Abstract: A combination of temsirolimus and trastuzumab in the treatment of cancer is provided. A combination of temsirolimus and HKI-272 is provided. A combination of a trastuzumab and a HKI-272 is also provided. Regimens and kits for treatment of metastatic breast cancer, containing trastuzumab, temsirolimus and/or HKI-272, optionally in combination with other anti-neoplastic agents, or immune modulators are described.

Abstract: A computing system can determine a vehicle action based on inputting vehicle sensor data to a first neural network including a first safety agent that can determine a probability of unsafe vehicle operation. The first neural network can be adapted, at a plurality of times, by a periodically retrained deep reinforcement learning agent that includes a second deep neural network including a second safety agent. A vehicle can be operated based on the vehicle action.

Abstract: This invention is directed to novel aliphatic prolinamide derivatives of Formula I, and pharmaceutically acceptable salts, solvates, solvates of the salt and prodrugs thereof, useful in the prevention (e.g., delaying the onset of or reducing the risk of developing) and treatment (e.g., controlling, alleviating, or slowing the progression of) of age-related macular degeneration (AMD) and related diseases of the eye. These diseases include dry-AMD, wet-AMD, geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells. The invention disclosed herein is further directed to methods of prevention, slowing the progress of, and treatment of dry-AMD, wet-AMD, and geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells, comprising: administration of a therapeutically effective amount of compound of the invention.

Abstract: In various embodiments, methods, systems, and vehicles are provided that include obtaining first camera images from a first camera onboard a first vehicle; generating, via one or more computer processors, a first situation awareness graph with respect to objects near the first vehicle, using the first camera images; obtaining second camera images from a second camera of a second device that is in proximity to the first vehicle; generating, via one or more computer processors, a second situation awareness graph with the respect to the objects, using the second camera images; and generating, via one or more computer processor, a global situation awareness graph with respect to the objects, by merging the first situation awareness graph with the second situation awareness graph, using respective first and second weights for the first and second situation awareness graphs.

Abstract: A device is provided that includes (a) an antenna that includes at least one conductor, (b) a housing that includes an inner-upper surface and an inner-lower surface separated by a first distance, (c) a battery disposed within the housing, where a base surface of the battery is proximate to the inner-lower surface of the housing, where a first portion of the battery has a height, which is substantially equal to the first distance, and where a second portion of the battery is of lesser height than the first portion of the battery such that space exists between the second portion of the battery and the inner-upper surface of the housing, and (d) where the one conductor is arranged over the second portion of the battery in the space, such that the one conductor and the battery do not contact one another, and where, as arranged, the antenna is capable of a far-field communication.

Abstract: A heat pipe assembly of a nuclear apparatus includes a number of elongated heat pipes and a detection system having one or more fiber optic cable assemblies that are elongated and are wrapped in a helical fashion along an exterior surface of one or more of the heat pipes. The detection system further includes an optical signal generator that supplies to each, fiber optic assembly an optical signal and additionally includes a sensor that detects a number of reflections of the optical signal and generates an output. The output is usable by an instrumentation and control system to determine a number of temperatures along one or more of the heat tubes by detecting a temperature at each of a plurality of locations along each fiber optic cable assembly.

Abstract: The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.

Abstract: Compressed domain processors configured to perform operations on data compressed in a format that preserves order. The Compressed domain processors may include operations such as addition, subtraction, multiplication, division, sorting, and searching. In some cases, compression engines for compressing the data into the desired formats are provided.

Abstract: An agricultural implement includes a main frame assembly, a track assembly coupled to the main frame assembly, and a toolbar coupled to the main frame assembly. Furthermore, the agricultural implement includes a caster wheel assembly including a linkage assembly coupled to the toolbar, an actuator, and a caster wheel. The caster wheel is pivotally coupled to the linkage assembly to enable the caster wheel to caster relative to the linkage assembly while the toolbar is in a working position and in a raised position. In addition, the actuator is configured to control a vertical position of the caster wheel relative to the toolbar. The actuator has a first end and a second end, and the second end is positioned between a bottom link and a top link of the linkage assembly.

Abstract: Polyurethane foams including a polyurethane prepolymer composition, a catalyst, and a propellant are provided. The polyurethane prepolymer composition is produced from a formulation that includes an isocyanate reactive component in an amount of from about 1% to about 70% by weight based on the polyurethane prepolymer composition and an isocyanate component in an amount of from about 1% to about 70% by weight based on the polyurethane prepolymer composition. The isocyanate component includes toluene diisocyanate biuret in an amount of from about 1 to about 100% by weight based on the isocyanate component. The isocyanate reactive component includes one or more polyols. The polyurethane prepolymer composition has a viscosity of less than about 10,000 mPa*s at 50° C. and is substantially free of monofunctional reactive components. The polyurethane prepolymer composition also includes a free isocyanate monomer content of the toluene diisocyanate biuret of less than about 1% by weight.

Abstract: Disclosed is a method of matching job seekers with job providers. The method may include receiving a plurality of job seeker values and a plurality of job provider values corresponding to at least one attribute. The method may further include receiving a job seeker priority associated with a job seeker value. Furthermore, the method may include receiving a job provider priority associated with a job provider value. Subsequently, matching between job seekers and job providers may be performed based on comparison between job seeker values and job provider values. Additionally, the matching may be based on a comparison of job provider priority and job seeker priority.

Abstract: Described are seat backs (102) for aircraft passenger seats (100). Such a seat back (102) can include a unitary structural core (112) formed as a single piece that includes a body (138) and a flange (140). The body (138) and the flange (140) can each include carbon fiber composite material. The flange (140) can include portions extending from the rearward-facing side (132) of the body respectively along a left lateral side edge, a top (134) side edge, and a right lateral side edge of the unitary structural core (112). The flange (140) can be non-tubular.

Abstract: Wireless systems and methods are disclosed for establishing a continuous real-time data link communicating flight data of a small UAV to a first smart device over a wireless network. An airborne wireless sensor system is adapted to be removably attached to the UAV. The airborne wireless sensor system has a sensor module for sensing UAV flight data, a communication module for establishing the wireless data-link network and transmitting the sensed UAV flight data the smart device. The smart device may have a software application which permits the user to define data formats for display which may them be communicated to the airborne sensor system to use in building the data pages transmitted to the smart device. Smart devices such as smart phones, smart watches, tablet computers and the like are contemplated to be used.

Abstract: A three-dimensional semiconductor device includes bit lines formed in the lower-interconnect-level dielectric material layers located over a substrate, bit-line-connection via structures contacting a respective one of the bit lines, pillar-shaped drain regions contacting a respective one of the bit-line-connection via structures, an alternating stack of insulating layers and electrically conductive layers located over the pillar-shaped drain regions, and memory stack structures extending through the alternating stack. A source layer overlies the alternating stack, and is electrically connected to an upper end of each vertical semiconductor channel within a subset of the vertical semiconductor channels. Vertical bit line interconnections structures extending through the levels of the alternating stack may be eliminated by forming the bit lines underneath the alternating stack, and the footprint of the layout of the three-dimensional memory device may be reduced.

Abstract: A variable refrigerant package air conditioner is shown that is easy to install in new construction with a unique base that causes collected mixture that overflows to drain outside the building. A control system is shown that has motors and compressor that are pulse width modulated so the air conditioner is infinitely variable while maintaining the highest possible power factor. Dehumidification of outside air occurs as it is mixed with inside air. By gradually approaching a temperature set point and even reheating after dehumidification, moisture is removed from the room.

Abstract: A crisscross thermoforming assist plug assembly having a pair of oppositely outwardly facing thermoforming assist plugs each carried by a respective one of a pair of thermoforming assist plug linkage arrangements, where at least one link of the linkage arrangement is used to extend one of the assist plugs in one direction crosses but does not contact in a side view or profile of the thermoforming assist plug assembly, and at least one link of the other linkage arrangement is used to extend the other one of the assist plugs in an opposite direction. The links of the linkage arrangement preferably pivot about a common pivot axis that preferably is an elongate pivot shaft extending transversely between elongate upper rails of a frame of the assembly. At least one of the links of the linkage arrangement is a drive link that extends or retracts one of the plugs that crosses a drive link that extends and/or retracts the other one of the plugs.

Abstract: A material includes a base polymer, cellulose fibers dispersed through the base polymer, a pigment coloring the base polymer and the cellulose fibers, and a sealant selected from epoxidized soybean oil and polyolefin. The sealant coats and seals the cellulose fibers.

Abstract: A magazine loader include a main body, a rounds recess, and a magazine recess. A plurality of rounds are provided to the rounds recess and positionally maintained by a rounds recess bottom, first and second rounds recess ledges, and first and second rounds recess sides. With a magazine positioned within the magazine recess and the rounds within the rounds recess, as the rounds are slidably moved towards the magazine recess, pivot points of each round successively abuts a downwardly angled portion of the second rounds recess side and pivots to angle a second round end of each round towards the magazine and over another downwardly angled portion of the first rounds recess side, so that each round successively enters the magazine.