Patents Assigned to American Home Products Corporation
  • Patent number: 7630838
    Abstract: This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of BACE. Such agents may represent new therapeutics in the treatment and/or prevention of Alzheimer's Disease.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: December 8, 2009
    Assignee: American Home Products Corporation
    Inventors: Rajiv Chopra, Kristine Svenson, Bethany Annis Freeman, Tatos N. Akopian, Jonathan Bard, Mark Lloyd Stahl, William S. Somers
  • Patent number: 7157568
    Abstract: The present invention provides isolated nucleic acids encoding full-length human estrogen receptor-? (hER?), which comprises 530 amino acids. The invention also provides isolated hER? polypeptides and hER?-reactive antibodies, including those that specifically recognize amino acids 1–45 of hER?. The invention also encompasses methods for identifying hER?-interactive compounds, including agonists, antagonists, and co-activators.
    Type: Grant
    Filed: August 5, 1997
    Date of Patent: January 2, 2007
    Assignee: American Home Products Corporation
    Inventors: Ramesh A. Bhat, Ruth Henderson, Chulai Hsiao, Sotirios A. Karathanasis
  • Publication number: 20040214328
    Abstract: A multifunctional molecular complex for the transfer of a nucleic acid composition to a target cell is provided The complex is comprised of A) said nucleic acid composition and B) a transfer moiety comprising 1) one or more cationic polyamines bound to said nucleic acid composition, 2) one or more endosome membrane disrupting components attached to at least one nitrogen of the polyamine and 3) one or more receptor specific binding components.
    Type: Application
    Filed: November 13, 2001
    Publication date: October 28, 2004
    Applicant: American Home Products Corporation
    Inventor: Raymond H. Boutin
  • Publication number: 20040147512
    Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
    Type: Application
    Filed: December 29, 2003
    Publication date: July 29, 2004
    Applicants: Elan Pharmaceuticals, Inc., American Home Products Corporation.
    Inventors: Andrei W. Konradi, Michael A. Pleiss, Eugene D. Thorsett, Susan Ashwell, Gregory S. Welmaker, Anthony Kreft, Dimitrios Sarantakis, Darren B. Dressen, Francine S. Grant, Christopher Semko, Ying-Zi Xu
  • Publication number: 20040127486
    Abstract: Disclosed are a series of phenylalanine derivatives, to compositions containing them, to processes for their preparation, and to their use in medicine.
    Type: Application
    Filed: December 12, 2003
    Publication date: July 1, 2004
    Applicants: Elan Pharmaceuticals, Inc., American Home Products Corporation
    Inventors: Andrei W. Konradi, Michael A. Pleiss, Eugene D. Thorsett, Susan Ashwell, Gregory S. Welmaker, Anthony Kreft, Dimitrios Sarantakis, Darren B. Dressen, Francine S. Grant, Christopher Semko, Ying-Zi Xu
  • Patent number: 6689781
    Abstract: Disclosed are a series of phenylalanine derivatives, to compositions containing them, to processes for their preparation, and to their use in medicine.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: February 10, 2004
    Assignees: Elan Pharmaceuticals, Inc., American Home Products Corporation
    Inventors: Andrei W. Konradi, Michael A. Pleiss, Eugene D. Thorsett, Susan Ashwell, Gregory S. Welmaker, Anthony Kreft, Dimitrios Sarantakis, Darren B. Dressen, Francine S. Grant, Christopher Semko, Ying-Zi Xu
  • Publication number: 20030186967
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: February 6, 2002
    Publication date: October 2, 2003
    Applicant: American Home Products Corporation
    Inventors: Kenneth Lewis Kees, Lloyd M. Garrick, Ariamala Gopalsamy
  • Publication number: 20030186413
    Abstract: The present invention provides a solution structure of free RGS4 determined using NMR techniques. The structure includes a G&agr; binding site and an allosteric binding site. The structural information provided can be employed to identify, select or design agonists and antagonists of RGS4 activity. The invention includes two dimensional and three dimensional models and representations of the structure of free RGS4 based upon structural coordinates that are provided that are useful in the methods described.
    Type: Application
    Filed: August 29, 2001
    Publication date: October 2, 2003
    Applicant: American Home Products Corporation
    Inventors: Robert Powers, Franklin J. Moy
  • Publication number: 20030180929
    Abstract: Disclosed herein are structure-based modelling methods for the preparation of acetohydroxy acid synthase (AHAS) variants, including those that exhibit selectively increased resistance to herbicides such as imidazoline herbicides and AHAS inhibiting herbicides. The invention encompasses isolated DNAs encoding such variants, vectors that include the DNAs, and methods for producing the variant polypeptides and herbicide resistant plants containing specific AHAS gene mutations. Methods for weed control in crops are also provided.
    Type: Application
    Filed: April 4, 2003
    Publication date: September 25, 2003
    Applicant: American Home Products Corporation
    Inventors: Genichi Kafefuda, Karl-Heinz Ott, Jae-Gyu Kwagh, Gerald W. Stockton
  • Publication number: 20030170251
    Abstract: This invention provides a feline vaccine composition comprising an immunogenically active component having inactivated mammalian chlamydial cells or antigens derived therefrom, in combination with an effective amount of an immunogencally suitable adjuvant; and a veterinary pharmaceutically acceptable carrier or diluent. The vaccine composition is useful to prevent chlamydia, e.g. C. psittaci, infections or diseases in felines, and may also be combined with other vaccine compositions or therapy. A process for producing C. psittaci suitable for use in the production of safe and effective chlamydia vaccines, and a method for preventing chlamydia infections or diseases in felines, are also provided.
    Type: Application
    Filed: February 10, 2003
    Publication date: September 11, 2003
    Applicant: American Home Products Corporation
    Inventors: Hsien-Jue Chu, Lloyd Chavez, William M. Acree, Lucille W.S. Chang
  • Publication number: 20030153751
    Abstract: Novel compounds are disclosed which inhibit the activity of phospholipase enzymes in a mammal, particularly cytosolic phospholipase A2. Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclosed.
    Type: Application
    Filed: May 8, 2002
    Publication date: August 14, 2003
    Applicant: American Home Products Corporation
    Inventors: Jasbir S. Seehra, Neelu Kaila, John C. McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang
  • Publication number: 20030139468
    Abstract: Parenteral solutions suitable for intravenous injection are provided comprising amiodarone in an amount of from 0.9 mg/ml to 30 mg/ml, a lactic acid buffer and water, the solution having a pH of 2.5 to 4.5.
    Type: Application
    Filed: January 22, 2002
    Publication date: July 24, 2003
    Applicant: American Home Products Corporation
    Inventors: Mahdi B. Fawzi, Christian L. Ofslager, Yong J. Lee, Syed M. Shah
  • Publication number: 20030104406
    Abstract: Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
    Type: Application
    Filed: February 8, 2002
    Publication date: June 5, 2003
    Applicant: American Home Products Corporation
    Inventors: Neil M. Wolfman, Soo-Peang Khor
  • Publication number: 20030105313
    Abstract: Novel aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: January 25, 2002
    Publication date: June 5, 2003
    Applicant: American Home Products Corporation
    Inventors: Lisa A. Racie, Natalie C. Twine, Michael J. Agostino, Neil Wolfman, Elisabeth A. Morris
  • Publication number: 20030077671
    Abstract: Methods and compositions for identifying compounds which disrupt the functional interaction of an intracellular receptor region of an &agr;-subunit of a voltage-gated ion channel and an amino-terminal inactivation region of an ion channel protein are disclosed. Compounds that disrupt the functional or binding interaction of these two regions have significant modulatory effects on ion channel activity, and thus are likely to be useful for treating and/or preventing a wide variety of diseases and pathological conditions associated with ion channel dysfunction. Such conditions include, for example, neurological disorders, cardiac diseases, metabolic diseases, tumor-driven diseases, and autoimmune diseases.
    Type: Application
    Filed: January 17, 2002
    Publication date: April 24, 2003
    Applicant: American Home Products Corporation
    Inventors: Kathleen H. Young, Kenneth J. Rhodes
  • Publication number: 20030065180
    Abstract: This invention provides compounds of Formula (I), 1
    Type: Application
    Filed: March 28, 2001
    Publication date: April 3, 2003
    Applicant: American Home Products Corporation
    Inventors: Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • Publication number: 20030054016
    Abstract: Methods and compositions for protecting avian hosts (e.g., turkeys and/or chickens) from turkey rhinotracheitis virus and/or TRT or SHS respiratory distress utilize in ovo administration of live, avirulent strains of TRTV at appropriate dosage levels on a per egg basis to provide an effective and efficient vaccination having acceptable safety and efficacy features, and additionally provides higher titers in vaccinated birds than conventionally administered vaccines.
    Type: Application
    Filed: November 13, 2001
    Publication date: March 20, 2003
    Applicant: American Home Products Corporation
    Inventor: Frans Gerrit Davelaar
  • Publication number: 20030045583
    Abstract: A novel salt of O-desmethyl venlafaxine is provided, O-desmethylvenlafaxine succinate. Pharmaceutical compositions, dosage forms and methods of use are also provided.
    Type: Application
    Filed: February 11, 2002
    Publication date: March 6, 2003
    Applicant: American Home Products Corporation
    Inventors: Anthony F. Hadfield, Syed M. Shah, Michael W. Winkley, Karen W. Sutherland, James A. Provost, Aeri Park, Rex A. Shipplett, Brenton W. Russell, Beat T. Weber
  • Patent number: 6524592
    Abstract: The invention relates to vaccines which are suitable for the prevention of clostridial diseases of sheep (and lambs), providing an effective immunity for up to a year or more following a single injection or dose.
    Type: Grant
    Filed: May 23, 2000
    Date of Patent: February 25, 2003
    Assignee: American Home Products Corporation
    Inventors: Richard Buchta, Christopher Leigh Schwartzkoff, Philip Ralph Lehrbach
  • Patent number: 6525026
    Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
    Type: Grant
    Filed: November 16, 2001
    Date of Patent: February 25, 2003
    Assignees: Elan Pharmaceuticals, Inc., American Home Products Corporation
    Inventors: Eugene D. Thorsett, Christopher M. Semko, Dimitrios Sarantakis, Michael A. Pleiss, Anthony Kreft, Andrei W. Konradi, Francine S. Grant, Darren B. Dressen, Susan Ashwell, Reinhardt Bernhard Baudy, Louis John Lombardo