Abstract: An antagonistic small molecule compound having a Toll-like receptor (TLR) 7/9 inhibitory function, a method for producing the same, and a composition containing the compound are disclosed. The novel small molecule compound has a function of inhibiting a TLR7/9 signaling path. The novel compound not only blocks secretion of TMF-? induced by CpG-ODN (TLR9 agonist) or IMQ (TLR7 agonist) but also inhibits generation of inflammatory cytokines and, thus, is useful for prevention or treatment of TLR7/9-related autoimmune diseases and inflammatory diseases including systemic lupus erythematosus and psoriasis, in particular.

Abstract: A semiconductor interconnect and an electrode for semiconductor devices may include a thin film including a multielement compound represented by Formula 1 and having a thickness equal to or less than about 50 nm, a grain size (A) to thickness (B) ratio (A/B) equal to or greater than about 1.2, and a resistivity equal to or less than about 200 µ?·cm: M n+1 AX n ­­­Formula 1 In Formula 1, M, A, X, and n are as described in the specification.

Abstract: A composition containing a chemokine inhibitor, a colony stimulating factor inhibitor, and an cancer immunotherapy agent, and a method for treatment of cancer, and a combination therapy are disclosed. The composition containing a CXCL12 inhibitor, a colony stimulating factor 1 (CSF1) inhibitor, and a cancer immunotherapy agent, for prevention and/or treatment of cancer, increases the infiltration and activity of CD8 cytotoxic T cells in cancers resistant to cancer immunotherapy agents, especially PD-1/PD-L1 immune checkpoint inhibitors, to effectively reduce tumor sizes and thus is useful for prevention and treatment of cancers resistant to immunotherapy agents, especially cancers overexpressing p16INK4A.

Abstract: An antibody fragment includes only constant regions of an antibody having no variable regions of an antibody is disclosed. The antibody fragment (IgCw-?1?2-4/?) contains heavy chain and light-chain constant regions in which a gamma constant region ((C?1) and an epsilon constant region (C?2-4) are fused; a nucleic acid encoding the antibody fragment; a kit including the antibody or nucleic acid; and use thereof. The recombinant protein IgCw-?1?2-4/? containing only of the constant regions of an antibody can be used as an Fc epsilon receptor inhibitor for inhibiting allergic responses. Therefore, IgCw-?1?2-4/? can be used in various ways in the biomedical science field.

Abstract: Provided are a system and method of automatically measuring spinal parameters. The system includes an image acquisitor configured to acquire an overall image of a spine and a parameter extractor configured to generate a learning model for extracting designated points from various spinal images and detecting relationships between the extracted points as angles, search for the designated points in the overall spinal image of the image acquisitor using the generated learning model, and check angular relationships between the points.

Abstract: Disclosed are an apparatus and method for successive cancellation flip decoding of a polar code. The apparatus for successive cancellation flip decoding of a polar code according to an embodiment includes an iterative unit subtotal matrix generator configured to generate an iterative unit subtotal matrix corresponding to a preset iterative unit size based on a portion of an entire subtotal matrix, a selection logic configured to determine one or more selection bits based on a bit string representing a position of a bit returned when re-decoding and generate an auxiliary matrix for generating the entire subtotal matrix from the one or more selection bits, and an entire subtotal matrix generator configured to generate the entire subtotal matrix by using the iterative unit subtotal matrix and the auxiliary matrix.

Abstract: The present disclosure relates to a pharmaceutical composition for treating or preventing inflammatory diseases including nicotinamide mononucleotide (NMN) as an active ingredient. When NAMPT was knocked out, removal of dead cells for tissue repair was failed, which leads to a significant increase in susceptibility to colitis, whereby systemic administration of NMN to supply NAD+ can effectively suppress inflammatory severity, making it a potential therapeutic strategy for managing inflammatory diseases.

Abstract: The present invention relates to a plasma radical solution and a method for preparing the same, and more particularly, to a plasma radical solution and a method for preparing the same capable of being used in various bio-fields such as sterilization, antibacterial, wound healing, acne relief, atopy treatment, psoriasis treatment, dermatitis treatment, viral skin disease treatment, skin soothing and muscle regeneration by preparing a plasma radical solution containing radicals generated through plasma.

Abstract: A methane cracking apparatus includes a supply pipeline that supplies a gas, a reactor having an interior space, and in which a catalyst for decomposing the gas may be disposed in the interior space, an agitator provided in the interior space and that agitates a material in the interior space, a first discharge pipeline connected to the reactor and that discharges decomposition materials generated as the gas may be decomposed, and a second discharge pipeline connected to the reactor, that discharges the decomposition materials, and disposed on an upper side of the first discharge pipeline.

Abstract: A semiconductor interconnect and an electrode for semiconductor devices may include a thin film including a multielement compound represented by Formula 1 and having a thickness equal to or less than about 50 nm, a grain size (A) to thickness (B) ratio (A/B) equal to or greater than about 1.2, and a resistivity equal to or less than about 200 ??·cm: Mn+1AXn??Formula 1 In Formula 1, M, A, X, and n are as described in the specification.

Abstract: The present disclosure relates to a method for analyzing a grain boundary of a polycrystalline two-dimensional material including transferring a polycrystalline two-dimensional material onto a substrate for analysis including a single crystalline two-dimensional material formed on a substrate; analyzing the polycrystalline two-dimensional material; depositing a metal thin film on the polycrystalline two-dimensional material; and exfoliating the polycrystalline two-dimensional material.

Abstract: The present disclosure relates to a preparing method of two-dimensional materials with a controlled number of layer including depositing a metal thin film on a surface of a bulk material; exfoliating a two-dimensional material from the surface of the bulk material together with the metal thin film; and transferring the two-dimensional material onto a substrate, in which the number of layers of the two-dimensional material to be exploited is controlled by controlling an internal stress of the metal thin film.

Abstract: Provided are a method, apparatus and system for prediction of a neonatal brain development prognosis. The computing device includes a memory; and at least one processor performing communication with the memory, wherein the processor is configured to extract cerebral blood flow (CBF) and brain tissue relaxation times T1 and T2 from the input magnetic resonance imaging (MRI) of a subject newborn; generate brain neurodevelopment prediction data of the subject newborn using a pregenerated brain neurodevelopment prediction model; and control the output of the generated brain neurodevelopment prediction data of the subject newborn.

Abstract: The present invention relates to a surface treatment method for dental zirconia, including sandblasting the surface of three types of dental zirconia (3Y-TZP, 4Y-PSZ and 5Y-PSZ) with alumina particles, and this method optimizes sandblasting conditions for each type of zirconia and enhances mechanical properties by strengthening residual stress. In addition, a dental article including dental zirconia made by the surface treatment method for zirconia, and suitable protocols for the durable bond between resin cements and high-translucent zirconia are suggested.

Abstract: The present embodiments relate to a method for manufacturing a two-dimensional material using a top-down method, the method includes the steps of preparing a bulk crystal, forming a metal layer on the bulk crystal, and then attaching a thermal release tape on the metal layer, exfoliating a two-dimensional material to which the metal layer and the thermal release tape have been attached from the bulk crystal, transferring the two-dimensional material to which the metal layer and the thermal release tape have been attached onto a substrate, and removing the thermal release tape and the metal layer from the substrate onto which the two-dimensional material has been transferred.

Abstract: A method of screening a skin whitening agent uses the stromal cell-derived factor 1 (SDF1) promoter region, the correlation between the expression amount of the skin pigment and the expression of the SDF1 promoter is observed and thus it is expected to be available in systems for pre-screening pigmentation substances and pigment reduction materials, and the drugs screened by the method is used for treatment of skin pigment-related diseases.

Abstract: The present invention relates to a heterodimeric Fc-fused protein comprising a first Fc region and a second Fc region of an immunoglobulin Fc pair and a physiologically active protein composed of two or more different subunits, wherein one or more subunits of the physiologically active protein are linked separately to one or more ends of the N-terminus or C-terminus of the first Fc region and/or the second Fc region, and CH3 domains of the first Fc region and the second Fc region are mutated so as to promote the heterodimeric Fc formation. Moreover, the present invention relates to a pharmaceutical composition comprising the heterodimeric Fc-fused protein.

Abstract: The present invention relates to an apparatus and method for forming a silicon nitride film by performing plasma enhanced atomic layer deposition (PE-ALD) employing very high frequency (VHF). An atomic layer deposition apparatus according to an embodiment of the present invention may comprise: a chamber providing a space in which a process is performed; a substrate support unit for supporting a substrate in the chamber; a gas supply unit for supplying gas to the chamber; an exhaust unit for discharging gas in the chamber; a plasma generation unit installed in the chamber to generate plasma in the chamber; and a VHF (very high frequency) power source for applying a VHF band signal to the plasma generation unit.

Abstract: A self-tilt training apparatus according to an exemplary embodiment of the present disclosure includes a storage unit which stores a daily training setting value including a training tilt angle and a training time of a patient, a first sensor unit which includes a plurality of sensors in close contact with the patient and measures the tilt angle of the patient and a motion of the patient, a control unit which determines whether the patient stands up according to the set training tilt angle at the time of starting the training and whether the patient maintains the tilt angle during the training time on the basis of the daily training setting value and the measurement values of the first sensor unit, and an output unit which outputs a message, through any one or more manners of sight, touch, and hearing, according to a direction of the control unit.

Abstract: The present invention relates to a non-thermal atmospheric-pressure plasma keloid treatment device and a use thereof. The non-thermal atmospheric-pressure plasma keloid treatment device according to the present invention has effects of inhibiting collagen deposition in keloid fibroblasts and mobility thereof, and thus, is expected to be greatly useful for preventing and treating keloids.