Abstract: Methods systems and computer readable media for testing operation of an instrument controlled by a system under test. Raw data, used by the system under test to calculate reduced data, is inputted to an independent data reduction engine. Independent reduced data is calculated using at least one independent algorithm independent of a corresponding algorithm used by the system under test to calculate the reduced data. Values of the reduced data are compared with corresponding values of the independent reduced data, and at least one of outputting a result of the comparing for use by a human user, and storing a result of the comparing in memory are performed.

Abstract: A mass spectrometer using a variable energy photoionization device for ionizing and/or cleaving molecules is disclosed. The device permits ionizing photon wavelengths to be selected from a range of wavelengths allowing the ionizing photon energies to be tuned so as to ionize molecules without excessive fragmentation or to cleave molecules in a controlled manner by breaking only certain molecular bonds. Selection of the wavelengths is afforded by the choice of a plasma-forming gas combined with windowlessly radiating the ionizing photons from a plasma chamber. A method of mass spectrometry featuring selected ionizing photon wavelengths is also disclosed.

Abstract: An automated laboratory device that comprises a mechanism that performs operations on laboratory samples, a scheduler that causes the mechanism to process laboratory samples in accordance with programmed processes, logic that detects an error occurring in a process controlled by the scheduler, logic that accepts a user-defined error handling routine for the error, and logic that executes the error handling routine when the error is encountered. Also described is an embodiment of the invention directed to a laboratory automation system, a method of laboratory automation, a computer implemented software program product, a method of doing business, and a laboratory automation network.

Abstract: Embodiments of the present invention include methods and systems for analysis of comparative genomic hybridization (“CGH”) data, including CGH data obtained from microarray experiments.

Abstract: In accordance with the invention, a computer pointing device is interfaced with an SPM system to provide real time control of the SPM and improve the ease of use.

Abstract: The present invention provides methods, kits and compositions for the detection of an analyte. In the methods of the invention, a complex is formed between two or more analyte specific probes (ASP) and an analyte. The analyte specific probes each have a portion of a polymerase which interact to form a functional polymerase complex upon binding of the ASP to the analyte. The functional polymerase complex then generates a detectable signal which is indicative of the presence and/or amount of the analyte in the sample.

Abstract: A method for verifying interoperability of an implementation of a communication standard includes monitoring a symbol comprising a set of subcarrier symbols in a communication stream, in which some of the subcarrier symbols of the symbol are generated from pilot symbols, transmitted on subcarriers in accordance with the standard. For a given implementation and a given symbol, it is known which subcarriers will be pilot symbols, and what their pilot symbol values will be. A communication stream, generated by an implementation that is interoperable with the standard, will contain expected pilot information. Using the implementation to be verified, a communication stream is generated, containing pilot information. The generated pilot information is compared with the expected pilot information, and interoperability is determined based on the result of the comparing.

Abstract: A coupling for bringing a first conduit in communication with a second conduit. Each of the conduits comprises an end to be coupled and each of the conduits is adapted for conducting a medium. The coupling has a housing and at least one aperture in said housing. The housing is adapted for introducing said first and second conduits into the housing. Furthermore, the coupling comprises a recess in the housing. The recess is adapted for partly receiving the ends of the first and second conduits. The coupling has a seal adapted for sealing the first and second conduits within the recess.

Abstract: The present invention provides, inter alia, methods of analyzing mass spectral data. In some embodiments, the methods can be used for differential profiling of samples, such as comparing a sample comprising a compound and a sample comprising metabolites of the same compound. The methods can also be used to identify and isolate biomarkers. Systems for performing the methods, as well as computer-readable media for performing the methods, are also described.

Abstract: An interferometer has a first reflective surface having a nominal orientation; a second reflective surface having a nominal orientation orthogonal to the nominal orientation of the first reflective surface; a retroreflector facing the first reflective surface; a double polarizing beam splitter (DPBS) between the first reflective surface and the retroreflector; and a respective quarter-wave plate between the DPBS and each of the reflective surfaces. The DPBS has first and second beam-splitting surfaces each having a nominal orientation with respect to the first reflective surface. At least part of at least one of the first reflective surface, the second reflective surface and the beam-splitting surfaces is effectively tilted relative to the respective nominal orientation of such surface, and constitutes a respective tilted surface.

Abstract: In one method of calibrating an instrument having N ports, where N>=2, cables of a first type are characterized by connecting a first cable between two of the ports; performing an “unknown-thru” full two-port calibration between the two ports; obtaining a S-parameter of the first cable; saving the S-parameter of the first cable; and then repeating the connecting, performing, obtaining and saving for additional cables having the first type. The cables having the first type are then disconnected from one of the two ports and a measurement plane is transferred from the connected end of the cable to the disconnected end of the cable. Cables of a second type are then characterized by connecting a second cable between the second of the two ports and the disconnected end of the first cable; measuring a S-parameter of the second cable; and saving the S-parameter of the second cable.

Abstract: A high-precision measurement of a duration is calculated from a coarse duration measurement and at least one trigger-phase measurement.

Abstract: A temperature control unit (216) for a column (201) of a fluidic device (200) for analyzing a fluidic sample, wherein the fluidic device (200) is adapted to conduct the fluidic sample through the column (201), the temperature control unit (216) being arranged to adjust a temperature of the fluidic sample in a flow path between an inlet 5 (207) of the column (201) and an outlet (208) of the column (201) so that a temperature adjustment effect occurs selectively in an interior of the column (201).

Abstract: The invention relates to methods for treating samples of RNA. In an embodiment the method includes contacting the sample of RNA with a set of oligodeoxynucleotides to provide a DNA/RNA duplex. The method includes contacting the DNA/RNA duplex with an enzyme having a DNA:RNA nuclease activity to provide a digested RNA sample. Kits in accordance with the invention are also described.

Abstract: A process methodology and application for change control monitoring and identification used with a circuit board testing platform. This methodology uses “baselines” to track an approved collection of changes for testing a circuit board. An approver is an authorized user or a user that have permission to modify board-test parameters. Modifications of board-test parameters made by unauthorized persons are reported though a change notification system that can alert quality control systems so corrective action of the change can be taken. The change notification system associates the identity of the circuit board to the changes being made. The system uses digital signature encryption to protect the integrity and verifiability of the data from the test system and prevents data forgery.

Abstract: An ESD protection circuit has a polysilicon bounded SCR connected between a signal input/output interface contact of the integrated circuit and a power supply connection of the integrated circuit and a biasing circuit. The biasing circuit is connected to the polysilicon bounded SCR to bias the polysilicon bounded SCR to turn on more rapidly during the ESD event. The biasing circuit is formed by at least one polysilicon bounded diode and a first resistance. Other embodiments of the biasing circuit include a resistor/capacitor biasing circuit and a second diode triggering biasing circuit.

Abstract: In accordance with the invention, auxiliary structures are used in conjunction with a microfluidic chip to form a microfluidic electrospray structure that allows gas assisted nebulization for use in a mass spectrometry system.

Abstract: Methods and devices are disclosed for microarray analysis. In one embodiment a method is disclosed for processing a non-standard size slide having an array of chemical compounds attached to a surface of the slide. A sample is exposed to the surface of the non-standard size slide wherein components in the sample bind to the chemical compounds on the surface of the slide. The sample and the slide are incubated under conditions for carrying out the binding reactions, and the surface of the non-standard size slide is examined for the results of the binding reactions. Prior to the exposing step or the incubating step or the examining step, the non-standard size slide is placed into a slide holder comprising a slide-holding section a slide-holding section adapted to dispose the non-standard size slide to a processing instrument in a manner similar to that for a standard size slide. The non-standard size slide may also include an identifier such as a bar code.

Abstract: Removal of abundant proteins from a sample enhances detection and resolution of less abundant proteins in the sample such as in two-dimensional gel electrophoresis. The removal is accomplished by immunosubtraction of several high abundance, interfering or contaminating proteins simultaneously.

Abstract: Systems and methods are provided for optimizing the performance of a mass spectrometer system when multiple measurements are made. For example, the total settling time of different components or stages of a mass spectrometer, such as a tandem mass spectrometer, are decreased by optimally ordering the measurements.