Patents Assigned to A. Nattermann & Cie GmbH
  • Patent number: 4873350
    Abstract: The present invention relates to new diselenobis-benzoic acid amides of primary and secondary amines of the general formula (I): ##STR1## and processes for the treatment of diseases in humans caused by a cell injury.
    Type: Grant
    Filed: October 3, 1988
    Date of Patent: October 10, 1989
    Assignee: A Nattermann & CIE GmbH
    Inventors: Andre Welter, Harmut Fischer, Leon Christiaens, Albrecht Wendel, Eugen Etschenberg, Norbert Dereu, Peter Kuhl, Eric Graf
  • Patent number: 4857236
    Abstract: A process for isolating phosphatidylcholine free of lysophospholipid from egg powder wherein the egg powder is treated with a solvent mixture of a low boiling petroleum ether fraction (40.degree. to 80.degree. C.), a lower C.sub.1 -C.sub.4 -alkanol and water, the undissolved material is separated from the solution phase, the solution phase is given onto a column filled with silica gel at a temperature in the range from 20.degree. to 50.degree. C., the elution is carried out at that temperature with the same solvent mixture, the main run is collected and the dissolved phosphatidylcholine is isolated therefrom as usual.
    Type: Grant
    Filed: May 26, 1987
    Date of Patent: August 15, 1989
    Assignee: A. Nattermann & Cie GmbH
    Inventor: Bernd-Rainer Gunther
  • Patent number: 4842865
    Abstract: Use of glycofurol for the liquidization of pharmaceutical preparations containing more than 50% phosphatidyl choline with a high content of unsaturated fatty acids, which preparations can contain another active ingredient as well as phosphatidyl choline, and in which the viscosity so obtained permits filling into soft gelatine capsules.
    Type: Grant
    Filed: April 23, 1987
    Date of Patent: June 27, 1989
    Assignee: A. Nattermann & CIE GmbH
    Inventors: Manfred Durr, Hans U. Fribolin, Ekkerhard Harhausen, Jurgen Seidel
  • Patent number: 4784994
    Abstract: The invention relates to a process for the treatment of inflammatory and allergic skin diseases.
    Type: Grant
    Filed: May 12, 1987
    Date of Patent: November 15, 1988
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Axel Romer, Jorg Hager
  • Patent number: 4774252
    Abstract: The present invention relates to new benzisoselenazolonyl derivatives of the general formula (I) ##STR1## and processes for the treatment of rheumatic diseases.
    Type: Grant
    Filed: February 17, 1988
    Date of Patent: September 27, 1988
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Andre Welter, Christian Lambert, Norbert Dereu, Andrea Huther, Eugen Etschenberg
  • Patent number: 4757063
    Abstract: The invention is related to a process for the treatment of diseases caused by oxidative stress in human beings comprising administering to said human being a pharmaceutical preparation comprising 2-phenyl-1,2-benzisoselenazol-3(2H)-one as active agent in an amount of 10 to 2000 mg per day.
    Type: Grant
    Filed: May 12, 1987
    Date of Patent: July 12, 1988
    Assignee: A. Nattermann & CIE. GmbH
    Inventor: Michael J. Parnham
  • Patent number: 4730053
    Abstract: The present invention is related to new S-(Carbamoyl-phenylselenyl) derivatives of mercaptanes of the general formula (I) ##STR1## and to a process for the treatment of diseases caused by cell injury due to the increased formation of active oxygen metabolites.
    Type: Grant
    Filed: November 25, 1985
    Date of Patent: March 8, 1988
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Norbert Dereu, Albrecht Wendel, Helmut Sies, Sigurd Leyck, Axel Romer, Erich Graf
  • Patent number: 4720550
    Abstract: The invention is related to a new process for producing imidazolylthiophenaldehydes of the general formula I ##STR1##
    Type: Grant
    Filed: February 6, 1987
    Date of Patent: January 19, 1988
    Assignee: A. Nattermann & CIE GmbH
    Inventors: Bernd-Rainer Gunther, Rainer Losch, Klaus Steiner
  • Patent number: 4711961
    Abstract: The invention relates to new benzisoselenazolethiones of the general formula I ##STR1## and to processes for the treatment of various diseases by administering them to such beings.
    Type: Grant
    Filed: February 26, 1985
    Date of Patent: December 8, 1987
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Andre Welter, Sigurd Leyck, Eugen Etschenberg
  • Patent number: 4705802
    Abstract: The invention relates to new .omega.-aryl-alkylthienyl compounds having the Formula I ##STR1## i.e. omega-aryl-alkyl thienyl alkanoic acids and, respectively, omega-aryl-alkyl thienyl alkenoic acids, the alkali metal salts of such acids and certain esters thereof. The invention further relates to processes for the treatment of chronically inflammatory processes in humans.
    Type: Grant
    Filed: February 26, 1985
    Date of Patent: November 10, 1987
    Assignee: A. Nattermann & CIE GmbH
    Inventors: Hans-Heiner Lautenschlager, Michael J. Parnham, Sigurd Leyck, Johannes Winkelmann, Axel Brekle
  • Patent number: 4699914
    Abstract: The present invention is directed to new, an imidazole group containing 2(1H)-pyridones of formula I ##STR1## salts thereof and process for treating congestive heart failure in humans.
    Type: Grant
    Filed: September 3, 1985
    Date of Patent: October 13, 1987
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Gerd Hilboll, Ille-Stephanie Doppelfeld, Gerrit Prop
  • Patent number: 4684632
    Abstract: Pharmaceutical formulations for the treatment of gastrointestinal disorders, which contain as the active component an effective gastrointestinal disorder alleviating amount of a 1,2-diacylglycero-3-phosphocholine in which 75-86% by weight of the acyl radicals are unsaturated fatty acid radicals having a chain length of 16, 18 or 20 carbon atoms. The mixtures of fatty acid radicals in the acyl groups in the 1- and 2-positions preferably have different compositions. The formulations can also contain other active compounds, in particular those which display injurious gastrointestinal side effects.
    Type: Grant
    Filed: December 21, 1984
    Date of Patent: August 4, 1987
    Assignee: A. Nattermann & CIE. GmbH
    Inventors: Volker Schulz, Sigurd Leyck, Manfred Durr, Miklos Ghyczy, Armin Wendel, Jorg Hager
  • Patent number: 4681617
    Abstract: Phospholipid concentrates from natural or synthetic phospholipids and physiologically acceptable organic solvents and further additives of the following composition:20-60 wght. % phospholipids0-23 wght. % glycerin5-62.5 wght. % organic solvent0-30 wght. % co-emulsifier0-35 wght. % dissolving intermediary0-15 wght. % water0-15 wght. % vegetable oil or neutral oilThe phospholipids are a mixture of phosphatidyl choline, phosphatidyl ethanol amine, N-acetyl phosphatidyl ethanol amine, and other phosphatides, the concentrates perferably containing a mixture of 10-50 wght. % phosphatidyl choline, 10-30 wght. % phosphatidyl diethanol amine, 10-30 wght. % N-acylphosphatidyl ethanol amine, and 3-10 wght. % other phosphatides, in relation to the total quantity of phospholipids. The phospholipid concentrates are particularly suitable as auxiliary agents in the production and application of spray mixtures containing plant protectants.
    Type: Grant
    Filed: July 17, 1985
    Date of Patent: July 21, 1987
    Assignee: A. Nattermann & Cie, GmbH
    Inventors: Miklos Ghyczy, Paul-Robert Imberge, Armin Wendel
  • Patent number: 4667033
    Abstract: The invention refers to substituted 6-(thien-2-yl)-3(2H)-pyridazinones of Formula I ##STR1##
    Type: Grant
    Filed: June 8, 1984
    Date of Patent: May 19, 1987
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Gerd Hilboll, Sigurd Leyck, Gerrit Prop
  • Patent number: 4661487
    Abstract: The invention relates to a new process for the treatment of hypertension and thromboembolic diseases in humans by simultaneous administration of (.+-.)- or (-)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene hydrochloride on the one side, and 4,5-dihydro-6-[4-(1-imidazolyl)-phenyl]-5-methyl-3(2H)-pyridazinone or 4,5-dihydro-6-[4-(1-imidazolyl)-thien-2-yl]-5-methyl-3(2H)-pyridazinone, on the other side, as the active substances.
    Type: Grant
    Filed: February 26, 1985
    Date of Patent: April 28, 1987
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Jurgen Biedermann, Harald Borbe, Erich Graf, Gerd Hilboll, Gerrit Prop
  • Patent number: 4654358
    Abstract: The invention is related to imidazol-2-yl mercapto alkanoic acids having the formula I ##STR1## process for the treatment of humans suffering from inflammatory diseases or diseases in relation with the lipid metabolism.
    Type: Grant
    Filed: June 25, 1984
    Date of Patent: March 31, 1987
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Hans-Heiner Lautenschlager, Gerrit Prop, Helmut Wetzig
  • Patent number: 4618669
    Abstract: The present invention relates to new S-(carbamoylphenylselenyl) derivatives of glutathione and of .alpha.
    Type: Grant
    Filed: June 14, 1985
    Date of Patent: October 21, 1986
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Norbert Dereu, Andre Welter, Albrecht Wendel, Sigurd Leyck, Michael Parnham, Erich Graf, Helmut Sies, Hans Betzing, Hartmut Fischer
  • Patent number: 4610979
    Abstract: The invention relates to new O-acyl-alkanediol-phospholipids of the general formula I ##STR1## processes for their preparation and process for the treatment of certain diseases in humans.
    Type: Grant
    Filed: February 27, 1984
    Date of Patent: September 9, 1986
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Hans-Heiner Lautenschlager, Erich Graf, Sigurd Leyck
  • Patent number: 4600722
    Abstract: The invention relates to new 3-amino-1-(4,5,6,7-tetrahydro-benzothiazolyl)-2-pyrazolines of the Formula I ##STR1## and acid addition salts thereof and a process for the treatment of inflammatory and allergic processes in humans.
    Type: Grant
    Filed: February 26, 1985
    Date of Patent: July 15, 1986
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Joachim Uhlendorf, Harald O. Borbe, Sigurd Leyck, Michael J. Parnham, Helmut Wetzig
  • Patent number: 4599205
    Abstract: The invention is related to 1-O-alkyl-3-amino-propan-1.
    Type: Grant
    Filed: June 25, 1984
    Date of Patent: July 8, 1986
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Hans-Heiner Lautenschlager, Michael J. Parnham, Gerrit Prop