Patents Assigned to Advanced Cardiovascular Systems
  • Method of using support device to coat a stent
    Patent number: 7402329
    Abstract: A support device for a stent and a method of coating a stent using the device are provided.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: July 22, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Stephen D. Pacetti, Plaridel K. Villareal
  • Device And Active Component For Inhibiting Formation Of Thrombus-Inflammatory Cell Matrix
    Publication number: 20080167711
    Abstract: A combination drug treatment for inhibiting stenosis or restenosis is disclosed. The combination treatment is an active component containing both an anti-inflammatory substance and an anti-thrombotic substance which, together, contribute to an inhibiting effect on the initial stages of stenosis or restenosis. The active component can be delivered to a site of treatment by being carried on a device, such as a stent.
    Type: Application
    Filed: March 20, 2008
    Publication date: July 10, 2008
    Applicant: Advanced Cardiovascular Systems Inc.
    Inventor: Wouter E. Roorda
  • Heparin prodrugs and drug delivery stents formed therefrom
    Patent number: 7396541
    Abstract: A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
    Type: Grant
    Filed: September 15, 2005
    Date of Patent: July 8, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed Faiyaz Ahmed Hossainy, Ni Ding
  • Stent coatings with engineered drug release rate
    Patent number: 7396539
    Abstract: Coatings and methods of forming coatings for implantable medical devices, such as stents, are described. The coatings are used for the sustained release of a therapeutic agent or drug.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: July 8, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F A. Hossainy, Gordon Stewart
  • Medical device chemically modified by plasma polymerization
    Patent number: 7396582
    Abstract: Medical devices, and particularly intracorporeal devices for therapeutic or diagnostic uses, having a component chemically modified by plasma polymerization. The medical device comprises a substrate with a plasma polymerized functionality bonded to a surface of at least a section thereof. The plasma polymerized film on a first component of the medical device allows for bonding an agent or a second component to the first component. In one embodiment, the plasma polymerized film facilitates fusion or adhesive bonding of a first component to a second component formed of a material which is dissimilar to, incompatible with, or otherwise not readily bondable to the substrate material of the first component. In another embodiment, a bioactive agent is bonded to the plasma polymerized film on the component, for presenting or delivering the bioactive agent within a body lumen of the patient.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: July 8, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Charles D. Claude, Jeong S. Lee
  • Poly(ester amide) filler blends for modulation of coating properties
    Patent number: 7390497
    Abstract: Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom. The PEA polymer blend is formed of a PEA polymer and a material capable of hydrogen bonding with the PEA. The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: June 24, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Jessica Renee DesNoyer, Stephen Dirk Pacetti, Syed Faiyaz Shmed Hossainy, Lothar Kleiner, Yiwen Tang, Gina Zhang
  • Biodegradable drug delivery material for stent
    Patent number: 7390333
    Abstract: A stent is fabricated utilizing a polymer that is selected for its tendency to degrade from the surface inwardly rather than undergo bulk erosion so as to substantially reduce the risk of large particles becoming detached and being swept downstream. Such polymer is hydrophobic yet has water-labile linkages interconnecting the monomers. Ester or imide bonds are incorporated in the polymer to render the surface degrading materials suitable for use in stent applications. The stent may be coated with such polymer or may be wholly formed therefrom.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: June 24, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Debashis Dutta
  • Method for electrostatic spraying of an abluminal stent surface
    Patent number: 7390524
    Abstract: A method for electrostatic spraying of an abluminal surface of a stent is provided.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: June 24, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Yung-Ming Chen
  • Method of forming a diffusion barrier layer for implantable devices
    Patent number: 7390523
    Abstract: A method of forming a diffusion barrier for an implantable medical device carrying a therapeutic or bioactive substance is disclosed. The diffusion barrier reduces the rate at which the therapeutic or bioactive substance is released from the device. The diffusion barrier can be made from a polymeric material impregnated with particles.
    Type: Grant
    Filed: September 8, 2003
    Date of Patent: June 24, 2008
    Assignee: Advanced Cardiovascular Systems Inc.
    Inventors: Stephen D. Pacetti, Syed F. A. Hossainy
  • Severable Support For A Stent
    Publication number: 20080145515
    Abstract: A stent with at least one severable supporting device and methods of coating using the same are disclosed. The severable supporting device can be an end tube or a tab attached to some portion of the stent by at least one “gate” or attachment. The end tube or tab may be part of the design of the stent when it is originally manufactured, or it may be attached to the stent in a secondary process by a biocompatible glue or solder. The end tube or tab can be used to support a stent during a coating process eliminating the need for a mandrel which would otherwise contact the stent during the coating process.
    Type: Application
    Filed: February 25, 2008
    Publication date: June 19, 2008
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: Yung-Ming Chen, Eric Aldenbrook
  • Severable Support For A Stent
    Publication number: 20080147161
    Abstract: A stent with at least one severable supporting device and methods of coating using the same are disclosed. The severable supporting device can be an end tube or a tab attached to some portion of the stent by at least one “gate” or attachment. The end tube or tab may be part of the design of the stent when it is originally manufactured, or it may be attached to the stent in a secondary process by a biocompatible glue or solder. The end tube or tab can be used to support a stent during a coating process eliminating the need for a mandrel which would otherwise contact the stent during the coating process.
    Type: Application
    Filed: February 25, 2008
    Publication date: June 19, 2008
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: Yung-Ming Chen, Eric Aldenbrook
  • Method of forming rate limiting barriers for implantable devices
    Patent number: 7387810
    Abstract: A method is disclosed for forming a coating on implantable medical devices including an interpenetrating polymer network that serves as a rate limiting barrier.
    Type: Grant
    Filed: February 7, 2005
    Date of Patent: June 17, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Syed F. A. Hossainy
  • Implantable device having substances impregnated therein and a method of impregnating the same
    Patent number: 7384660
    Abstract: A method of impregnating an implantable device, such as a vasclar graft or a covering adapted to be disposed over a prosthesis, is provided. The substances may be impregnated within the implantable device as a passive coating or as a delivery matrix for a matrix for a therapeutic substance. Also provided is an implantable device having such substances impregnated therein.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: June 10, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Jacqueline Ghio, Li Chen
  • Stents with profiles for gripping a balloon catheter and molds for fabricating stents
    Patent number: 7381048
    Abstract: Embodiments of stents having profiles that improve gripping of the stent on a stent delivery system are provided. Additionally, embodiments of molds for fabricating the stents are provided.
    Type: Grant
    Filed: April 12, 2005
    Date of Patent: June 3, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Daniel Gene Brown, Hector Onelio Torres, Mark Harris, Chris Andrews
  • Biologically absorbable coatings for implantable devices and methods for fabricating the same
    Patent number: 7378106
    Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising a biologically degradable, biologically erodable, and/or biologically resorbable ABA or AB block copolymer. A biologically active agent can be conjugated to the block copolymer.
    Type: Grant
    Filed: December 18, 2006
    Date of Patent: May 27, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Eugene T. Michal, Yiwen Tang
  • Controlled morphologies in polymer drug for release of drugs from polymer films
    Patent number: 7364748
    Abstract: The present invention includes a drug release system. The drug release system comprises a bulk polymer phase and a polymeric drug-enriched phase within the bulk polymer phase. At least one drug is incorporated into the drug-enriched phase.
    Type: Grant
    Filed: April 1, 2004
    Date of Patent: April 29, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Charles David Claude
  • Blends of poly(ester amide) polymers
    Patent number: 7365133
    Abstract: Provided herein is a poly(ester amide) (PEA) polymer blend and coatings and medical devices formed of the blend.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: April 29, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Jessica Renee DesNoyer, Stephen Dirk Pacetti, Lothar Kleiner
  • Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles
    Patent number: 7361726
    Abstract: Polymers containing poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles are disclosed along with methods of fabricating medical articles comprising these polymers. The medical articles generally comprise an implantable substrate having a coating containing a poly(hydroxyalkanoate-co-ester amide).
    Type: Grant
    Filed: February 8, 2007
    Date of Patent: April 22, 2008
    Assignee: Advanced Cardiovascular Systems Inc.
    Inventors: Stephen D. Pacetti, Syed F. A. Hossainy
  • Device and method for combining a treatment agent and a gel
    Patent number: 7361368
    Abstract: A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first annular member having a first lumen disposed about a length of the first annular member and a first entry port at a proximal end of the first annular member, and a second annular member coupled to the first annular member having a second lumen disposed about a length of the second annular member and a second entry port at a proximal end of the second annular member, wherein the first annular member and the second annular member are positioned to allow a combining of treatment agents introduced through each annular member at the treatment site.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: April 22, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Charles D. Claude, Paul J. Kawula, Syed Faiyaz Ahmed Hossainy, Kimchi Tran
  • Coatings comprising self-assembled molecular structures and a method of delivering a drug using the same
    Patent number: 7363074
    Abstract: A coating for an implantable medical device is disclosed, the coating including a self-assembled molecular structure. The coating can be used for altering the release rate of a therapeutic substance from the implantable device.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: April 22, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Connie S. Kwok, Charles D. Claude