Patents Assigned to Arizona Board of Regents
  • Vertical flow molecular assay apparatus
    Patent number: 11860160
    Abstract: Provided are vertical flow detection devices and related methods. The devices may comprise a membrane having a first surface and a second surface with a plurality of porous structures extending between the first and second surfaces to form fluid conduits from a first fluid chamber formed by the first surface and a second fluid chamber formed by the second fluid surface. A capture agent is immobilized on and/or in the membrane. A rigid porous membrane support mechanically supports the membrane and to provide a relatively uniform flow across the membrane. Various gaskets or holder elements are positioned around an outer edge of the membrane to prevent fluid leakage around the membrane. A fluid pump is configured to force a fluid sample flow in a direction from the first fluid chamber to the second fluid chamber.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: January 2, 2024
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Frederic Zenhausern, Peng Chen, Jian Gu, Jerome Lacombe
  • Vaccine for prevention of necrotic enteritis in poultry
    Patent number: 11857613
    Abstract: In certain embodiments, the present invention provides a poultry vaccine comprising an antigenic protein comprising a PlcC protein unit that is operably linked to a peptide linker that is operably linked to a NetB protein unit, where the vaccine is effective in stimulating a protective cellular and/or humoral immune response to C. perfringens. Methods are also provided for making the vaccine and for vaccinating poultry by administering such a vaccine.
    Type: Grant
    Filed: December 27, 2022
    Date of Patent: January 2, 2024
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF ARIZONA STATE UNIVERSITY
    Inventors: Kenneth Roland, Andrew Diamos, Hugh Mason
  • MRI streak-artifact suppression, system and method
    Patent number: 11860256
    Abstract: A method for producing a streak-suppressed MR image of a subject includes (i) generating an interference correlation matrix from M coil images, (ii) producing eigenvectors of the interference correlation matrix, and (iii) determining, from the subspace-eigenvectors, a projection matrix of the interference null space. The subspace-eigenvectors include a plurality of subspace-eigenvectors that span an interference subspace and a plurality of null-space-eigenvectors that span an interference null space.
    Type: Grant
    Filed: April 19, 2022
    Date of Patent: January 2, 2024
    Assignee: Arizona Board of Regents on Behalf of The University of Arizona
    Inventors: Zhiyang Fu, Maria I. Altbach, Ali Bilgin
  • PASSIVE WIRELESS MULTI-CHANNEL IMPLANTABLE DEVICE
    Publication number: 20230414954
    Abstract: A wireless multi-channel implantable device. In some embodiments, the system includes: a wireless reception element, for receiving power wirelessly through tissue of a subject; a power management and storage circuit, for storing a portion of the received power; and a control circuit for controlling the delivery of current from the power management and storage circuit to each of a plurality of stimulation electrodes individually, based on a modulation of the received power.
    Type: Application
    Filed: June 27, 2023
    Publication date: December 28, 2023
    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Jennifer BLAIN CHRISTEN, Shiyi LIU, Ahmed Abed BENBUK, Daniel GULICK
  • ENCAPSULATION DEVICE SYSTEMS WITH OXYGEN SENSORS WITH OR WITHOUT EXOGENOUS OXYGEN DELIVERY
    Publication number: 20230414134
    Abstract: An encapsulation device system for therapeutic applications such as but not limited to regulating blood glucose. The system may comprise an encapsulation device with a first oxygen sensor integrated inside the device and a second oxygen sensor disposed on an outer surface of the device, wherein the sensors allow for real-time measurements (such as oxygen levels) related to cells (e.g., islet cells, stem cell derived beta cells, etc.) housed in the encapsulation device. The system may also feature an exogenous oxygen delivery system operatively connected to the encapsulation device via a channel, wherein the exogenous oxygen delivery system is adapted to deliver oxygen to the encapsulation device.
    Type: Application
    Filed: July 24, 2023
    Publication date: December 28, 2023
    Applicant: Arizona Board of Regents on Behalf of the University of Arizona
    Inventor: Klearchos K. Papas
  • DNA methylation biomarkers for cancer diagnosing
    Patent number: 11851711
    Abstract: Cancer specific DNA methylation regions have been studied to find cancer specific DNA methylation markers for most common cancers. Differentially methylated regions for individual cancer types were identified and those were further filtered against data from normal tissues to obtain marker regions with cancer specific methylation, resulting in total of 1,250 hypermethylated and 584 hypomethylated marker CpGs. Optimal sets of six markers for each TCGA cancer type that could identify most tumors with high specificity and sensitivity (AUC 0.969-1.00) were chosen from hypermethylated markers and a universal 12 marker set that can detect tumors of all 33 TCGA cancer types (AUC>0.84) was also chosen from hypermethylated markers.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: December 26, 2023
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Lukas Vrba, Bernard W. Futscher
  • Emitters based on octahedral metal complexes
    Patent number: 11856840
    Abstract: Iridium, rhodium, and platinum complexes suitable for use as phosphorescent emitters or as delayed fluorescent and phosphorescent emitters having the following structures:
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: December 26, 2023
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Jian Li, Guijie Li
  • METHODS AND RELATED ASPECTS FOR ANALYZING EXOSOMES
    Publication number: 20230408409
    Abstract: Provided herein are methods of detecting exosomes, including unlabeled exosomes. In some embodiments, the methods include disposing a fluidic sample that comprises a plurality of exosomes in a chamber that is positioned at least partially within a fluidic device in which an inner surface of the chamber comprises a first set of exosome binding moieties that are capable of binding the exosomes. In some embodiments, the methods also include binding a portion of the plurality of exosomes to a portion of the first set of exosome binding moieties to produce surface-bound exosomes, introducing an incident light toward the inner surface of the chamber prior to, concurrent with, and/or after, producing the surface-bound exosomes, and detecting light scattered by the surface-bound exosomes to produce a set of exosome imaging data. Related fluidic devices, systems, and computer readable media are also provided.
    Type: Application
    Filed: June 1, 2023
    Publication date: December 21, 2023
    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Shaopeng WANG, Pengfei ZHANG
  • DIRECT METAL PRINTING WITH STEREOLITHOGRAPHY
    Publication number: 20230405918
    Abstract: An additive manufacturing process for forming a metallic layer on the surface of the substrate includes fabricating a substrate from a polymerizable composition by a stereolithographic process, and contacting the reactive surface with an aqueous solution including a metal precursor. The metal precursor includes a metal, and the polymerizable composition includes a multiplicity of multifunctional components. Each multifunctional component includes a reactive moiety extending from a surface of the substrate to form a reactive surface. An interface between the reactive surface and the aqueous solution is selectively irradiated to form nanoparticles including the metal in a desired pattern. The nanoparticles are chemically coupled to the reactive surface by reactive moieties, thereby forming a metallic layer on the surface of the substrate.
    Type: Application
    Filed: July 27, 2023
    Publication date: December 21, 2023
    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Zhi Zhao, Chao Wang, Yu Yao
  • Enhanced water electrolysis with protic co-catalysts
    Patent number: 11846032
    Abstract: Catalyst systems employing inexpensive and readily-available protic co-catalysts to increase a proton reduction rate in a hydrogen evolution reaction (HER) are described herein. The protic co-catalysts function to increase the rate without being consumed in the process of water splitting to hydrogen and oxygen. They may simultaneously serve to stabilize the pH of the water and be the electrolyte to carry the current for the electrolytic splitting of water. The protic co-catalysts also decrease the overpotential energy requirement for the process of water splitting. These protic co-catalysts can be used with both heterogeneous and homogenous catalysts, as well as assist photocatalysis and other processes for the reduction of protons.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: December 19, 2023
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Dennis Lichtenberger, Richard S. Glass, Dong-Chul Pyun, William Brezinski, Kayla Clary, Metin Karayilan
  • Compositions and methods for augmenting the nasal microbiome
    Patent number: 11844816
    Abstract: Embodiments of the invention provide a method of reducing colonization of a subject's anterior nares and/or nasal cavity by a microorganism (e.g., Staphylococcus aureus). In some aspects, the method may include administering a pharmaceutical composition to the subject, wherein the pharmaceutical composition comprises a therapeutically effective amount of at least one probiotic.
    Type: Grant
    Filed: July 20, 2022
    Date of Patent: December 19, 2023
    Assignees: The Translational Genomics Research Institute, Arizona Board of Regents on behalf of Northern Arizona University
    Inventors: Cindy Liu, Lance B. Price
  • Kinematic optical mount with stabilizing locking clamp
    Patent number: 11846828
    Abstract: A stabilizing locking clamp for a kinematic optical mount includes a clamp plate configured for optical access and a plurality of clamp actuators affixed to the clamp plate. The clamp actuators are positioned such that each clamp actuator exerts a force on a front plate of the kinematic optical mount in a push-push configuration. A stabilizing kinematic optical mount includes a kinematic optical mount and a plurality of clamp arms, each clamp arm including a clamp actuator positioned to exert a force on a front plate of the kinematic optical mount in a push-push configuration. The stabilizing locking clamp and stabilizing kinematic optical mount reduce temperature-dependent and vibration-induced changes in pitch and yaw, thereby improving pointing stability for optical setups that rely on critical beam alignment.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: December 19, 2023
    Assignee: Arizona Board of Regents on Behalf of The University of Arizona
    Inventors: Laird M. Close, Maggie Y. Kautz
  • SYSTEMS AND METHODS FOR A FULL-STACK OBFUSCATION FRAMEWORK TO MITIGATE NEURAL NETWORK ARCHITECTURE THEFT
    Publication number: 20230401422
    Abstract: A full-stack neural network obfuscation framework obfuscates a neural network architecture while preserving its functionality with very limited performance overhead. The framework includes obfuscating parameters or “knobs”, including layer branching, layer widening, selective fusion and schedule pruning, that increase the number of operators, reduce/increase the latency, and number of cache and DRAM accesses. In addition, a genetic algorithm-based approach is adopted to orchestrate the combination of obfuscating knobs to achieve the best obfuscating effect on the layer sequence and dimension parameters so that the architecture information cannot be successfully extracted.
    Type: Application
    Filed: June 9, 2023
    Publication date: December 14, 2023
    Applicant: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Jingtao Li, Chaitali Chakrabarti, Deliang Fan, Adnan Siraj Rakin
  • Methods for detection and quantification of infectious carbapenem resistant enterobacteriaceae (CRE)
    Patent number: 11840723
    Abstract: Provided herein are qPCR-based methods for quantitatively detecting and differentiating between live and dead pathogenic bacteria such as carbapenem-resistant Enterobacteriaceae (CRE). Also provided herein are simple, fast, and reliable genomic DNA extraction methods with improved efficiency.
    Type: Grant
    Filed: June 11, 2021
    Date of Patent: December 12, 2023
    Assignees: Arizona Board of Regents on behalf of Arizona State University, Mayo Foundation for Medical Education and Research
    Inventors: Joshua LaBaer, Vel Murugan, Merica Vorachitti, Rahul Pannala, Douglas Faigel
  • Depolymerization of recovered plastic materials
    Patent number: 11840667
    Abstract: Described herein are systems and methods for the depolymerization of polyethylene-based plastics. In one embodiment, a method is disclosed that comprises combining a polyethylene-based plastic with a solvent in a reactor to generate a plastic solvent mixture, heating the plastic solvent mixture in the reactor, and fractionating the plastic solvent mixture into a gas phase product, a solid phase product, and a liquid phase product. In another embodiment, a system is disclosed that comprises a solvent, and a reactor configured to receive the polyethylene-based plastic and the solvent and convert the polyethylene-based plastic into a gas phase product, a solid phase product, and a liquid phase product, the reactor being configured to operate at a temperature greater than 275° C. and at a pressure greater than 2 megapascals.
    Type: Grant
    Filed: July 7, 2022
    Date of Patent: December 12, 2023
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Shuguang Deng, Yixin Liu, Kapil Chandra Akula, Kodanda Phani Raj Dandamudi
  • Compositions comprising recombinant probiotic bacteria and methods of use thereof
    Patent number: 11839649
    Abstract: The invention features probiotic bacteria expressing Clostridium difficile SlpA, or fragment thereof, and its use for the treatment or prevention of Clostridium difficile infection and gut colonization.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: December 12, 2023
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Gayatri Vedantam, Virinchipuram K. Viswanathan, Michael Mallozzi
  • Autonomous solar field and receiver inspections based on polarimetric-enhanced imaging
    Patent number: 11843350
    Abstract: Provided herein are systems and related methods of performing solar field and receiver inspections based on polarimetric-enhanced imaging.
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: December 12, 2023
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Yu Yao, Chao Wang, Julius Yellowhair, Jing Bai, Jiawei Zuo
  • SYSTEMS AND METHODS FOR A SYNTHETIC INFRASTRUCTURE MODEL FOR VULNERABILITY, FAILURE, AND FUTURE TRANSITION PLANNING
    Publication number: 20230394192
    Abstract: A computer-implemented SynF (Synthetic Infrastructure) model is designed to estimate the location and characteristics of urban water and power distribution networks, estimate how those networks are interconnected and connect to buildings and transportation systems, and assess how failures propagate within and across the systems. The model was designed using Phoenix metro area cities but has been extended to other cities.
    Type: Application
    Filed: June 2, 2023
    Publication date: December 7, 2023
    Applicant: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Mikhail Chester, SK Nasir Ahmad, Nathan Johnson, Ryan Hoff
  • SYSTEMS AND METHODS FOR GENERATING LIQUID WATER FROM AIR
    Publication number: 20230390696
    Abstract: This disclosure includes systems and methods for extracting water vapor from atmospheric air and, more particularly, but not by way of limitation, systems and methods for optimizing liquid water production from air, in some instances, taking into account diurnal variations. The systems comprise an adsorption zone and a desorption zone, an actuator to move a desiccant between the adsorption zone and the desorption zone. The liquid water production is optimized based, at least in part, on measurements of one or more of: an ambient air temperature, ambient air relative humidity, and a level of solar insolation.
    Type: Application
    Filed: June 6, 2023
    Publication date: December 7, 2023
    Applicant: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Cody Friesen, Elise Switzer, Heath Lorzel
  • MODIFIED GUAYULE RESIN/SOY PROTEIN BLENDS FOR BIO-BASED ADHESIVES, ASSOCIATED METHODS FOR FORMING SAME, AND ASSOCIATED STRUCTURES INCLUDING SUCH ADHESIVES
    Publication number: 20230392054
    Abstract: An adhesive composition for use in coupling together two substrates to form a structure, such as for use in coupling together two wooden substrates to form a wooden structure, includes a mixture of a modified guayule resin and soy protein. The modified guayule resin can be a base-solvent modified guayule resin or can be an HiCh-modified guayule resin each respectively formed from an unmodified guayule base resin. The unmodified guayule base resin is obtained in a rubber extraction process of guayule at solvent removal temperatures ranging from 104 to 166 degrees Celsius. The method for forming the adhesive composition includes forming a modified guayule resin and mixing the formed modified guayule resin with soy protein. The adhesive composition, when used in forming structures, provides enhanced wet shear strength as compared with adhesive compositions including soy protein alone.
    Type: Application
    Filed: October 13, 2021
    Publication date: December 7, 2023
    Applicant: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Kimberly Ogden, Sarocha Pradyawong