Patents Assigned to Bar-Ilan University
  • DISTRIBUTED SENSING EMPLOYING STIMULATED BRILLOUIN SCATTERING IN OPTICAL FIBERS
    Publication number: 20140083197
    Abstract: Disclosed are methods and devices for distributed sensing of a measurable parameter employing stimulated Brillouin scattering in an optical fiber. A frequency-modulated or phase-modulated light wave is transmitted into the optical fiber. A scattered light wave in the optical fiber is monitored for sensing a measurable parameter. In some embodiments, the calculating step may include calculating a distance of a sensed location along the optical fiber using the monitored time of arrival.
    Type: Application
    Filed: May 17, 2012
    Publication date: March 27, 2014
    Applicant: BAR ILAN UNIVERSITY
    Inventors: Avinoam Zadok, Yair Antman, Luc Thevenaz
  • Motion detection system and method
    Patent number: 8638991
    Abstract: A method is presented for imaging an object. The method comprises imaging a coherent speckle pattern propagating from an object, using an imaging system being focused on a plane displaced from the object.
    Type: Grant
    Filed: July 21, 2008
    Date of Patent: January 28, 2014
    Assignees: Bar Ilan University, Universtitat de Valencia
    Inventors: Zeev Zalevsky, Javier Garcia
  • 5-AMINOLEVULINIC ACID DERIVATIVES, METHODS FOR THEIR PREPARATION AND USES THEREOF
    Publication number: 20140024710
    Abstract: The present invention provides drug conjugates comprising 5-aminolevulinic acid (ALA), an aldehyde and a carboxylic acid that may function as a histone deacetylase inhibitor (HDACI). These conjugates may serve as co-drugs which release a plurality of active species in vivo. The novel drug conjugates may be used, for the treatment or prevention of cancer in PDT-dependent and/or PDT-independent (nonPDT) treatments, as well as for cosmetic uses. In addition the present invention provides novel uses for both the novel and known compounds. According to some embodiments, the present invention provides drug conjugates (co-drugs) comprising (i) ALA, (ii) an aldehyde and (iii) a carboxylic acid that may function as a histone deacetylase inhibitor (HDACO for the treatment of anemia and/or for the induction of erythropoiesis.
    Type: Application
    Filed: March 22, 2012
    Publication date: January 23, 2014
    Applicants: RAMOT AT TEL AVIV UNIVERSITY LTD., BAR ILAN UNIVERSITY
    Inventors: Ada Rephaeli, Nataly Tarasenko, Zvi Malik, Abraham Nudelman, Gili Berkovitch-Luria, Dvir Doron
  • URIDINE DI- OR TRI-PHOSPHATE DERIVATIVES AND USES THEREOF
    Publication number: 20130324495
    Abstract: The invention provides particular uridine di- and tri-phosphate derivatives, and pharmaceutical compositions thereof. These compounds are useful for treatment of diseases, disorders and conditions modulated by P2Y6 receptors, and particularly for lowering intraocular pressure and thereby treating ocular hypertension and/or glaucoma.
    Type: Application
    Filed: December 1, 2011
    Publication date: December 5, 2013
    Applicants: UNIVERSIDAD COMPLUTENSE DE MADRID, BAR-ILAN UNIVERSITY
    Inventors: Bilha fischer, Jesus Jeronimo Pintor, Shay Elyahu, Tamar Ginsburg-Shmuel
  • IMAGING SYSTEM AND METHOD USING MULTICORE FIBER
    Publication number: 20130278740
    Abstract: The present invention provides a system for imaging an object comprising: an optical imaging unit for imaging an object on a detection array, the optical imaging unit defining an optical axis and comprising a multicore fiber configured to collect light from the object at an input edge of the multicore fiber and transfer collected light to an output edge of the multicore fiber; a displacing unit configured to shift the input edge of the multicore fiber relatively to the object in a plane substantially perpendicular to the optical axis to obtain a set of shifted images of the object; and an operating unit configured to operate the displacing unit by setting a shifting amplitude to either a first amplitude inferior or equal to the diameter of a core of the multicore fiber or a second amplitude superior or equal to the diameter of the multicore fiber.
    Type: Application
    Filed: January 5, 2012
    Publication date: October 24, 2013
    Applicant: BAR ILAN UNIVERSITY
    Inventors: Zeev Zalevsky, Asaf Shahmoon, Hamutal Slovin
  • BLIND SIGHT
    Publication number: 20130253608
    Abstract: A sensory substitution device (SSD) for providing a person with neural signals responsive to features of an environment, the SSD comprising: at least one camera that acquires an image of the environment; and at least one corneal neural stimulator that stimulates nerve endings in the cornea of an eye of the person to generate neural signals responsive to the image that propagate to the person's brain.
    Type: Application
    Filed: October 17, 2011
    Publication date: September 26, 2013
    Applicants: RAMOT AT TEL AVIV UNIVERSITY LTD., BAR-ILAN UNIVERSITY
    Inventors: Zeev Zalevsky, Michael Belkin
  • Surface-modified polymer films
    Patent number: 8486534
    Abstract: Surface-modified polymer films for coating are provided, wherein the surface is modified by covalent binding of nano- or micro-particles comprising a photoreactive species. The surface of the polymer film, e.g. a parylene film, may be modified by covalent binding of nano- or micro-particles of a polymer, e.g. a conductive bifunctional polymer further comprising a chemically reactive functional group, or of a hybrid organic-inorganic oxide, e.g., silica, network comprising a photoreactive species. Further provided are: (i) polymerizable monomers, the conductive bifunctional polymers obtained therefrom; (ii) a hybrid photoreactive organic-inorganic oxide network; and (iii) micro- or nano-particles made from (i) or (ii).
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: July 16, 2013
    Assignee: Bar-Ilan University
    Inventors: Jean-Paul Lellouche, Maria Naddaka, Anna Peled, Esabul Mondal
  • SnoRNAi-small nucleolar RNA degradation by RNA interference in trypanosomatids
    Patent number: 8486910
    Abstract: Polynucleotides and a method suitable for downregulation of small nuclear RNA which can be used to treat diseases associated with activity of small nuclear RNA are provided. Specifically, the present invention can be used to downregulate snoRNA molecules or box H/ACA-containing RNA molecules which are involved in diseases such as cancer.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: July 16, 2013
    Assignee: Bar-Ilan University
    Inventor: Shulamit Michaeli
  • CHIMERIC AVIAN-BASED SCREENING SYSTEM CONTAINING MAMMALIAN GRAFTS
    Publication number: 20130171680
    Abstract: The present invention relates to animal model systems comprising a chimera between an avian embryo and a mammalian organism. Specifically, chimeric model systems comprising normal, diseased or genetically transformed mammalian cells and tissues transplanted into avian embryos, and uses thereof for in vivo testing of drugs and therapeutic modalities are disclosed.
    Type: Application
    Filed: December 3, 2012
    Publication date: July 4, 2013
    Applicants: MEDICAL RESEARCH FUND OF TEL-AVIV SOURASKY MEDICAL CENTER, BAR ILAN UNIVERSITY
    Inventors: BAR ILAN UNIVERSITY, Medical Research Fund of Tel-Aviv Sourasky Medi
  • CRYSTALLINE FORMS OF THE TRI-MESYLATE SALT OF PERPHENAZINE-GABA AND PROCESS OF PRODUCING THE SAME
    Publication number: 20130150352
    Abstract: Novel crystalline form of perphenazine 4-aminobutyrate trimesylate and a process of producing the same are disclosed. The novel crystalline form is characterized by a unique XRPD pattern and a DSC that exhibits an endothermic peak at a relatively high temperature (e.g., higher than 209° C.). Also disclosed are a process of preparing perphenazine 4-aminobutyrate trimesylate by in situ deprotection and salification, in a single-step synthesis, and a highly pure perphenazine 4-aminobutyrate trimesylate obtained thereby. Uses of any of the described perphenazine 4-aminobutyrate trimesylate are also disclosed.
    Type: Application
    Filed: February 11, 2013
    Publication date: June 13, 2013
    Applicants: Ramot at Tel-Aviv University Ltd., BioLineRX Ltd., Bar-Ilan University
    Inventors: Ramot at Tel-Aviv University Ltd., Bar-Ilan University, BioLineRX Ltd.
  • METHOD AND SYSTEM FOR NON-INVASIVELY MONITORING BIOLOGICAL OR BIOCHEMICAL PARAMETERS OF INDIVIDUAL
    Publication number: 20130144137
    Abstract: A system and method are presented for use in monitoring one or more conditions of a subject's body. The system includes a control unit which includes an input port for receiving image data, a memory utility, and a processor utility. The image data is indicative of data measured by a pixel detector array and is in the form of a sequence of speckle patterns generated by a portion of the subject's body in response to illumination thereof by coherent light according to a certain sampling time pattern. The memory utility stores one or more predetermined models, the model comprising data indicative of a relation between one or more measurable parameters and one or more conditions of the subject's body. The processor utility is configured and operable for processing the image data to determine one or more corresponding body conditions; and generating output data indicative of the corresponding body conditions.
    Type: Application
    Filed: August 1, 2012
    Publication date: June 6, 2013
    Applicants: Universitat de Valencia, Bar Ilan University
    Inventors: Zeev ZALEVSKY, Javier GARCIA, Vicente MICO, Michael BELKIN, Yevgeny BIEDERMAN, Israel MARGALIT, Revital BARELLY
  • SOLAR CELLS ARRANGEMENT
    Publication number: 20130087182
    Abstract: A solar energy conversion system is presented. The system comprises at least one waveguide arrangement having at least one light input respectively. The waveguide arrangement comprises a core unit for passing input solar radiation therethrough and a cladding material arrangement interfacing with the core therealong. The cladding material arrangement is configured as an array of spaced-apart solar cells arranged along the core unit and having different optical absorption ranges, such that an interface between the waveguide core and the cladding arrangement spectrally splits the photons of the input solar radiation by causing the photons of different wavelengths, while passing through the core unit, to be successively absorbed and thereby converted into electricity by the successive solar cells of said array.
    Type: Application
    Filed: November 29, 2012
    Publication date: April 11, 2013
    Applicants: BAR ILAN UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.
    Inventors: Bar Ilan University, Yeda Research and Development Company, Ltd., The Regents of the University of California
  • CONJUGATES COMPRISING A GABA- OR GLYCINE COMPOUND, PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS THEREOF AS WELL AS THEIR USE IN TREATING CNS DISORDERS
    Publication number: 20130059910
    Abstract: A novel use of conjugates of psychotropic drugs (e.g., antidepressants or anti-epileptic drugs) and organic acids such as GABA in the treatment of pain is disclosed. A novel GABA conjugate and uses thereof is also disclosed.
    Type: Application
    Filed: September 6, 2012
    Publication date: March 7, 2013
    Applicants: Bar-Ilan University, Ramot at Tel-Aviv University Ltd.
    Inventors: Abraham NUDELMAN, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman
  • Conjugates comprising a psychotropic drug or a GABA agonist and an organic acid and their use in treating pain and other CNS disorders
    Patent number: 8377990
    Abstract: A novel use of conjugates of psychotropic drugs (e.g., antidepressants or anti-epileptic drugs) and organic acids such as GABA in the treatment of pain is disclosed. A novel GABA conjugate and uses thereof is also disclosed.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: February 19, 2013
    Assignees: Ramot at Tel-Aviv University Ltd., Bar-Ilan University
    Inventors: Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman
  • Crystalline forms of the tri-mesylate salt of perphenazine-GABA and process of producing the same
    Patent number: 8377929
    Abstract: Novel crystalline form of perphenazine 4-aminobutyrate trimesylate and a process of producing the same are disclosed. The novel crystalline form is characterized by a unique XRPD pattern and a DSC that exhibits an endothermic peak at a relatively high temperature (e.g., higher than 209° C.). Also disclosed are a process of preparing perphenazine 4-aminobutyrate trimesylate by in situ deprotection and salification, in a single-step synthesis, and a highly pure perphenazine 4-aminobutyrate trimesylate obtained thereby. Uses of any of the described perphenazine 4-aminobutyrate trimesylate are also disclosed.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: February 19, 2013
    Assignees: Ramot at Tel-Aviv University Ltd., Bar-Ilan University, BioLineRX Ltd.
    Inventors: Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman, Mazal Shaul, Efrat Halbfinger
  • "Growth from surface" Methodology for the Fabrication of Functional Dual Phase Conducting Polymer polypyrrole/polycarbazole/Polythiophene (CP/polyPyr/polyCbz/PolyTh)-Carbon Nanotube (CNT) Composites of Controlled Morphology and Composition - Sidewall versus End-Selective PolyTh Deposition
    Publication number: 20130040049
    Abstract: A “growth from the surface” method for selectively depositing oxidative Liquid Phase Polymerizations (LPPs) onto the carbon nanotube (CNT) surface, said method comprising steps of: a. obtaining Multi-walled Carbon Nanotubes (MWC-NT); b. oxidized said MWCNTs to obtain oxidized COOH-MWCNTs; thereby (a) carboxylative opening oxidation-sensitive end-caps (polyCOOH end cluster); and, (b) introducing defect carboxylic (COOH) groups onto predetermined areas of said oxidized COOH-MWCNTs; c. COOH activating the polyCOOH shell using various COOH activating species; and, d.
    Type: Application
    Filed: April 14, 2011
    Publication date: February 14, 2013
    Applicant: BAR-ILAN UNIVERSITY
    Inventors: Jean-Paul Lellouche, Diana Goldman
  • SYNTHESIS AND CHARACTERIZATION OF NEAR IR FLUORESCENT MAGNETIC AND NON-MAGNETIC ALBUMIN NANOPARTICLES FOR BIOMEDICAL APPLICATIONS
    Publication number: 20130030282
    Abstract: The present invention discloses Near Infrared (NIR) fluorescent albumin nanoparticles having a structure selected from a core structure or a core-shell structure. Also disclosed are a process of preparing these NIR fluorescent albumin nanoparticles, and a method of in vivo detection of pathologies, in particular cancer pathology, by using administering these NIR fluorescent albumin nanoparticles to a patient.
    Type: Application
    Filed: July 17, 2012
    Publication date: January 31, 2013
    Applicant: BAR ILAN UNIVERSITY
    Inventors: Shlomo Margel, Sarit Cohen, Enav Corem Salkmon, Michal Pellach
  • Solar cells arrangement
    Patent number: 8354583
    Abstract: A solar energy conversion system is presented. The system comprises at least one waveguide arrangement having at least one light input respectively. The waveguide arrangement comprises a core unit for passing input solar radiation therethrough and a cladding material arrangement interfacing with the core therealong. The cladding material arrangement is configured as an array of spaced-apart solar cells arranged along the core unit and having different optical absorption ranges, such that an interface between the waveguide core and the cladding arrangement spectrally splits the photons of the input solar radiation by causing the photons of different wavelengths, while passing through the core unit, to be successively absorbed and thereby converted into electricity by the successive solar cells of said array.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: January 15, 2013
    Assignees: Bar Ilan University, Yeda Research and Development Company Ltd, The Regents of The University of California
    Inventors: Arie Zaban, David Cahen, Igor Lubomirsky, Oscar M. Stafsudd
  • Fault current limiters (FCL) with the cores saturated by superconducting coils
    Patent number: 8351167
    Abstract: A current limiting device (30, 40, 50, 60) comprising for each phase of an AC supply a closed magnetic core (31) of reduced volume and mass having first and second pairs of opposing limbs (32a, 32b; 33a, 33b), and at least one AC coil (35a, 35b) enclosing opposing limbs (33a, 33b) of the magnetic core (31) and adapted for series connection with a load. A superconducting DC bias coil (34) encloses a limb) (32a, 32b) of the magnetic core (31) for saturating each of the opposing limbs (33a, 33b) in opposite directions by the bias coil (34). Under fault conditions, the AC flux in at least one limb counteracts the DC bias flux, bringing the limb out of saturation. Preferably, current is reduced in the DC bias coils thus bringing both opposing limbs of the core out of saturation.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: January 8, 2013
    Assignees: Bar Ilan University, Ricor Cryogenic & Vacuum Systems
    Inventors: Shuki Wolfus, Alexander Friedman, Yosef Yeshurun, Vladimir Rozenshtein, Zvi Bar-Haim
  • ANTIMICROBIAL WATER TREATMENT MEMBRANES AND PRODUCTION THEREOF
    Publication number: 20120325748
    Abstract: The present invention discloses antimicrobial water treatment membranes, comprising a water treatment membrane, covalently attached to one or more antimicrobial peptides or derivatives thereof, either directly or via one or more tether molecules. There are also provided a process for preparing these antimicrobial membranes, and uses thereof in water treatment applications.
    Type: Application
    Filed: December 7, 2010
    Publication date: December 27, 2012
    Applicant: BAR-ILAN UNIVERSITY
    Inventors: Roni Kasher, Ze'ev Ronen, Ehud Banin