Abstract: This packaging includes a grouping nest, a first tub, and a sealing cover. Lateral walls of the first tub are sloped to allow a nesting of this first tub in a second identical tub; the first tub includes recesses on the outer side of the tub forming tub and/or nest supporting pillars on the inner side of each wall, and having a tub and/or nest supporting surface opposite the bottom of the tub. The positioning of the recess forming a tub supporting pillar on one opposed lateral wall is different from the positioning of the recess forming a tub supporting pillar on the other opposed lateral wall allowing nesting of this first tub into a second identical tub in a first relative position of the first tub, while allowing the stacking of said first and second tubs one onto the other in a second relative position of the first tub.

Abstract: A syringe assembly includes a syringe barrel having a first end, a second end, and a sidewall extending between the first end and the second end. The syringe assembly further includes a stopper disposed within a chamber of the syringe barrel, a plunger adapter engaged with the stopper and defining a recessed portion therein, and first and second plunger arms each having a first end pivotally secured to the plunger adapter. The first and second plunger arms each have a pre-use position where the plunger arms are spaced from each other, and a use position where the plunger arms are positioned adjacent to each other and configured to displace the stopper relative to the syringe barrel. The recessed portion of the plunger adapter receives a portion of a first end of a plunger rod when the first and second plunger arms are in the pre-use position and the use position.

Abstract: A syringe assembly includes a syringe barrel having a first end, a second end, and a sidewall extending between the first end and the second end. The syringe assembly further includes a stopper disposed within a chamber of the syringe barrel, a plunger adapter engaged with the stopper, and a plunger rod having first and second ends. The first end of the plunger rod is pivotally secured to the plunger adapter. The plunger rod has a pre-use position where the second end of the plunger rod is positioned adjacent to the syringe barrel, and a use position where the plunger rod is configured to displace the stopper relative to the syringe barrel. A recessed portion of the plunger adapter receives a portion of the first end of the plunger rod when the plunger rod is in the pre-use position and the use position.

Abstract: Provided herein, generally, are pharmaceutical formulations, e.g., injectable pharmaceutical formulations with improved stability, comprising morphine sulfate or a hydrate thereof, and methods of producing and using the same. Also provided herein are kits comprising the formulations, e.g., injectable morphine formulations.

Abstract: The present invention relates to a device for automatic injection of a product into an injection site, the device comprising: a container having a displaceable piston; a tubular housing having at least a flexible part which, in a rest state, defines a first opening; a piston rod; and, an intermediate part fixed to the piston rod which defines a diameter larger than the first opening. With sufficient distal displacement of the piston rod, the intermediate part causes the at least a flexible part to deflect outwardly with further distal displacement of the piston rod causing the intermediate part to wholly pass through the first opening with the at least a flexible part returning towards the at rest state, engagement of the at least a flexible part with a surrounding element under force of movement towards the at rest state generating a sound.

Abstract: The invention relates to a drug delivery device comprising a container for a product, said container comprising a distal tip having a longitudinal axis A and a channel providing a passageway for the transfer of said product, the outer surface of said distal tip comprising a proximal portion and a distal portion linked to each other by a coupling portion, said proximal portion, distal portion and coupling portion being aligned on said longitudinal axis A, wherein the greatest external diameter of said coupling portion is greater than the greatest external diameter of said distal portion on a length L measured along said longitudinal axis A at least equal to 1 mm. The invention also relates to an assembly comprising such a drug delivery device and an adaptor.

Abstract: The invention relates to a sleeve for an injection device comprising a container having an outer flange, said sleeve being provided with one inner radial projection intended to prevent the proximal movement of said outer flange with respect to said sleeve once said container is received within said sleeve, said sleeve being further provided with one inner longitudinal projection extending distally from said inner radial projection and intended to limit the radial movement of said outer flange, said inner radial projection and inner longitudinal projection being provided on a longitudinal leg connected to said sleeve by a deformable bridge allowing radial deflection of said longitudinal leg outwardly when a distal pressure is exerted on said inner radial projection, and inwardly when a proximal pressure is exerted on said inner radial projection. The invention also pertains to an injection device comprising such a sleeve.

Abstract: The present invention relates to a device for automatic injection including a container, a piston and a piston rod coupled to the piston during the injection. A biasing element is provided for causing distal movement of the piston rod with respect to the container, with a housing receiving the container, the piston rod and the biasing element. The device further including a controlling arrangement for producing an audible indicator at the end of injection.

Abstract: The present invention relates to a shield (10) for the distal extremity of an administration device (3) comprising a hub (2) on which said shield (10) is to be removably engaged, said shield (10) having a wall (13) the internal face (14) of which defining an interior cavity (15) for receiving the extremity of the administration device (3), at least a portion (14a) of said internal face (14) being intended to be in contact with said hub (2) when said shield (10) is engaged on the extremity of said administration device (3), whereby said portion (14a) has, distributed over a major portion of said portion (14a), a surface feature (16, 17) that defines the amount of contact between said portion (14a) and said hub (2).

Abstract: The application relates to a needle protection assembly (1) comprising:—a supporting element (18) and a needle shield (8),—one locking element (20) located within said needle protection assembly (1) and not accessible to the user,—urging means (24) for displacing said needle shield (8),—a peg (19) located on said supporting element (18) or on said needle shield (8), and a cam (9) located on said needle shield (8) or on said supporting element (18), and—said locking element (20) is not formed by said peg (19) and cam (9). The respective longitudinal axis of the needle shield (8) and of the locking element (20) are merged when said needle shield (8) is in its before use or in use positions, and they form an angle (a) when said needle shield (8) is in its after use position.

Abstract: A packaging including a grouping nest for receiving syringes, a packaging tub, and a sealing cover for sealing the packaging tub. The packaging includes a plate intended to be positioned close to the flanges of the syringes before sealing of the tub; this plate includes a plurality of first surfaces intended to be placed in contact with the flanges and a plurality of second surfaces located on the side of the cover plate opposite this plurality of first surfaces, the distance between the plurality of first surfaces and the plurality of second surfaces being chosen in such a way that, when the plurality of first surfaces lies against the flanges, the plurality of second surfaces is in contact or in close proximity to the sealing cover.

Abstract: The present invention pertains to a stackable packaging unit (1) for the packaging of products (100), the said packaging unit (1) comprising at least one encircling wall (2) provided at least with a corner ridge (3) dividing it into at least two retaining panels (2a) Partially folded down towards one another about the said corner ridge (3) so as to hold the said products (100) to be packaged, at least one end of the said corner ridge (3) being connected to the corresponding edges of the said retaining panels (2a) by at least one inclined centring profile. The stackable packaging unit (1) also comprises an intermediate element. The invention also pertains to a packaging comprising at least one such packaging unit (1).

Abstract: Provided herein is a tray for holding medical containers, including a plurality of elongated parallel cavities that are intended to receive at least one container. Each of said cavities includes a first set of contact surfaces for holding said at least one container, and each of said cavities includes a second set of contact surfaces for holding said at least one container when provided with a cap. The first set of contact surfaces and the second set of contact surfaces are arranged such that said at least one capped container is held in the cavity in a reverse orientation with respect to said at least one container when provided without a cap. A packaging for medial containers and a method for packaging medical containers are also provided herein.

Abstract: The present invention relates to a container comprising: a body; a pusher movable with respect to the body between an initial position and an end-of-use position; a locker located on the pusher and forming an abutment so as to be able to abut against the body between the initial position and the end-of-use position, wherein, the abutment abuts against the body to limit distal movement of the pusher relative to the body to a pusher locking position located between the initial position and the end-of-use position; a locking arrangement capable of, temporarily, locking the locker on the pusher so as to define a locker locking position of the locker on the pusher, the locker locking position establishing the position of the abutment relative to the pusher so as to set the pusher locking position; and, an unlocking arrangement designed so that, with triggering, the locking arrangement is released so as to allow the locker to be displaced relative to the pusher and for the pusher to be moved past the pusher locking

Abstract: A device comprising a body, a sleeve mobile in relation to the body, and a lock enabling locking of the sleeve in a protective position; the sleeve can be moved between a non-protective position, in which an injection member is exposed, and the protective position; the lock comprising at least one flexible proximal leg. According to the invention, the at least one leg comprises at least one bearing surface and the device comprises at least one corresponding bearing surface, these respective bearing surfaces being able to bear against each other when a stress is exerted on the sleeve in a direction tending to return the sleeve toward the non-protective position.

Abstract: The present invention relates to a plunger rod for an injection device, having a distal element slidingly coupled to a proximal element having at least one radially flexible branch. The plunger rod includes a lock for selectively locking the distal element and the proximal element in a plurality of relative axial positions defining a plurality of intermediate positions of the plunger rod, wherein the lock is movable from a locked state, in which the distal element and the proximal element are fixed with respect to each other in the axial direction, and an unlocked state, in which the distal element and the proximal element are displaceable in the axial direction with respect to each other, when the at least one radially flexible branch is displaced radially. The invention also relates to an injection device having such a plunger rod.

Abstract: A syringe assembly includes a syringe barrel defining a chamber, a stopper disposed within the chamber, and a plunger assembly. The plunger assembly includes an elongated plunger rod, a housing, and a handle portion connecting the plunger rod and housing. The plunger assembly transitions from a first position disposed about the syringe barrel, to a second position with the plunger rod engaged with the stopper. Transition of the plunger assembly includes rotational engagement of the plunger rod and stopper.