Abstract: Processes for localized lasering of a lamination stack and graphene-coated printed circuit board (PCB) are disclosed. An example PCB may include a lamination stack, post-lamination, that may further include a core, an adhesive layer, and at least one graphene-metal structure. A top layer of graphene of the graphene-metal structure may have never been grown before the lamination process or may have been removed post-lamination such that a portion of the top layer of graphene is missing. The localized lasering process described herein may grow (for the first time) or re-grow the graphene layer of the exposed portion of the metal layer without adverse effects to the rest of the lamination stack or PCB and while promoting a uniform layer of graphene on the top surface. A process of growing graphene through application of molecular layer and a self-assembled monolayer (SAM), are also described herein.

Abstract: A technique to mitigate timing errors induced by power supply droops includes an inverter-based droop detector as well as Dual Mode Logic (DML) to achieve a droop-resist ant timing response. The droop detector is based on capacitor ratios and is thus less sensitive to Process/Voltage/Temperature (PVT) and to random offset than the prior art. The DML can alter its power/performance ratio based on the droop level input it receives from the detector, such that the critical timings are preserved.

Abstract: A system for speech separation includes data processing hardware and memory hardware in communication with the data processing hardware, the memory hardware storing instructions that when executed on the data processing hardware cause the data processing hardware to perform operations including (i) generating a two-dimensional representation of a speech mixture, (ii) separating the speech mixture into an initial separation (iii) supplying the initial separation and speaker representations to a refinement module, (iv) refining the initial separation based on the initial separation and the speaker representations, (v) estimating a mask per speaker, and (vi) applying the masks to the two-dimensional representation to create two-dimensional, per-speaker representations.

Abstract: A method for using a storage array of a circuit includes generating a netlist of components and connections of circuitry of a storage array using behavioral description and random logic synthesis, using a write port to clock-gate each register of the storage array, and multiplexing data based on a selected word line of the storage array.

Abstract: An article comprising a ferroelectric material in its ferroelectric phase, wherein the article is configured to enable low-loss propagation of signals with ultra-low dielectric loss at one or more select frequencies.

Abstract: A method of evaluating a subject's visuospatial ability includes: displaying an original drawing on a screen; receiving input on the screen from a stylus, corresponding to a reproduction of the drawing by the subject; during the receiving step, collecting metadata regarding the process of the reproduction; comparing a resemblance of the reproduction to the original drawing; evaluating the reproduction and the metadata to infer therefrom the subject's understanding of the drawing; and issuing a combined evaluation of the subject's gestalt understanding of the drawing based on a combination of the resemblance comparison and the metadata evaluation.

Abstract: Complexes comprising a coordinated Cu(II) ion are described herein, which are capable of binding to an extracellular portion of Ctr1 such that the complex with the Cu(II) ion is transported through the Ctr1. The complexes may comprise a Cu(II) ion coordinated to a ligand and to a peptide, wherein the peptide is released upon contact of the complex with an extracellular portion of Ctr1, thereby forming a second complex comprising the ligand, the copper ion and the extracellular portion of Ctr1. Further described herein are uses and methods utilizing the complex, in imaging, in radiation therapy, and for determining a redox state of cells.

Abstract: There is provided a computer implemented method of determining a state of a medical condition of a subject, comprising: computing a tree that includes representations computed from genetic sequences of a plurality of microbes within a microbiome sample of a subject, wherein the tree includes the representations of the plurality of microbes arranged according to a taxonomy hierarchy, mapping the tree to a data structure that defines the taxonomy hierarchy and defines positions between neighboring representations of the plurality of microbes, feeding the data structure into a machine learning model that processes neighboring representations according to position, and obtaining the state of the medical condition of the subject as an outcome of the machine learning model.

Abstract: An assay method for target molecules in a sample using optical emission from magnetic beads, comprising: a) preparing the magnetic beads so, if excited, they produce optical emission as a consequence of contact between the beads, reporter molecules and target molecules in the sample; b) providing the prepared magnetic beads in a solution in a container, with one or more magnets producing a magnetic field inside the container that causes the beads to aggregate into a clump inside the container in less than 30 seconds; c) exciting the optical emission from the magnetic beads in the clump; and d) measuring the optical emission from the magnetic beads in the clump.

Abstract: It has been found that the prodrug 1-(butyryloxy)ethyl-5-amino-4-oxopentanoate (AN-233), an oral active conjugate of BA (histone deacetylase inhibitor) and ALA (heme precursor), is useful for the treatment of hemoglobinopathies including but not limited to sickle cell disease and thalassemias. In one embodiment, AN-233 activates ?-globin transcription, induces HbF expression, produces an anti-sickling effect, or combinations thereof when administered to a subject in need thereof.

Abstract: Processes for laminating a graphene-coated printed circuit board (PCB) are disclosed. An example laminated PCB may include a lamination stack that may include an inner core, an adhesive layer, and at least one graphene-metal structure. Pressure and heat—which may be applied under vacuum or controlled gas atmosphere—may be applied to the lamination stack, after all materials have been placed. The graphene of the graphene-metal structure is designed to promote high frequency performance and heat management within the PCB.

Abstract: A method for measuring voltage droop and temperature in a circuit include using capacitive coupling to couple a bias voltage of a current controlled oscillator (CCO) to a noisy digital Vcc (VCCD) supply, so that a frequency of the CCO is independent of a DC Vcc level of the noisy VCCD supply and the CCO measures an AC voltage droop of the noisy VCCD supply and a temperature which is dependent upon the AC voltage droop.

Abstract: Systems and methods are disclosed for generating cluster quantum states usable for quantum computing. An example system can generate a plurality of qumodes. The plurality of qumodes can include at least two successive qumodes in frequency domain, wherein a frequency spacing between two successive qumodes is equal to a free-spectral range of an optical frequency comb. The plurality of qumodes can include a plurality of bipartite entangled states. A cluster quantum state can be generated by modulating a phase of a portion of the optical fields associated with the plurality of qumodes received from the optical frequency comb, at one or more modulation frequencies. In some embodiments, each of the one or more modulation frequencies can be equal to an integral multiple of the free-spectral-range. In certain embodiments, a property of a cluster graph (such as a dimension of the cluster graph) associated with the cluster quantum state can be controlled by adjusting one or more modulation frequencies.

Abstract: An electrolyte composition for use in a battery system including a silicon-based negative electrode having active material particles is provided. The electrolyte composition includes a polar solvent selected from the group consisting of ethylene carbonate, propylene carbonate, sulfolane, ?-butyrolactone, and combinations thereof and at least one lithium salt dissolved in the polar solvent at a concentration of at least 2 moles of the at least one lithium salt per 1 liter of the polar solvent. The at least one lithium salt and the polar solvent add dipoles to the electrolyte composition configured for reducing an electric field present at a surface of each of the active material particles in the silicon-based negative electrode of the battery system.

Abstract: Oligonucleotide probes for detecting target nucleic acid sequences are disclosed.

Abstract: There is provided a computer implemented method of compressing a baseline dataset comprising a sequence of a plurality of instances of a plurality of unique data elements, the method comprising: providing a weight function that calculates an increasing value for a weight for each one of the plurality of instances of each one of the plurality of unique data elements in the baseline dataset, as a function of increasing number of previously processed sequential locations of each of the plurality of instances of each respective unique data element within the baseline dataset relative to a current sequential location of the baseline dataset, computing an encoding for the baseline dataset according to a distribution of the weight function computed for the plurality of unique data elements in the baseline dataset, and creating a compressed dataset according to the encoding.

Abstract: Compositions and methods for identifying antisense guide RNA for RNA editing are provided. Accordingly, there is provided a polynucleotide comprising: (i) a nucleic acid sequence encoding a reporter polypeptide comprising a heterologous nucleic acid sequence introducing an in-frame premature stop codon comprising an adenosine preventing translation of a functional reporter polypeptide; and (ii) an additional nucleic acid sequence heterologous to said reporter polypeptide having at least 60% complementarity to said nucleic acid sequence comprising said in-frame premature stop codon.

Abstract: A hardware memory includes at least one memory cell, peripheral circuitry and randomization circuitry. The memory cell(s) store data, which may be written to, read from and held in the hardware memory. The peripheral circuitry reads and writes data to the memory cell(s) and may perform other functions necessary for facilitating the data read, write and hold. The randomization circuitry randomizes operations performed by the peripheral circuitry to reduce a correlation between the data and the current consumed by the hardware memory.

Abstract: There is provided a computer implemented method of compressing a baseline dataset comprising a sequence of a plurality of instances of a plurality of unique data elements, the method comprising: providing a weight function that calculates an increasing value for a weight for each one of the plurality of instances of each one of the plurality of unique data elements in the baseline dataset, as a function of increasing number of previously processed sequential locations of each of the plurality of instances of each respective unique data element within the baseline dataset relative to a current sequential location of the baseline dataset, computing an encoding for the baseline dataset according to a distribution of the weight function computed for the plurality of unique data elements in the baseline dataset, and creating a compressed dataset according to the encoding.

Abstract: A device that is configured to detect spectrally resolved emission from a material is disclosed. The device includes an optical cavity comprising a pair of substrates separated by a distance defined to restrict a photonic density of states (DOS) of the material to be detected, a detector oriented with respect to the optical cavity to receive emission from the optical cavity and a controller configured to control the distance. The pair of substrates includes facing reflective surfaces.