Abstract: The invention relates to the field of pharmaceutical formulations. More particularly it is directed to freeze-dried formulations of Fibroblast Growth Factor 18 (FGF-18) compound and to methods of producing such formulations. The freeze-dried formulations according to the invention are stable upon storage for an appropriate period of time. They can be used, after reconstitution, for the treatment of cartilage disorders such as osteoarthritis or cartilage injury.
Abstract: The present invention relates to a method for separating and preparing a TNFR-Fc fusion protein using hydrophobic interaction chromatography (HIC). More particularly, the present invention relates to a method for separating and preparing a highly pure active protein from clipped proteins due to displacement effect by adjusting the conductivity of a protein sample using a high concentration of salt solution and by adjusting a loading amount thereof, and a TNFR-Fc fusion protein prepared by the method.
Type:
Grant
Filed:
August 17, 2012
Date of Patent:
March 8, 2016
Assignee:
ARES TRADING S.A.
Inventors:
Hye Soon Won, Byung Je Sung, Yong Ho Ahn, Sang Kyung Park
Abstract: The present invention pertains to interferon-beta (IFN-beta) compositions comprising interferon-beta and a grafted poly(glutamic acid) polymer having an average molecular weight between 26,000 and 40,000 g/mol, grafted with alpha-tocopherol substituents, the average molar grafting ratio being 4.5-5.5 moles %, the weight/weight ratio between said grafted poly(glutamic acid) polymer and IFN-beta being between 24 and 125. The present invention also pertains to the preparation methods of such compositions and their application to obtain therapeutic compositions in dosage unit form delivering IFN-beta over an extended period of time.
Type:
Grant
Filed:
May 16, 2012
Date of Patent:
March 1, 2016
Assignee:
ARES TRADING S.A.
Inventors:
Daniel Leblanc, Evert Nicolaas Lamme, Helen Gabriela Baldascini, Joel Richard, Frederic Checot, You-Ping Chan, Roger Kravtzoff, Gauthier Pouliquen
Abstract: The invention relates to novel combination therapies involving BLyS or BLyS/APRIL inhibition and anti-CD20 agents for the treatment of autoimmune diseases. One preferred method is where the BLyS antagonist is a Fc-fusion protein which can be a TACI-Fc-fusion protein comprising the extracellular domain of TACI or a functional fragment thereof, a BAFF-R-Fc-fusion protein comprising the extracellular domain of BAFF-R or a functional fragment thereof, or a BCMA-Fc-fusion protein comprising the extracellular domain of BCMA or a functional fragment thereof. In the methods of the present invention some of anti-CD20 agents contemplated include RITUXAN®, ocrelizumab, ofatumumab (HuMax-CD20®), TRU-015, and DXL625, although any agent that binds to CD 20 may be suitable. The methods of the present invention reduce the levels of B cells in patients in need of such reduction, such as those suffering from autoimmune diseases.
Type:
Application
Filed:
January 12, 2015
Publication date:
February 25, 2016
Applicants:
ARES TRADING S.A., ZYMOGENETICS, INC.
Inventors:
Rafael A. Ponce, JR., Herve Broly, Hans Otto Lennart Graffner, Sergio Peano
Abstract: The present invention relates to the use of genetic markers to identify the response to growth hormone treatment in Growth Hormone Deficiency (GHD) or Turner Syndrome (TS) patients as well as a method of treating GHD or TS patients and kits for genotyping.
Type:
Grant
Filed:
May 10, 2012
Date of Patent:
December 8, 2015
Assignee:
ARES TRADING S.A.
Inventors:
Pascal Croteau, Benoit Destenaves, Clement Olivier, John Raelson
Abstract: The present invention refers to the use of N-acetyl-5-methoxytryptamine (melatonin) and/or an analogue thereof, for use in the medical or veterinary field in the assisted reproduction for promoting the mechanism of implantation of the embryo, and in particular for the prevention of implantation failure into the uterus, by topical administration of an effective amount in a mammalian subject female in need of such treatment, and related compositions, culture media and medical devices.
Abstract: The invention relates to pharmaceutical compositions comprising PPAR agonists and Nrf2 activators and methods of using combinations of PPAR agonists and Nrf2 activators for treating diseases such as psoriasis, asthma, multiple sclerosis, inflammatory bowel disease, and arthritis.
Abstract: The invention relates to a stable, pharmaceutically acceptable, aqueous formulation of TNF-binding protein, comprising a TNF-binding protein, a buffer and an isotonicity agent.
Type:
Application
Filed:
December 15, 2014
Publication date:
April 9, 2015
Applicant:
ARES TRADING S.A.
Inventors:
Fabrizio Samaritani, Alessandra Del Rio, Rita Agostinetto
Abstract: An injection device for injecting medication to a patient, comprising a surface (5) having a through hole (3) for passage of a needle, is characterised by further comprising a capacitive proximity sensor (12, 13, 30) for detecting proximity or contact of human skin to/with said surface (5).
Type:
Grant
Filed:
November 30, 2011
Date of Patent:
April 7, 2015
Assignee:
Ares Trading S.A.
Inventors:
Gerhard Lauchard, Martin Reindl, Claudia-Carolin Guggenberger
Abstract: The present invention relates to a process for the production of interferon beta, and to an interferon beta composition having a unique glycosylation pattern.
Type:
Grant
Filed:
June 14, 2011
Date of Patent:
March 31, 2015
Assignee:
Ares Trading S.A.
Inventors:
Dina Fischer, Alain Bernard, Paul Ducommun, Mara Rossi
Abstract: The invention relates to novel combination therapies involving BLyS or BLyS/APRIL inhibition and anti-CD20 agents for the treatment of autoimmune diseases. One preferred method is where the BLyS antagonist is a Fc-fusion protein which can be a TACI-Fc-fusion protein comprising the extracellular domain of TACI or a functional fragment thereof, a BAFF—R-Fc-fusion protein comprising the extracellular domain of BAFF—R or a functional fragment thereof, or a BCMA-Fc-fusion protein comprising the extracellular domain of BCMA or a functional fragment thereof. In the methods of the present invention some of anti-CD20 agents contemplated include RITUXAN®, (rituximab),ocrelizumab, ofatumumab (HuMax-CD20®), TRU-015, and DXL625, although any agent that binds to CD 20 may be suitable. The methods of the present invention reduce the levels of B cells in patients in need of such reduction, such as those suffering from autoimmune diseases.
Type:
Grant
Filed:
October 16, 2008
Date of Patent:
February 17, 2015
Assignees:
ZymoGenetics, Inc., Ares Trading S.A.
Inventors:
Rafael A. Ponce, Jr., Sergio Peano, Herve Broly, Hans Otto Lennart Graffner
Abstract: The invention relates to a stable, pharmaceutically acceptable, aqueous formulation of TNF-binding protein, comprising a TNF-binding protein, a buffer and an isotonicity agent.
Type:
Grant
Filed:
February 11, 2004
Date of Patent:
January 20, 2015
Assignee:
Ares Trading S.A.
Inventors:
Fabrizio Samaritani, Alessandra Del Rio, Rita Agostinetto