Patents Assigned to Advanced Custom Engineered Systems & Equipment Inc.
  • MICROFLUIDIC NUCLEOTIDE SYNTHESIZER
    Publication number: 20250144620
    Abstract: A microfluidic system for performing nucleic acid synthesis includes a microfluidic reactor site. A first reactor site valve is coupled upstream of the reactor site. A second reactor site valve is coupled downstream of the reactor site. The system includes a plurality of microfluidic inlets to couple to multiple pressurized reagent containing chambers. A plurality of reagent valves are coupled to individually control a size of droplets of reagent provided by respective pressurized reagent containing chambers. A pressurized gas source is coupled to propel droplets downstream to the microfluidic reactor site.
    Type: Application
    Filed: November 2, 2023
    Publication date: May 8, 2025
    Inventors: Henrique Reis Wisinewski, Bruno Ramos, Sabrina Esperanca Nunes, Ariel Pereira Lima, Bruno Marinaro Verona
  • METHODS FOR ENCAPSULATING AND ASSAYING CELLS
    Publication number: 20250144622
    Abstract: In biosciences and related fields, it can be useful to study cells in isolation so that cells having unique and desirable properties can be identified within a heterogenous mixture of cells. Processes and methods disclosed herein provide for encapsulating cells within a microfluidic device and assaying the encapsulated cells. Encapsulation can, among othere benefits, facilitate analyses of cells that generate secretions of interest which would otherwise rapidly diffuse away or mix with the secretions of other cells.
    Type: Application
    Filed: November 14, 2024
    Publication date: May 8, 2025
    Inventors: Volker L.S. KURZ, Jason M. MCEWEN, Kellen C. MOBILIA, Alexander J. MASTROIANNI, Joshua J. CARDIEL RIVERA
  • COATING DEVICE
    Publication number: 20250144661
    Abstract: A coating device comprises a stage, a coater and a dryer. A substrate is configured to be placed on the stage. The coater is configured to eject a coating liquid from a nozzle to form a coating film on the substrate that is placed on the stage while moving relative to the substrate. The dryer is configured to dry the coating film on the substrate. Drying promotion force of the dryer for promoting drying is adjusted on the basis of drying distribution information of the coating film on the substrate in accordance with a region of the coating film.
    Type: Application
    Filed: January 9, 2025
    Publication date: May 8, 2025
    Inventors: Takayuki MIYOSHI, Toshiaki IKADA, Toshifumi ITO
  • METHODS OF PREPARING COATINGS AND RELATED DEVICES AND SYSTEMS
    Publication number: 20250144665
    Abstract: Coated substrates and methods of preparing such coated substrates are described. The method may include introducing an aerosol into a non-thermal plasma, wherein the aerosol comprises at least one organic compound and a first solvent. depositing the at least one organic compound on a surface of a substrate positioned downstream of the plasma to form a coating on the surface. and spraying a second solvent in aerosol form on the coating. the second solvent being the same or different from the first solvent. Spraying the second solvent may increase uniformity of the coating.
    Type: Application
    Filed: February 8, 2023
    Publication date: May 8, 2025
    Applicant: THERADEP TECHNOLOGIES, INC.
    Inventors: Denis O'SULLIVAN, Liam O'NEILL, Chloe FREWEN
  • MICROSWITCH AUTOMATIC ASSEMBLY APPARATUS, MICROSWITCH, AND ASSEMBLY METHOD
    Publication number: 20250144760
    Abstract: The present application discloses a microswitch automatic assembly apparatus, microswitch, and assembly method, the microswitch automatic assembly apparatus comprises a base, a material carrying rotary table and an installation disc that are provided on the base, a base loading mechanism, a support installation mechanism, a swing rod installation mechanism, and a tension spring installation mechanism are sequentially provided along a rotation direction of the material carrying rotary table, the tension spring installation mechanism comprises a tension spring pre-installation platform, a tension spring position detection platform, a tension spring installation platform, and a tension spring elasticity detection platform.
    Type: Application
    Filed: January 29, 2024
    Publication date: May 8, 2025
    Inventors: Delian WU, Zhimin HU, Liming SHENG
  • CHAIRS WITH ADJUSTABLE BACK SUPPORTS
    Publication number: 20250143469
    Abstract: An adjustable chair can support an occupant that sits on a front portion of a seat cushion. When the user leans back, the chair can provide back support without requiring that the user slide rearwardly along the seat cushion, thereby providing back support to minimize, limit, or substantially eliminate lower back fatigue, discomfort, or the like. A back support of the chair can be located at a desired forward/rearward position based on the user's position on the seat. In some settings, the chair can be used by a card dealer who tends to sit on a forward portion of the seat when dealing cards. The back support can be positioned to comfortably support the dealer's back when, for example, the dealer sits generally upright. The chair can also be used by other individuals that frequently sit on the front of the seat cushion.
    Type: Application
    Filed: September 10, 2024
    Publication date: May 8, 2025
    Inventor: Kevin Richardson
  • GRAVITY FEED DISPENSER FIXTURE AND REFILL ASSIST
    Publication number: 20250143485
    Abstract: A gravity-feed dispensing system includes a dispenser having a hopper and a valve. The hopper is configured to hold a bulk material. The valve is configured to selectively connect to the hopper. The valve includes an actuator assembly operable between open and closed conditions to selectively permit bulk material to pass from the hopper through the valve. A fixture includes a shelf configured to support the dispenser. A rail is at the front of the shelf. The dispenser is configured for pivotable engagement with the rail. A latch is configured to releasably retain the dispenser in an operative position on the shelf.
    Type: Application
    Filed: October 29, 2024
    Publication date: May 8, 2025
    Applicant: Trade Fixtures, LLC
    Inventor: Craig Pavlich
  • Booster Seats Storage and Organizer Device
    Publication number: 20250143487
    Abstract: A booster seat organizer stand adapted to accommodate a plurality of children's booster seats in a stacked vertical orientation is disclosed. The stand features a flat base with raised walls forming a cavity to securely hold the booster seats. A vertical back panel extends from the rear edge of the base to provide additional support and a pair of side panels extend from side edges of the back panel and has wavy contours to offer lateral stability to the stacked booster seats. The stand can include one or more storage compartments for accessories, a detachable hook for wall mounting, and an additional storage compartment integrated or detachably attached to the base. The stand can be used in homes, daycares, restaurants, and public facilities and enhances safety, convenience, and organization for storing children's booster seats.
    Type: Application
    Filed: October 16, 2024
    Publication date: May 8, 2025
    Inventor: Hugh Parker
  • Portable Restroom
    Publication number: 20250143523
    Abstract: A portable restroom with a base spaced apart from a ceiling. There are a plurality of walls therebetween that together define an interior of the restroom with one or more toilets. The restroom has at least one door configured to provide ingress into the interior. A plurality of fork tine ports are provided over the door that receive forklift tines for moving the portable restroom by its ceiling.
    Type: Application
    Filed: October 31, 2024
    Publication date: May 8, 2025
    Inventor: William L. Gibson
  • VEHICLE HAVING AUXILIARY FAN TO IMPROVE HVAC PERFORMANCE
    Publication number: 20250144976
    Abstract: A vehicle including an engine bay and a passenger cabin. The engine bay includes an engine and an HVAC system that is configured to condition the passenger cabin. The HVAC system includes a condenser and a primary fan for drawing ambient air through the condenser; a controller configured to control the HVAC system; at least one sensor in communication with the controller; and at least one auxiliary fan in communication with the controller for drawing air away from the engine bay that has been heated by the engine, wherein based on a signal received from the at least one sensor, the controller is configured to operate the auxiliary fan to draw the air heated by the engine away from the engine bay to minimize the air heated by the engine from intermixing with the ambient air and being circulated through the condenser by the primary fan.
    Type: Application
    Filed: November 2, 2023
    Publication date: May 8, 2025
    Inventors: Paolo Cremasco, Uday Kiran Mahakali, Sreekanth Surapaneni
  • AIR GUIDE ELEMENT FOR A VENTILATION NOZZLE
    Publication number: 20250144979
    Abstract: An air guide element for a ventilation nozzle in a motor vehicle includes a main body at least partially enclosing the cross-section of the ventilation nozzle and on which air guiding fins are arranged. The air guide element also includes a lighting device. The main body and the air guiding fins are produced as a single piece by multi-component 3D printing. The main body has a transparent core. Portions of the surface of the main body and the air guiding fins are printed onto the core at least partially from a semi-transparent material and at least partially from an opaque material.
    Type: Application
    Filed: July 21, 2022
    Publication date: May 8, 2025
    Inventors: Volker GERHARDT, Alexander OHM, Felix HEINRICH, Harald WOLF
  • CLOAK BRACKET FOR REAR BUCKET OF PICKUP TRUCK
    Publication number: 20250144985
    Abstract: The present disclosure discloses a cloak bracket for rear bucket of pickup truck including fixed crossbars that are symmetrically provided on a left inner side and a right inner side of the rear bucket. Two fixed crossbars are provided with a first hinge member and a second hinge member on a side of the fixed crossbars along a length direction thereof, respectively. Two second hinge members are hinged with two tail ends of a first arched support bracket, respectively; middle sections on two sides of the first arched support bracket are hinged with a head end of a support arm, respectively; a tail end of the support arm is detachably hinged with the first hinge member. The beneficial effect of the present disclosure is that a detachable characteristic of the support arm can be used to quickly detach the support arm from the first hinge member.
    Type: Application
    Filed: January 4, 2024
    Publication date: May 8, 2025
    Inventors: TAIPING YANG, HUANZHI GONG, ZHIFENG ZHU, JIANWEN XIAO
  • FIBER TRANSITION HOUSING
    Publication number: 20250145406
    Abstract: A cable storage assembly is provided including a first cable configured to be used outdoors, a second cable configured to be used outdoors and indoors, a connector, an external cable storage reel, and a housing. The external cable storage reel defines a first flange, a second flange, and a first space between the first flange and the second flange. The external cable storage reel is configured to receive the first cable within the first space, and the housing defines an internal volume and includes at least one opening. The housing is configured to receive an extra portion of the first cable within the internal volume. The first cable extends from the first space into the internal volume through the opening(s). The first cable is connected to the second cable within the internal volume using the connector. The second cable is configured to extend from the internal volume through the opening(s).
    Type: Application
    Filed: October 30, 2024
    Publication date: May 8, 2025
    Inventors: Henry B. Carlile, II, Michael John Hrin, John Austin Keenum
  • HOSE REEL SYSTEM
    Publication number: 20250145407
    Abstract: In accordance with example embodiments a hose reel system including a layout guide is provided.
    Type: Application
    Filed: January 10, 2025
    Publication date: May 8, 2025
    Inventor: Mick Zoske
  • PYRAZOLOPYRIMIDINES, COMPOSITIONS COMPRISING THEM AND USES THEREOF
    Publication number: 20250145628
    Abstract: The present document relates to pyrazolopyrimidine compounds, pharmaceutical compositions comprising the same and their use in the treatment or prevention of diseases and disorders associated with the cannabinoid CB1 receptor. For example, the pyrazolopyrimidine compounds, or a tautomeric form and/or salt thereof, are of Formula I: Formula I wherein R1 to R4 are as defined herein.
    Type: Application
    Filed: February 2, 2023
    Publication date: May 8, 2025
    Inventors: Jeremy Green, Shawn Gallagher-Duval, Alexandre Lemire, Yuchen Zhou, Hong Wang
  • PHARMACEUTICAL COMPOSITIONS FOR IMAGING, DIAGNOSIS AND TREATMENT OF CANCER
    Publication number: 20250145664
    Abstract: The present invention relates to a pharmaceutical cold kit composition comprising a chelating agent linked to somatostatin receptor binding organic moiety, a stabilizer, a buffer, and a caking agent or bulking agent, wherein the composition is free of sequestering agent. Further, the present invention also relates to the process of preparing reconstituted or radiolabeled solution composition having high in use stability and radiochemical purity and use thereof for diagnostic and/or therapeutic purposes.
    Type: Application
    Filed: January 14, 2025
    Publication date: May 8, 2025
    Inventors: Vijayaraj Kuniyil Kulangara, Riadh Zriba, Tusharmouli Mukherjee, Indranil Nandi, Miriam Ruiz Pena
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF HEPATITIS B INFECTION
    Publication number: 20250145669
    Abstract: Disclosed herein are compositions and methods for the treatment of hepatitis B infection, including chronic hepatitis B (CHB).
    Type: Application
    Filed: December 10, 2024
    Publication date: May 8, 2025
    Applicant: MELBOURNE HEALTH
    Inventors: Renae Walsh, Stephen Locarnini, Hans Netter, Ronald Farquhar
  • BISPECIFIC ANTIBODY AND APPLICATION THEREOF
    Publication number: 20250145701
    Abstract: A VEGF-targeting VHH, a bispecific antibody targeting PD-1 and VEGF developed on the basis of the VHH, and an application thereof. The VHH has high stability, and has a plurality of excellent effects, such as ease of expression and purification. The constructed bispecific antibody targeting PD-1 and VEGF has high stability, can target enrichment in a high-expression VEGF tumor region, has good medicinal efficacy and safety, and has excellent treatment potential.
    Type: Application
    Filed: December 29, 2023
    Publication date: May 8, 2025
    Inventors: Dong LI, Jianmin FANG, Mei YUAN, Shanshan CHEN, Sisi WANG, Yinghao XIN, Yuanhao LI, Guorui ZHAO, Xinting MA
  • GPRC5D ANTIBODY AND APPLICATION THEREOF
    Publication number: 20250145705
    Abstract: The present invention relates to an antibody against G protein coupled receptor C5 family subtype D (GPRC5D) and an application of the antibody. Specifically, disclosed are an antibody specifically binding to GPRC5D or an antigen-binding fragment thereof, and an encoding nucleic acid thereof, an expression vector and an expression cell, a preparation method, a pharmaceutical composition, and a use thereof in the preparation of a pharmaceutical composition for treating diseases, for example, a use in treating tumors. The present invention has important significance for the development of GPRC5D antibody treatment drugs and detection reagents.
    Type: Application
    Filed: December 30, 2022
    Publication date: May 8, 2025
    Inventors: Yayuan FU, Jingli LIAO, Bowei YIN, Zhuoxiao CAO, Renhong TANG, Jinsheng REN
  • PROTEINS COMPRISING CD3 ANTIGEN BINDING DOMAINS AND USES THEREOF
    Publication number: 20250145711
    Abstract: The disclosure provides antigen binding domains that bind cluster of differentiation 3 (CD3) protein, comprising the antigen binding domains that bind CD3?, polynucleotides encoding them, vectors, host cells, methods of making and using them.
    Type: Application
    Filed: September 10, 2024
    Publication date: May 8, 2025
    Inventors: Adam Zwolak, Raymond Brittingham, Scott R. Brodeur, Rajkumar Ganesan, Sherry Lynn La Porte, Jinquan Luo, Fang Yi, Colleen M. Kane, Triveni K. Bhatt