Abstract: A fitting (200) for providing a fluid connection between a capillary (202) and a fluidic conduit (204) of a fluidic component (30), the fitting (200) comprising a male piece (240) and a female piece (250) for connection with the male piece (240), wherein the male piece (240) comprises a housing (252) with a capillary reception (212) configured for receiving the capillary (202), wherein a part of the capillary (202) being received in the capillary reception (212) is circumferentially covered by a sleeve (214), an elastic biasing mechanism (206) being arranged at least partially within the housing (252), being configured for biasing the capillary (202) against the female piece (250) and being supported by the sleeve (214), and a locking mechanism (208) being arranged at least partially within the housing (252) and being configured for locking the capillary (202) to the fitting (200).

Abstract: The collision cross section (CCS) of a sample ion may be calculated by measuring a total drift time taken by the sample ion to travel through an ion mobility spectrometry drift cell to an ion detector. The CCS may be calculated based on the total drift time measured, and on a proportionality coefficient that defines the time taken by the sample ion to travel through a mobility dominated region between the drift cell and the detector. The proportionality coefficient may be determined from measuring the total drift times of reference ions. Calculation of the CCS of the sample ion may also be based on a proportionality coefficient that defines the time taken by the sample ion to travel through a mobility-independent region where the velocity of the ion depends on the electrostatic field strength, mass and the charge state of the ion.

Abstract: A method is provided for isolating a compound in a sample by chromatography. The method includes determining an analytical gradient of an analytical system; performing an analytical run using the analytical gradient; identifying a target compound in the sample and determining an analytical retention time of the target compound using chromatographic results of the analytical run; determining an elution point of the target compound using the analytical retention time, the analytical gradient and characteristics of the analytical system; determining automatically a focusing gradient of a preparative system, including a slope segment; and performing a preparative run using the focusing gradient to separate the target compound from the sample. The slope segment includes a slope determining a concentration of solvent in a solvent mixture, which linearly increases from a first offset below the elution point of the target compound to a second offset above the elution point of the target compound.

Abstract: An apparatus having a variable angle light source characterized by a pivot point, a variable response optical receiver, and a first optical system is disclosed. The variable response optical receiver receives light generated by the light source on a receiving surface, the receiver generating a signal indicative of an intensity of light that impinges on a receiving surface. The first optical system images the pivot point to a fixed point relative to the receiver surface. In one aspect of the invention the first optical system is chosen such that light from the variable angle light source covers more& than half the receiving surface. The variable angle light source can include a gain chip in a semiconductor laser having a pivot point located substantially on a facet of the gain chip.

Abstract: A fluid supply system configured for metering two or more fluids in controlled proportions, including a plurality of solvent supply lines, a pumping unit configured for taking in fluids from selected solvent supply lines and for supplying a pressurized mixture, a proportioning valve configured for modulating solvent composition by sequentially coupling selected ones of the solvent supply lines with the inlet of the pumping unit, a sensor configured for sensing process information in the fluid supply system, an analysis entity configured for analyzing the process information for determining reciprocating element related information at a beginning of fluid intake, and a control unit configured for switching the proportioning valve to sequentially couple selected ones of the solvent supply lines to the inlet of the pumping unit at one or more switching points based on the given metering scheme and based on the reciprocating element related information.

Abstract: An interface for an ion mobility spectrometry-mass spectrometry (IMS-MS) system includes a first ion guide for receiving ions from an IMS drift cell, and a second ion guide for receiving ions from the first ion guide, and positioned in a chamber separate from the first ion guide. Electrodes of the second ion guide subject the ions to an axial DC electric field while the second ion guide is held at a lower pressure than the first ion guide. In some embodiments, the first ion guide may be an ion funnel and the second ion guide may be a linear multipole device.

Abstract: An intramedullary fixation assembly usable with different long bone types and a guide assembly for guiding deployment of the intramedullary fixation assembly. The intramedullary fixation assembly includes a fixation member that has ends and a curved body extending between the ends. The curved body of the fixation member has a radius of curvature configured to extend through the medullary canal regardless of the long bone anatomy. Fasteners fix the fixation member to the bone fragments and are guided by a guide assembly. The guide assembly includes a guide body defining openings configured to guide the fasteners through openings defined in the fixation member and into the bone fragments. A fixation end of the guide body includes a pair of opposing, converging surfaces that are configured to engage in a positive fit with an exposed end of the fixation member accessible through the side aperture in the first fragment.

Abstract: A flame photometric detector (FPD) for use in a gas chromatography (GC) apparatus is described. The FPD has an emission block that is maintained in a first temperature range, and a transfer line that is maintained in a second temperature range that is greater than the first temperature range. The FPD is coupled to a light detector, such as a photomultiplier tube (PMT).

Abstract: A charged particle processing apparatus includes a vacuum chamber, an optics plate, charged particle optics mounted to the optics plate, and mounting members coupled between the optics plate and a chamber wall. The mounting members are configured for isolating the optics plate from deformation of the chamber wall, as may occur due to a pressure differential between the chamber interior and the environment outside the chamber. The isolation may prevent deformation from affecting the alignment and positioning of the charged particle optics. The charged particles may, for example, be ions or electrons. Thus, the apparatus may be utilized, for example, in analytical instruments such as for mass spectrometry, or inspection instruments such as for electron microscopy.

Abstract: An ion guide generates a first RF field of Nth order where N is an integer equal to or greater than 2, and a second RF field of 2Nth order superimposed on the first RF field. The first and second RF fields may be generated by respective first and second sets of electrodes. Another ion guide may include a converging entrance section followed by an exit section. The converging section may have a hyperbolic profile. A hyperbolic profile may be presented by electrodes having a twisted configuration relative to an ion guide axis.

Abstract: A connector assembly configured to join an induction coil to a radio frequency generator to provide together with a plasma torch, an inductively coupled plasma source for a spectrometer is disclosed. The connector assembly includes a radial clamping member associated with the radio frequency generator and a sealing member. The radial clamping member has an internal surface configured to receive an end of an induction coil. The connector assembly is configured to provide a secure connection between the end of the induction coil and the RF generator that is substantially electrically conductive and substantially liquid-tight without causing lasting deformation of the radial clamping member or the induction coil. An inductively coupled plasma spectrometer comprising such a connector assembly and a method for securing a connection between an induction coil and a radio frequency generator are also disclosed.

Abstract: A sample injector (200) for use in a fluid separation system (10) for separating compounds of a fluidic sample in a mobile phase, the sample injector (200) comprising a switchable valve (202), a sample loop (204) in fluid communication with the valve (202) and configured for receiving the fluidic sample, a metering device (206) in fluid communication with the sample loop (204) and configured for introducing a metered amount of the fluidic sample on the sample loop (204), and a control unit (208) configured for controlling switching of the valve (202) to transfer the sample loop (204) between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device (206) during the intermediate state to at least partially equilibrate a pressure difference in the sample loop (204) between the low pressure state and the high pressure state.

Abstract: A scroll pump isolates vibrations of a pump head/motor assembly of the pump from the exterior of the pump and thus, suppresses the production of airborne noise. The pump includes a sound-muffling enclosure surrounding the pump head/motor assembly, feet supporting the enclosure, and elastic vibration isolators. The pump head/motor assembly is fixed to the tops of the vibration isolators, and the sound-muffling enclosure is fixed to the vibration isolators at the bottoms of the isolators. The scroll pump also has a locking system by which motion of the pump head/motor assembly relative to the sound-muffling enclosure can be limited or prevented, and by which the sound-muffling enclosure can be hard-mounted to a support surface independently of the feet.

Abstract: A plasma source for generating microwave-induced plasma includes a plasma torch integrated with a microwave energy source. The torch establishes a gas flow path from one side of the plasma source to the other side. The torch may be integrated with the microwave energy source such that a plasma-forming gas flowing through the torch is subjected to microwave radiation, which serves to initiate and/or sustain plasma in the torch. The plasma may be ejected from the torch and utilized in various applications involving the use of plasma, including analytical techniques such as optical emission spectrometry and mass spectrometry.

Abstract: The present invention relates to methods and systems for controlling depressurization of a vial containing a gas sample. The disclosed systems and methods are employed during sampling and/or analysis of the gas sample. One exemplary method for controlling depressurization of a vial containing a gas sample includes establishing fluid communication between a sample loop of a head space sampling device and the head space of the vial. A sample gas pressure is established within the head space of the vial. The sample loop is connected in fluid communication with a lower pressure environment through a ventilation pathway. A ventilation valve within the ventilation pathway is used to vent gas from the vial through the sample loop to the lower pressure environment at a predetermined rate. Devices and systems for depressurizing a vial containing a gas sample at a predetermined rate are also disclosed.

Abstract: A scroll pump includes a frame, a stationary plate scroll, an orbiting plate scroll, a non-energized type of tip seal or seals, an eccentric drive mechanism assembled to and supported by the frame and to which the orbiting plate scroll is assembled so as to be drivable by the eccentric drive mechanism in an orbit about a longitudinal axis of the pump, and an axial compliance system including a flexure. The flexure is interposed between a bearing of the eccentric drive mechanism and a flexure-locating surface of the eccentric drive mechanism. The flexure allows the orbiting plate scroll to move away from the stationary plate scroll in the case of an assembly process which would otherwise result in the tip seal(s) being too forcefully engaged with the plate of the opposing plate scroll.

Abstract: An apparatus (200) for deriving an operation mode from a first fluidic device to a second fluidic device, wherein the first fluidic device has a first target operation mode (300) representing a desired behavior of the first fluidic device and has a first real operation mode (304) representing the actual behavior of the first fluidic device, wherein the second fluidic device has a second target operation mode (312) representing a desired behavior of the second fluidic device and has a second real operation mode (314) representing the actual behavior of the second fluidic device, the apparatus (200) comprising a first determining unit (202) adapted for determining the first real operation mode (304) based on the first target operation mode (300) and based on a preknown parameterization (302) of the first fluidic device, and a second determining unit (204) adapted for determining the second target operation mode (312) based on the determined first real operation mode (304) and based on a preknown parameterizatio

Abstract: A mass spectrometer includes: a plasma generation device for generating plasma for ionizing an introduced sample; an interface device for drawing the plasma into vacuum; an ion lens device for extracting and inducing ions as an ion beam from the plasma; a collision/reaction cell for removing an interference ion from the ion beam; a mass analyzer or filter for allowing a predetermined ion in the ion beam from the collision/reaction cell to pass along a first axis based on a mass-to-charge ratio; an ion detector for detecting the ion; an ion deflection device before the mass analyzer, and also an ion deflection device between the mass analyzer and the ion detector. The mass spectrometer reduces background noises in a mass analyzer by removing neutral particles from the ion beam without reducing the measurement sensitivity on ions to be analyzed as much as possible.

Abstract: A sample separation device for separating a sample comprises a first fluid supply path for supplying a first fluid, a second fluid supply path for supplying a second fluid, a sample separation unit adapted for separating the sample, a sensor configured for determining a value of a parameter related to the fluid, and a valve configured for selectively coupling both of the first and second fluid supply paths to the sensor and to the sample separation unit, or coupling one of the first and second fluid supply paths to the sensor.

Abstract: A method of sample analysis is provided. In certain embodiments, the method may comprise: a) contacting under primer extension conditions a genomic sample comprising a test genome with a set of at least ten sequence-specific primers that are complementary to sites in only one strand of a reference chromosomal region, to produce primer extension products, and b) analyzing the primer extension products to identify a chromosomal rearrangement in the test genome.