Abstract: The invention relates to compounds of general formula I wherein D, E, F, G, W, Y, R1, A, R9, X, B, R8 are as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for treating diseases associated with deregulated angiogenesis, such as cancer.

Abstract: Novel cyclic and linear peptides of the formula R1—X—X1—X2—X3—X4—X5—X6—X7—X8—X9—X10—X11—R2 are useful in the treatment of obesity are provided.

Abstract: The invention relates to the use of Factor VIIa or a Factor VIIa equivalent for the manufacture of a medicament for preventing complications in ICH patients.

Abstract: Analogues of the peptide PYY (1-36) are described in which the tertiary structure of the peptide is preserved and stabilised particularly to enhance binding and activation of the Y2 receptor by the use of cross links or rigid bends in the peptide to constrain conformationally the positions of the N-terminal part of the peptide sequence and amino acid 34. The analogues are useful in the control of food intake.

Abstract: An insecticidal composition having improved storage stability is disclosed. Said insecticidal composition comprises Dimethoate stabilized with maleic anhydride. Also a process for the control of insects is disclosed, wherein the insecticidal composition, possibly following a dilution, is apportioned to an area, in which crops are grown.

Abstract: The invention relates to an improved method of storing data within a persistent data space of a hearing aid and a hearing aid utilizing the improved storage methodology. The invention prevents that erroneous or corrupted data are written into and/or loaded from the persistent data space due to unexpected and uncontrollable power supply failures in the hearing aid.

Abstract: The invention relates to a leak control system (1) in two-stringed pipe installations and a method of executing a leak control system comprising one stop valve (2) with an associated flow meter (3) arranged in the supply pipe (4) of the pipe installation, and one stop valve (5) with an associated flow meter (6) arranged in the return pipe (7) of the pipe installation, said stop valves (2,5) as well as associated flow meters (3, 6) being connected to a control box (8), said box (8) comprising one valve monitor (9) connected to each stop valve (2, 5) to control/record the possible state of the individual stop valve (2, 5): open or closed, as well as an executer which, in combination with the control logics of the control box and the operating conditions of the pipe installation, controls/monitors the valve monitors (9) during a given sequence of actions, said leak control system (1) being capable of performing a number of measurements and data collections to evaluate the functionality of the stop valves (2, 5)

Abstract: The present invention relates to novel isatin derivatives, pharmaceutical compositions comprising the isatin derivatives of the invention, methods of preparing the isatin derivatives of the invention, their use in the treatment of neurodegenerative diseases and for the regeneration or prevention of degeneration of lesioned and damaged neurons, and methods of treatment of neurodegenerative diseases and for the regeneration or prevention of degeneration of lesioned and damaged neurons.

Abstract: A method and a system (400) for detection and position determination of chips (100), which transmit ultrasound signals in a room. The system (400) comprises electronic identification chips (100), which are attached to objects that have to be monitored. Each chip (100) is equipped with a transmitter (179) and a receiver (180). The signals are received by a plurality of detector units (290), which are connected to a detector base unit (200) that registers and interprets the signals transmitted form the identification chips (100). Detector base units (200) located in different rooms are interconnected in a network (215) and transmit processed information to one or more central units (410) for further interpretation and sorting. The special feature of the invention is that line interference is substantially removed, and it is possible to determine position even though the identification chips (100) are in motion.

Abstract: The present invention relates to novel heteroaryl diazacycloalkane derivatives, which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

Abstract: Lipolytic enzymes are chemically modified by covalently linking one or more (particularly 1-3) hydrophobic groups to the enzyme molecule. The chemical modification improves the performance of the lipolytic enzyme, e.g., in baking or in detergents.

Abstract: The invention relates to a method of mounting a wind turbine at a mounting location, said method comprising the steps of providing a foundation (33A, 33B), said foundation comprising a foundation body and pre-fitted upper attachment means vibrating at least a part of the foundation into the earth by transferring of vibrations into the structure of the foundation, mounting at least a part of said wind turbine to said upper attachment means (12) of said foundation. According to the invention, large scale wind turbines, especially offshore wind turbines, may be transported and mounted at the site in a cost-effective and expedient way.

Abstract: A method of self treating a disease, such as diabetes, includes collecting in one or more databases data representing values of parameters that related to the self treatment. The data is processed to provide a plurality of alternate choices between two or more actions that may be taken and a corresponding value for each action is calculated. A computerized system may be employed to perform the above method and the system may include a computer readable medium for executing the method.

Abstract: A hinge for a child safety barrier, consisting of first (1, 9) and second (2, 10) bracket parts, wherein the first bracket part is formed with a pin (4) whose free end is formed with a shoulder (5). The second bracket part (2, 10) is formed with a hole (7) with two sections, where the first section has a larger diameter than the second section. This provides an edge between the two sections, which, together with the shoulder (5) of the pin, serves as a lock between the two bracket parts. If the length of the pin is larger than the length of the section of the smallest diameter, then the two hinge parts may be displaced relative to each other in the direction of the pin, which is an advantage when the hinge is used in connection with child safety barriers. The two bracket parts of the hinge are formed with respective locking parts which cooperate such that when one bracket part is displaced relative to the other bracket part, the bracket parts may be rotated relative to each other.

Abstract: This invention relates to cation conducting GABAA receptors, mutated GABAA receptor subunits, polynucleotide sequences encoding mutated subunits, expression vectors comprising the mutated subunits, host cells capable of expressing the mutated subunits, drug screening methods, and chemical substances identified by the drug screening methods of the invention.

Abstract: Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

Abstract: The present invention relates in general to coupling of light from one or more input waveguides to an output waveguide or output section of a waveguide having other physical dimensions and/or optical properties than the input waveguide or waveguides. The invention relates to an optical component in the form of a photonic crystal fibre for coupling light from one component/system with a given numerical aperture to another component/system with another numerical aperture. The invention further relates to methods of producing the optical component, and articles comprising the optical component, and to the use of the optical component. The invention further relates to an optical component comprising a bundle of input fibres that are tapered and fused together to form an input coupler e.g. for coupling light from several light sources into a single waveguide. The invention still further relates to the control of the spatial extension of a guided mode (e.g.

Abstract: This invention relates to a doser comprising a syringe (2) with a needle (3) which extends beyond the doser (1), which comprises an engagement face (4) in the vicinity of the needle so that the engagement face rests against the surface of the tissue into which the needle is inserted. Detector means (5) are provided on said engagement face to sample signals on the skin of the patient. The invention further provides means (13) for receiving external information related to health monitoring of a patient. This provides a doser that may record heart rate, EKG, BGM and hypo-alarm administered medicine. The doser may further be arranged to calculate an appropriate dose of medication on the basis of a number of acquired inputs.

Abstract: A chain link is described which may be assembled with other chain links to form a conveyor belt which is particular in that along the front and rear edges, recesses are provided such that a recess along one edge corresponds to no recess at the opposite edge, and that the recesses along one edge inside each recess is provided with two notches protruding into the recess along a common axis parallel to the front/rear edges, and that apertures are provided inside the recesses along the opposite edge, where the apertures can accommodate notches from an adjacent chain link, and that an opening substantially perpendicular to the bottom and top sides connects the aperture with the bottom side for allowing the notches to pass into the aperture.

Abstract: Provided are mammalian secreted and non-secreted diabetes mediating proteins, including protective and deleterious diabetes-mediating proteins, as well as polynucleotides encoding same, drug screening methods for identifying a test compound capable of altering the expression of a diabetes-mediating protein, and methods of preventing or ameliorating diabetes by administering a compound capable of the expression of a diabetes-mediating protein.