Patents Assigned to American Home Products Corporation
  • Publication number: 20020142971
    Abstract: This invention provides tissue selective estrogens of formula I having the structure 1
    Type: Application
    Filed: March 1, 2002
    Publication date: October 3, 2002
    Applicant: American Home Products Corporation
    Inventors: Chris P. Miller, Michael D. Collini, Bach D. Tran, Anita Wai-Yin Chan, Arkadiy Z. Rubezhov
  • Publication number: 20020139012
    Abstract: Methods and compositions for identifying compounds which disrupt the functional interaction of an intracellular receptor region of an &agr;-subunit of a voltage-gated ion channel and an amino-terminal inactivation region of an ion channel protein are disclosed. Compounds that disrupt the functional or binding interaction of these two regions have significant modulatory effects on ion channel activity, and thus are likely to be useful for treating and/or preventing a wide variety of diseases and pathological conditions associated with ion channel dysfunction. Such conditions include, for example, neurological disorders, cardiac diseases, metabolic diseases, tumor-driven diseases, and autoimmune diseases.
    Type: Application
    Filed: January 17, 2002
    Publication date: October 3, 2002
    Applicant: American Home Products Corporation
    Inventors: Kathleen H. Young, Kenneth J. Rhodes
  • Patent number: 6459996
    Abstract: The present invention provides for crystalline GFS. The crystal structure of GFS has also been solved using such material. Models based upon such crystal structure are also provided. Methods of identifying inhibitors of GFS activity using such models are also disclosed.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: October 1, 2002
    Assignee: American Home Products Corporation
    Inventors: William S. Somers, Mark L. Stahl, Francis X. Sullivan
  • Publication number: 20020137049
    Abstract: The present invention relates, at least in part, to polypeptides which include Bcl-xL binding domains, novel Bcl-xL binding domains of Pablo polypeptides, nucleic acid molecules encoding such polypeptides, and uses thereof. For example, such polypeptides and nucleic acid molecules are useful in modulating apoptosis, particularly in neural cells, as well as in the treatment or prevention of disorders that can benefit from modulation of cell death.
    Type: Application
    Filed: May 15, 2001
    Publication date: September 26, 2002
    Applicant: American Home Products Corporation
    Inventors: Robert Mark, Kathleen H. Young, Andrew Wood
  • Publication number: 20020128477
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: December 20, 2001
    Publication date: September 12, 2002
    Applicant: American Home Products Corporation
    Inventors: Ping Zhou, Michael Gerard Kelly, Yanfang Li
  • Publication number: 20020128283
    Abstract: The invention is a process improvement for producing the carbapenem antibacterial agent (4R, 5S, 6S)-3-[[(2R, 3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid by hydrogenation of 4-nitrobenzyl (4R, 5S, 6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3-{[(2R, 3R)-2-({[(2S)-3-methyl-2-({[(4-nitrobenzyl)oxy]carbonyl}amino)butanoyl]amino}methyl)-tetrahydrofuran-3-yl]thio}-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate in a biphasic solvent mixture comprising a water portion and an organic solvent portion, not containing an acid acceptor.
    Type: Application
    Filed: July 9, 2001
    Publication date: September 12, 2002
    Applicant: American Home Products Corporation
    Inventors: Tarek Mansour, Phaik-Eng Sum, Yang-I Lin, Zhong Li
  • Publication number: 20020128261
    Abstract: This invention provides compounds of the formula: 1
    Type: Application
    Filed: November 2, 2001
    Publication date: September 12, 2002
    Applicant: American Home Products Corporation
    Inventors: Annmarie L. Sabb, Robert L. Vogel
  • Publication number: 20020128305
    Abstract: This invention comprises methods of inducing or maintaining sphincter continence, or inhibiting or alleviating incontinence, in a mammal comprising administration of a compound of the formulae I or II: 1
    Type: Application
    Filed: March 1, 2002
    Publication date: September 12, 2002
    Applicant: American Home Products Corporation
    Inventors: Simon Nicholas Jenkins, Timothy Michael Argentieri
  • Patent number: 6444704
    Abstract: Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF-&agr; converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-&agr; from membrane bound TNF-&agr; precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF-&agr; converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: September 3, 2002
    Assignee: American Home Products Corporation
    Inventors: Aranapakam Mudumbai Venkatesan, Janniee Lea Baker
  • Publication number: 20020119966
    Abstract: This invention provides compounds of formula I having the structure 1
    Type: Application
    Filed: November 2, 2001
    Publication date: August 29, 2002
    Applicant: American Home Products Corporation
    Inventors: Annmarie Louise Sabb, Robert Lewis Vogel
  • Patent number: 6441023
    Abstract: Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF-&agr; converting enzyme (TACE), a pro-inflmatory cytokine, catalyzes the formation of TNF-&agr; from membrane bound TNF-&agr; precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states.
    Type: Grant
    Filed: July 3, 2001
    Date of Patent: August 27, 2002
    Assignee: American Home Products Corporation
    Inventors: Aranapakam Mudumbai Venkatesan, Jannie Lea Baker, Jeremy Ian Levin
  • Publication number: 20020115670
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: November 1, 2001
    Publication date: August 22, 2002
    Applicant: American Home Products Corporation
    Inventors: Michael Gerard Kelly, Derek Cecil Cole
  • Patent number: 6436904
    Abstract: Disclosed are compounds which bind VAL-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: August 20, 2002
    Assignees: Elan Pharmaceuticals, Inc., American Home Products Corporation
    Inventors: Susan Ashwell, Reinhardt Bernhard Baudy, Michael A. Pleiss, Dimitrios Sarantakis, Eugene D. Thorsett
  • Publication number: 20020111355
    Abstract: This invention provides compounds of the formula: 1
    Type: Application
    Filed: January 16, 2002
    Publication date: August 15, 2002
    Applicant: American Home Products Corporation
    Inventors: Puwen Zhang, Arthur A. Santilli, Andrew Fensome, Eugene A. Terefenko, Andrew Q. Viet, Jay E. Wrobel, James P. Edwards, Todd K. Jones, Christopher M. Tegley, Lin Zhi
  • Publication number: 20020111379
    Abstract: This invention provides methods for treating, preventing or inhibiting anxiety, anxiety-related conditions and phobias in a mammal using compounds of the formula: 1
    Type: Application
    Filed: December 17, 2001
    Publication date: August 15, 2002
    Applicant: American Home Products Corporation
    Inventors: Mark R. Bowlby, Sharon J. Rosenzweig-Lipson
  • Publication number: 20020111369
    Abstract: This invention provides compounds of formula I having the structure 1
    Type: Application
    Filed: January 10, 2002
    Publication date: August 15, 2002
    Applicant: American Home Products Corporation
    Inventors: Jay E. Wrobel, John F. Rogers, Daniel M. Green, Wenling Kao, James W. Jetter
  • Publication number: 20020107242
    Abstract: This invention provides compounds of the formulae: 1
    Type: Application
    Filed: November 2, 2001
    Publication date: August 8, 2002
    Applicant: American Home Products Corporation
    Inventors: Annmarie L. Sabb, Robert L. Vogel, James A. Nelson, Sharon J. Rosenzweig-Lipson, Gregory S. Welmaker, Joan E. Sabalski
  • Publication number: 20020107254
    Abstract: Novel piperazine derivatives are provided having the formula 1
    Type: Application
    Filed: November 13, 2001
    Publication date: August 8, 2002
    Applicant: American Home Products Corporation
    Inventors: Wayne E. Childers, Michael G. Kelly, Sharon J. Rosenzweig-Lipson
  • Publication number: 20020102552
    Abstract: Regulatory elements responsible for tissue-specific transcriptional regulation of the human &bgr;3-adrenergic receptor (&bgr;3-AR) were identified. A region localized between −6.50 and −6.30 kb of the proximal promoter contained three sequences that act synergistically to achieve full transcriptional activity. One segment, termed segment A, contains an Sp1 binding site. Another of the sequences, termed segment B, is a binding site for a trans-acting factor present in cells that constitutively express &bgr;3-AR. In a specific embodiment, the trans-acting factor is expressed in neuroblastoma (SK-N-MC) and brown adipose tissue cells, but little or not at all in CV-1, HeLa, or white adipose tissue cells. The third segment, C, is an S1 nuclease-sensitive site having CCTT repeats.
    Type: Application
    Filed: January 16, 2001
    Publication date: August 1, 2002
    Applicant: American Home Products Corporation
    Inventors: Vedrana S. Susulic, Emir Duzic
  • Publication number: 20020102645
    Abstract: The present invention relates to a novel lysyl oxidase genes, termed EER-7. The invention relates to the protein and nucleic acids encoding the protein. The invention further relates to an assay system to identify compounds that selectively modulate EER-7 protein activity by interaction with estrogen receptors.
    Type: Application
    Filed: August 8, 2001
    Publication date: August 1, 2002
    Applicant: American Home Products Corporation
    Inventors: Mark J. Evans, Marshall S. Scicchitano, Ashok R. Bapat, Eric Beer, Ramesh A. Bhat, Elissa Ferris, Robert Mastroeni, Jianxiong Zhang, Sotirios K. Karathanasis