Abstract: The present invention is directed to a nucleic acid encoding a lepidopteran glutamate-gated chloride channel. Vectors and host cells comprising the nucleic acid are also provided. A method of identifying agents that modulate the activity of a lepidopteran glutamate-gated chloride channel is also provided. Such agents are useful as insecticides.

Abstract: The present invention relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of stanniocalcin as a biomarker for VEGFR2 inhibitors.

Abstract: The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.

Abstract: The present invention relates to novel pyrazolyl-substituted heterocycles of the formula (I) in which X, Y, Z and Het are as defined in the disclosure, to processes for their preparation, and to their use as pesticides, microbicides and herbicides.

Abstract: The invention provides a human 5-HT7 which is associated with the cardiovascular disorders, dermatological disorders, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, dermatological disorders, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of 5-HT7 as well as pharmaceutical compositions comprising such compounds.

Abstract: The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.

Abstract: The invention relates to antibacterial amide macrocycles, to methods for the production thereof, and to the use of the same for producing pharmaceuticals for the treatment and/or prophylaxis of illness, especially bacterial infections.

Abstract: The invention relates to novel 2-halo-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives of the formula (I) in which A, B, G, X, Y and Z are as defined above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising firstly the 2-halo-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives of the formula (I) and secondly at least one crop plant compatibility-improving compound.

Abstract: A process for monitoring and/or controlling a nitrating process, having the following steps: measuring inline infrared spectra of nitric acid content in a reaction mixture stream downstream of the nitration reaction, preferably near-infrared spectra, evaluating the measured spectra by means of a computer-assisted, matrix-specific calibration model for the purpose of determining the content of nitric acid, transmitting the results of spectrometric examination to a process control system, inputting the results of spectrometric examination for the purpose of specifying the content of nitric acid in the acid phase into a regulator (224) for control of the metering (207,217) of nitric acid into a nitrating reactor.

Abstract: The present invention provides a method of preparing 1-acetyl-1-chlorocyclopropane from 1,3 dichloro-2-pentanone by reaction with base in the presence of a phase transfer catalyst. The reaction may be run in the presence or absence of an organic solvent and in a continuous or batch process.

Abstract: The invention relates to novel phenyl-substituted cyclopentane- and cyclohexane-1,3-dione derivatives of the formula (I) in which W, X, Y, Z, A, B, Q1, Q2, Q3, Q4, G and m are as defined in the disclosure, to processes and intermediates for their preparation and to their use as pesticides, microbicides and/or herbicides.

Abstract: The invention relates to aqueous suspension concentrates which comprise: (1) one or more active substances from the group consisting of the oxadiazoles, (2) one or more surfactants based on non-salt-like substituted phenol ethers, (3) one or more thickeners based on aluminum silicate, and (4) optionally additional formulation auxiliaries, and also (5) optionally additional surfactants other than component (2). This makes possible, in addition to avoiding crystal growth, inter alia also highly concentrated aqueous herbicidal compositions with good distribution of active substance.

Abstract: The invention relates to aqueous suspension concentrates comprising (1) one or more active ingredients from the group of the 2,4-diamino-s-triazines, which are N-substituted on one amino group by a (hetero)aryl(hetero)alkyl group, (2) one or more surfactants based on nonsaltlike substituted phenol ethers, (3) one or more aluminum silicate-based thickeners, and (4) if desired, additional formulation assistants, and also (5) if desired, additional surfactants different from component (2). Besides the highly concentrated formulation of active ingredients this also allows the biological effect to be improved for the same application rate.

Abstract: The invention concerns a novel nucleic acid fragment of the genome of rice pathogenic fungus Magnaporthe grisea comprising a gene coding for a protein (hereafter referred to as gene 763) whereof the presence and integrity are indispensable for pathogenesis of said fungus with respect to rice and barley. The invention also concerns the promoter of said gene, the gene coding for protein 763, protein 763 and uses thereof for identifying potential biological targets for novel fungicide molecules and for isolating genes coding for proteins controlling biochemical functions essential to the pathogenesis of the fungus Magnaporthe grisea with respect to rice and barley. The invention further concerns compounds inhibiting pathogenesis of fungi related to the expression of gene 763.

Abstract: The invention relates to a method of finding compounds which increase the tolerance of plants to abiotic stress factors acting on this plant, such as, for example, temperature (such as chill, frost or heat), water (such as dryness, drought or anoxia), or the chemical load (such as lack of or excess of mineral salts, heavy metals, gaseous noxious substances) by increasing the expression of plant-endogenous proteins, and to the use of these compounds for increasing the tolerance in plants to abiotic stress factors.

Abstract: The present invention is directed to polyols prepared in the presence of double metal cyanide catalysts (“DMC”) which are prepared by combining i) at least one metal salt; ii) at least one metal cyanide salt; iii) at least one organic complexing ligand; iv) at least one alkali metal salt; and, optionally, v) at least one functionalized polymer under conditions sufficient to form a catalyst; and adding a sufficient amount of the at least one alkali metal salt to the catalyst so formed in an amount such that the catalyst includes the at least one alkali metal salt in an amount of from about 0.4 to about 6 wt. % based on the total weight of the catalyst. The polyols produced by the process of the present invention have reduced levels of high molecular weight tail.

Abstract: The present invention relates to an improved isocyanate reactive mixture containing at least one DMC-catalyzed polyol and about 0.25 to about 15 wt. %, based on the total weight of the isocyanate-reactive mixture, of at least one ethylene oxide (EO) containing water compatibilizer. The isocyanate reactive mixtures of the present invention may find use in the preparation of polyurethane foams, coatings, elastomers, sealants, adhesives and the like.

Abstract: A thermoplastic molding composition containing talc is disclosed. The composition wherein talc has a median particle size of less than 1000 nm further contains a polycarbonate and/or polyester-carbonate, and a graft polymer having as graft base a rubber having a glass transition temperature of below about 10° C. is suitable for preparing molded articles having improved mechanical properties, such as weld line strength, elongation at break and toughness at low temperatures.

Abstract: The present invention relates to a data processing system and method for seamlessly integrating laboratory information management system (LIMS) functionalities into an enterprise resource planning (ERP) system. The invention enables to keep the additional complexity that is required for the provision of LIMS functionalities at a minimum as all laboratory instrumentation setup information is centrally stored in a server computer but not in the ERP system.

Abstract: The invention relates to compounds of the formulae