Abstract: Conformationally rigid aryl prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic pharmaceutical compositions comprising said prostaglandins.
Type:
Grant
Filed:
May 12, 1999
Date of Patent:
January 2, 2001
Assignee:
Alcon Laboratories, Inc.
Inventors:
Paul W. Zinke, John E. Bishop, Thomas R. Dean, Mark R. Hellberg
Abstract: Compositions containing DP-agonist and FP-agonists prostaglandin agonists and methods of their use in treating glaucoma or ocular hypertension are disclosed.
Type:
Grant
Filed:
August 2, 1999
Date of Patent:
December 26, 2000
Assignee:
Alcon Laboratories, Inc.
Inventors:
Thomas R. Dean, Mark Hellberg, Verney L. Sallee
Abstract: 14-Aza analogs of PGF.sub.2.alpha., PGD.sub.2, and PGE.sub.2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.
Abstract: A surgical handpiece tip with at least two coaxially spaced electrically conductive tubes. The tubes are separated by an electrical insulator. The interior of the inner tube is used for aspiration of liquefied tissue. The distal portion of the interior tube terminates just inside of the outer tube so as to form a boiling region. Electrical current is passed between the inner and outer tube to rapidly boil any surgical fluid in the boiling region. The boiling fluid rapidly expands out of the ring between the tubes and contacts the targeted tissue, thereby liquefying the tissue and allowing the tissue to be aspirated.
Type:
Grant
Filed:
June 11, 1999
Date of Patent:
December 5, 2000
Assignee:
Alcon Laboratories, Inc.
Inventors:
Glenn Sussman, Martin J. Padget, Donald M. Cohen
Abstract: Anionic amino acid based surfactants are used to enhance antimicrobial effectiveness in topically administrable pharmaceutical compositions containing at least one active ingredient, a cationic preservative and an anionic polyelectrolyte, such as carboxyvinyl polymers, xanthan gum, polystyrene sulfonic acid polymers and cationic exchange resins.
Type:
Grant
Filed:
September 21, 1999
Date of Patent:
November 14, 2000
Assignee:
Alcon Laboratories, Inc.
Inventors:
Ernesto J. Castillo, Steven Howard Gerson, Wesley Wehsin Han
Abstract: Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.
Type:
Grant
Filed:
July 2, 1998
Date of Patent:
November 7, 2000
Assignee:
Alcon Laboratories, Inc.
Inventors:
Masood Chowhan, Nissanke L. Dassanayake
Abstract: A lens injector cartridge having an asymmetric bore. The asymmetric bore initiates the folding of the lens on one side only, thereby reducing the amount of energy imparted to the lens and the potential for damage to the lens. The gentle folding of the lens also assists in positioning the travel of the haptics down the bore, thereby reducing the potential for damage to the haptics.
Abstract: Improved stability, liquid enzyme compositions containing an alkylated trypsin and methods involving the combined use of these compositions with an aqueous composition are disclosed for the cleaning or simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
Type:
Grant
Filed:
October 18, 1999
Date of Patent:
October 31, 2000
Assignee:
Alcon Laboratories, Inc.
Inventors:
Bahram Asgharian, Bor-Shyue Hong, Ronald P. Quintana
Abstract: Methods of heat sterilizing polymers are disclosed. The methods involve the preparation of a polymer suspension in an water-miscible organic liquid and subsequent application of moderate heat for a period of time sufficient to sterilize the polymer.
Abstract: Coatings for surgical instruments which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated fluorophobic ends.
Type:
Grant
Filed:
January 23, 1998
Date of Patent:
September 26, 2000
Assignees:
Alcon Laboratories, Inc., University of Southern Mississippi
Inventors:
Mark E. Hammer, Steven T. Charles, John C. Lang, Robert Y. Lochhead, Lon J. Mathias
Abstract: An apparatus and method to elevate an infusion source, the pole of a control unit is increased by about thirty-two (32) cm to increase the height of an infusion bottle attached to a hanger on the pole during ophthalmic surgery including that performed with a phacoemulsification surgical handpiece. The control unit being for irrigation and suction lines that lead to the phacoemulsification surgical handpiece used to conduct eye surgery.
Abstract: A surgical handpiece having at least two lumens mounted to a body. At least one lumen is used for aspiration and at least one other lumen is used to inject heated surgical fluid for liquefying a cataractous lens. A portion of the second lumen is enlarged to form a pumping chamber. The pumping chamber works by boiling a small volume of the surgical fluid. As the fluid boils, it expands rapidly, thereby propelling the liquid downstream of the pumping chamber out of the second lumen. The pumping chamber may use any type of heater, such as a resistive heater or an induction heater. The handpiece may also contain other lumens for injecting relatively cool surgical fluid.
Type:
Grant
Filed:
August 16, 1999
Date of Patent:
August 29, 2000
Assignee:
Alcon Laboratories, Inc.
Inventors:
Glenn Sussman, Thomas G. Capetan, Donald M. Cohen
Abstract: Various embodiments of optical fiber cables and laser probes are disclosed for providing multi-spot laser beams from a single laser beam source. This permits time-intensive but repetitive laser surgical procedures such as panretinal photocoagulation to be performed with increased accuracy and in a fraction of the time currently allotted for such procedures.
Abstract: A method for polishing articles comprising soft acrylic materials is disclosed. The method includes a polishing step and a cleaning step. In the polishing step, a receptacle is charged with polishing beads of various sizes, alumina, a swelling agent and the articles to be polished, and agitated for a period of time and at a speed sufficient to remove surface irregularities. Following the polishing step, the polished articles are cleaned by agitating them with a cleaning slurry comprising cleaning beads of various sizes, alumina, a solvent and a surfactant for a period of time and at a speed sufficient to clean the surface of the polished articles. Agitation is preferably accomplished by a tumbling machine.
Abstract: Cyclobutane analogs of PGF.sub.2.alpha., PGD.sub.2, and PGE.sub.2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.
Abstract: A lens injector cartridge having an asymmetric bore. The asymmetric bore initiate; the folding of the lens on one side only, thereby reducing the amount of energy imparted to the lens and the potential for damage to the lens. The gentle folding of the lens also assists in positioning the travel of the haptics down the bore, thereby reducing the potential for damage to the haptics.
Type:
Grant
Filed:
April 19, 1999
Date of Patent:
July 4, 2000
Assignee:
Alcon Laboratories, Inc.
Inventors:
Stephen J. Van Noy, Kyle Brown, David A. Downer, David Eister, Lars D. Jensen
Abstract: A surgical handpiece having at least two lumens mounted to a body. At least one lumen is used for aspiration and at least one other lumen is used to inject heated surgical fluid for liquefying a cataractous lens. A portion of the second lumen is enlarged to form a pumping chamber. The pumping chamber works by boiling a small volume of the surgical fluid. As the fluid boils, it expands rapidly, thereby propelling the liquid downstream of the pumping chamber out of the second lumen. The pumping chamber may use any type of heater, such as a resistive heater or an induction heater. The handpiece may also contain other lumens for injecting relatively cool surgical fluid.
Type:
Grant
Filed:
June 4, 1998
Date of Patent:
June 27, 2000
Assignee:
Alcon Laboratories, Inc.
Inventors:
Glenn Sussman, Thomas G. Capetan, Donald M. Cohen