Patents Assigned to Advanced Cardiovascular Systems
  • Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents
    Patent number: 7435788
    Abstract: This disclosure covers polymers, some of which are useful in medical device applications. The polymers comprise at least two different blocks, at least one L1 block with the formula and at least one L2 block with the formula Medical devices comprising these polymers, mixtures of these polymers with therapeutic agents, and methods of making these polymers and mixtures are within the scope of this disclosure. Some of these medical devices are implantable within a mammalian body, such as in a body lumen.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: October 14, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Stephen D. Pacetti
  • Method and system for irradiation of a drug eluting implantable medical device
    Patent number: 7431959
    Abstract: A method and system for modifying a drug eluting polymeric substrate for an implantable device, such as a stent, is disclosed.
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: October 7, 2008
    Assignee: Advanced Cardiovascular Systems Inc.
    Inventor: Houdin Dehnad
  • Reduced slippage balloon catheter and method of using same
    Patent number: 7431714
    Abstract: A balloon catheter having a balloon with a reduced slippage lubricious coating, and a method of performing a medical procedure such as a balloon dilatation procedure in a patient's blood vessel. The second coating (i.e., the balloon coating) is lubricious to facilitate movement of the catheter in the patient's body lumen, yet has sufficiently low lubricity such that the slippage of the inflated balloon from a desired site within the blood vessel is reduced compared to a balloon coated with the first lubricious coating.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: October 7, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Cheryl Rice, Rosabel Chang, Jacky G. Duchamp
  • Stent Spin Coating Method
    Publication number: 20080233268
    Abstract: A method is disclosed for spin coating a stent. The method comprises applying a coating substance to the stent; rotating the stent about an axis of rotation, the axis of rotation being perpendicular to a longitudinal axis of the stent; and rotating the stent about the longitudinal axis of the stent contemporaneously with rotating the stent about the axis of rotation. The axis of rotation can intersect a center of the mass of the stent.
    Type: Application
    Filed: June 3, 2008
    Publication date: September 25, 2008
    Applicant: Advanced Cardiovascular Systems Inc.
    Inventor: Stephen D. Pacetti
  • Stent Spin Coating Apparatus
    Publication number: 20080230000
    Abstract: A system or device for spin coating an implantable medical device, such as a stent, is disclosed. The device includes a coating table to support the stent, the stent being positioned on top of the coating table and supported on the table by a support fixture. The coating table has an axis of rotation. The axis of rotation of the table can intersect a center of the mass of the stent. A driving means can be provided for rotating the stent about the longitudinal axis of the stent and for rotating the coating table about the axis of rotation.
    Type: Application
    Filed: June 3, 2008
    Publication date: September 25, 2008
    Applicant: Advanced Cardiovascular Systems Inc.
    Inventor: Stephen D. Pacetti
  • Surface modification of expanded ultra high molecular weight polyethylene(eUHMWPE) for improved bondability
    Patent number: 7425357
    Abstract: A balloon catheter and a method of making the balloon catheter, having a balloon which is bonded to an elongated shaft, and which has a first layer and a second layer and an improved bond between the balloon and the shaft. One aspect of the invention is directed to a balloon in which the balloon first layer includes eUHMWPE and has at least a section that has been oxidized with a chromic acid solution to provide improved bondability.
    Type: Grant
    Filed: November 16, 2004
    Date of Patent: September 16, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Florencia Lim
  • Delivery systems for embolic filter devices
    Patent number: 7425215
    Abstract: A delivery system for an expandable filter device includes a dual lumen delivery sheath which has a lumen for receiving the expandable filter device and a lumen for receiving a primary guide wire. The primary guide wire is utilized to place the delivery sheath and expandable filter into the desired region of the patient's vasculature via an over-the-wire or rapid-exchange arrangement. The delivery sheath can be protracted over the expandable filter device to allow the filter to be deployed within the patient's vasculature at the desired location. The delivery system can be embodied in an alternative design in which the primary guide wire extends through a guide wire lumen located in an obturator which forms part of the expandable filter device. Again, the primary guide wire is utilized to maneuver the filter device into the desired area via an over-the-wire arrangement.
    Type: Grant
    Filed: March 10, 2003
    Date of Patent: September 16, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: William J. Boyle, Benjamin C. Huter, Scott J. Huter
  • Poly(ester amide) block copolymers
    Patent number: 7419504
    Abstract: Provided herein is a copolymer that includes a soft block (A) that contains poly(ester amide) (PEA) and a hard block (B). The copolymer can be any of AB, ABA or BAB type block copolymers. By varying the relative amount of the PEA block and the hard block, one can obtain a copolymer with a Tg for mechanical integrity in drug-delivery stent applications. The copolymer can be used alone or optionally in combination with a biobeneficial material and/or a biocompatible polymer to form an implantable device or a coating on an implantable device. When the copolymer is used in combination with a biobeneficial material, the copolymer and the biobeneficial material can be co-deposited or applied in sequence during the coating process. A coating formed of the copolymer may also include a bioactive agent.
    Type: Grant
    Filed: December 27, 2004
    Date of Patent: September 2, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Syed Faiyaz Ahmed Hossainy
  • Intracoronary Device And Method Of Use Thereof
    Publication number: 20080206207
    Abstract: Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.
    Type: Application
    Filed: February 7, 2008
    Publication date: August 28, 2008
    Applicant: Advanced Cardiovascular Systems Inc.
    Inventors: Paul Consigny, Gabriel Asongwe, Mary Beth Michaels, Gene Michal, Evgenia Mandrusov, Jeong Lee, Florian Ludwig, John Eric Henckel, Joseph J. Sciacca, Ken Bueche, Richard Todd Thornton, Fidel Albert Urrabazo, Daniel Wiegand
  • Drug-eluting stent cover and method of use
    Patent number: 7416558
    Abstract: An intravascular stent includes an eluting sheath fabricated from a mesh for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood vessel. The eluting sheath is attached to at least a portion of an outside surface area of the stent structure and is fabricated from a mesh designed to neck down in response to a radially outward directed force resulting in the uniform expansion of the stent. The eluting sheath can be loaded with at least one therapeutic drug for the release thereof at a treatment site to facilitate repair of a damaged vessel. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen.
    Type: Grant
    Filed: August 1, 2006
    Date of Patent: August 26, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Philip S. Yip, James Jacobs, Syed Hossainy, Jon Becker, Timothy A. Limon
  • Support assembly for a stent
    Patent number: 7416609
    Abstract: A support assembly for a stent and a method of using the same to coat a stent are provided. The support assembly provides for minimum contact between the stent and the support assembly so as to reduce or eliminate coating defects.
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: August 26, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Domingo S Madriaga, Anh Tran, Arthur J Wen
  • COMPOSITE GUIDEWIRE WITH DRAWN AND FILLED TUBE CONSTRUCTION
    Publication number: 20080200879
    Abstract: The present invention is directed to an intracorporeal device, preferably a guidewire, and method for making the device. The guidewire of the present invention is formed, at least in part, of a composite elongate core formed, at least in part, of precipitation hardened material. The elongate core members of the present invention will have an ultimate tensile strength and modulus of elasticity greater than the same for an identically dimensioned elongate member formed from superelastic NITINOL alone.
    Type: Application
    Filed: March 12, 2008
    Publication date: August 21, 2008
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: Marc Mehrzad Jalisi, David M. Anderson, Wayne E. Cornish, Nancy A. Nicotra, Mark T. Richardson
  • Drug-eluting stent cover method of use
    Patent number: 7413574
    Abstract: An intravascular stent includes an eluting sheath fabricated from a mesh for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood vessel. The eluting sheath is attached to at least a portion of an outside surface area of the stent structure and is fabricated from a mesh designed to neck down in response to a radially outward directed force resulting in the uniform expansion of the stent. The eluting sheath can be loaded with at least one therapeutic drug for the release thereof at a treatment site to facilitate repair of a damaged vessel. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen.
    Type: Grant
    Filed: August 1, 2006
    Date of Patent: August 19, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Philip S. Yip, James Jacobs, Syed Hossainy, Jon Becker, Timothy A. Limon
  • Stent coatings containing self-assembled monolayers
    Patent number: 7413746
    Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a self-assembled monolayer.
    Type: Grant
    Filed: May 15, 2007
    Date of Patent: August 19, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Ni Ding
  • Coating Abluminal Surfaces Of Stents And Other Implantable Medical Devices
    Publication number: 20080190363
    Abstract: A sleeve is positioned over a radially-expandable rod assembly and a stent is positioned over the sleeve. A mandrel is inserted into the rod assembly to thereby press the sleeve against the inner surface of the stent and expand the stent. A coating (such as a solvent, a polymer and/or a therapeutic substance) is then applied to the outer (abluminal) surfaces of the stent, by spraying, for example. The sleeve advantageously prevents the coating material from being applied to inner (luminal) surfaces of the stent and also allows the coating material to be efficiently applied to the abluminal surfaces.
    Type: Application
    Filed: April 15, 2008
    Publication date: August 14, 2008
    Applicant: Advanced Cardiovascular Systems Inc.
    Inventors: Yung Ming Chen, Jeff H. Smith, Celenia Gutierrez
  • Spin coating apparatus and a method for coating implantable devices
    Patent number: 7404979
    Abstract: A device for spin coating an implantable medical device, such as a stent, is disclosed. A method is also disclosed for spin coating a stent.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: July 29, 2008
    Assignee: Advanced Cardiovascular Systems Inc.
    Inventor: Stephen D Pacetti
  • Valve aptation assist device
    Patent number: 7404824
    Abstract: An apparatus including a tether, and an aptation device coupled to the tether at a position corresponding to a location to contact cusps of an atrioventricular valve during systole, wherein the tether and aptation device are suitable for percutaneous delivery to a patient. An apparatus including a support annulus comprising a length corresponding to a circumference of one of an interior portion of an atrium and an atrioventricular valve annulus; and an aptation device coupled to the support annulus corresponding to a location to contact cusps of an atrioventricular valve during at least one of systole when the support annulus is seated in one of an atrium and an atrioventricular valve annulus, wherein the support annulus and aptation device are suitable for percutaneous delivery to a patient. Also, a method of introducing an aptation device to contact cusps or leaflets of an atrioventricular valve.
    Type: Grant
    Filed: November 12, 2003
    Date of Patent: July 29, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: William E. Webler, James D. Breeding, Brad D. Bisson, Firas Mourtada, Gregory M. Hyde, Stephanie A. Szobota, Gabriel Asongwe, Jeffrey T. Ellis
  • Blends Of Poly(Ester Amide) Polymers
    Publication number: 20080177008
    Abstract: Provided herein is a poly(ester amide) (PEA) polymer blend and a polymeric coating containing the PEA polymer blend. The PEA polymer blend has a Tg above the Tg of poly(ester amide benzyl ester) (PEA-Bz) or the Tg of poly(ester amide TEMPO). The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
    Type: Application
    Filed: March 26, 2008
    Publication date: July 24, 2008
    Applicant: Advanced Cardiovascular Systems Inc.
    Inventors: Jessica Renee DesNoyer, Stephen Dirk Pacetti, Lothar Kleiner
  • Blends Of Poly(Ester Amide) Polymers
    Publication number: 20080175886
    Abstract: Provided herein is a bioabsorbable implantable device comprising a bioactive agent and a poly(ester amide) (PEA) polymer blend.
    Type: Application
    Filed: March 26, 2008
    Publication date: July 24, 2008
    Applicant: Advanced Cardiovascular System Inc.
    Inventors: Jessica Renee DesNoyer, Stephen Dirk Pacetti, Lothar Kleiner
  • Severable Support For A Stent
    Publication number: 20080177375
    Abstract: A stent with at least one severable supporting device and methods of coating using the same are disclosed. The severable supporting device can be an end tube or a tab attached to some portion of the stent by at least one “gate” or attachment. The end tube or tab may be part of the design of the stent when it is originally manufactured, or it may be attached to the stent in a secondary process by a biocompatible glue or solder. The end tube or tab can be used to support a stent during a coating process eliminating the need for a mandrel which would otherwise contact the stent during the coating process.
    Type: Application
    Filed: February 25, 2008
    Publication date: July 24, 2008
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: Yung-Ming Chen, Eric Aldenbrook