Patents Assigned to A. Nattermann & Cie GmbH
  • Patent number: 4303673
    Abstract: The invention provides N-propionylsarcosineanilides of the formula: ##STR1## wherein n is an integer of 1 to about 3 and the substituent A which can be the same or different when n is greater than 1 is selected from the group consisting of trifluoromethyl; halogen; nitro; acetyl; a straight-chain or branched alkyl group having 1 to 4 carbon atoms; a straight-chain or branched alkoxy group having 1 to 4 carbon atoms; a straight-chain or branched alkylmercapto group having 1 to 7 carbon atoms; a substituted alkylmercapto group of the formula: ##STR2## wherein n is an integer of 1 or 2, R.sub.1 can represent hydrogen and methyl, and R.sub.2 can represent hydroxyl, and an amino group of the formula:--NR.sub.6 R.sub.7 Vwherein R.sub.6 can represent hydrogen, and methyl, and R.sub.7 can represent methyl, substituted benzyl, and R.sub.6 and R.sub.7, together with the nitrogen, can constitute a substituted pyrrolidine ring; a sulphonyl group of the formula:--SO.sub.2 R.sub.3 IIIwherein R.sub.
    Type: Grant
    Filed: September 5, 1980
    Date of Patent: December 1, 1981
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: Jurgen Biedermann, Armin Wendel, Hans Betzing, Volker Neuser
  • Patent number: 4277483
    Abstract: The present invention is related to the new 2.6-dimethyl-4-(3'-nitrophenyl)-1.4-dihydropyridine-3-carboxylic acid beta-trimethylsilylethyl ester-5-carboxylic acid lower alkyl esters with improved antihypertensive and to a process for the treatment of humans suffering from hypertension with such compounds.
    Type: Grant
    Filed: April 14, 1980
    Date of Patent: July 7, 1981
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: Carsten Materne, Hans Betzing
  • Patent number: 4269855
    Abstract: (3-Alkylamino-2-hydroxypropoxy)-furan-2-carboxylic acid anilides of the formula: ##STR1## in which R.sub.1 denotes a straight or branched C.sub.1 to C.sub.5 alkyl group or a cyclopropyl or cyclopentyl group, R.sub.2 denotes a hydrogen or halogen atom or a methyl, methoxy, nitro or acetyl group, R.sub.3 denotes a hydrogen or halogen atom or a nitro group and A denotes a single bond or the --CH.sub.2 -- or --CH.dbd.CH-- group, and physiologically tolerated acid addition salts thereof possess .beta.-adrenolytic properties and a low toxicity.
    Type: Grant
    Filed: June 3, 1980
    Date of Patent: May 26, 1981
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: Joachim Uhlendorf, Hans Betzing, Hamied Gabbar, Erich Graf, Ille-Stephanie Doppelfeld
  • Patent number: 4254115
    Abstract: Novel n-oleyl derivatives of natural and synthetic phosphatidyl ethanolamines are provided. Such derivatives exhibit antilipemic and antiarteriosclerotic properties and are thus useful in pharmaceutical preparations.
    Type: Grant
    Filed: June 18, 1979
    Date of Patent: March 3, 1981
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: Herbert Dawidson, Hans Betzing
  • Patent number: 4235793
    Abstract: An improved process for obtaining highly purified phosphatidylcholines (lecithin) including a high content of essential fatty acids is disclosed. Raw lecithins are first extracted with a lower alcohol of 1 to 3 carbon atoms. The resulting two phases are separated and the alcohol-rich upper phase is treated with an aluminum oxide adsorbent. Elution of the adsorbent with an alcohol (as in known processes) results in an oily phosphatidylcholine, free of cephalin and inositol phosphatides but possessing a high content of essential fatty acids.
    Type: Grant
    Filed: April 24, 1978
    Date of Patent: November 25, 1980
    Assignee: A. Nattermann & Cie. GmbH
    Inventor: Hans Betzing
  • Patent number: 4221732
    Abstract: Structural analogs of natural phospholipids of the general formulae ##STR1## where R.sub.1 and R.sub.2 represent either hydrogen and/or saturated or unsaturated straight-chain and branched acyl radicals with 2 to 24 C-atoms and R.sub.3 an amino group or a substituted amino group of the formula ##STR2## and n is a number from 1-3, are useful in the preparation of stable liposomes useful as vehicles for pharmaceutical preparations.
    Type: Grant
    Filed: May 11, 1979
    Date of Patent: September 9, 1980
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: Kurt Oette, Tschae S. Tschung
  • Patent number: 4203433
    Abstract: A spreading device for the treatment of hip dysplasties comprises a back support for engagement with a patient's back in the area of the sacrum. From the back support two side portions extend to the front, to each of which a thigh splint in the nature of a leaf spring is connected. The ends of the thigh splints form supporting dishes each to be engaged with a thigh of the patient at or above the ham.
    Type: Grant
    Filed: February 12, 1979
    Date of Patent: May 20, 1980
    Assignee: A. Nattermann & Cie. GmbH
    Inventor: Gertraud Prahl
  • Patent number: 4140770
    Abstract: Processes for preparing benzoylethers, their acid additive salts and their quaternary ammonium salts are disclosed. These compounds have useful pharmacodynamic properties.
    Type: Grant
    Filed: April 12, 1977
    Date of Patent: February 20, 1979
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: Gudrun Repplinger, Hans Betzing
  • Patent number: 4129650
    Abstract: A compound of the formula ##STR1## (wherein R.sub.1 and R.sub.2 are each H or a fatty-acid residue, and R.sub.3 is ##STR2## and PG is a prostaglandin radical or optical isomer thereof) is found to have a substantially increased duration of effect, compared with the corresponding prostaglandin per se, and also a strong organ specificity.
    Type: Grant
    Filed: June 28, 1977
    Date of Patent: December 12, 1978
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: Hans Betzing, Dac Lekim
  • Patent number: 4088539
    Abstract: Lipase is obtained by treating comminuted pancreas tissue with a mixture of 80- 95% by volume (a) halogenated hydrocarbon having a boiling point of 47.degree. - 130.degree. C. and a density greater than 1.3, or (b) hydrocarbon having a boiling point of 47.degree. - 130.degree. C. and a density of from 0.655 to 0.88, and a water immiscible alcohol having 4- 6 carbons.
    Type: Grant
    Filed: May 3, 1977
    Date of Patent: May 9, 1978
    Assignee: A. Nattermann & Cie GmbH
    Inventor: Klaus P. Muller
  • Patent number: 4025639
    Abstract: 2-[.alpha.-(2,6-Dichlorophenoxy)-ethyl]-.DELTA..sup.2 -imidazoline, and physiologically acceptable acid addition salts thereof, which provide vasoactivity and hypotensive activity.
    Type: Grant
    Filed: December 5, 1975
    Date of Patent: May 24, 1977
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Horst Baganz, Hans-Joachim May
  • Patent number: 3966757
    Abstract: 2-[.alpha.-(2,6-DICHLOROPHENOXY)-ETHYL]-.DELTA..sup.2 -IMIDAZOLINE, AND PHYSIOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, WHICH PROVIDE VASOACTIVITY AND HYPOTENSIVE ACTIVITY.
    Type: Grant
    Filed: April 8, 1975
    Date of Patent: June 29, 1976
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Horst Baganz, Hans-Joachim May