by the pump to better accommodate a patient's particular needs.

Abstract: A method for increasing the number of CD4+ T-lymphocytes in the serum of a subject in need of such treatment comprising administering to the subject a pharmaceutical composition comprising an amount of an L-isomer of ?-lactam effective to increase the number of CD4+ T-lymphocytes in said patient's serum.

Abstract: A catheter pump includes a cannula and an impeller system. The cannula has an inlet zone with a first maximum outer diameter, an outlet zone with a second maximum outer diameter and a blood flow channel extending between the inlet zone and the outlet zone. The first maximum outer diameter is greater than the second maximum outer diameter, and the impeller system has a rotatable impeller body operable to convey blood from the inlet zone to the outlet zone. The impeller body may be axially spaced from the cannula in a separated position.

Abstract: Systems, assemblies, and related modules for connecting components of medical devices employ connector cables with electrical conductors and optical fibers. A connector assembly for coupling a battery module with a medical system including an implanted or worn medical device includes an input connector and an output connector. The input connector includes metal contact plates, has no moving parts, and is sealed to prevent water or dust ingression into the housing. The output connector includes metal pins to electrically couple to the metal plates of the input connector, a connector cable including electrical conductors coupled to the metal pins configured to transmit electrical power and an optical fiber configured to transmit data, and a latching mechanism disposed at an end of the output connector configured to physically attach the output connector to the housing. The cable body has a substantially flat cross-section.