Abstract: The present invention relates to a drug delivery device defining a reservoir for containing a product, having a distal end comprising an end-piece defining a channel for the transfer of the product from the reservoir, said drug delivery device comprising means for coupling said end-piece with a connector, said coupling means comprising a collar defined around a portion of the end-piece and extending from the distal end, said coupling means comprising connection means connectable to said collar, said connection means comprising a tubular wall portion having an interface defined thereon for engagement with an internal face of said collar, and a retaining hook having engagement means engageable with at least part of an external face of said collar when said connection means is connected to said collar.

Abstract: A device is presented for injection of a product into an injection site, comprising: a container provided with a needle, a housing receiving the container, and a needle shield releasably coupled with the container. The device also includes a retaining arrangement provided at or near the distal end of the device, designed for preventing the container from moving distally with respect to the housing until the needle shield is removed from the container.

Abstract: This connection assembly includes a tip defining a longitudinal axis and including a mounting area for mounting an adaptor thereon, and the adaptor including a mounting portion of thermoplastic material, forming a radial surface, which define a mounting opening for mounting the adaptor onto the tip. The mounting area includes at least one first portion having an outer surface which is located at a first distance from the longitudinal axis (A) and at least one second portion, adjacent to the first portion, having an outer surface which is located at a second distance from the longitudinal axis, the second distance being different from the first distance, the radial surface being located after assembly of the adaptor over the first portion and the second portion; The mounting opening and the at least one first portion and second portion are so dimensioned such that the radial surface of the mounting portion is in close contact with the outer surfaces of both the first portion and the second portion.

Abstract: The present invention relates to an injection device (1) comprising:—a body (3) designed to receive a product to be injected, furnished at its distal end with an injection needle (7) and receiving a piston (5) capable of being moved between a storage position and an end-of-injection position under the effect of a distal pressure exerted on a piston rod (8) to the distal end of which it is attached,—means of protecting the injection needle (7) capable of adopting an initial position, during which the injection needle (7) is uncovered, and a final position, in which the said injection needle (7) is covered,—biasing means (26) aiming at moving the said covering element (6) from its initial position to its final position,—immobilization means (16, 31) aiming at keeping the said covering element (6) in its initial position, the said injection device (1) being characterized in that:—the said piston rod (8) comprises at least a first portion (9) and at least one second portion (10) coupled to the said piston (8), th

Abstract: Described herein are pharmaceutical packaging systems which prevent oxidative degradation of oxygen-sensitive drugs, such systems including a primary packaging container with an oxygen permeable component, a secondary packaging with very low permeability to oxygen and an oxygen absorber.

Abstract: Provided herein, generally, are pharmaceutical formulations, e.g., injectable pharmaceutical formulations with improved stability, comprising morphine sulfate or a hydrate thereof, and methods of producing and using the same. Also provided herein are kits comprising the formulations, e.g., injectable morphine formulations.

Abstract: The present invention relates to an injection assistance device including a body with a needle, grasping arrangement and first elastic return arrangement to dampen limited movement of the grasping arrangement, in at least one of the two directions, respectively distal or proximal, during an injection phase, and to maintain the body in its insertion position and the needle at a constant insertion length during the injection step, when the user increases, respectively releases, a distal pressure on the grasping arrangement. The invention also relates to an injection set including an injection device and the assistance device.

Abstract: The invention relates to a device (1) for automatic injection of a product into an injection site, said device (1) further comprising a needle (6) and a needle shield (2) for protection of said needle (6) prior to use of said device, and a housing (300) receiving the container (50) and a deshielder (8) for removing said needle shield (2) from said device (1), said deshielder (8) being coupled to said needle shield (2) and being mounted on the housing (300) in a separable manner, for example through breakable or snap-fit means, said deshielder (8) comprising tamper evidence means that are activated by the removal of at least one part of said deshielder (8). Said at least one part of said deshielder (8) can be removed from the housing (300) by exerting a traction force equal or less to 30 N.

Abstract: Medical devices comprising a syringe barrel and a two-piece plunger rod are provided. According to one or more embodiments, the two-piece plunger rod includes a distal portion and proximal portion slidably mounted to the distal portion. The distal and proximal portions include a tab and plurality of grooves which engage to adjust the overall length of the plunger rod to a plurality of locked lengths. The locked lengths of the plunger rod permit varying amount of fluid to be expelled from the barrel.

Abstract: The invention relates to the use of plasma treated silicone oil as a coating in a medical injection device (1) comprising a barrel (2) and a stopper (3) in gliding engagement within the barrel, for limiting the number of particles present on the surface of the coating and for limiting the number of particles released in a pharmaceutical composition contained in the injection device.

Abstract: A container containing a therapeutic protein, characterized in that chaperones molecules are bound by a molecular linker to an inner surface of the container. The linker being interposed between the surface and the chaperone.

Abstract: A device is provided for automatic injection of a product comprising a container, a needle and a piston. The device includes a housing receiving the container, the container being movable with respect to the housing between an initial position and an insertion position, distally spaced relative to the initial position; a safety shield coupled to the housing and movable with respect thereto between a rest position, an activation position, proximally spaced relative to the rest position, and a safety position; biasing feature for causing the movement of the safety shield to the safety position; triggering feature for causing the container to move from its initial position to its insertion position, the triggering feature being releasable by movement of the safety shield to the activation position; and, isolating feature for isolating the safety shield from the biasing feature when the safety shield is moved to its activation position.

Abstract: This packaging includes a grouping nest, a first tub, and a sealing cover. Lateral walls of the first tub are sloped to allow a nesting of this first tub in a second identical tub; the first tub includes recesses on the outer side of the tub forming tub and/or nest supporting pillars on the inner side of each wall, and having a tub and/or nest supporting surface opposite the bottom of the tub. The positioning of the recess forming a tub supporting pillar on one opposed lateral wall is different from the positioning of the recess forming a tub supporting pillar on the other opposed lateral wall allowing nesting of this first tub into a second identical tub in a first relative position of the first tub, while allowing the stacking of said first and second tubs one onto the other in a second relative position of the first tub.

Abstract: Provided is a drug delivery device including: a reservoir for a product, having a distally projecting end-piece defining an axial passageway for the transfer of the product, with a distal portion, an adaptor having a collar engageable around said end-piece said collar being axially movable with respect to said end-piece, securing structure for limiting the axial movement of said collar with respect to said end-piece, between a most distal position and a most proximal position of said collar, and biasing element for urging said collar towards its most distal position. An adaptor for forming a drug delivery device is also provided.

Abstract: Provided herein is a drug delivery device including: a reservoir for a product, said reservoir having a distally projecting end-piece defining an axial passageway for the transfer of the product, said end-piece having a distal portion, an adaptor having a collar engageable around said end-piece, and a securing structure for locking the axial movement of said collar with respect to said end-piece. The adaptor further comprises a foldable element capable of going from a folded configuration in which said foldable element substantially surrounds said distal portion of said end-piece, to an unfolded configuration, in which said foldable element leaves said distal portion uncovered. An adaptor for forming a drug delivery device is also provided.

Abstract: The present invention relates to an injection device comprising: a body receiving a product, having a needle and a piston attached to a piston rod movable between a storage position and an end-of-injection position, a sleeve for protecting the needle, movable between an initial position, where the needle is uncovered, and a final position, where the needle is covered, biasing means for moving said sleeve from its initial position to its final position, immobilization means for keeping said sleeve in its initial position, characterized in that: said piston rod comprises a first portion and a second portion, said second portion being able to switch between a locked position, in which said second portion is fixed to said first portion and an unlocked position, in which said second portion is movable with respect to said first portion on a predetermined distance along the longitudinal axis of said piston rod.

Abstract: The invention relates to an automatic injection device including a container provided with a needle; a housing receiving a container movable relative to the housing between an initial position to an insertion position; a needle shield for receiving the needle and in which the needle is embedded prior to use of the device; and a deshielder coupled to the needle shield by a first connecting arrangement and removably assembled to the distal part of the housing by a second connecting arrangement. The first and second connecting arrangements are designed so that a rotational movement of the deshielder about the device axis of the device with respect to the housing causes an axial displacement of the needle shield in the distal direction with substantially no rotational movement of the needle shield with respect to the needle.

Abstract: The present invention relates to a device for automatic injection of a product comprising a container, a needle and a piston. The device includes a housing receiving the container, the container being movable with respect to the housing between an initial position and an insertion position, distally spaced relative to the initial position; a safety shield coupled to the housing and movable with respect thereto between a rest position, an activation position, proximally spaced relative to the rest position, and a safety position, distally spaced with respect to the rest position; biasing feature for causing the movement of the safety shield to the safety position; triggering feature for causing the container to move from its initial position to its insertion position, the triggering feature being releasable by movement of the safety shield to the activation position; and, isolating feature for isolating the safety shield from the biasing feature when the safety shield is moved to its activation position.