Abstract: A method for operating a mass spectrometer (MS) includes establishing a pressure differential across a membrane wherein an upstream pressure in a calibrant gas inlet line on an upstream side of the membrane is greater than a downstream pressure in an ion source on a downstream side of the membrane; flowing a calibrant gas from the calibrant gas inlet line, through a nano-scale orifice of the membrane, and into the ion source; and maintaining the upstream pressure at a constant value. The calibrant may be flowed at a low flow rate. An MS system includes a membrane interposed between a calibrant gas introduction system and a mass spectrometer. The membrane may include an orifice of nano-scale diameter.

Abstract: Systems to obtain a chemical array layout are provided. Systems of the invention include input and output managers for receiving information from and sending information to one or more users and a processing module having an array layout developer that applies rules relating to array layout design. The array layout developer develops an array layout based on the application of one or more of the rules to array request information received from one or more users. Also provided are computer program products for executing the subject methods.

Abstract: In a mass spectrometer or gas chromatograph/mass spectrometer system, a conditioning gas such as, for example, hydrogen is added to condition or clean one or more components or regions of the mass spectrometer such as the ion source. The conditioning gas may be added upstream of the mass spectrometer such as, for example, into a sample inlet or a chromatographic column, or may be added directly into the mass spectrometer. The conditioning gas may be added off-line, when the mass spectrometer is not analyzing a sample, or on-line during sample analysis. When added on-line, the conditioning gas may be mixed with a carrier gas such as, for example, helium. In another embodiment, the conditioning gas also serves as the carrier gas through the column; another gas such as, for example, helium may be added to the carrier gas stream.

Abstract: The invention refers to analyzing a digitally modulated test signal received from a device under test -DUT-, comprising providing a first sampled signal by assigning a first sequence of digital values as result of a level comparison of the test signal with a first threshold at first successive timing points, generating a first masking signal indicating matches between a second sequence of digital values expected from the DUT and one or a plurality of first data patterns, and analyzing the first sampled signal in conjunction with the masking signal.

Abstract: In a communication network architecture, a service provider monitors its customer's experience as the customer selects and uses services offered by the service provider. An agent, such as software installed on-board the customer's mobile equipment, measures parameters that are related to the services, and communicates the measured parameters to the service provider, over the communication network.

Abstract: A method and compositions for sulfurizing at least one phosphite or thiophosphite linkage in an oligonucleotide. The addition of N-alkyl imidazole to the acetyldisulfide sulfurization solution enables the use of industrially preferred solvents or solvents that are derived from renewable resources.

Abstract: The optical multiplexer system comprises an optical multiplexer, an output path and an adjustable beam steering element. The optical multiplexer comprises an input port characterized by an original acceptance range. The output path is disposed relative to the optical multiplexer such that a light beam incident on the input port within the original acceptance range enters the output path. The adjustable beam steering element is located adjacent the input port and is adjustable such that a light beam incident on the beam steering element within an enhanced acceptance range enters the output path as an output beam. The enhanced acceptance range is at least angularly greater than the original acceptance range.

Abstract: An apparatus for archiving robust channel estimation in a communication system includes a training sequence generator to generate a training sequence. A formatter inserts the training sequence to a frame. A transmitting module is employed to transmit the frame. The training sequence generator further includes a symbol generator to generate a plurality of training symbols satisfying a predetermined constraint such that the training symbols are insensitive to synchronization error and a training sequence forming unit that forms the training sequence from the training symbols generated by the training symbol generator.

Abstract: An atomic force microscope (AFM) apparatus for determining a topography of a sample surface is disclosed. The AFM apparatus comprises: a controller having a controller frequency response and being configured to provide a controller output signal. The controller comprises an integrator that provides an integrator output signal, and a filter block. The AFM apparatus also comprises a physical system having a physical system response and being configured to receive the controller output signal and to provide a probe height in response to the controller output signal. The physical system comprises an actuator configured to maintain a deflection of a probe tip relative to the sample surface. The deflection being is indicated by a deflection signal, and the filter block of the controller provides an inverse of the physical system response, such that the probe height is substantially equal to the integrator output signal.

Abstract: A method for semi-automatically generating configuration information for a gas chromatograph uses an identification device reader of the gas chromatograph to 1) determine a presence and location of sample flow component identification devices in or on identification device holders that hold the sample flow component identification devices; 2) read information from sample flow component identification devices held in the identification device holders; and 3) output configuration information for the gas chromatograph. The configuration information is based on the presence and location of particular sample flow component identification devices in or on particular identification device holders, and on associations of particular identification device holders with particular sample flow component connections to the gas chromatograph. The configuration information indicates if and how sample flow components are connected to the gas chromatograph.

Abstract: An electromagnet structure comprises a magnetic shell having a cavity, a magnetic pole located within the cavity and having a magnetic gap for focusing a magnetic field on a magnetically tunable filter, a conductive coil located within the cavity of the magnetic shell and forming multiple turns around the magnetic pole, and a heater located within the cavity of the magnetic shell and configured to maintain the conductive coil at a substantially constant temperature when the magnetically tunable filter is tuned to different frequencies.

Abstract: A peripheral component interconnect express (PCI-E) system has a reconfigurable link architecture. The system comprises a system slot adapted to receive a PCI-E compatible system controller, a plurality of peripheral slots adapted to receive a plurality of peripheral modules, and a reconfigurable switch fabric configured to create a variable number of PCI-E links between the system slot and the plurality of peripheral slots.

Abstract: A support for a rolling bearing of the kind equipped with an outer rotating ring for a rotary vacuum pump, the support comprising an inner portion that can be associated with the rotating ring, a fastening outer portion and a connecting portion, interposed between the inner and outer portions, wherein the connecting portion is a frusto-conical resilient element.

Abstract: The present invention is a process for making an inorganic/organic hybrid totally porous spherical silica particles by self assembly of surfactants that serve as organic templates via pseudomorphic transformation.

Abstract: A method for evaluating hepatocellular carcinoma in a subject is provided. In certain embodiments, the method comprises: a) obtaining a hepatocellular carcinoma protein marker profile for a sample obtained from the subject; and b) comparing the protein marker profile to a control profile.

Abstract: An apparatus for acquiring analytes from a dried biological fluid sample includes a tube, a substrate in a proximal section of the tube, and a sorbent bed in a distal section of the tube. A biological fluid sample is dispensed on the substrate and is dried to form a dried sample. A conditioning solvent is flowed into the distal section to condition the sorbent bed. A first elution solvent is flowed through the substrate and the sorbent bed. Analytes are eluted from the dried sample and retained on the sorbent bed. A second elution solvent is flowed through the substrate and the sorbent bed. The analytes are eluted from the sorbent bed, pass through an opening, and are collected. Alternatively, an elution solvent is flowed through the substrate and the sorbent bed such that analytes eluted from the dried sample pass through the sorbent bed and the opening for collection, while non-analytes are retained on the sorbent bed.

Abstract: In one embodiment, a measurement apparatus has an input stage, an output stage and a multiplexer. The input stage has a signal input, a plurality of measurement range outputs, and a plurality of selectable gain stages, with each of the selectable gain stages being coupled between the signal input and a respective one of the measurement range outputs. The output stage has a measurement acquisition path between an analog measurement input and a digital measurement output. The measurement acquisition path includes an analog-to-digital converter. The multiplexer has i) a plurality of data inputs, at least two of which are coupled to respective ones of the plurality of measurement range outputs, and at least one of which is a reference input configured to receive a signal to which signals appearing at the measurement range outputs are commonly referenced, ii) a data output coupled to the analog measurement input of the output stage, and iii) a control input.

Abstract: In accordance with a representative embodiment, a method for reducing the effect of jitter in a sampled signal is described. The method comprises: obtaining a frequency-domain data set representing the sampled signal; obtaining an average sideband amplitude distribution generated by jitter around one or more principal frequencies of the signal; estimating the jitter phases for sidebands generated by jitter in the frequency-domain data set; subtracting a jitter contribution characterized by the average sideband amplitude distribution and the estimated jitter phases from the data record.

Abstract: A fluid supply system configured for metering two or more fluids in controlled proportions, including a plurality of solvent supply lines, a pumping unit configured for taking in fluids from selected solvent supply lines and for supplying a pressurized mixture, a proportioning valve configured for modulating solvent composition by sequentially coupling selected ones of the solvent supply lines with the inlet of the pumping unit, a sensor configured for sensing process information in the fluid supply system, an analysis entity configured for analyzing the process information for determining reciprocating element related information at a beginning of fluid intake, and a control unit configured for switching the proportioning valve to sequentially couple selected ones of the solvent supply lines to the inlet of the pumping unit at one or more switching points based on the given metering scheme and based on the reciprocating element related information.

Abstract: A control device for a sample separation apparatus, the sample separation apparatus including a first separation unit and a second separation unit downstream of the first separation unit and supplied with the fluidic sample after treatment by the first separation unit. A control device is configured for controlling the first separation unit to execute a primary separation sequence within a time interval for separating the fluidic sample into fractions, and for controlling the second separation unit to execute secondary separation sequences within the time interval for further separating the separated fractions into sub-fractions, wherein the secondary separation sequences form part of a common sample separation method defined by a common specification of the sample separation involving a set of parameters, and adjusting, over a progress of the primary separation sequence, at least one parameter according to which at least one of the plurality of secondary separation sequences is executed.