Patents Assigned to Arkray, Inc.
  • Method for forming an immune-tolerant site and method for attracting immunosuppressive cells
    Patent number: 10238714
    Abstract: A method for forming an immune-tolerant site, and a method for attracting immunosuppressive cells, comprising contacting an agent comprising SEK-1005 (Ser, 3-hydroxy-N-[2-hydroxy-1-oxo-2-tetrahydro-2-hydroxy-6-methyl-5-(2-methylpropyl)-2H-pyran-2-yl-propyl]-Leu-Pip(hexahydro-3-pyridazinecarbonyl)-N-hydroxy-Ala-N-methyl-Phe-Pip-rho-lactone) and/or fibroblast growth factor (FGF) with a site in the body tissue.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: March 26, 2019
    Assignees: KYOTO UNIVERSITY, ARKRAY, Inc., KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION
    Inventors: Hiroo Iwata, Rei Kuwabara, Masahide Hamaguchi, Kunio Hirano, Shimon Sakaguchi
  • Measurement apparatus, and method for operating measurement apparatus
    Patent number: 10234414
    Abstract: A measurement apparatus to measure a physical quantity related to a measurement target by use of a sensor, comprising: an apparatus enclosure; a control unit to be electrically connected to the sensor; and a moving member including a sensor holding unit to hold the sensor, the moving member being movable to protrude the sensor holding unit outwardly of the apparatus enclosure and further including a conductive member to electrically connect the sensor to the control unit.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: March 19, 2019
    Assignee: ARKRAY, Inc.
    Inventors: Yuji Kurata, Kazuo Fukuda, Yoshiharu Sato, Gai Go
  • Biosensor
    Patent number: 10228341
    Abstract: A biosensor includes a plurality of electrodes including a working electrode, and a detection layer which is immobilized on the working electrode and contains a crosslinking agent, an electrically conductive macromolecule and an enzyme transferring and receiving electrons to and from the working electrode. The working electrode is in an open system.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: March 12, 2019
    Assignees: ARKRAY, Inc., Ultizyme International Ltd.
    Inventors: Koji Katsuki, Megumi Saeda, Junko Shimazaki
  • Novel Biosensing Technology Based on Enzymatic Electrochemical Impedance Measurement
    Publication number: 20190064100
    Abstract: A method for quantifying a substance, which method includes the steps of: introducing a sample containing a measurement target substance to a biosensor comprising an enzyme electrode comprising an electrode and an oxidoreductase placed on the electrode in a state where direct electron transfer with the electrode occurs, and a counter electrode; applying an AC voltage to the enzyme electrode to carry out impedance measurement; and calculating the substance concentration based on an index obtained by the impedance measurement; is provided.
    Type: Application
    Filed: August 24, 2018
    Publication date: February 28, 2019
    Applicants: ARKRAY, Inc., Ultizyme International Ltd.
    Inventors: Koji Sode, Junko Shimazaki
  • Measuring Method and Measuring Apparatus
    Publication number: 20190056346
    Abstract: A measuring method includes applying a first signal, which is a direct current signal, having a first value to a sample in a flow passage using a first electrode and a fourth electrode which is different from the first, second, and third electrodes, measuring a first electric response value, applying a second signal having a second value higher than the first value to the sample using the second and third electrodes, measuring a second electric response value, and correcting a value obtained from the first electric response value based on the second electric response value.
    Type: Application
    Filed: August 17, 2018
    Publication date: February 21, 2019
    Applicant: ARKRAY, Inc.
    Inventors: Hisashi Kaneda, Ayano Nakatani
  • Measuring Method and Measuring Apparatus
    Publication number: 20190056347
    Abstract: A measuring method includes applying a first signal having a first value to a sample disposed in the flow passage by using a working electrode and a counter electrode, measuring a first electric response value of the sample to the first signal, applying contiguously for a given time a second signal having a second value higher than the first value to the sample disposed in the flow passage by using the working electrode and the counter electrode, measuring a second electric response value of the sample within the given time to the second signal, the second electric response value indicating amount of electric charge generated by electrolysis of water in the sample, and correcting a value obtained from the first electric response value based on the second electric response value.
    Type: Application
    Filed: August 17, 2018
    Publication date: February 21, 2019
    Applicant: ARKRAY, Inc.
    Inventors: Hisashi Kaneda, Ayano Nakatani
  • ANALYSIS APPARATUS AND ANALYSIS METHOD
    Publication number: 20190051011
    Abstract: Detection and analysis of a tangible component in a sample are implemented at lower cost. Provided is an analysis apparatus including a flow cell which includes a flow path for a sample, a branch section configured to cause light having passed through the flow path to branch at least to a first optical path and a second optical path, a first imaging section and a second imaging section configured to capture images of the sample in the flow path by using the light in the first optical path and the light in the second optical path, and a controller configured to process the captured images. The first imaging section and the second imaging section capture images that have the same angle of view but have different characteristics.
    Type: Application
    Filed: August 8, 2018
    Publication date: February 14, 2019
    Applicant: ARKRAY, Inc.
    Inventors: Shigeki MASUDA, Yukio WATANABE
  • Glutamine Synthetase Reaction and Method for Quantifying Ammonia Utilizing the Same
    Publication number: 20190048373
    Abstract: A reagent for glutamine synthetase reaction comprising a chelating agent and glutamine synthetase, and a reagent for quantification of ammonia comprising a chelating agent, ATP, glutamic acid, glutamine synthetase, glucose, an oxidized NAD compound, ADP-dependent hexokinase, and glucose-6-phosphate dehydrogenase, are provided.
    Type: Application
    Filed: August 8, 2018
    Publication date: February 14, 2019
    Applicant: ARKRAY, Inc.
    Inventors: Masaki Murakami, Takehiro Funamoto
  • Analysis Chip
    Publication number: 20190041358
    Abstract: The disclosure provides an analysis chip that includes a microchip employing capillary electrophoresis and a cartridge.
    Type: Application
    Filed: July 30, 2018
    Publication date: February 7, 2019
    Applicant: ARKRAY, Inc.
    Inventor: Naotsugu Onuma
  • ANALYSIS APPARATUS AND FOCUSING METHOD
    Publication number: 20190020825
    Abstract: An analysis apparatus comprises a flow cell which has a flow passage for a liquid containing a tangible component; an image pickupper which picks up images of the liquid flowing through the flow passage; an adjuster which adjusts a relative position of the flow cell with respect to the image pickupper in relation to an optical axis direction of the image pickupper and a direction in which the liquid flows through the flow passage; and a controller which determines an image pickup position of the flow cell in at least one of the optical axis direction and the direction in which the liquid flows, on the basis of a number of pieces of the tangible component in focusing states existing in the images of the liquid picked up by the image pickupper at a plurality of positions at which the relative position differs.
    Type: Application
    Filed: July 2, 2018
    Publication date: January 17, 2019
    Applicant: ARKRAY, Inc.
    Inventors: Shigeki MASUDA, Kenji NAKANISHI
  • Target Analysis Method and Target Analyzing Chip
    Publication number: 20190017102
    Abstract: A target analysis method and target analyzing chip are provided to directly detect a target, such as microRNA, without performing PCR. The target analysis method of the present embodiment includes: a process in which a target in a sample, a labeled probe that binds to the target, and a carrier-binding probe that binds to the target and to a carrier, contact each other, and the target, the labeled probe, and the carrier-binding probe react to bind to each other to form a first bound body; a process in which the first bound body and the carrier contact each other, and the first bound body and the carrier react to bind to each other to form a second bound body; a process to concentrate the carrier; and a process in which the target in the sample is analyzed by detecting a label of the labeled probe bound to the concentrated carrier.
    Type: Application
    Filed: January 16, 2017
    Publication date: January 17, 2019
    Applicants: ARKRAY, Inc., National University Corporation Kyoto Institute of Technology
    Inventors: Akira Murakami, Akio Kobori, Asako Yamayoshi, Yuichiro Noda
  • PRESENTATION METHOD, PRESENTATION DEVICE, AND COMPUTER READABLE MEDIUM
    Publication number: 20190015054
    Abstract: A presentation method for presenting a time period to measure a blood glucose level, the presentation method includes: acquiring first information, the first information including a measurement result in which a glucose level of a user is measured with a time interval using a first measurement device and a measurement time at which the measurement result was acquired; determining, based on a comparison result obtained by comparing the first information with a predetermined threshold of the glucose level and a preset period, the time period for the user to measure the blood glucose level by using a second measurement device; and presenting the time period at a display.
    Type: Application
    Filed: July 13, 2018
    Publication date: January 17, 2019
    Applicant: ARKRAY, Inc.
    Inventors: Keiko KOIDE, Atsushi WADA, Hideaki TAKEDA
  • LIQUID ACCOMMODATING CONTAINER
    Publication number: 20190009269
    Abstract: A liquid accommodating container includes an accommodating portion configured to accommodate, in a hermetically closed state, a liquid for testing a measuring apparatus, a storage portion configured to store the liquid, and a coupling portion configured to couple the accommodating portion and the storage portion in a state that one of the accommodating portion and the storage portion is foldable back to the other.
    Type: Application
    Filed: July 2, 2018
    Publication date: January 10, 2019
    Applicant: ARKRAY, Inc.
    Inventor: Yoshiharu SATO
  • Plasma Spectroscopy Analysis Method
    Publication number: 20190011370
    Abstract: The disclosure provides plasma spectroscopy analysis methods using a preparatory process of adding a control metal species that is different from an analyte metal species to a sample so as to have a known concentration; a concentration process of introducing the sample to a measurement container, and applying an electric current across a pair of electrodes disposed in the measurement container to concentrate the analyte metal species and the control metal species in the sample in a vicinity of at least one of the electrodes; a detection process; a correction process; and a quantification process.
    Type: Application
    Filed: July 2, 2018
    Publication date: January 10, 2019
    Applicant: ARKRAY, Inc.
    Inventors: Kojiro Honma, Kentaro Kiriyama, Hirofumi Yamada
  • Mutant Cytochrome Protein and Use Thereof
    Publication number: 20190010215
    Abstract: A mutant cytochrome protein originated from a cytochrome protein having three heme-binding domains, which mutant cytochrome protein lacks the first heme-binding domain and the second heme-binding domain as counted from the N-terminus, is provided. The mutant cytochrome protein may lack a region(s) containing the first and second heme-binding domains.
    Type: Application
    Filed: July 3, 2018
    Publication date: January 10, 2019
    Applicants: ARKRAY, Inc., Ultizyme International Ltd.
    Inventors: Koji Sode, Junko Shimazaki, Kazushige Mori, Katsuhiro Kojima
  • Measuring Apparatus, Computer Readable Medium Storing Measuring Program and Measuring Method
    Publication number: 20190008424
    Abstract: A measuring apparatus includes: a sensor configured to be indwelled in vivo; an identifying unit configured to identify a setting position of the sensor; a calculation unit configured to calculate a concentration of a specified substance contained in a sample, based on a signal given from the sensor; and a storage unit configured to store plural pieces of arithmetic information, wherein the calculation unit selects one of the plural pieces of arithmetic information from the storage unit, based on the sensor setting position identified by the identifying unit and calculates the concentration of the specified substance contained in the sample by using the selected arithmetic information.
    Type: Application
    Filed: July 2, 2018
    Publication date: January 10, 2019
    Applicant: ARKRAY, Inc.
    Inventor: Takeshi Shimizu
  • Plasma Spectroscopy Analysis Method
    Publication number: 20190011427
    Abstract: The disclosure provides plasma spectroscopy analysis methods using a preparatory process of diluting a urine sample assumed to contain mercury or lead as an analyte metal species, and then adding a known concentration of thallium as a control metal species to the diluted urine sample; a concentration process of introducing the urine sample containing the control metal species to a measurement container, and applying an electric current across a pair of electrodes disposed in the measurement container to concentrate the analyte metal species and the control metal species present in the urine sample in a vicinity of at least one of the electrodes; a detection process; a correction process; and a quantification process.
    Type: Application
    Filed: July 2, 2018
    Publication date: January 10, 2019
    Applicant: ARKRAY, Inc.
    Inventor: Kentaro Kiriyama
  • Measuring Apparatus and Display Apparatus
    Publication number: 20190014607
    Abstract: A measuring apparatus performs wireless communications with a display apparatus, the display apparatus displaying a measurement result of a specified substance in a body fluid. The measuring apparatus includes a sensor, a transmitting unit and a touch sensor. The sensor is configured to be indwelled in vivo. The transmitting unit is configured to transmit data relating to the specified substance obtained by using the sensor. The touch sensor is configured to detect a touch operation of a user. The transmitting unit transmits a connection request to the display apparatus when the touch sensor detects the touch operation.
    Type: Application
    Filed: July 2, 2018
    Publication date: January 10, 2019
    Applicant: ARKRAY, Inc.
    Inventor: Takeshi Shimizu
  • Measuring Apparatus, Computer Readable Medium Storing Measuring Program and Measuring Method
    Publication number: 20190011467
    Abstract: A measuring apparatus includes: a measuring unit to measure a signal value corresponding to a concentration of a specified substance of a first sample; an acquiring unit to acquire a reference value pertaining to the specified substance of a second sample; a calculating unit to calculate a concentration value of the specified substance of the first sample, based on the signal value and the reference value; a timing determination unit to determine timing for calibrating the reference value when satisfying at least one of a first condition that an activity status of a user is a predetermined status and a second condition that a variation in the concentration value of the specified substance of the first sample is equal to or smaller than a threshold value; and an input request unit to request the user to input the reference value at the determined timing.
    Type: Application
    Filed: July 2, 2018
    Publication date: January 10, 2019
    Applicant: ARKRAY, Inc.
    Inventor: Takeshi Shimizu
  • Method for Recovering Metal and Method for Analyzing Metal
    Publication number: 20190011428
    Abstract: A method for recovering a metal that uses a reduced amount of a chelating agent is described, where the method includes a complex forming step of forming, in a mixture, a complex between a metal in a sample and a chelating agent; a complex depositing step of depositing the complex in the mixture; and a metal recovering step of recovering the deposited complex from the mixture, thereby recovering the metal in the sample.
    Type: Application
    Filed: September 14, 2018
    Publication date: January 10, 2019
    Applicant: ARKRAY, Inc.
    Inventors: Hirofumi Yamada, Akitsugu Kudo