Abstract: The present disclosure is directed to systems and methods of forming a modular footwear sole. The modular sole includes a midsole layer having a first attachment fixture disposed on at least a portion of the lower surface of the midsole layer. A heel member includes a deformable heel layer that includes a plurality of deformable elements having the same or different mechanical properties. The heel member includes a second attachment fixture that couples to the first attachment fixture. An outsole member includes a deformable outsole layer that includes a plurality of deformable elements having the same or different mechanical properties. The outsole member includes a third attachment fixture that couples to the first attachment fixture. The deformable elements may be selected based on a user's foot pressure map.

Abstract: Provided herein are methods of detecting and measuring disease-associated analytes such as proteins and antibodies in a sweat sample. Also provided are methods of determining and monitoring the disease state or physiological condition of a subject using small sweat samples.

Abstract: A method for deep learning video microscopy-based antimicrobial susceptibility testing of a bacterial strain in a sample by acquiring image sequences of individual bacterial cells of the bacterial strain in a subject sample before, during, and after exposure to each antibiotic at different concentrations. The image sequences are compressed into static images while preserving essential phenotypic features. Data representing the static images is input into a pre-trained deep learning (DL) model which generates output data; and antimicrobial susceptibility for the bacterial strain is determined from the output data.

Abstract: This invention is in the field of medicinal chemistry and relates to a new class of small-molecules having a pyrazolopyridine (or similar) structure (e.g., Formula I) which function as inhibitors of the viral protein 2C protein activity and/or expression, and which function as therapeutics for the treatment of viral infection characterized with viral protein 2C activity and/or expression (e.g., non-polio enterovirus infection) (e.g., enterovirus D68 (EV-D68) infection, enterovirus A71 (EV-A71) infection, and coxsackievirus B3 (CVB3) infection.

Abstract: Platinum complexes suitable for use as phosphorescent emitters or as delayed fluorescent and phosphorescent emitters having the following structure:

Abstract: Disclosed herein are methods for treating or limiting development of cardiovascular disease-related neurological disorders by administering a compound of general formula (I), as defined herein.

Abstract: Various embodiments of a system and associated method for determining a volume of surgical freedom using a plurality of three-dimensional extrema points along a surgical corridor in relation to a structure of interest are disclosed herein.

Abstract: Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical polymeric materials or ocular tissues is performed to address various types of vision correction, and the laser induced changes to the refractive index avoid ablation and removal of the optical polymer materials while minimizing scattering losses.

Abstract: Methods and systems for measuring viability and function of islet cells or stem cell-derived beta cells in an implantable device featuring setting the temperature of the cells in the implantable device to a low temperature to reduce metabolic levels of the cells and reduce oxygen requirements of the cells, and measuring oxygen consumption rates. An oxygen sensor at the inlet of the implantable device and an oxygen sensor at the outlet of the implantable device are used to calculate oxygen consumption rates of the cells, which in turn are indicative of viability. The reduction in temperature can also be used for loading cells into the implantable devices to help reduce ischemic and/or physical injury. The present invention may be used with other cell types, e.g. hepatocytes, heart cells, muscle cells, etc.

Abstract: The operational characteristics of a cyber-physical system (CPS) may deviate from the certified system due to intended (in case of cheating) or unintended (wear and tear) reasons. A computer-implemented certification system makes test case search aware of the multidimensional interactions between the cyber and physical subsystems and addresses practical dynamical system problems like Zeno behavior and dynamical model divergence. The system dynamically modulates an input search space by predicting and limiting input variations that can potentially cause divergence or Zeno behavior.

Abstract: A particleboard includes a fiber component and an adhesive composition including a mixture of a modified guayule resin and soy protein. The modified guayule resin can be a base-solvent modified guayule resin or an H2O2-modified guayule resin. The fiber component can be a natural fiber such as a natural fiber selected from guayule bagasse, wood chips, wood particles, wood waste straw, wood fiber, and any combination thereof. The particleboard is formed by mixing the adhesive composition with the fiber component, introducing the mixture to a press, and pressing the mixture in the press.

Abstract: A device for neurostimulation having an extendable headband having first and second arms each having a proximal end and a distal end, the two arms connected to one another at the proximal ends via an extension mechanism, an electrode band having first and second ends, the first end rotatably connected to a point on the first arm, and the second end rotatably connected to a point on the second arm, and first and second electrodes slidably positioned on the electrode band configured to deliver neurostimulation to a subject. A method of encouraging a behavior of a subject, for example physical activity, is also described.

Abstract: Many biologic processes taking place inside a living organism are unpredictable in time and space, and cannot be known exactly. These mechanisms and interactions among them are better modeled as physiological random processes, the statistics of which are fully described by joint characteristic functionals. The present invention provides methods for the estimation of joint characteristic functionals through imaging of multiple physiological random processes. This technology can be used to study complex diseases, such as tumors and viral infections, by imaging the biological processes involved with disease progression and response to treatment.

Abstract: Adhering to the objective of modelling and selecting the most optimal winding configuration for a high frequency planar transformer (HFPT) for auxiliary charging systems for more electric aircrafts (MEA) this disclosure elucidates numerous fabrication and design-based constraints and correlations to enable parametric modelling of various magnetic components. This disclosure characterizes possible winding configurations for HFPT employed in a bidirectional CUE DC/DC converter. A detailed analytical study is presented for each component and verified using several instances of 3D Finite Element Analysis (FEA) based model to synthesize the effective field and current density distribution in the windings. Several design-based trade-offs are graphically explained with various criteria pertaining to optimal winding selection to study the interdependence of the resultant parameters on hardware specifications, such as the PCB thickness and its fabrication layout, air gaps and conductor thickness.

Abstract: Provided herein are methods of detecting unlabeled biomolecules. In some embodiments, the methods include disrupting a cell population sufficient to release unlabeled biomolecules from the cell population to produce released biomolecules in which the cell population is disposed on a first inner surface of a chamber that is disposed substantially within a fluidic device and in which the chamber comprises a fluidic material. In some embodiments, the methods also include binding the released biomolecules to a second inner surface of the chamber to produce surface-bound biomolecules, introducing an incident light toward the second inner surface of the chamber concurrent with, and/or after, producing the surface-bound biomolecules, and detecting light scattered by the surface-bound biomolecules over a duration to produce a set of biomolecule imaging data. Related fluidic devices, systems, and computer readable media are also provided.

Abstract: A system and method for computing in memory with artificial neurons. According to an embodiment of the present disclosure, there is provided a system, including: a computer-readable memory; a neuron processing element communicatively connected to the computer-readable memory, the neuron processing element including: a plurality of configurable processing circuits each having a plurality of outputs and a plurality of inputs; and a network connecting one or more of the outputs of the configurable processing circuits to one or more of the inputs of the configurable processing circuits, each of the configurable processing circuits including: an artificial neuron having a plurality of inputs; and a register connected to the inputs of the artificial neuron.

Abstract: The present invention relates to a truncated form of chlorotoxin and chlorotoxin-like protein that are useful for glioma immunotherapy, in particular the treatment of glioblastoma. Thus, the invention also encompasses a therapeutic fusion protein comprising the truncated form of chlorotoxin and chlorotoxin-like protein, its methods of use, and its method of production.

Abstract: The present invention provides compositions and methods for improving cardiac function. Specifically, the present invention provides compositions and methods for treating a subject having a disorder or condition associated with aberrant cardiac tissue function, comprising contacting a patient having a disorder or condition associated with aberrant cardiac tissue function with a construct, or a construct associated with therapeutic cells, or a construct associated with fibroblast cells and therapeutic cells.

Abstract: An additive manufacturing process for forming a metallic layer on the surface of the substrate includes fabricating a substrate from a polymerizable composition by a stereolithographic process, and contacting the reactive surface with an aqueous solution including a metal precursor. The metal precursor includes a metal, and the polymerizable composition includes a multiplicity of multifunctional components. Each multifunctional component includes a reactive moiety extending from a surface of the substrate to form a reactive surface. An interface between the reactive surface and the aqueous solution is selectively irradiated to form nanoparticles including the metal in a desired pattern. The nanoparticles are chemically coupled to the reactive surface by reactive moieties, thereby forming a metallic layer on the surface of the substrate.

Abstract: Various embodiments of an amphibious submersible vehicle for use in non-destructive testing of pipe interiors and walls are disclosed herein. In one aspect, the vehicle is operable for amphibious submersible operation such that pipes of various diameters can be inspected under full, partially full, and dry conditions. In another aspect, the vehicle is equipped with a plurality of propellers for travel when fully or partially submerged in water and a plurality of wheels for traveling when in contact with a pipe wall or for traveling over debris. In some embodiments, the vehicle is equipped with a plurality of sensors configured for imaging and navigation which enable the vehicle for pipe inspection and identification of problem areas.