Patents Assigned to Agilent Technologies, Inc.
  • WAVEGUIDE-BASED APPARATUS FOR EXCITING AND SUSTAINING A PLASMA
    Publication number: 20150282289
    Abstract: An apparatus includes an electromagnetic which supports propagation of an electromagnetic wave in a first direction between a first end thereof and a second end thereof, and an electromagnetic-field shaping structure within the electromagnetic waveguide. The electromagnetic-field shaping structure defines a channel extending from a first aperture in a first wall of the apparatus to a second aperture in a second, opposite, wall. The channel has an axis extending in a second direction which is nonparallel with the first direction. The distance between the first aperture and the second aperture in the second direction is less than the width of the interior region of the waveguide at the first and second ends thereof. In some embodiments, a plasma torch is disposed within the channel. The length of the torch closely matches its interaction region.
    Type: Application
    Filed: March 28, 2014
    Publication date: October 1, 2015
    Applicant: Agilent Technologies, Inc.
    Inventors: Mehrnoosh Vahidpour, Peter T. Williams, Syed Zaidi
  • Method and Apparatus for Determining the Configuration of a Cellular Transmission System
    Publication number: 20150281983
    Abstract: A method for operating a data processing system to determine the operational parameters of a communication system between an REC and an RE that utilizes a CPRI data link for communication. The data processing system is synchronized with the CPRI frames and determines a plurality of CPRI frame characteristics from the CPRI frames by examining a plurality of predetermined locations in the CPRI frames. The plurality of CPRI frame characteristics for one or more of the CPRI frames, and a first model of the communication system are used to generate a first broadcast frame that would be generated by the one or more CPRI frames if the first model accurately described the communication system. The first broadcast frame is tested to determine if the first broadcast frame is consistent with the first model. If the broadcast frame is inconsistent, a new model is chosen and the process repeated.
    Type: Application
    Filed: March 31, 2014
    Publication date: October 1, 2015
    Applicant: Agilent Technologies, Inc.
    Inventor: Francisco Javier Garcia
  • Ceramic injection needle
    Patent number: 9134335
    Abstract: A needle for handling a fluid in an analysis system is described. The needle includes a needle body made of a ceramic material and having a fluid conduit extending between a fitting end and a seat end. The fitting end is configured to be connected to a fitting and the seat end (308) being insertable into a seat. The needle body is tapering towards the fitting end. A fixing body is arranged on the needle body next to the fitting end for exerting an axial force when the needle body is connected to the fitting, and a slide-on element to be slid over the needle body so as to push the fixing body towards the fitting end.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: September 15, 2015
    Assignee: Agilent Technologies, Inc.
    Inventors: Bernhard Dehmer, Joachim-Richard Wagner
  • Method and apparatus to reduce noise caused by mode hopping in external cavity lasers
    Patent number: 9124068
    Abstract: An external cavity laser and method for operating same are disclosed. The external cavity laser includes a gain chip, a grating, an actuator and actuator driver. The grating diffracts light leaving the gain chip in a band of wavelengths back to the gain chip, the grating is characterized by an angle relative to light leaving the gain chip and distance from the gain chip, the angle and distance is controlled by the actuator. Part of the diffracted light is amplified by the gain chip. The actuator driver causes the angle to be dithered about an equilibrium angle in a motion characterized by an amplitude and average frequency. The amplitude of the dithering motion is chosen to either excite a plurality of adjacent laser modes of the gain chip or provide a servo signal for maintaining the grating angle at a target value.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: September 1, 2015
    Assignee: Agilent Technologies, Inc.
    Inventors: Miao Zhu, Charles Hoke
  • METHOD AND APPARATUS TO REDUCE NOISE CAUSED BY MODE HOPPING IN EXTERNAL CAVITY LASERS
    Publication number: 20150244150
    Abstract: An external cavity laser and method for operating same are disclosed. The external cavity laser includes a gain chip, a grating, an actuator and actuator driver. The grating diffracts light leaving the gain chip in a band of wavelengths back to the gain chip, the grating is characterized by an angle relative to light leaving the gain chip and distance from the gain chip, the angle and distance is controlled by the actuator. Part of the diffracted light is amplified by the gain chip. The actuator driver causes the angle to be dithered about an equilibrium angle in a motion characterized by an amplitude and average frequency. The amplitude of the dithering motion is chosen to either excite a plurality of adjacent laser modes of the gain chip or provide a servo signal for maintaining the grating angle at a target value.
    Type: Application
    Filed: February 27, 2014
    Publication date: August 27, 2015
    Applicant: Agilent Technologies, Inc.
    Inventors: Miao Zhu, Charles Hoke
  • Axial magnetic ion source and related ionization methods
    Patent number: 9117617
    Abstract: An ion source is configured for electron ionization and produces coaxial electron and ion beams. The ion source includes an ionization chamber along an axis, a magnet assembly configured for generating an axial magnetic field in the ionization chamber, an electron source, and a lens assembly configured for directing the ion beam out from the ionization chamber along the axis, reflecting the electron beam back toward the electron source, and transmitting higher energy ions out from the ion source while reflecting lower energy ions toward a lens element for neutralization.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: August 25, 2015
    Assignee: Agilent Technologies, Inc.
    Inventors: Charles William Russ, IV, Harry F. Prest, Jeffrey T. Kernan
  • System and process for an active drain for gas-liquid separators
    Patent number: 9114330
    Abstract: A device includes a gas-liquid separator that receives and separates a biphasic pressurized flow stream and delivers flow to at least one exit port enriched in vapor phase composition and at least one exit port enriched in liquid phase composition. The device further includes a low restriction inlet conduit in communication with the separator exit port enriched in liquid phase composition, and a positive displacement pump having an inlet port in communication with the inlet conduit to receive flow from the gas-liquid separator and an outlet port in communication with an outlet conduit.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: August 25, 2015
    Assignee: Agilent Technologies, Inc.
    Inventors: Kimber D. Fogelman, Edwin E. Wikfors, Terry A. Berger
  • Thermostable Type-A DNA Polymerase Mutant with Increased Resistance to Inhibitors in Blood
    Publication number: 20150232821
    Abstract: The invention provides mutants of DNA polymerases having an enhanced resistance to inhibitors of DNA polymerase activity. The mutant polymerases are well suited for PCR amplification of targets in samples that contain inhibitors of wild-type polymerases.
    Type: Application
    Filed: December 12, 2014
    Publication date: August 20, 2015
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Nancy Mckinney, Holly H. Hogrefe, Jeffrey Fox, Connie J. Hansen, Bahram Arezi
  • Dried blood spotting paper device and method
    Patent number: 9110053
    Abstract: A dried blood-spotting device includes a carrier card having a window therethrough along with a punchable glass fiber paper disposed in the window for a uniform absorption of a blood droplet sample into a homogeneous circular sport. The glass fiber paper is configured for enabling improved analysis for small molecules by liquid chromatography/mass spectrometry of punched specimens of the sample absorbed glass fiber paper.
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: August 18, 2015
    Assignee: Agilent Technologies, Inc.
    Inventors: Susan L. Cohen, Wilford C. Downs, William C. Hudson, Paul Boguszewski
  • Method and Apparatus for Reducing Pointing-Error Noise
    Publication number: 20150226606
    Abstract: An apparatus having a variable angle light source characterized by a pivot point, a variable response optical receiver, and a first optical system is disclosed. The variable response optical receiver receives light generated by the light source on a receiving surface, the receiver generating a signal indicative of an intensity of light that impinges on a receiving surface. The first optical system images the pivot point to a fixed point relative to the receiver surface. In one aspect of the invention the first optical system is chosen such that light from the variable angle light source covers mores than half the receiving surface. The variable angle light source can include a gain chip in a semiconductor laser having a pivot point located substantially on a facet of the gain chip.
    Type: Application
    Filed: February 12, 2014
    Publication date: August 13, 2015
    Applicant: Agilent Technologies, Inc.
    Inventors: Yuri Beregovski, Miao Zhu, Adam Kleczewski, Varun Raghunathan
  • Spectrographic System Utilizing a Chirped, Pulsed Optical Source
    Publication number: 20150226667
    Abstract: An apparatus and method for measuring the attenuation and dispersion introduced by a sample into an optical signal are disclosed. The apparatus includes a chirped light source, a beam splitter and an optical detector. The beam splitter splits the optical signal generated by the light source into a reference optical signal and a sample optical signal. The sample and reference optical signals are mixed on the detector after the sample optical signal has traversed an experimental sample thus generating a signal having an AC component related to an attenuation and a dispersion introduced by the experimental sample. The optical paths traversed by the reference and sample optical signals between the beam splitter and the detector are chosen such that the reference optical signal and the sample optical signal overlap in time but do not arrive at the optical detector at the same time.
    Type: Application
    Filed: February 7, 2014
    Publication date: August 13, 2015
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventor: William I. McAlexander
  • Liquid handler with dual pipetting groups
    Patent number: 9103809
    Abstract: An automated liquid handling system is disclosed. A system includes a first pipetting group, which includes at least one pipettor, movably arranged on a first arm; and a second pipetting group, which includes at least one pipettor, movably arranged on a second arm, wherein the first arm and the second arm are movably arranged on at least one track such that the first arm and the second arm can independently move along the at least one track while keeping the first arm parallel with the second arm, wherein the at least one pipettor of the first pipetting group is arranged on a side of the first arm facing the second pipetting group, wherein the at least one pipettor of the second pipetting group is arranged on a side of the second arm facing the first pipetting group.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: August 11, 2015
    Assignee: Agilent Technologies, Inc.
    Inventors: Daniel West, David Knorr, James E. Young, Kimberly Subrahmanyan, Nicholas Fleming, Randy K. Roushall
  • Method of adaptor-dimer subtraction using a CRISPR CAS6 protein
    Patent number: 9102936
    Abstract: A method of processing a target RNA is provided. In certain embodiments, this method comprises: contacting the products of an RNA ligase-mediated ligation reaction with an CAS6 protein, wherein: (i) the RNA ligase-mediated ligation reaction comprises: a target RNA, an RNA ligase, and first and second adaptors that can ligate together to produce an adaptor dimer that contains a CRISPR stem loop; and (ii) the CAS6 protein recognizes the CRISPR stem loop; thereby preventing the adaptor dimer from being reverse transcribed.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: August 11, 2015
    Assignee: Agilent Technologies, Inc.
    Inventors: Gusti Zeiner, Laurakay Bruhn
  • Plasma-based electron capture dissociation (ECD) apparatus and related systems and methods
    Patent number: 9105454
    Abstract: An electron capture dissociation (ECD) apparatus includes a plasma source for generating plasma. Analyte ions are exposed to the plasma in an ECD interaction region, either inside or outside the plasma source. The apparatus may include one or more devices for refining the plasma in preparation for interaction with the analyte ions. Refining may entail removing unwanted species from the plasma, such as photons, metastable particles, neutral particles, and/or high-energy electrons unsuitable for ECD, and/or controlling a density of low-energy electrons in the plasma.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: August 11, 2015
    Assignee: Agilent Technologies, Inc.
    Inventors: Trygve Ristroph, Mark Denning, Kenneth R. Newton, Guthrie Partridge
  • FAST METHOD FOR MEASURING COLLISION CROSS SECTION OF IONS UTILIZING ION MOBILITY SPECTROMETRY
    Publication number: 20150219598
    Abstract: The collision cross section (CCS) of a sample ion may be calculated by measuring a total drift time taken by the sample ion to travel through an ion mobility spectrometry drift cell to an ion detector. The CCS may be calculated based on the total drift time measured, and on a proportionality coefficient that defines the time taken by the sample ion to travel through a mobility dominated region between the drift cell and the detector. The proportionality coefficient may be determined from measuring the total drift times of reference ions. Calculation of the CCS of the sample ion may also be based on a proportionality coefficient that defines the time taken by the sample ion to travel through a mobility-independent region where the velocity of the ion depends on the electrostatic field strength, mass and the charge state of the ion.
    Type: Application
    Filed: January 31, 2014
    Publication date: August 6, 2015
    Applicant: Agilent Technologies, Inc.
    Inventors: Alexander Mordehai, Ruwan T. Kurulugama, Christian Klein, John Fjeldsted
  • FAST HYBRIDIZATION FOR NEXT GENERATION SEQUENCING TARGET ENRICHMENT
    Publication number: 20150211047
    Abstract: The present invention relates to compositions and methods of target enrichment or selection of nucleic acids using hybridization, which can be used in, e.g., next-generation sequencing.
    Type: Application
    Filed: January 29, 2014
    Publication date: July 30, 2015
    Applicant: Agilent Technologies, Inc.
    Inventor: Michael Borns
  • CAS9-based Isothermal Method of Detection of Specific DNA Sequence
    Publication number: 20150211058
    Abstract: The present invention relates to an isothermal method for detecting in a sample a target nucleic acid strand.
    Type: Application
    Filed: January 28, 2015
    Publication date: July 30, 2015
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventor: Carsten-Peter Carstens
  • Compositions and methods using split polymerases
    Patent number: 9085762
    Abstract: The invention relates to compositions and methods utilizing split polymerase enzymes composed of at least two discrete polypeptides that stably associate to form a single polymerase. The invention further relates to nucleic acid constructs for expressing the split polymerases of the invention, and methods for using the split polymerases of the invention. The enzymes of the invention are useful in many applications calling for the detectable labeling of nucleic acids and are particularly useful in quantitative PCR (QPCR) and DNA sequencing applications.
    Type: Grant
    Filed: December 31, 2007
    Date of Patent: July 21, 2015
    Assignee: Agilent Technologies, Inc.
    Inventors: Holly Hogrefe, Lydia Wu, Jeffrey D. Fox, Connie Jo Hansen
  • Ferrule
    Patent number: D735853
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: August 4, 2015
    Assignee: Agilent Technologies, Inc.
    Inventor: Ponna Peter Pa
  • Modular dried matrix spotting device
    Patent number: D736403
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: August 11, 2015
    Assignee: Agilent Technologies, Inc.
    Inventors: William C. Hudson, Paul Boguszewski, Robert Lee Grenz