Abstract: Provided herein is a drug delivery device including: a reservoir for a product, said reservoir having a distally projecting end-piece defining an axial passageway for the transfer of the product, said end-piece having a distal portion, an adaptor having a collar engageable around said end-piece, and a securing structure for locking the axial movement of said collar with respect to said end-piece. The adaptor further comprises a foldable element capable of going from a folded configuration in which said foldable element substantially surrounds said distal portion of said end-piece, to an unfolded configuration, in which said foldable element leaves said distal portion uncovered. An adaptor for forming a drug delivery device is also provided.

Abstract: A syringe assembly includes a syringe barrel having an exterior surface, an inside surface defining a chamber, an open proximal end, a distal end, and an outlet disposed adjacent the distal end in fluid communication with the chamber; and a plunger assembly disposed at least partially within the syringe barrel. The plunger assembly includes an elongated plunger rod and a plunger head. The elongated plunger rod is associated with the plunger head to move the plunger head within the chamber of the syringe barrel through an injection cycle. The plunger rod is adapted to move from a collapsed position extending alongside the exterior surface of the syringe barrel to an extended position engaging the plunger head to move the plunger head through the injection cycle.

Abstract: A syringe assembly including a plunger rod having a first end, a second end, and a rod portion extending therebetween, wherein at least a portion of the rod portion is flexible is disclosed. The flexible portion of the rod portion allows a stopper to be moved between a first position and a second position within a syringe barrel while the overall length of the syringe assembly remains the same throughout the movement between the first position and the second position. In another embodiment, a syringe assembly including a restraining member adapted to communicate with the flexible portion of the rod portion such that movement of the first end of the plunger rod in a first direction actuates movement of the second end of the plunger rod in a second direction different than the first direction is disclosed.

Abstract: The present invention relates to a sealing device for a container having an opening and an outer projection, including: a septum for closing said opening, a cap having a retainer capable of switching from a first position, in which the retainer does not limit the axial movement of said cap with respect to said container, to a second position, in which the retainer limits the axial movement of the cap, and a sleeve receiving said cap and movable axially with respect to said cap between a distal position, in which said sleeve does not exert a radial inward force on said retainer, and a proximal position, in which said sleeve exerts a radial inward force on said retainer. The sleeve includes a guiding element capable of cooperating directly or indirectly with said outer projection, so as to limit rotation of said sleeve.

Abstract: The invention relates to a protection device for a needle of an assembly or of an injection device having a hub portion provided with a needle, the said protection device comprising: an outer casing formed of a first material; and an inner casing formed of a second material different from the said first material and defining a cavity for receiving in a sealing way at least the hub portion, said cavity having an inner wall; attachment means defined in the said cavity to removably engage and secure said protection device at least along a sealing line to the injection device; the protection device being characterized in that it further comprises aspiration limiting means for limiting the deformation of said cavity when said protection device is separated from the assembly or the injection device.

Abstract: The present invention relates to a needle assembly (1) to be used in combination with a storing device (200) comprising a barrel (8) defining a chamber (9) receiving a product (4) and a piston (2), the assembly (1) comprising: —needle-bearing portion (7) in a first material, movable between an exposed and a retracted positions of the needle (5), —engaging means (8a, 10, 11, 18,) for securing said needle-bearing portion (7) to said barrel (8) in the exposed position, characterized in that it comprises: —sealing means (15) in a second material for tightly sealing the distal end (9a) of said chamber (9) to said needle-bearing portion (7), —a breakable portion (7a) located between said engaging means (8a, 10, 11, 18,) and said needle-bearing portion (7), which, when broken, allows independent proximal displacement of said needle-bearing portion (7) relative to said engaging means (8a, 10, 11, 18,) between said exposed and said retracted positions, said first material being more rigid than said second material.

Abstract: Described herein are pharmaceutical packaging systems which prevent oxidative degradation of morphine, hydromorphone, promethazine and other oxygen-sensitive drugs, such systems including a syringe with an oxygen permeable tip cap, a hermetically sealed oxygen barrier blister packaging with very low permeability to oxygen and comprises ethylene vinyl, and an oxygen absorber.

Abstract: The invention relates to an automatic injection device including a container provided with a needle; a housing receiving a container movable relative to the housing between an initial position to an insertion position; a needle shield for receiving the needle and in which the needle is embedded prior to use of the device; and a deshielder coupled to the needle shield by a first connecting arrangement and removably assembled to the distal part of the housing by a second connecting arrangement. The first and second connecting arrangements are designed so that a rotational movement of the deshielder about the device axis of the device with respect to the housing causes an axial displacement of the needle shield in the distal direction with substantially no rotational movement of the needle shield with respect to the needle.

Abstract: A device is provided for automatic injection of a product comprising a container, a needle and a piston. The device includes a housing receiving the container, the container being movable with respect to the housing between an initial position and an insertion position, distally spaced relative to the initial position; a safety shield coupled to the housing and movable with respect thereto between a rest position, an activation position, proximally spaced relative to the rest position, and a safety position; biasing feature for causing the movement of the safety shield to the safety position; triggering feature for causing the container to move from its initial position to its insertion position, the triggering feature being releasable by movement of the safety shield to the activation position; and, isolating feature for isolating the safety shield from the biasing feature when the safety shield is moved to its activation position.

Abstract: Provided herein, generally, are pharmaceutical formulations, e.g., injectable pharmaceutical formulations with improved stability, comprising morphine sulfate or a hydrate thereof, and methods of producing and using the same. Also provided herein are kits comprising the formulations, e.g., injectable morphine formulations.

Abstract: The invention relates to a lubricant coating for a medical container comprising a cross-linked lubricant composition comprising a mixture of non-reactive silicone with reactive silicone, characterized in that the reactive silicone comprises a mixture of vinyl-based silicone and acrylate-based silicone. The invention further relates to a lubricant composition usable as an intermediate product in the fabrication of a lubricant coating. The invention further relates to a medical container comprising a barrel and a stopper in gliding engagement within the barrel, comprising such a lubricant coating. The invention also relates to a process of manufacturing a medical container comprising a barrel and a stopper in gliding engagement within the barrel including depositing a lubricant composition on the inner surface of the barrel and/or on the stopper, and irradiating the coated barrel and/or stopper so as to cross-link the lubricant composition to form a lubricant coating.

Abstract: The invention relates to a device for inspecting the surface of an article having an edge with an end face, said device including: a support for supporting said article, a light source capable of emitting a light in a direction D, and a filter for stopping part of the light of said light source which is emitted or diffused out of direction D, said filter being provided with a hole intended to receive said article when said article is provided on said support, said support being positioned with respect to said light source and said filter so that, when said article is provided on said support, the end face of said edge is substantially perpendicular to said direction D. The invention also relates to a kit comprising such a device and to a method for inspecting the surface of the article.

Abstract: A syringe assembly having an exterior surface and defining a chamber having a stopper disposed therein is disclosed. The syringe assembly includes a plunger assembly having an elongated plunger rod and a handle portion connected thereto, the plunger rod including a depending leg and at least one hinge connecting the depending leg with the handle portion. The plunger rod is adapted to transition from a collapsed position, in which at least a portion of the depending leg extends along at least a portion of the exterior surface of a syringe barrel, to an extended position in which at least a portion of the depending leg engages the stopper. The at least one hinge maintains the depending leg substantially parallel to a longitudinal axis of the syringe barrel in both the collapsed position and the extended position.

Abstract: The present invention relates to a prefillable drug delivery device having a housing receiving a needle hub which is movable with respect to said needle hub between a retracted position and a protection position. The device also includes a tubular barrel intended to receive a drug that is pre-mountable on said housing so that said needle hub closes its distal end. The device further includes a sealing member actionable once said tubular barrel is pre-assembled on said housing, capable of transitioning from an inactive state where no sealing contact is present between said needle hub and said tubular barrel, to an active state, in which sealing contact is performed. In the active state of said sealing member, said tubular barrel is movable in translation with respect to said needle hub between a proximal position and a distal position, for realizing delivery of the drug.

Abstract: A piston rod for an injection device, including first and second legs, each leg being foldable on itself and including a proximal region. The piston rod is capable of transitioning from a folded position to an unfolded position, and includes a mechanism for coupling the proximal regions of the legs when the piston rod is in the unfolded position. The invention also relates to a kit which includes the piston rod.

Abstract: This packaging includes a grouping nest, a first tub, and a sealing cover. Lateral walls of the first tub are sloped to allow a nesting of this first tub in a second identical tub; the first tub includes recesses on the outer side of the tub forming tub and/or nest supporting pillars on the inner side of each wall, and having a tub and/or nest supporting surface opposite the bottom of the tub. The positioning of the recess forming a tub supporting pillar on one opposed lateral wall is different from the positioning of the recess forming a tub supporting pillar on the other opposed lateral wall allowing nesting of this first tub into a second identical tub in a first relative position of the first tub, while allowing the stacking of said first and second tubs one onto the other in a second relative position of the first tub.