Abstract: A system and method for tuning and controlling ultrasonic handpieces by incorporating a broad-spectrum signal as at least a component of the signal used to drive the handpiece. The response of the handpiece to this broad-spectrum signal is measured and the frequency or amplitude or both of the drive signal are adjusted in order to maintain the desired level of handpiece performance. The operation of the systems and the performance of the methods described enables the handpiece to be operated in a most effective manner over a more widely varying range of mechanical load and thermal conditions than was possible through the use of prior control systems and methods.

Abstract: A process employing a supercritical fluid anti-solvent for sizing prednisolone acetate is disclosed. The process optionally incorporates sterilization filters. Average particle sizes of about 1 .mu.m or less (number average) and narrow particle size ranges are obtainable. The process comprises the steps of (a) forming a solution by dissolving prednisolone acetate in acetone such that the concentration of prednisolone acetate is approximately 80% or less of its solubility in acetone; and (b) transporting the solution formed in step (a) through an orifice having a diameter of 50-100 .mu.m into a mixer/expander containing compressed CO.sub.2, wherein the compressed CO.sub.2 is at a temperature from about 40.degree. to 80.degree. C. and has a density less than the density of the solution by at least 0.3 g/cc, to expand the solution so that the acetone dissolves in the CO.sub.2 and the prednisolone acetate precipitates.

Abstract: A self-contained adapter that is connected to a surgical console. The adapter contains all of the components necessary to allow different cassettes to be used with the surgical console.

Abstract: The present invention is directed to compositions containing angiostatic compounds and methods for their use in preventing pathological neovascularization.

Abstract: Compositions and methods directed to the use of adenosine uptake inhibitors for the treatment of retinal and optic nerve head damage following acute or chronic glaucoma, edema, ischemia, hypoxia or trauma are disclosed.

Abstract: Methods and formulations for treating ocular neovascularization using angiostatic steroids are disclosed.

Abstract: An array of four infrared LEDs and an array of four phototransistor receivers with each LED and phototransistor mounted inside a light baffle. The LEDs are positioned in a substantially vertical array just outside one side wall of the cassette. The vertical line on which the LEDs are arranged is substantially parallel to the direction in which the fluid/air interface moves within the cassette. The LEDs are aimed upwardly at an angle of approximately 20.degree. from horizontal. A corresponding substantially vertical array of four phototransistor receivers is mounted outside the cassette opposite the LEDs such that each of the receivers is aimed at its corresponding LED.

Abstract: Compositions containing a stable, liquid, ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.

Abstract: 9-Halo-13,14-dihydroprostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.

Abstract: An aspiration tip having a relatively rigid cannula attached to a hub and an open end opposite the hub. The open end is sealed with a cap made from a soft, flexible material, such as rubber or soft plastic. The soft material reduces the likelihood that the posterior capsule will tear during cortical clean-up and capsule polishing.

Abstract: The present invention is directed to compositions containing angiostatic compounds and methods for their use in preventing pathological neovascularization.

Abstract: Compositions containing an ophthalmically acceptable, modified enzyme exhibiting a low pI and methods involving the combined use of these compositions with a polymeric antimicrobial agent, are disclosed for the simultaneous cleaning and disinfecting of contact lens.

Abstract: A single piece soft foldable IOL having open loop haptics of specific thickness and geometry. The unique geometry provides an IOL with improved fixation and centration.

Abstract: The intraocular use of combinations of stromal cell growth stimulators (e.g., TGF-.beta.) and antimetabolites (e.g., mitomycin C) in connection with glaucoma filtration surgery is described. The combination is applied to the surgical site to attract, mitogenically activate, and neutralize the potential for extracellular matrix synthesis leading to scar formation by stromal cells. Without such treatment, the formation of scar tissue may lead to impairment of the outflow of aqueous humor at the surgical site, particularly the fistula. The mitogenic activation of the stromal cells makes these cells susceptible to the anti-metabolites. This enables the antimetabolites to suppress the proliferation of the fibroblasts and other associated stromal cells to a much greater extent, relative to the proliferation seen when the metabolites alone are utilized.

Abstract: The use of certain dopaminergic compounds for controlling elevations of intraocular pressure is disclosed. The compounds are ergoline derivatives. The most preferred compound is cabergoline. The compounds have been found to produce a significant reduction of intraocular pressure.

Abstract: A surgical handpiece holder for use in protecting a surgical handpiece during storage or autoclaving, and providing a template for the storage of excess handpiece wire is disclosed.

Abstract: A single piece intraocular lens folder that has a generally planar, open frame in the shape of a rounded "A" with a rimmed, open head at the top of the "A". The base of the "A" forms a pairs of opposing legs or handles that join to form a hinge at the intersection where the handles attach to the head. The hinge allows the handle to be squeezed together and spring apart when released. Squeezing the handles together causes the sides of the head to spread apart, thereby stretching the top edge of the head rim and pulling the top edge downward toward the hinge. The open head contains a pair of support jaws and a pair of serpentine folding jaws. The location of the serpentine jaws is such that when the top edge of the head rim moves toward the hinge, the serpentine jaws are squeezed together, causing the IOL to be folded in half. The serpentine shape of the folding jaws allow the haptics to pivot downward, thereby permitting the IOL to be folded along a plurality of axes.

Abstract: Compositions containing 3-Oxa-D-prostaglandins and methods of their use in treating glaucoma or ocular hypertension are disclosed.

Abstract: Methods for treating ocular hypotony are disclosed.