Patents Assigned to American Home Products Corporation
  • Publication number: 20020061875
    Abstract: This invention provides a method of providing contraception which comprises administering to a female of child bearing age a combination of a non-uterotrophic anti-estrogen and a progestin for 28 days per 28-day menstrual cycle.
    Type: Application
    Filed: November 21, 2001
    Publication date: May 23, 2002
    Applicant: American Home Products Corporation
    Inventors: Michael J. Gast, Christopher P. Miller
  • Publication number: 20020062022
    Abstract: This invention provides processes for synthesizing compounds of formula I: 1
    Type: Application
    Filed: November 2, 2001
    Publication date: May 23, 2002
    Applicant: American Home Products Corporation
    Inventors: Annmarie L. Sabb, Robert L. Vogel, Madelene M. Antane, Panolil Raveendranath, Sreenivasulu Megati, Michael D. Smith, James A. Nelson
  • Publication number: 20020061900
    Abstract: Antiatherosclerotic compounds are provided which have the following structure: 1
    Type: Application
    Filed: September 28, 2001
    Publication date: May 23, 2002
    Applicant: American Home Products Corporation
    Inventors: Hassan M. Elokdah, Theodore S. Sulkowski, Sie-Yearl Chai, John Babiak
  • Publication number: 20020061905
    Abstract: This invention provides ethers of 7-desmethylrapamycin which are useful in inducing immunosuppression and in the treatment of transplantation rejection, autoimmune diseases, solid tumors, fungal infections, and vascular disease.
    Type: Application
    Filed: September 19, 2001
    Publication date: May 23, 2002
    Applicant: American Home Products Corporation
    Inventors: Tianmin Zhu, Robin Enever
  • Publication number: 20020061903
    Abstract: This invention provides 1-oxorapamycins, which are useful in inducing immunosuppression, as a neurotrophic agent, and in the treatment of transplantation rejection, autoimmune diseases, solid tumors, fungal infections, and vascular disease.
    Type: Application
    Filed: September 18, 2001
    Publication date: May 23, 2002
    Applicant: American Home Products Corporation
    Inventor: Tianmin Zhu
  • Publication number: 20020061883
    Abstract: 1
    Type: Application
    Filed: September 28, 2001
    Publication date: May 23, 2002
    Applicant: American Home Products Corporation
    Inventors: Hassan M. Elokdah, Theodore S. Sulkowski
  • Patent number: 6391897
    Abstract: This invention provides substituted compounds of the general formulae: wherein B and E are C or N; D, G and W are O, S, or N; or salt forms thereof, and methods and pharmaceutical compositions for their use in treating disorders related to insulin resistance or hyperglycemia.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: May 21, 2002
    Assignee: American Home Products Corporation
    Inventors: Michael S. Malamas, Robert E. McDevitt, Folake O. Adebayo
  • Patent number: 6391907
    Abstract: This invention relates to substituted indoline derivative compounds which are antagonists of the progesterone receptor, their preparation and pharmaceutical utility, particularly including contraception and treatment of benign or malignant neoplastic diseases, having the general structure: wherein R1 and R2 may be single substituents or fused to form spirocyclic rings.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: May 21, 2002
    Assignees: American Home Products Corporation, Ligand Pharmaceuticals, Inc.
    Inventors: Andrew Fensome, Lori L. Miller, John W. Ullrich, Reinhold H. W. Bender, Puwen Zhang, Jay E. Wrobel, Lin Zhi, Todd K. Jones, James P. Edwards, Christopher M. Tegley
  • Patent number: 6391902
    Abstract: Compounds of the Formulae (I) and (II): wherein R1, R2, R3, X, Y and Z are as defined in the specification which compounds are useful in the treatment of disorders associated with smooth muscle contraction via potassium channel modulation.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: May 21, 2002
    Assignee: American Home Products Corporation
    Inventors: Schuyler A. Antane, John A. Butera, Joseph R. Lennox
  • Publication number: 20020058267
    Abstract: Novel proteins which bind human &bgr;-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.
    Type: Application
    Filed: May 9, 2001
    Publication date: May 16, 2002
    Applicant: American Home Products Corporation
    Inventors: Bradley A. Ozenberger, Jonathan A. Bard, Eileen M. Kajkowski, Jack S. Jacobsen, Stephen G. Walker, Heidi Sofia, David Howland
  • Publication number: 20020058689
    Abstract: This invention provides processes for preparing compounds formula: 1
    Type: Application
    Filed: November 2, 2001
    Publication date: May 16, 2002
    Applicant: American Home Products Corporation
    Inventors: Gregory S. Welmaker, Joan E. Sabalski, Michael D. Smith
  • Publication number: 20020055630
    Abstract: The present invention provides processes for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b][1, 4]diazepino[6, 7, 1-hi]indole derivatives of the general formula: 1
    Type: Application
    Filed: November 2, 2001
    Publication date: May 9, 2002
    Applicant: American Home Products Corporation
    Inventors: Gregory S. Welmaker, Joan E. Sabalski
  • Publication number: 20020055518
    Abstract: This invention provide pegylated hydroxyesters of rapamycin which are useful in inducing immunosuppression and in the treatment of transplantation rejection, autoimmune diseases, solid tumors, fungal infections, and vascular disease.
    Type: Application
    Filed: September 18, 2001
    Publication date: May 9, 2002
    Applicant: American Home Products Corporation
    Inventors: Tianmin Zhu, Mahdi Fawzi
  • Patent number: 6384058
    Abstract: The present invention relates to novel substituted pyridine compounds of Formula (I) wherein the moiety Z, R1, R2 and R3 are as herein defined, having estrogenic activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, to methods of treatment and to pharmaceutical compositions thereof.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: May 7, 2002
    Assignee: American Home Products Corporation
    Inventors: Chingfan Chiu, Zhilian Tang, John W. Ellingboe
  • Patent number: 6384060
    Abstract: The present invention relates to novel substituted pyridine compounds of Formula (I) wherein the moiety Z, R1, R2 and R3 are as herein defined, having estrogenic activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, to methods of treatment and to pharmaceutical compositions thereof.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: May 7, 2002
    Assignee: American Home Products Corporation
    Inventors: Chingfan Chiu, Zhilian Tang, John W. Ellingboe
  • Patent number: 6384223
    Abstract: This invention provides a process for preparing compounds of formula 1: wherein: X is phenyl optionally substituted with one or more substituents selected from the group consisting of halogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, hydroxy, trifluoromethyl, cyano, nitro, carboxy, carboalkoxy of 2-7 carbon atoms, carboalkyl of 2-7 carbon atoms, amino, and alkanoylamino of 1-6 carbon atoms; R and R1 are each, independently, hydrogen, halogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, hydroxy, or trifluoromethyl; R2 is hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, hydroxy, trifluoromethyl; R3 is independently hydrogen, alkyl of 1-6 carbon atoms, carboxy, carboalkoxy of 1-6 carbon atoms, phenyl, or carboalkyl of 2-7 carbon atoms; n=2-4; or a pharmaceutically acceptable salt thereof, with the proviso that each R3 of Y may be the same or different.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: May 7, 2002
    Assignee: American Home Products Corporation
    Inventor: Constantine Gletsos
  • Patent number: 6383512
    Abstract: Composition comprising lamellar vesicles that comprise a local anesthetic and a nucleic acid molecule are disclosed. Methods of making such compositions are disclosed. Method of delivering proteins to cells of individuals are disclosed. Methods of inducing immune responses in individuals are disclosed. Methods of delivering nucleic acid molecules to cells of individuals are disclosed.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: May 7, 2002
    Assignee: American Home Products Corporation
    Inventors: Richard B. Ciccarelli, C. Satishchandran, Catherine J. Pachuk
  • Patent number: 6384057
    Abstract: The present invention relates to novel substituted pyridine compounds of Formula (I) wherein the moiety Z, R1, R2 and R3 are as herein defined, having estrogenic activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, to methods of treatment and to pharmaceutical compositions thereof.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: May 7, 2002
    Assignee: American Home Products Corporation
    Inventors: Chingfan Chiu, Zhilian Tang, John W. Ellingboe
  • Patent number: 6380178
    Abstract: This invention relates to cyclic combination therapies and regimens utilizing, in combination with progestins, substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general structure: where A and B are independent substituents selected from S, CH or N; provided that when A is S, B is CH or N; and when B is S, A is CH or N; and A and B cannot both be CH; and when A and B both equal N, one N may be optionally substituted with an C1 to C6 alkyl group; R1 and R2 are independent substituents selected from the group of H, C1 to C6 alkyl, substituted C1 to C6 alkyl, C2 to C6 alkenyl, substituted C2 to C6 alkenyl, C2 to C6 alkynyl, substituted C2 to C6 alkynyl, C3 to C8 cycloalkyl, substituted C3 to C8 cycloalkyl, aryl, substituted aryl, heterocyclic, substituted heterocyclic, CORA, or NRBCORA; or R1 and R2 are fused to form optionally substituted 3 to 8 membered spirocyclic alkyl, alkenyl or heterocyclic ring, the heterocyclic ring containing one to
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: April 30, 2002
    Assignees: American Home Products Corporation, Ligand Pharmaceuticals, Inc.
    Inventors: Gary S. Grubb, Arthur A. Santilli, Andrew Q. Viet, Puwen Zhang, Andrew Fensome, Jay E. Wrobel, James P. Edwards, Todd K. Jones, Christopher M. Tegley, Lin Zhi
  • Patent number: D456953
    Type: Grant
    Filed: June 1, 2000
    Date of Patent: May 7, 2002
    Assignee: American Home Products Corporation
    Inventor: Jee Loon Look