Abstract: Angiostatic steroids for use in controlling ocular hypertension are disclosed. Pharmaceutical compositions of the angiostatic steroids and methods for their use in treating ocular hypertension, including controlling the ocular hypertension associated with primary open angle glaucoma, are disclosed. In addition, the combination of the compounds with glucocorticoids for the prevention of elevated IOP during the treatment of inflammation is disclosed.

Abstract: Disclosed are 9-deoxyprostaglandins which are useful in the treatment of glaucoma and ocular hypertension. Some of these 9-deoxyprostaglandins are novel. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.

Abstract: A diffractive, multifocal ophthalmic lens including an apodization zone with echelettes having a smoothly reduced step height to shift the energy balance from the near image to the distant image and thus reduce the glare perceived when viewing a discrete, distant light source.

Abstract: The intraocular use of combinations of lens epithelial cell growth stimulators (e.g., TGF-.beta.) and antimetabolites (e.g., mitomycin C) is described. The combination is applied to the capsular bag to prevent or retard the formation of secondary cataracts following cataract surgery. The lens epithelial cell stimulators activate DNA synthesis in dormant lens epithelial cells, and thereby make those cells susceptible to the anti-metabolites. This enables the antimetabolites to suppress the proliferation of lens epithelial cells to a much greater extent, relative to the proliferation observed when the metabolites alone are utilized. The increased suppression of the growth of lens epithelial cells results in a significant improvement in the ability to prevent or retard the formation of opacities on the lens capsule (i.e., secondary cataracts).

Abstract: Improved soft, foldable acrylic lens materials which are particularly suited for use as IOLs, but which are also useful as other ophthalmic devices, such as contact lenses, keratoprostheses, and corneal rings or inlays, are disclosed. These materials contain only two principal components: one aryl acrylic hydrophobic monomer and one hydrophilic monomer. The materials of the present invention are copolymers comprising at least about 90% by weight of the two principal monomeric components; provided that the amount of the hydrophilic component is not greater than that of the aryl acrylic hydrophobic component. The remainder of the material comprises up to 10% by weight of one or more additional components, such as cross-linking, UV-light absorbing, and blue-light absorbing components.The aryl acrylic hydrophobic monomers suitable for use in the materials of the present invention have the formula ##STR1## wherein: X is H or CH.sub.3 ;m is 0-6;Y is nothing, O, S, or NR, wherein R is H, CH.sub.3, C.sub.n H.sub.

Abstract: Compounds having both calcium antagonist and antioxidant activity are disclosed. The compounds are useful in preventing or alleviating damage to tissues at the cellular level. Methods of treatment which employ these properties of the compounds and corresponding pharmaceutical compositions are also disclosed.

Abstract: Compositions containing certain sulfur containing compounds and methods of use in the treatment and prevention of cataracts is disclosed.

Abstract: Substituted hydrindanes and their use in controlling angiogenesis-dependent diseases in warm blooded animals are disclosed.

Abstract: Methods for controlling IOP with compositions of HGF Receptor Activators are disclosed.

Abstract: Compositions and methods treating inflammation are disclosed wherein the compositions contain a pharmaceutically effective anti-inflammatory amount of a polyethoxylated castor oil.

Abstract: Compositions containing certain sulfur containing compounds and methods of use in the treatment and prevention of cataracts is disclosed.

Abstract: Compounds of the following structure are disclosed: ##STR1## Wherein G, J and the two atoms of the thiophene ring to which they are attached are the group ##STR2##

Abstract: The use of certain aliphatic carboxylic acid derivatives to treat persons suffering from retinal or optic nerve head damage is disclosed.

Abstract: Methods and formulations for treating ocular neovascularization using angiostatic steroids are disclosed.

Abstract: Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.

Abstract: Aqueous pharmaceutical compositions containing a synergistic combination of a quinolone and a polystyrene sulfonic acid polymer are described, wherein the compositions are clear solutions which are comfortable and have sustained release. Methods for use of the compositions are also disclosed. This type of formulation is particularly useful with ciprofloxacin-type quinolones by greatly increasing the solubility of these quinolones, making it feasible to have aqueous solutions containing such quinolones at or near physiological pH.

Abstract: The use of 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic acid anilides for treating ocular diseases with immune etiology is disclosed.

Abstract: A cutting tip having an asymmetric, hydrodynamic channel that tightens the cutting tip during operation.

Abstract: A cassette latching mechanism generally including an articulating clamp mounted on the end of a pneumatic cylinder. The clamp interacts with a slot, tab or tang on the cassette housing to hold the cassette firmly within a surgical console.

Abstract: A process control system according to the present invention uses analog control circuitry in which a differential amplifier stage is incorporated into the feedback path rather that the feedforward path to enable the control of highly non-linear processes that may also exhibit high levels of hysteresis. Such processes often have superior performance characteristics that conventional control circuitry cannot exploit. The present invention additionally incorporates an automatic control circuit which varies the gain of various stages the control circuitry when the output of the process is within a predetermined range. An embodiment of the present invention is used to control a nonlinear proportional valve with severe hysteresis. The valve regulates the pressure within pressure-driven ophthalmic surgical instruments, which must be controlled extremely precisely to enable successful eye surgery.