Patents Assigned to American Home Products Corporation
  • Publication number: 20030036653
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: March 15, 2002
    Publication date: February 20, 2003
    Applicant: American Home Products Corporation
    Inventors: Jonathan Bloom, Martin DiGrandi, Russell Dushin, Stanley Lang, Bryan O'Hara
  • Publication number: 20030017133
    Abstract: The invention is directed to a topical medicament-containing composition which exhibits excellent bioadhesive properties suitable for application to the human body, including to mucous membranes.
    Type: Application
    Filed: June 17, 2002
    Publication date: January 23, 2003
    Applicant: Wyeth (formerly American Home Products Corporation)
    Inventors: Khawla Abdullah Abu-Izza, Krishna Pattabi Raman, Vincent Hon-Kin Li, Sauwaluzana Tongaree
  • Patent number: 6509334
    Abstract: This invention provides compounds of Formula (I): wherein R1 and R2 may be single substituents or fused to form spirocyclic or hetero-spirocyclic rings; R3 is H, OH, NH2, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C6 alkenyl, substituted C1 to C6 alkenyl, alkynyl, or substituted alkynyl, CORC; RC is H, C1 to C3 alkyl, substituted C1 to C3 alkyl, aryl, substituted aryl, C1 to C3 alkoxy, substituted C1 to C3 alkoxy, C1 to C3 aminoalkyl, or substituted C1 to C3 aminoalkyl; R4 is H, halogen, CN, NO2, C1 to C6 alkyl, substituted C1 to C6 alkyl, alkynyl, or substituted alkynyl, C1 to C6 alkoxy, substituted C1 to C6 alkoxy, amino, C1 to C6 aminoalkyl, or substituted C1 to C6 aminoalkyl; and R5 is selected from a trisubstituted benzene ring of a five or six membered ring with 1, 2, or 3 heteroatoms from the group including O, S, SO, SO2 or NR6 and containing one or two independent substituents from the group including H, halogen, CN, N02, amino, and C1 to C3 alkyl, C1 to C3 alkoxy, C1 to C3 a
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: January 21, 2003
    Assignees: American Home Products Corporation, Ligand Pharmaceuticals, Inc.
    Inventors: Puwen Zhang, Eugene A. Terefenko, Andrew Fensome, Jay E. Wrobel, Horace Fletcher, III, Lin Zhi, Todd K. Jones, James P. Edwards, Christopher M. Tegley
  • Publication number: 20020198213
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: December 20, 2001
    Publication date: December 26, 2002
    Applicant: American Home Products Corporation
    Inventors: Ping Zhou, Derek Cecil Cole, Michael Gerard Kelly, William Joseph Lennox
  • Patent number: 6492372
    Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: December 10, 2002
    Assignees: Elan Pharmaceuticals, Inc., American Home Products Corporation
    Inventors: Andrei W. Konradi, Michael A. Pleiss, Eugene D. Thorsett, Susan Ashwell, Gregory S. Welmaker, Anthony Kreft, Dimitrios Sarantakis, Darren B. Dressen, Francine S. Grant, Christopher Semko, Ying-Zi Xu
  • Publication number: 20020182306
    Abstract: The present invention provides a coating system for solid pharmaceutical dosage units, such as tablets. The coating system comprising (a) a subcoat; (b) an optional colorcoat; and (c) a polish coat. In a preferred embodiment, the present invention provides (a) a subcoat comprising (i) hydroxypropyl methylcellulose (HPMC) and (ii) a polysaccharide; (b) a colorcoat comprising (i) a colorant and (ii) a polysaccharide which may be the same as or different from the polysaccharide of the subcoat; and (c) a polish coat comprising (i) a polyethylene glycol and, optionally, (ii) a wax. Also disclosed is a method for providing gloss to a coated pharmaceutical solid dosage unit by coating a pharmaceutical core with the aforementioned polish coat.
    Type: Application
    Filed: June 12, 2002
    Publication date: December 5, 2002
    Applicant: AMERICAN HOME PRODUCTS CORPORATION
    Inventors: Roger Berlin, Justin Bianco
  • Publication number: 20020183330
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: April 23, 2002
    Publication date: December 5, 2002
    Applicant: American Home Products Corporation
    Inventors: Gary P. Stack, James A. Nelson
  • Publication number: 20020183336
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: April 25, 2002
    Publication date: December 5, 2002
    Applicant: American Home Products Corporation
    Inventors: Gary P. Stack, Adam M. Gilbert, Megan Tran
  • Publication number: 20020177613
    Abstract: 4-Substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones having the Formula (I): 1
    Type: Application
    Filed: March 12, 2002
    Publication date: November 28, 2002
    Applicant: American Home Products Corporation
    Inventors: John Anthony Butera, Joseph Richard Lennox, Douglas John Jenkins
  • Publication number: 20020173486
    Abstract: The present invention relates to a method of increasing the bulk density of chondroitin, such as that derived from marine life, by roller compacting the chondroitin. The roller compacted chondroitin may be incorporated into a solid dosage form. The claimed method may also be applied to chondroitin/glucosamine mixtures.
    Type: Application
    Filed: March 6, 2002
    Publication date: November 21, 2002
    Applicant: American Home Products Corporation
    Inventors: Nkere Kanu Ebube, William Antonio Mark
  • Publication number: 20020169184
    Abstract: Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.
    Type: Application
    Filed: February 23, 2001
    Publication date: November 14, 2002
    Applicant: American Home Products Corporation
    Inventors: Frances Christy Nelson, Arie Zask, James Ming Chen, Dominick Mobilio, Ramaswamy Nilakantan
  • Publication number: 20020161055
    Abstract: This invention provides pharmaceutically active enantiomers of the venlafaxine metabolite O-Desmethyl venlafaxine, R(−)-4-[2-(Dimethylamino-1-(1-hydroxycyclo-hexyl)ethyl]phenol or R(−)1-[2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclo-hexanol, and S(+)-1-[2-(Dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol or S(+)-4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol, or one or more pharmaceutically acceptable salts or salt hydrates thereof, as well as pharmaceutical compositions utilizing these enantiomers and methods of using the enantiomers to treat, inhibit or control central nervous system disorders.
    Type: Application
    Filed: May 23, 2002
    Publication date: October 31, 2002
    Applicant: Wyeth (formerly known as American Home Products Corporation)
    Inventors: John P. Yardley, Andre A. Asselin
  • Publication number: 20020155607
    Abstract: A multifunctional molecular complex for the transfer of a nucleic acid composition to a target cell is provided The complex is comprised of A) said nucleic acid composition and B) a transfer moiety comprising 1) one or more cationic polyamines bound to said nucleic acid composition, 2) one or more endosome membrane disrupting components attached to at least one nitrogen of the polyamine and 3) one or more receptor specific binding components.
    Type: Application
    Filed: November 13, 2001
    Publication date: October 24, 2002
    Applicant: American Home Products Corporation
    Inventor: Raymond H. Boutin
  • Publication number: 20020156075
    Abstract: This invention relates to compounds which have activity as 5-HT1A agonists and antagonists which may be useful for the treatment of anxiety, depression, cognitive deficits, and prostate cancer, having the formula 1
    Type: Application
    Filed: March 27, 2002
    Publication date: October 24, 2002
    Applicant: Wyeth (formerly American Home Products Corporation)
    Inventors: Wayne E. Childers, Michael G. Kelly, Yvette L. Palmer, Edward J. Podlesny
  • Publication number: 20020151548
    Abstract: The present invention provides a new process and intermediates for the production of antiviral compound 4′,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2′-disulfonic acid and its pharmaceutically acceptable salts.
    Type: Application
    Filed: January 31, 2002
    Publication date: October 17, 2002
    Applicant: American Home Products Corporation
    Inventors: Silvio Iera, Christopher A. Demerson, Jacqueline F. Lunetta, Maria Papamichelakis, Michael F. MacEwan, Wayne G. McMahon, John R. Potoski, Arthur G. Mohan
  • Publication number: 20020147178
    Abstract: The 6-(spirocyclopropyl)-penicillanic acid 4,4-dioxides of the general Formula (I): 1
    Type: Application
    Filed: January 26, 2001
    Publication date: October 10, 2002
    Applicant: American Home Products Corporation
    Inventors: Vincent P. Sandanayaka, Amarnauth S. Prashad
  • Publication number: 20020146760
    Abstract: Novel proteins which contain a structural module conserved in the G protein coupled receptor superfamily, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided.
    Type: Application
    Filed: April 12, 2001
    Publication date: October 10, 2002
    Applicant: American Home Products Corporation
    Inventors: Bradley A. Ozenberger, Eileen M. Kajkowski, Ching-Hsiung Frederick Lo, Stephen G. Walker, Heidi Sofia
  • Patent number: 6462073
    Abstract: Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-&agr; from membrane bound TNF-&agr; precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states.
    Type: Grant
    Filed: July 5, 2001
    Date of Patent: October 8, 2002
    Assignee: American Home Products Corporation
    Inventors: Aranapakam Mudumbai Venkatesan, George Theodore Grosu, Jamie Marie Davis, Jannie Lea Baker, Jeremy Ian Levin
  • Publication number: 20020141963
    Abstract: The present invention relates to a method of removing or masking odor associated with chondroitin derived from marine life. The method comprises blending the chondroitin with citric acid, silicon dioxide, and optionally a flavorant to yield a substantially non-malodorous blend.
    Type: Application
    Filed: March 8, 2002
    Publication date: October 3, 2002
    Applicant: American Home Products Corporation
    Inventors: Nkere Kanu Ebube, William Antonio Mark
  • Patent number: D468524
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: January 14, 2003
    Assignee: American Home Products Corporation
    Inventors: Alexander James Sinton, Paul Raymond Finkelston