Patents Assigned to American Home Products Corporation
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Patent number: 7630838Abstract: This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of BACE. Such agents may represent new therapeutics in the treatment and/or prevention of Alzheimer's Disease.Type: GrantFiled: September 19, 2001Date of Patent: December 8, 2009Assignee: American Home Products CorporationInventors: Rajiv Chopra, Kristine Svenson, Bethany Annis Freeman, Tatos N. Akopian, Jonathan Bard, Mark Lloyd Stahl, William S. Somers
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Patent number: 7157568Abstract: The present invention provides isolated nucleic acids encoding full-length human estrogen receptor-? (hER?), which comprises 530 amino acids. The invention also provides isolated hER? polypeptides and hER?-reactive antibodies, including those that specifically recognize amino acids 1–45 of hER?. The invention also encompasses methods for identifying hER?-interactive compounds, including agonists, antagonists, and co-activators.Type: GrantFiled: August 5, 1997Date of Patent: January 2, 2007Assignee: American Home Products CorporationInventors: Ramesh A. Bhat, Ruth Henderson, Chulai Hsiao, Sotirios A. Karathanasis
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Publication number: 20040214328Abstract: A multifunctional molecular complex for the transfer of a nucleic acid composition to a target cell is provided The complex is comprised of A) said nucleic acid composition and B) a transfer moiety comprising 1) one or more cationic polyamines bound to said nucleic acid composition, 2) one or more endosome membrane disrupting components attached to at least one nitrogen of the polyamine and 3) one or more receptor specific binding components.Type: ApplicationFiled: November 13, 2001Publication date: October 28, 2004Applicant: American Home Products CorporationInventor: Raymond H. Boutin
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Publication number: 20040147512Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.Type: ApplicationFiled: December 29, 2003Publication date: July 29, 2004Applicants: Elan Pharmaceuticals, Inc., American Home Products Corporation.Inventors: Andrei W. Konradi, Michael A. Pleiss, Eugene D. Thorsett, Susan Ashwell, Gregory S. Welmaker, Anthony Kreft, Dimitrios Sarantakis, Darren B. Dressen, Francine S. Grant, Christopher Semko, Ying-Zi Xu
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Publication number: 20040127486Abstract: Disclosed are a series of phenylalanine derivatives, to compositions containing them, to processes for their preparation, and to their use in medicine.Type: ApplicationFiled: December 12, 2003Publication date: July 1, 2004Applicants: Elan Pharmaceuticals, Inc., American Home Products CorporationInventors: Andrei W. Konradi, Michael A. Pleiss, Eugene D. Thorsett, Susan Ashwell, Gregory S. Welmaker, Anthony Kreft, Dimitrios Sarantakis, Darren B. Dressen, Francine S. Grant, Christopher Semko, Ying-Zi Xu
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Patent number: 6689781Abstract: Disclosed are a series of phenylalanine derivatives, to compositions containing them, to processes for their preparation, and to their use in medicine.Type: GrantFiled: July 20, 2001Date of Patent: February 10, 2004Assignees: Elan Pharmaceuticals, Inc., American Home Products CorporationInventors: Andrei W. Konradi, Michael A. Pleiss, Eugene D. Thorsett, Susan Ashwell, Gregory S. Welmaker, Anthony Kreft, Dimitrios Sarantakis, Darren B. Dressen, Francine S. Grant, Christopher Semko, Ying-Zi Xu
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Publication number: 20030186967Abstract: Compounds of the formula 1Type: ApplicationFiled: February 6, 2002Publication date: October 2, 2003Applicant: American Home Products CorporationInventors: Kenneth Lewis Kees, Lloyd M. Garrick, Ariamala Gopalsamy
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Publication number: 20030186413Abstract: The present invention provides a solution structure of free RGS4 determined using NMR techniques. The structure includes a G&agr; binding site and an allosteric binding site. The structural information provided can be employed to identify, select or design agonists and antagonists of RGS4 activity. The invention includes two dimensional and three dimensional models and representations of the structure of free RGS4 based upon structural coordinates that are provided that are useful in the methods described.Type: ApplicationFiled: August 29, 2001Publication date: October 2, 2003Applicant: American Home Products CorporationInventors: Robert Powers, Franklin J. Moy
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Publication number: 20030180929Abstract: Disclosed herein are structure-based modelling methods for the preparation of acetohydroxy acid synthase (AHAS) variants, including those that exhibit selectively increased resistance to herbicides such as imidazoline herbicides and AHAS inhibiting herbicides. The invention encompasses isolated DNAs encoding such variants, vectors that include the DNAs, and methods for producing the variant polypeptides and herbicide resistant plants containing specific AHAS gene mutations. Methods for weed control in crops are also provided.Type: ApplicationFiled: April 4, 2003Publication date: September 25, 2003Applicant: American Home Products CorporationInventors: Genichi Kafefuda, Karl-Heinz Ott, Jae-Gyu Kwagh, Gerald W. Stockton
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Publication number: 20030170251Abstract: This invention provides a feline vaccine composition comprising an immunogenically active component having inactivated mammalian chlamydial cells or antigens derived therefrom, in combination with an effective amount of an immunogencally suitable adjuvant; and a veterinary pharmaceutically acceptable carrier or diluent. The vaccine composition is useful to prevent chlamydia, e.g. C. psittaci, infections or diseases in felines, and may also be combined with other vaccine compositions or therapy. A process for producing C. psittaci suitable for use in the production of safe and effective chlamydia vaccines, and a method for preventing chlamydia infections or diseases in felines, are also provided.Type: ApplicationFiled: February 10, 2003Publication date: September 11, 2003Applicant: American Home Products CorporationInventors: Hsien-Jue Chu, Lloyd Chavez, William M. Acree, Lucille W.S. Chang
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Publication number: 20030153751Abstract: Novel compounds are disclosed which inhibit the activity of phospholipase enzymes in a mammal, particularly cytosolic phospholipase A2. Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclosed.Type: ApplicationFiled: May 8, 2002Publication date: August 14, 2003Applicant: American Home Products CorporationInventors: Jasbir S. Seehra, Neelu Kaila, John C. McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang
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Publication number: 20030139468Abstract: Parenteral solutions suitable for intravenous injection are provided comprising amiodarone in an amount of from 0.9 mg/ml to 30 mg/ml, a lactic acid buffer and water, the solution having a pH of 2.5 to 4.5.Type: ApplicationFiled: January 22, 2002Publication date: July 24, 2003Applicant: American Home Products CorporationInventors: Mahdi B. Fawzi, Christian L. Ofslager, Yong J. Lee, Syed M. Shah
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Publication number: 20030105313Abstract: Novel aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.Type: ApplicationFiled: January 25, 2002Publication date: June 5, 2003Applicant: American Home Products CorporationInventors: Lisa A. Racie, Natalie C. Twine, Michael J. Agostino, Neil Wolfman, Elisabeth A. Morris
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Publication number: 20030104406Abstract: Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).Type: ApplicationFiled: February 8, 2002Publication date: June 5, 2003Applicant: American Home Products CorporationInventors: Neil M. Wolfman, Soo-Peang Khor
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Publication number: 20030077671Abstract: Methods and compositions for identifying compounds which disrupt the functional interaction of an intracellular receptor region of an &agr;-subunit of a voltage-gated ion channel and an amino-terminal inactivation region of an ion channel protein are disclosed. Compounds that disrupt the functional or binding interaction of these two regions have significant modulatory effects on ion channel activity, and thus are likely to be useful for treating and/or preventing a wide variety of diseases and pathological conditions associated with ion channel dysfunction. Such conditions include, for example, neurological disorders, cardiac diseases, metabolic diseases, tumor-driven diseases, and autoimmune diseases.Type: ApplicationFiled: January 17, 2002Publication date: April 24, 2003Applicant: American Home Products CorporationInventors: Kathleen H. Young, Kenneth J. Rhodes
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Publication number: 20030065180Abstract: This invention provides compounds of Formula (I), 1Type: ApplicationFiled: March 28, 2001Publication date: April 3, 2003Applicant: American Home Products CorporationInventors: Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
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Publication number: 20030054016Abstract: Methods and compositions for protecting avian hosts (e.g., turkeys and/or chickens) from turkey rhinotracheitis virus and/or TRT or SHS respiratory distress utilize in ovo administration of live, avirulent strains of TRTV at appropriate dosage levels on a per egg basis to provide an effective and efficient vaccination having acceptable safety and efficacy features, and additionally provides higher titers in vaccinated birds than conventionally administered vaccines.Type: ApplicationFiled: November 13, 2001Publication date: March 20, 2003Applicant: American Home Products CorporationInventor: Frans Gerrit Davelaar
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Publication number: 20030045583Abstract: A novel salt of O-desmethyl venlafaxine is provided, O-desmethylvenlafaxine succinate. Pharmaceutical compositions, dosage forms and methods of use are also provided.Type: ApplicationFiled: February 11, 2002Publication date: March 6, 2003Applicant: American Home Products CorporationInventors: Anthony F. Hadfield, Syed M. Shah, Michael W. Winkley, Karen W. Sutherland, James A. Provost, Aeri Park, Rex A. Shipplett, Brenton W. Russell, Beat T. Weber
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Patent number: 6525026Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.Type: GrantFiled: November 16, 2001Date of Patent: February 25, 2003Assignees: Elan Pharmaceuticals, Inc., American Home Products CorporationInventors: Eugene D. Thorsett, Christopher M. Semko, Dimitrios Sarantakis, Michael A. Pleiss, Anthony Kreft, Andrei W. Konradi, Francine S. Grant, Darren B. Dressen, Susan Ashwell, Reinhardt Bernhard Baudy, Louis John Lombardo
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Patent number: 6524592Abstract: The invention relates to vaccines which are suitable for the prevention of clostridial diseases of sheep (and lambs), providing an effective immunity for up to a year or more following a single injection or dose.Type: GrantFiled: May 23, 2000Date of Patent: February 25, 2003Assignee: American Home Products CorporationInventors: Richard Buchta, Christopher Leigh Schwartzkoff, Philip Ralph Lehrbach