Abstract: Chromogenic conjugates for color-based detection of targets are described. The conjugates comprise a chromogenic moiety such as rhodamine, rhodol or fluorescein. The chromogenic moiety is linked to a peroxidase substrate. The chromogenic conjugates can be used in immunohistochemical analysis and in situ hybridization. The conjugates can be used to detect 1, 2, 3 or more targets in a sample by color.

Abstract: To correct spectral interference due to a divalent ion of an interfering element on a measurement ion of an analysis element measured by a mass spectrometer using a plasma ion source by accounting for a mass-bias effect of the mass spectrometer, measurement values of ionic strength of divalent ions of two isotopes having different, odd mass numbers among isotopes of the interfering element are used. In measuring to obtain a measurement value where a correction method of the present invention is applied, it is suitable to set a mass resolution of the mass spectrometer to be higher than a time of normal analysis.

Abstract: A torch for use in analytic instruments includes a tube subassembly with substantially cylindrical nested inner and outer tubes with coincident central axes, the inner tube having a terminus. The torch also includes a removable injector extending at least partially in the inner tube and having an alignment feature, an inlet, an outlet, and a central axis that is coincident with the central axes of the inner and outer tubes, a seal having a channel for accommodating a portion of the injector, and a base for supporting the tube subassembly, injector, and seal. The seal has a complementary feature to engage the alignment feature of the injector to prevent axial misalignment of the injector and maintain a fixed gap between the terminus of the inner tube and the outlet of the injector.

Abstract: A flow meter for measuring a flow rate of a fluid may include a cartridge containing certain components such as a flow sensor. The cartridge is removable from the flow meter such that it may be replaced with a new cartridge, allowing calibration of the flow meter while enabling the flow meter to continue to be operated with another cartridge in the place of the removed cartridge. The flow meter may be configured to direct fluid flow away from selected components of the flow meter.

Abstract: An apparatus introduces a sample into a separation unit of a chromatography system with a mobile phase, including first and second mobile phase components. The apparatus includes first and second pump systems, and an injection unit. The first pump system provides the first mobile phase component, first and second portions of the first mobile phase component flowing through first and second branches, respectively. The second pump system provides the second mobile phase component, a first portion of the second mobile phase component flowing through a third branch. The injection unit receives a combined stream of the first portions of the first and second mobile phase components provided via the first and third branches, respectively, and injects the sample into the combined stream to form a sample-containing stream, which is subsequently combined with the second portion of the first mobile phase component to form a diluted sample-containing stream.

Abstract: A sample injector configured to introduce a sample fluid into a mobile phase, wherein the mobile phase is to be driven by a mobile phase drive through a separation unit for separating compounds of the sample fluid in the mobile phase, wherein the sample injector comprises a metering device being operable for displacing fluid and for intaking a metered amount of the sample fluid into the sample injector, an injector valve being switchable for operating the sample injector selectively in a sample intake mode in which the metering device is operable to intake the sample fluid from a sample container, or a separation mode in which intaken sample fluid is driven between the mobile phase drive and the separation unit for separating the compounds, and a flow direction controller configured for defining an enabled flow direction of fluid displaced by the metering device and for defining a disabled flow direction.

Abstract: A modular pump platform includes a pump head module, a pump motor module, an electronics module and a separable tray. The pump motor module includes a pump motor having a rotary output removably coupled to a crank shaft of the pump head, the pump motor being one of multiple types of pump motors, and the pump motor module being detachably connected to the pump head module. The electronics module includes an electronic control circuit configured to control operation of the pump motor, the electronic control circuit being one of multiple types of electronic control circuits corresponding to the types of pump motors. Each of the pump head module, the pump motor module and the electronics module is detachably connected to the separable tray. At least the pump motor module is interchangeable with another pump motor module comprising a pump motor of another type.

Abstract: An ion throughput pump (ITP) includes a pump inlet configured to communicate with a vacuum chamber; an ionization source fluidly communicating with the vacuum chamber via the pump inlet and configured for ionizing gas species received from the vacuum chamber; a pump outlet; ion optics configured for accelerating ions produced by the ionization source toward the pump outlet; and a roughing pump stage configured for receiving the ions from the ionization source, producing neutral species from the ions, and pumping the neutral species through the pump outlet.

Abstract: In embodiments, a packing material for supported liquid extraction has a sorbent media that includes synthetic silica particles. In embodiments, the synthetic silica particles can have physical properties relating to one or more of particle surface area, shape, size, or porosity. In one embodiment, synthetic silica particles have a surface area less than about 30 m2/g. In another embodiment, the synthetic silica particles have an approximately uniform particle shape. In further examples, synthetic silica particles have a particle size in a range of about 30-150 ?m inclusive or greater than about 200 ?m. In another embodiment, synthetic silica particles are arranged to have a pore size greater than about 500 Angstroms. In an embodiment, an apparatus for supported liquid extraction includes a container and a sorbent media that includes synthetic silica particles. In a further embodiment, a method for extracting target analytes through supported liquid extraction is provided.

Abstract: A multiple capillary florescent detection system employing optical fiber bundles that each fiber bundle has more than one fiber illuminating each sample vessel.

Abstract: Samples in an array of containers are processed by mounting the containers on a sample stage, moving magnets into proximity with bottoms of the containers of a first column of containers to apply a magnetic field, moving the magnets into proximity with bottoms of the containers of a second column, and moving heater elements into proximity with the container bottoms of the first column. While the magnetic field is applied to the containers of the second column, heat energy may be applied to the containers of the first column. The process may be repeated for additional columns. The containers may also be shaken to agitate the samples. A single apparatus may perform heating, shaking, and magnetic field application, without needing to transport the containers to different stations.

Abstract: An apparatus includes a first column heating apparatus, which includes: a first substrate; a second substrate including silicon; and a first heating element disposed between the first substrate and the second substrate. The apparatus also includes a second column heating apparatus, which includes: a third substrate; a fourth substrate including silicon; and a second heating element disposed between the third substrate and the fourth substrate.

Abstract: A method for operating a data processing system to find peaks in a mass spectrum that includes an ordered set of measurements of the abundances of species as a function of the mass/charge ratio of the species is disclosed. The method includes selecting a candidate blob that has a plurality of blob peaks from the mass spectrum. The data processing system selects a candidate blob peak for characterization. The candidate blob peak is approximated by a first species peak using a species peak model having a plurality of parameters by fitting the species peak model to a portion of the blob that has values that are substantially free of contributions from other species peaks that overlap with the first species peak and that are not represented by the species peak model. The first species peak is then subtracted from the candidate blob.

Abstract: An ion transfer device for transferring ions from a first chamber to a second, reduced-pressure chamber includes a tube and a bore selector. The tube includes a plurality of tube bores. The bore selector is positioned at an inlet end of the tube and includes an inlet port. The tube is movable relative to the bore selector, and/or the bore selector is movable relative to the tube, to align the inlet port with a selected one of the tube bores while blocking the other tube bores. Alignment of the inlet port with the selected tube bore defines an ion transfer path from the first chamber, through the selected tube bore, and to the second chamber. The ion transfer device may be utilized, for example, in an atmospheric-pressure interface of a mass spectrometer.

Abstract: A pump for pumping fluid, wherein the pump includes a working chamber, a piston assembly configured for reciprocating within the working chamber to thereby displace fluid, a piston actuator being rigidly assembled with the piston assembly at least in a working mode of the pump to thereby transmit drive energy to the piston assembly to reciprocate along a common rigid axis of the piston-actuator-assembly, and a bearing arrangement bearing the piston assembly and the piston actuator in the pump so that the piston-actuator-assembly provided by the piston assembly and the piston actuator is capable of performing a pendulum-type compensation motion around a pendulum point at the piston actuator on the common rigid axis.

Abstract: A separator (e.g. an impact centrifugal separator) is for use in collection of liquid portions of a bi-phasic flowstream in a supercritical fluid system. A separator chamber defines an interior space, surrounded by a spiral channel and that has an exit at a lower portion of the separator chamber. A flowstream director (e.g. an entry lube) focuses the flowstream so that the flowstream impacts a wail of the spiral channel at an angle that promotes coalescence of the liquid component. The spiral channel may promote further coalescence of the liquid portions within the constraining spiral channel after impact. A central director may be included in the interior space of the separator chamber to promote flow of the gaseous component toward the exit. A dripper may be included in fluid communication with the spiral channel, for example, in the exit and to direct the coalesced liquid into a collection vessel.

Abstract: An environmental chamber having an interior compartment, an augmented display, and a controller is disclosed. The interior compartment is adapted for isolating an experimental setup from an environment external to the interior compartment. The augmented display is positioned to allow a user in the external environment to view the interior compartment and an image generated on the augmented display. The controller generates the image. The image includes information about a component within the interior compartment. The augment display can include a touch-enabled display screen that allows the user to interact with controller.

Abstract: A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured to adjust a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.

Abstract: Provided herein, among other things, is a method of ionizing a first stream of liquid by an electrospray ion source having a nebulizer, wherein the first stream of liquid may comprise an analyte. In some embodiments, the method may comprise: a) providing the first stream of liquid to the nebulizer; b) adding a second stream of liquid to the first stream of liquid, wherein the second stream of liquid comprises a co-solvent that has a relatively high boiling point and an enhancement solvent that a relatively high boiling; and c) nebulizing and ionizing the resulting liquid.

Abstract: An apparatus and method for generating images of specimens is disclosed. The apparatus includes an imaging system, controller, and user interface. The imaging system generates a plurality of component images of a specimen, each component image corresponding to a different viewing condition. Each image is represented by an intensity as a function of location on the specimen. The controller stores the component images and generates a compound image from a plurality of the component images. The compound image includes a weighted sum of first and second ones of the component images, the controller displaying the compound image on a display controlled by the controller. The user interface is adapted to control a weighting factor used in generating the weighted sum in response to user input. The controller redisplays the compound image after the weighting factor is changed in response to user input.