Abstract: Compositions containing one or more HETE derivative(s) and an effective concentration of ethanol and methods of use for treating dry eye are disclosed.

Abstract: A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I:

Abstract: HETE derivatives and methods of their use for treating dry eye are disclosed.

Abstract: 15-HETE derivatives with enhanced metabolic stability and methods of their use for treating dry eye are disclosed.

Abstract: Compositions and methods for the treatment of dry eye and related diseases utilizing EP4 receptor agonists are disclosed.

Abstract: Disclosed is the use of cloprostenol and fluprostenol analogues in combination with carbonic anhydrase inhibitors for the treatment of glaucoma and ocular hypertension and ophthalmic compositions therefor.

Abstract: Methods of synthesizing 9-Halo-13,14-dihydroprostaglandins useful in the treatment of glaucoma and ocular hypertension are disclosed. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.

Abstract: Methods and compositions for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The compositions contain a mast cell stabilizing disulfide derivative as an active ingredient.

Abstract: Disclosed are methods and compositions for the treatment of glaucoma and ocular hypertension, comprising the administration of a prostaglandin analog and a prostaglandin synthesis inhibitor.

Abstract: Benzenoid HETE derivatives and methods of their use for treating dry eye are disclosed.

Abstract: The use of polyethoxylated castor oils to treat dry eye disorders is disclosed.

Abstract: Topically administrable anti-allergy compositions comprising olopatadine and a polymeric quaternary ammonium preservative are suitable for use by patients wearing contact lenses.

Abstract: Heteroatom-interrupted HETE derivatives and methods of their use for treating dry eye are disclosed.

Abstract: A tip for a liquefraction surgical handpiece uses at least two tubes. One tube is used for aspiration and another, smaller tube is used to inject heated surgical fluid for liquefying a cataractous lens. The distal portion of the injection tube terminates just inside of the aspiration tube so that heated fluid escaping the injection tube is reflected off of the internal wall of the aspiration tube prior to entering the eye. The internal wall is textured or roughened to further diffract the fluid stream. Such an arrangement prevents the injected fluid from directly entering the eye. The handpiece may also contain other tube, for example, for injecting relatively cool surgical fluid.

Abstract: 3-heteroatom substituted and two carbon homologs of 15-HETE, and their derivatives, compositions and methods of their use for treating dry eye are disclosed.

Abstract: Pharmaceutical compositions containing a fluoroquinolone antibiotic drug, xanthan gum and a water-soluble calcium salt in an amount sufficient to make the fluoroquinolone antibiotic drug and xanthan gum compatible are disclosed.

Abstract: Solution formulations containing a corticosteroid, an antibiotic and a vitamin E tocopheryl derivative as a solubilizing agent are disclosed. The formulations are intended for topical application to the eye, ear, nose or skin.

Abstract: Omega chain modified 15-HETE derivatives and methods of their use for treating dry eye are disclosed.

Abstract: The use of low molecular weight amino alcohols in ophthalmic boric solution is described herein. These compounds have been found to enhance the efficacy of antimicrobial preservatives. Particularly preferred amino alcohols are 2-amino-2-methyl-1-propanol (AMP), 2-dimethylamino-2-methyl-1-propanediol (DMAMP), 2-amino-2-ethylpropanol (AMP), 2-amino-2-methyl-1,3-propanediol (AMPD), and 2-amino-1-butanol (AB). The ophthalmic compositions further optionally comprise a borate/polyol buffer system and an alkylamine.

Abstract: A cassette configuration, operative parts of which may be disposable or resterilizable, is configured with an adapter that may be mounted within the cassette receiving portal of a console that uses a peristaltic pump spaced apart from actuator and vent controls to engage the lower end wall of a cassette. The adapter is asymmetrically mounted in the available space, and allows a tubing loop from one side of a cassette inserted under it to be threaded through the peristaltic pump and to be seated in a bore in the adapter on the opposite side. A lower edge of the cassette fits into an interface slot in the console, and the interior tubing configuration enables clamping of irrigation and vent lines, while providing aspiration and irrigation flows to and from a handpiece. Within the cassette or in the console, flow control elements are provided to enable alternative venting of either air or fluid into the aspiration system to prevent excessive suction at the operative site.